| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Morteza Sadeghi, Seyedehmasoumeh Seyedebrahimi, Mustafa Ghanadian, Mehran Miroliae. Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: Current research in structural biology. vol 7. 2024-05-06. PMID:38707547. |
identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of alzheimer's disease: nowadays, one of the methods to prevent the progress of alzheimer's disease (ad) is to prescribe compounds that inhibit the acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. |
2024-05-06 |
2024-05-08 |
Not clear |
| Rosa Martha Pérez Gutiérrez, Luis Miguel Rodríguez-Serrano, José Fidel Laguna-Chimal, Mónica de la Luz Corea, Silvia Patricia Paredes Carrera, Julio Téllez Gome. Geniposide and Harpagoside Functionalized Cerium Oxide Nanoparticles as a Potential Neuroprotective. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673848. |
alzheimer's disease is associated with protein aggregation, oxidative stress, and the role of acetylcholinesterase in the pathology of the disease. |
2024-04-27 |
2024-04-29 |
Not clear |
| G A Reid, S Darves. Interaction of Exogenous Acetylcholinesterase and Butyrylcholinesterase with Amyloid-β Plaques in Human Brain Tissue. Chemico-biological interactions. 2024-04-22. PMID:38648920. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are associated with amyloid-β (aβ) plaques and exhibit altered biochemical properties in human alzheimer's disease (ad), as well as in the transgenic 5xfad mouse model of ad amyloidosis. |
2024-04-22 |
2024-04-26 |
mouse |
| Thana Sutthibutpong, Kewalin Posansee, Monrudee Liangruksa, Teerasit Termsaithong, Supanida Piyayotai, Paripok Phitsuwan, Patchreenart Saparpakorn, Supa Hannongbua, Teeraphan Laomettachi. Combining Deep Learning and Structural Modeling to Identify Potential Acetylcholinesterase Inhibitors from ACS omega. vol 9. issue 14. 2024-04-15. PMID:38617639. |
combining deep learning and structural modeling to identify potential acetylcholinesterase inhibitors from alzheimer's disease (ad) is the most common type of dementia, affecting over 50 million people worldwide. |
2024-04-15 |
2024-04-17 |
Not clear |
| Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi, Aida Iraj. Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study. BMC chemistry. vol 18. issue 1. 2024-04-10. PMID:38600537. |
amino-7,8-dihydro-4h-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for alzheimer's disease management; in vitro and in silico study. |
2024-04-10 |
2024-04-13 |
Not clear |
| Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi, Aida Iraj. Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study. BMC chemistry. vol 18. issue 1. 2024-04-10. PMID:38600537. |
in this article, we present the design and synthesis of amino-7,8-dihydro-4h-chromenone derivatives as possible inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) for the management of alzheimer's disease (ad). |
2024-04-10 |
2024-04-13 |
Not clear |
| Francesco Samarelli, Rosa Purgatorio, Gianfranco Lopopolo, Caterina Deruvo, Marco Catto, Michael Andresini, Antonio Carrieri, Orazio Nicolotti, Annalisa De Palma, Daniela Valeria Miniero, Modesto de Candia, Cosimo D Altomar. Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults. European journal of medicinal chemistry. vol 270. 2024-04-05. PMID:38579622. |
due to the putative role of butyrylcholinesterase (bche) in regulation of acetylcholine levels and functions in the late stages of the alzheimer's disease (ad), the potential of selective inhibitors (bcheis) has been envisaged as an alternative to administration of acetylcholinesterase inhibitors (acheis). |
2024-04-05 |
2024-04-10 |
Not clear |
| Deepali Shukla, Anjali Suryavanshi, Sanjay Kumar Bharti, Vivek Asati, Debarshi Kar Mahapatr. Recent Advances in the Treatment and Management of Alzheimer's Disease: A Precision Medicine Perspective. Current topics in medicinal chemistry. 2024-04-03. PMID:38566385. |
dolopezil, rivastigmine, galantamine, and other acetylcholinesterase inhibitors are among the medications now used to treat alzheimer's disease. |
2024-04-03 |
2024-04-05 |
human |
| A Saud, V Krishnaraju, A Taha, K Kalpana, V Malarkodi, S Durgaramani, V Vinoth Prabhu, F A Saleh, S Ezhilarasa. Potential acetylcholinesterase inhibitors to treat Alzheimer's disease. European review for medical and pharmacological sciences. vol 28. issue 6. 2024-04-03. PMID:38567612. |
potential acetylcholinesterase inhibitors to treat alzheimer's disease. |
2024-04-03 |
2024-04-05 |
Not clear |
| Paraskevi Papakyriakopoulou, Georgia Valsami, Kumlesh K De. The Effect of Donepezil Hydrochloride in the Twitcher Mouse Model of Krabbe Disease. Molecular neurobiology. 2024-04-01. PMID:38558359. |
acetylcholinesterase inhibitors (achei) are commonly used for symptomatic management of alzheimer's disease and are suggested to have potential disease-modifying effects, including regulating myelin state. |
2024-04-01 |
2024-04-04 |
mouse |
