| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikhail Matveyenka, Abid Ali, Charles L Mitchell, Harris C Brown, Dmitry Kurousk. Cholesterol Accelerates Aggregation of α-Synuclein Simultaneously Increasing the Toxicity of Amyloid Fibrils. ACS chemical neuroscience. 2024-10-29. PMID:39469734. |
a hallmark of parkinson disease (pd) is a progressive degeneration of neurons in the substantia nigra pars compacta, hypothalamus, and thalamus. |
2024-10-29 |
2024-10-31 |
Not clear |
| Kiryl Zhaliazka, Abid Ali, Dmitry Kurousk. Phospholipids and Cholesterol Determine Molecular Mechanisms of Cytotoxicity of α-Synuclein Oligomers and Fibrils. ACS chemical neuroscience. 2024-01-03. PMID:38166409. |
progressive loss of dopaminergic (da) neurons in the substantia nigra pars compacta, hypothalamus, and thalamus is a hallmark of parkinson's disease. |
2024-01-03 |
2024-01-10 |
rat |
| Yang Ruan, Kai-Yuan Li, Ran Zheng, Yi-Qun Yan, Zhong-Xuan Wang, Ying Chen, Yi Liu, Jun Tian, Li-Ya Zhu, Hui-Fang Lou, Yan-Qin Yu, Jia-Li Pu, Bao-Rong Zhan. Cholinergic neurons in the pedunculopontine nucleus guide reversal learning by signaling the changing reward contingency. Cell reports. vol 38. issue 9. 2022-03-02. PMID:35235804. |
activation of ppn cns projecting to the substantia nigra pars compacta, mediodorsal thalamus, and parafascicular nucleus in a time-locked manner with reward improves reversal learning. |
2022-03-02 |
2023-08-13 |
Not clear |
| Isobel T French, Kalai A Muthusam. A Review of the Pedunculopontine Nucleus in Parkinson's Disease. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29755338. |
the human ppn is divided into two subnuclei, the pars compacta (ppnc) and pars dissipatus (ppnd), and constitutes both cholinergic and non-cholinergic neurons with afferent and efferent projections to the cerebral cortex, thalamus, basal ganglia (bg), cerebellum, and spinal cord. |
2020-10-01 |
2023-08-13 |
human |
| Wim Mandemakers, An Snellinx, Michael J O'Neill, Bart de Stroope. LRRK2 expression is enriched in the striosomal compartment of mouse striatum. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22850484. |
cortex, thalamus, hippocampus, cerebellum), strongest expression is detected in striatum, whereas lrrk2 protein expression in substantia nigra pars compacta in contrast is low. |
2013-04-30 |
2023-08-12 |
mouse |
| D Nandi, N Jenkinson, J Stein, T Azi. The pedunculopontine nucleus in Parkinson's disease: primate studies. British journal of neurosurgery. vol 22 Suppl 1. 2009-05-01. PMID:19085345. |
the major inhibitory input is from the gpi and substantia nigra reticulata (snr), and bilateral output is to the substantia nigra compacta (snc), thalamus and spinal cord. |
2009-05-01 |
2023-08-12 |
rat |
| Philip Win. How best to consider the structure and function of the pedunculopontine tegmental nucleus: evidence from animal studies. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16765383. |
similarly, the pptg contains the ch5 acetylcholine containing neurons that project to the thalamus and corticostriatal systems (notably the pars compacta of substantia nigra and the subthalamic nucleus) while the non-cholinergic neurons of the pedunculopontine are in receipt of corticostriatal output. |
2007-01-23 |
2023-08-12 |
Not clear |
| Clifford M Knapp, Bella Printseva, Nicole Cottam, Conan Kornetsk. Effects of cue exposure on brain glucose utilization 8 days after repeated cocaine administration. Brain research. vol 950. issue 1-2. 2002-12-23. PMID:12231235. |
regions in which there were significant changes in the conditioned group included the basolateral amygdala, subiculum, medial thalamus, lateral habenula and the substantia nigra pars compacta. |
2002-12-23 |
2023-08-12 |
rat |
| Y Friedman, A Richter, R Raymond, W Löscher, J N Nobreg. Regional decreases in NK-3, but not NK-1 tachykinin receptor binding in dystonic hamster (dt(sz)) brains. Neuroscience. vol 112. issue 3. 2002-09-06. PMID:12074905. |
in contrast, nk-3 binding was significantly reduced in layers 4 and 5 of the prefrontal (-46%), anterior cingulate (-42%) and parietal (-45%) cortices, ventromedial thalamus (-42%) and substantia nigra pars compacta (-36%) in dystonic brains compared to controls. |
2002-09-06 |
2023-08-12 |
Not clear |
| Warren H Meck, Aimee M Benso. Dissecting the brain's internal clock: how frontal-striatal circuitry keeps time and shifts attention. Brain and cognition. vol 48. issue 1. 2002-04-16. PMID:11812042. |
it is concluded that prefrontal cortex, substantia nigra pars compacta, pedunculopontine nucleus, and the direct and indirect pathways from the caudate to the thalamus may provide the neuroanatomical and neurophysiological substrates that underlie the organism's ability to shift its attention from one temporal context to another. |
2002-04-16 |
2023-08-12 |
Not clear |
| P A Pahapill, A M Lozan. The pedunculopontine nucleus and Parkinson's disease. Brain : a journal of neurology. vol 123 ( Pt 9). 2000-09-28. PMID:10960043. |
the other component of the ppn, the cholinergic pars compacta (ppnc), is a principal component in a feedback loop from the spinal cord and limbic system back into the basal ganglia and thalamus. |
2000-09-28 |
2023-08-12 |
monkey |
| T Hida, Y Hasegawa, R Ara. Histochemical study of dopamine-degrading monoamine oxidase activity in dopaminergic neurons of rat brain. Brain research. vol 842. issue 2. 1999-12-21. PMID:10526149. |
the following dopaminergic cell groups were examined: a16 (glomerular layer of the olfactory bulb), a14 (hypothalamic periventricular region), a13 (zona incerta), a12 (arcuate nucleus), a11 (periventricular gray matter of the caudal thalamus), a10 (ventral tegmental area), a9 (substantia nigra pars compacta, snc) and a8 (retrorubral nucleus). |
1999-12-21 |
2023-08-12 |
rat |
| P N Anderson, G Campbell, Y Zhang, A R Lieberma. Cellular and molecular correlates of the regeneration of adult mammalian CNS axons into peripheral nerve grafts. Progress in brain research. vol 117. 1999-03-11. PMID:9932411. |
most of the axons which grow into grafts in the thalamus are derived from the thalamic reticular nucleus (trn), whereas grafts in the striatum promote regeneration of axons from the substantia nigra pars compacta (snpc) and grafts in the cerebellum promote regeneration from deep cerebellar nuclei (dcn) and brainstem precerebellar neurons. |
1999-03-11 |
2023-08-12 |
Not clear |
| E J Mufson, J S Kroin, Y T Liu, T Sobreviela, R D Penn, J A Miller, J H Kordowe. Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: distribution, retrograde transport and co-localization with substantia nigra dopamine-containing neurons. Neuroscience. vol 71. issue 1. 1996-11-27. PMID:8834401. |
in this case, retrogradely labelled brain-derived neurotrophic factor neurons were found within the parafascicular thalamus and substantia nigra, pars compacta, as well as within cortex, vertical limb of the diagonal band and nucleus basalis. |
1996-11-27 |
2023-08-12 |
monkey |
| J Court, F Clement. Distribution of nicotinic subtypes in human brain. Alzheimer disease and associated disorders. vol 9 Suppl 2. 1996-02-07. PMID:8534425. |
nicotine binding is high in the thalamus, striatum, and substantia nigra pars compacta, and although not generally high in the hippocampal formation, it is concentrated in the entorhinal cortex, the subicular complex, and the stratum lacunosum moleculare. |
1996-02-07 |
2023-08-12 |
human |
| O Vilela Filh. Thalamic ventrobasal stimulation for pain relief. Probable mechanisms, pathways and neurotransmitters. Arquivos de neuro-psiquiatria. vol 52. issue 4. 1995-08-16. PMID:7611957. |
the substantia nigra reticulata sends inhibitory gabaergic projections to the medial thalamus (nigrothalamic pathway) and excites the substantia nigra compacta. |
1995-08-16 |
2023-08-12 |
Not clear |
| G Percheron, J Yelnik, C François, G Fénelon, B Talb. [Informational analysis of the basal ganglia related system]. Revue neurologique. vol 150. issue 8-9. 1995-06-22. PMID:7754299. |
distinguishable include regulators of the striatum (the dopaminergic pars compacta and the central complex of the thalamus or centre median-parafascicularis), regulators of the pallidonigrum (the subthalamic nucleus and the pedunculopontine complex) and internal regulators (at first the lateral nucleus of the pallidum). |
1995-06-22 |
2023-08-12 |
Not clear |
| M Fujita, S Shimada, K Fukuchi, M Tohyama, T Nishimur. Distribution of cocaine recognition sites in rat brain: in vitro and ex vivo autoradiography with [125I]RTI-55. Journal of chemical neuroanatomy. vol 7. issue 1-2. 1995-01-31. PMID:7802967. |
further, in the presence of clomipramine, a selective ligand for 5htt, [125i]rti-55 binding was remarkably inhibited in the midline and lateral geniculate nuclei of the thalamus, the hypothalamic nuclei, the superior colliculus, the dorsal raphe nucleus, and the facial nucleus, while [125i]rti-55 binding remained in the olfactory tubercle, the caudate putamen, the accumbens nucleus, the substantia nigra compact part, the subthalamic nucleus, and the ventral tegmental area. |
1995-01-31 |
2023-08-12 |
rat |
| T Araki, M Tohyam. Region-specific expression of GABAA receptor alpha 3 and alpha 4 subunits mRNAs in the rat brain. Brain research. Molecular brain research. vol 12. issue 4. 1992-06-08. PMID:1315904. |
the cerebral cortex, anterior olfactory nucleus, lateral septum, subiculum, lateral and medial nuclei of the amygdaloid complex, anterior nuclei of the thalamus, pars compacta of the substantia nigra, trigeminal sensory nuclei, and cochlear nucleus were some of the areas where strong expression of mrna for both the alpha 3 and alpha 4 subunits was detected. |
1992-06-08 |
2023-08-11 |
rat |
| M L Kemel, M Desban, C Gauchy, J Glowinski, M J Besso. Topographical organization of efferent projections from the cat substantia nigra pars reticulata. Brain research. vol 455. issue 2. 1988-09-22. PMID:2456843. |
both the snr and the sn pars compacta (snc) were labelled when [14c]gaba was injected into the vm nucleus of the thalamus, confirming that the nigro vm projection is gabaergic and showing that recurrent collaterals of these gabaergic cells innervating the snc also contained the transported radioactive material. |
1988-09-22 |
2023-08-11 |
cat |