| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mansour Haidar, Benjamin Schmid, Agustín Ruiz, Andreas Ebneth, Alfredo Cabrera-Socorr. Generation of three isogenic, gene-edited iPSC lines carrying the APOE-Christchurch mutation into the three common APOE variants: APOE2Ch, APOE3Ch and APOE4Ch. Stem cell research. vol 77. 2024-05-04. PMID:38703665. |
late-onset alzheimer's disease (ad) has become the paradigm of a non-mendelian complex neurodegenerative disease, for which a major genetic determinant is known, the apoe locus. |
2024-05-04 |
2024-05-07 |
Not clear |
| Dylan J Finneran, Taylor Desjarlais, Alayna Henry, Brianna M Jackman, Marcia N Gordon, David Morga. Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno-associated virus vectors expressing human P301L tau. Alzheimer's & dementia (New York, N. Y.). vol 10. issue 2. 2024-05-01. PMID:38689599. |
alzheimer's disease (ad) is a progressive neurodegenerative disease in which extracellular aggregates of the amyloid beta (aβ) peptide precede widespread intracellular inclusions of the microtubule-associated protein tau. |
2024-05-01 |
2024-05-03 |
mouse |
| Hyun-Ju Lee, JinHan Nam, Jeong-Woo Hwang, Jin-Hee Park, Yoo Joo Jeong, Ji-Yeong Jang, Su-Jeong Kim, A-Ran Jo, Hyang-Sook Ho. L-DOPA regulates neuroinflammation and Aβ pathology through NEP and ADAM17 in a mouse model of AD. Molecular brain. vol 17. issue 1. 2024-04-30. PMID:38685105. |
dopamine plays important roles in cognitive function and inflammation and therefore is involved in the pathogenesis of neurodegenerative diseases, including alzheimer's disease (ad). |
2024-04-30 |
2024-05-03 |
mouse |
| Anastasiia Nefodova, Mariia Rudyk, Roman Dovhyi, Taisa Dovbynchuk, Nataliia Dzubenko, Ganna Tolstanova, Larysa Skivk. Systemic inflammation in Aβ Brain research. 2024-04-28. PMID:38679313. |
systemic inflammation in aβ alzheimer disease (ad) is the most frequent cause of dementia, and the most common neurodegenerative disease, which is characterized by memory impairment, neuronal death, and synaptic loss in the hippocampus. |
2024-04-28 |
2024-05-01 |
rat |
| Allwin Ebenezer Sahayaraj, Arshad Abdul Vahid, Asmita Dhara, Ann Teres Babu, Vinesh Vijaya. Role of G326 in Determining the Aggregation Propensity of R3 Tau Repeat: Insights from Studies on R1R3 Tau Construct. The journal of physical chemistry. B. 2024-04-27. PMID:38676652. |
the microtubule-binding repeat region (mtbr) of tau has been studied extensively due to its pathological implications in neurodegenerative diseases like alzheimer's disease. |
2024-04-27 |
2024-04-30 |
Not clear |
| Sachin P Patil, Bella R Kueh. Discovery of Small Molecule Glycolytic Stimulants for Enhanced ApoE Lipidation in Alzheimer's Disease Cell Model. Pharmaceuticals (Basel, Switzerland). vol 17. issue 4. 2024-04-27. PMID:38675451. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by pathophysiological deposits of extracellular amyloid beta (aβ) peptides and intracellular neurofibrillary tangles of tau. |
2024-04-27 |
2024-04-29 |
human |
| Faisal A Alzahrani, Yasir M Riza, Thamir M Eid, Reema Almotairi, Lea Scherschinski, Jessica Contreras, Muhammed Nadeem, Sylvia E Perez, Sudhanshu P Raikwar, Ruchira M Jha, Mark C Preul, Andrew F Ducruet, Michael T Lawton, Kanchan Bhatia, Naseem Akhter, Saif Ahma. Exosomes in Vascular/Neurological Disorders and the Road Ahead. Cells. vol 13. issue 8. 2024-04-26. PMID:38667285. |
neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis (als), huntington's disease (hd), stroke, and aneurysms, are characterized by the abnormal accumulation and aggregation of disease-causing proteins in the brain and spinal cord. |
2024-04-26 |
2024-04-28 |
Not clear |
| Ethan D Smith, Robert McKenna, Mario Mietzsch, David R Borchelt, Stefan Prokop, Paramita Chakrabart. Hyperacetylation mimetics within the tau filament core inhibits prion-like propagation of misfolded tau. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659970. |
acetylation of key lysine residues characterizes aggregates of the microtubule-associated protein tau constituting the neuropathological hallmark of many neurodegenerative diseases, such as alzheimer's disease (ad) and progressive supranuclear palsy (psp). |
2024-04-25 |
2024-04-28 |
Not clear |