| Arturo Coaviche-Yoval, Ricardo Tovar-Miranda, Jessica E Rodríguez, Jesus A Lagos-Cruz, Héctor Luna, Erik Andrade-Jorge, José Guadalupe Trujillo-Ferrar. Benzofurans as acetylcholinesterase inhibitors for treating Alzheimer's disease: synthesis, in vitro testing, and in silico analysis. ChemMedChem. 2024-03-30. PMID:38554286. |
benzofurans as acetylcholinesterase inhibitors for treating alzheimer's disease: synthesis, in vitro testing, and in silico analysis. |
2024-03-30 |
2024-04-02 |
Not clear |
| Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. |
identification of potent acetylcholinesterase inhibitors as new candidates for alzheimer disease via virtual screening, molecular docking, dynamic simulation, and molecular mechanics-poisson-boltzmann surface area calculations. |
2024-03-28 |
2024-03-30 |
Not clear |
| Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. |
huperzine a (hup) plays a crucial role in alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (ache) inhibitor. |
2024-03-28 |
2024-03-30 |
Not clear |
| Sabrina Lekmine, Ouided Benslama, Hichem Tahraoui, Mohammad Shamsul Ola, Aicha Laouani, Kenza Kadi, Antonio Ignacio Martín-García, Ahmad Al. Anti-Cholinergic Effects of the Phenolic Extract from the Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543134. |
cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), hold pivotal significance in alzheimer's disease (ad) treatment. |
2024-03-28 |
2024-03-30 |
Not clear |
| Mustafa Kemal Ozalp, Patricia A Vignaux, Ana C Puhl, Thomas R Lane, Fabio Urbina, Sean Ekin. Sequential Contrastive and Deep Learning Models to Identify Selective Butyrylcholinesterase Inhibitors. Journal of chemical information and modeling. 2024-03-27. PMID:38532612. |
butyrylcholinesterase (bche) is a target of interest in late-stage alzheimer's disease (ad) where selective bche inhibitors (bis) may offer symptomatic treatment without the harsh side effects of acetylcholinesterase (ache) inhibitors. |
2024-03-27 |
2024-03-29 |
Not clear |
| Xinyu Shan, Yichao Lu, Zhenyu Luo, Xiaoqi Zhao, Mei Pang, Hang Yin, Xuemeng Guo, Huanli Zhou, Junlei Zhang, Jiaxin Huang, Yingying Shi, Jinfang Lou, Lihua Luo, Jian Yo. A Long-Acting Lyotropic Liquid Crystalline Implant Promotes the Drainage of Macromolecules by Brain-Related Lymphatic System in Treating Aged Alzheimer's Disease. ACS nano. 2024-03-22. PMID:38517764. |
besides, by injecting a long-acting lyotropic liquid crystalline implant encapsulating cilostazol (an fda-approved selective pde-3 inhibitor) and donepezil hydrochloride (a commonly used symptomatic relief agent to inhibit acetylcholinesterase for alzheimer's disease) near the deep cervical lymph nodes of aged mice (about 20 months), an increase of lymphatic vessel coverage in the nodes and meninges was observed, along with accelerated drainage of macromolecules from brains. |
2024-03-22 |
2024-03-25 |
mouse |
| Varsha Mugundhan, Abirami Arthanari, Parameswari R Parthasarath. Protective Effect of Ferulic Acid on Acetylcholinesterase and Amyloid Beta Peptide Plaque Formation in Alzheimer's Disease: An In Vitro Study. Cureus. vol 16. issue 2. 2024-03-15. PMID:38487137. |
protective effect of ferulic acid on acetylcholinesterase and amyloid beta peptide plaque formation in alzheimer's disease: an in vitro study. |
2024-03-15 |
2024-03-17 |
Not clear |
| Varsha Mugundhan, Abirami Arthanari, Parameswari R Parthasarath. Protective Effect of Ferulic Acid on Acetylcholinesterase and Amyloid Beta Peptide Plaque Formation in Alzheimer's Disease: An In Vitro Study. Cureus. vol 16. issue 2. 2024-03-15. PMID:38487137. |
aim this study aims to comprehensively evaluate the effects of ferulic acid (fa) on acetylcholinesterase (ache) enzyme activity and amyloid beta (aβ) peptide plaque formation in an in vitro model of alzheimer's disease (ad). |
2024-03-15 |
2024-03-17 |
Not clear |
| Olivia Wyse Faria, Mayara Sandrielly Soares de Aguiar, Julia Eisenhardt de Mello, Fernando Lopez Alvez, Karina Pereira Luduvico, Driele Neske Garcia, Augusto Schneider, Michal M Masternak, Roselia Maria Spanevello, Francieli Moro Stefanell. Senolytics prevent age-associated changes in female mice brain. Neuroscience letters. 2024-03-14. PMID:38485080. |
considering that the combination of dasatinib and quercetin (d + q) demonstrated a neuroprotective, as well as that females experience a decline in hormonal levels during aging and this is linked to increased susceptibility to alzheimer's disease, in this study we evaluated the effect of d + q on inflammatory and oxidative stress markers and on acetylcholinesterase and na |
2024-03-14 |
2024-03-17 |
mouse |
| Yaqi Gao, Yulin Liu, Yanfang L. Safety and efficacy of acetylcholinesterase inhibitors for Alzheimer's disease: A systematic review and meta-analysis. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2024-03-05. PMID:38439609. |
safety and efficacy of acetylcholinesterase inhibitors for alzheimer's disease: a systematic review and meta-analysis. |
2024-03-05 |
2024-03-07 |
Not clear |