| Marcel Pérez-Morales, Paola C Bello-Medina, Diego A González-Franco, Sofía Díaz-Cintra, Jaime García-Mena, Gustavo Pacheco-Lópe. STEERING THE MICROBIOTA-GUT-BRAIN AXIS BY ANTIBIOTICS TO MODEL NEURO-IMMUNE-ENDOCRINE DISORDERS. Neuroimmunomodulation. 2024-04-17. PMID:38631302. |
over the last century, animal models have been employed to study the gut-brain axis and its relationship with physiological processes, including those necessary for survival, such as food intake regulation and thermoregulation; those involved in diseases, ranging from inflammation to obesity; and those concerned to the development of neurodegenerative diseases and neuropsychiatric disorders, such as alzheimer's disease and autism spectrum disorder, respectively. |
2024-04-17 |
2024-04-20 |
Not clear |
| Tingjun Dai, Jianwei Lou, Deyuan Kong, Jinyu Li, Qingguo Ren, Yujing Chen, Sujuan Sun, Yan Yun, Xiaohan Sun, Yiru Yang, Kai Shao, Wei Li, Yuying Zhao, Xiangshui Meng, Chuanzhu Yan, Pengfei Lin, Shuangwu Li. Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability. Fluids and barriers of the CNS. vol 21. issue 1. 2024-04-17. PMID:38632611. |
using in vivo neuroimaging techniques, growing evidence has demonstrated that the choroid plexus (cp) volume is enlarged in patients with several neurodegenerative diseases, including alzheimer's disease and parkinson's disease. |
2024-04-17 |
2024-04-20 |
Not clear |
| Akansh Goal, Khadga Raj, Shamsher Singh, Rimpi Aror. Protective effects of Embelin in Benzo[α]pyrene induced cognitive and memory impairment in experimental model of mice. Current research in neurobiology. vol 6. 2024-04-15. PMID:38616958. |
alzheimer's disease (ad) is a neurodegenerative disease that affects the neurons in the hippocampus, resulting in cognitive and memory impairment. |
2024-04-15 |
2024-04-17 |
mouse |
| Michael Anekson Widjaya, Shin-Da Lee, Wei-Chung Cheng, Bor-Tsang W. Effects of Exercise Training on Immune-Related Genes and Pathways in the Cortex of Animal Models of Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease : JAD. 2024-04-05. PMID:38578886. |
alzheimer's disease (ad) is a chronic neurodegenerative disease that affects the immune system due to the accumulation of amyloid-β (aβ) and tau associated molecular pathology and other pathogenic processes. |
2024-04-05 |
2024-04-10 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
neurodegenerative diseases, like alzheimer's, are associated with the presence of neurofibrillary lesions formed by tau protein filaments in the cerebral cortex. |
2024-03-30 |
2024-04-02 |
Not clear |
| Laia Ramos-Casademont, Daniel Martin-Jimenez, Brenda Villarreal-Garza, Serafín Sánchez-Gomez, María Amparo Callejon-Lebli. The Value of Subjective Olfactometry as a Predictive Biomarker of Neurodegenerative Diseases: A Systematic Review. Life (Basel, Switzerland). vol 14. issue 3. 2024-03-28. PMID:38541625. |
olfactory disorders (ods) are reported to be an early non-motor sign before the onset of deterioration in neurodegenerative diseases (nds) such as alzheimer's and parkinson's. |
2024-03-28 |
2024-03-30 |
Not clear |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
alzheimer's disease (ad) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (aβ) aggregates and intraneuronal hyperphosphorylated tau. |
2024-03-22 |
2024-03-24 |
mouse |
| Tabassum Khair Barbhuiya, Dulari K Jayarathna, Raechelle Gilmour, Caroline Smet-Nocca, Neha S Gandh. Characterization of Posttranslationally Modified PHF-1 Tau Peptides Using Gaussian Accelerated Molecular Dynamics Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512658. |
the microtubule-associated protein, tau, is an intrinsically disordered protein that plays a crucial role in neurodegenerative diseases like alzheimer's disease. |
2024-03-21 |
2024-03-24 |
Not clear |
| Yanxian Li. Preparation of Tau Condensates by Liquid-Liquid Phase Separation to Study Tau Amyloid Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512667. |
amyloid aggregation of tau is a hallmark of alzheimer's disease and other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. |
2024-03-21 |
2024-03-24 |
mouse |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
microtubule-associated protein tau is an intracellular protein that self-aggregates into neurofibrillary tangles in alzheimer's disease and many other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |