| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raquel Ramos, Nuno Val. Dual Drug Repurposing: The Example of Saracatinib. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674150. |
concomitantly, saracatinib was repurposed to treat alzheimer's disease, targeting fyn. |
2024-04-27 |
2024-04-29 |
Not clear |
| Mohammed Alrouji, Taghreed A Majrashi, Fahad A Alhumaydhi, Ali Zari, Talal A Zari, Waleed Al Abdulmonem, Sharaf E Sharaf, Moyad Shahwan, Saleha Anwar, Anas Shamsi, Akhtar Atiy. Unveiling Phytoconstituents with Inhibitory Potential Against Tyrosine-Protein Kinase Fyn: A Comprehensive Virtual Screening Approach Targeting Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-10-29. PMID:37899058. |
unveiling phytoconstituents with inhibitory potential against tyrosine-protein kinase fyn: a comprehensive virtual screening approach targeting alzheimer's disease. |
2023-10-29 |
2023-11-08 |
Not clear |
| Mohammed Alrouji, Taghreed A Majrashi, Fahad A Alhumaydhi, Ali Zari, Talal A Zari, Waleed Al Abdulmonem, Sharaf E Sharaf, Moyad Shahwan, Saleha Anwar, Anas Shamsi, Akhtar Atiy. Unveiling Phytoconstituents with Inhibitory Potential Against Tyrosine-Protein Kinase Fyn: A Comprehensive Virtual Screening Approach Targeting Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-10-29. PMID:37899058. |
dysregulation of fyn kinase has been implicated in various complex diseases, including neurodegenerative disorders such as alzheimer's and parkinson's diseases, as well as different cancer types. |
2023-10-29 |
2023-11-08 |
Not clear |
| Ramón Martínez-Mármol, Christopher Small, Anmin Jiang, Tishila Palliyaguru, Tristan P Wallis, Rachel S Gormal, Jean-Baptiste Sibarita, Jürgen Götz, Frédéric A Meunie. Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Molecular psychiatry. 2022-10-18. PMID:36258016. |
postsynaptic enrichment of fyn underpins synaptotoxicity in dementias such as alzheimer's disease and frontotemporal lobar degeneration with tau pathology (ftld-tau). |
2022-10-18 |
2023-08-14 |
Not clear |
| Giambattista Marotta, Filippo Basagni, Michela Rosini, Anna Minarin. Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways. Current medicinal chemistry. 2021-12-23. PMID:34939537. |
based on these premises, fyn emerges as an attractive target in cancer and neurodegenerative disease therapy, particularly alzheimer disease (ad), based on its activation by aβ via cellular prion protein and its interaction with tau protein. |
2021-12-23 |
2023-08-13 |
Not clear |
| Bianca Guglietti, Srisankavi Sivasankar, Sanam Mustafa, Frances Corrigan, Lyndsey E Collins-Prain. Fyn Kinase Activity and Its Role in Neurodegenerative Disease Pathology: a Potential Universal Target? Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34432266. |
more recently, fyn dysfunction has been associated with pathological processes observed in neurodegenerative diseases, such as multiple sclerosis (ms), alzheimer's disease (ad) and parkinson's disease (pd). |
2021-11-18 |
2023-08-13 |
Not clear |
| Efthalia Angelopoulou, Yam Nath Paudel, Thomas Julian, Mohd Farooq Shaikh, Christina Piper. Pivotal Role of Fyn Kinase in Parkinson's Disease and Levodopa-Induced Dyskinesia: a Novel Therapeutic Target? Molecular neurobiology. vol 58. issue 4. 2021-10-27. PMID:33175322. |
saracatinib, a nonselective fyn inhibitor, has already been tested in clinical trials for alzheimer's disease, and novel selective fyn inhibitors are under investigation. |
2021-10-27 |
2023-08-13 |
Not clear |
| Stefania Demuro, Rita M C Di Martino, Jose A Ortega, Andrea Cavall. GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways. International journal of molecular sciences. vol 22. issue 16. 2021-09-15. PMID:34445804. |
among them, gsk-3β, fyn, and dyrk1a play a crucial role in the neurodegeneration context, and the deregulation of all three pks has been linked to different cns disorders with unmet medical needs, including alzheimer's disease (ad), parkinson's disease (pd), frontotemporal lobar degeneration (ftld), and several neuromuscular disorders. |
2021-09-15 |
2023-08-13 |
Not clear |
| Clara Y B Low, Jasinda H Lee, Frances T W Lim, Chingli Lee, Clive Ballard, Paul T Francis, Mitchell K P Lai, Michelle G K Ta. Isoform-specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementias. Brain pathology (Zurich, Switzerland). vol 31. issue 2. 2021-09-04. PMID:33128789. |
cumulative data suggest the involvement of fyn tyrosine kinase in alzheimer's disease (ad). |
2021-09-04 |
2023-08-13 |
mouse |
| Goce Taleski, Diana Schuhmacher, Henry Su, Jean-Marie Sontag, Estelle Sonta. Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation. The Journal of biological chemistry. vol 296. 2021-08-24. PMID:33380425. |
deregulation of fyn and altered pp2a methylation are implicated in cancer and alzheimer's disease (ad). |
2021-08-24 |
2023-08-13 |
mouse |
| Guanghao Liu, Kimberly L Fiock, Yona Levites, Todd E Golde, Marco M Hefti, Gloria Le. Fyn depletion ameliorates tau Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32665013. |
fyn depletion ameliorates tau the src family non-receptor tyrosine kinase fyn has been implicated in neurodegeneration of alzheimer's disease through interaction with amyloid β (aβ). |
2021-05-31 |
2023-08-13 |
Not clear |
| Christopher H van Dyck, Haakon B Nygaard, Kewei Chen, Michael C Donohue, Rema Raman, Robert A Rissman, James B Brewer, Robert A Koeppe, Tiffany W Chow, Michael S Rafii, Devon Gessert, Jiyoon Choi, R Scott Turner, Jeffrey A Kaye, Seth A Gale, Eric M Reiman, Paul S Aisen, Stephen M Strittmatte. Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial. JAMA neurology. vol 76. issue 10. 2021-05-03. PMID:31329216. |
azd0530 is an investigational kinase inhibitor specific for the src family, including fyn, that has been repurposed for the treatment of alzheimer disease. |
2021-05-03 |
2023-08-13 |
Not clear |
| Carmela Matrone, Federica Petrillo, Rosarita Nasso, Gabriella Ferrett. Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions. International journal of molecular sciences. vol 21. issue 12. 2021-03-19. PMID:32580508. |
we will primarily focus on fyn-mediated signaling pathways involved in neuronal differentiation and plasticity that have been subjected to considerable attention lately, opening the fascinating scenario to target fyn tk for the development of potential therapeutic interventions for the treatment of cns injuries and certain neurodegenerative disorders like alzheimer's disease. |
2021-03-19 |
2023-08-13 |
Not clear |
| Filomena Iannuzzi, Rossana Sirabella, Nadia Canu, Thorsten J Maier, Lucio Annunziato, Carmela Matron. Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer's Disease Patients. Cells. vol 9. issue 8. 2021-03-08. PMID:32751526. |
fyn tyrosine kinase elicits amyloid precursor protein tyr682 phosphorylation in neurons from alzheimer's disease patients. |
2021-03-08 |
2023-08-13 |
Not clear |
| Marson Putra, Sreekanth Puttachary, Guanghao Liu, Gloria Lee, Thimmasettappa Thippeswam. Fyn-tau Ablation Modifies PTZ-Induced Seizures and Post-seizure Hallmarks of Early Epileptogenesis. Frontiers in cellular neuroscience. vol 14. 2021-02-02. PMID:33363455. |
both fyn and tau have been associated with neuronal hyperexcitability and neurotoxicity in many tauopathies, including alzheimer's disease (ad). |
2021-02-02 |
2023-08-13 |
Not clear |
| Ana M de Matos, M Teresa Blázquez-Sánchez, Andreia Bento-Oliveira, Rodrigo F M de Almeida, Rafael Nunes, Pedro E M Lopes, Miguel Machuqueiro, Joana S Cristóvão, Cláudio M Gomes, Cleide S Souza, Imane G El Idrissi, Nicola A Colabufo, Ana Diniz, Filipa Marcelo, M Conceição Oliveira, Óscar López, José G Fernandez-Bolaños, Philipp Dätwyler, Beat Ernst, Ke Ning, Claire Garwood, Beining Chen, Amélia P Raute. Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease. Journal of medicinal chemistry. vol 63. issue 20. 2020-12-28. PMID:32959649. |
glucosylpolyphenols as inhibitors of aβ-induced fyn kinase activation and tau phosphorylation: synthesis, membrane permeability, and exploratory target assessment within the scope of type 2 diabetes and alzheimer's disease. |
2020-12-28 |
2023-08-13 |
Not clear |
| Ana M de Matos, M Teresa Blázquez-Sánchez, Andreia Bento-Oliveira, Rodrigo F M de Almeida, Rafael Nunes, Pedro E M Lopes, Miguel Machuqueiro, Joana S Cristóvão, Cláudio M Gomes, Cleide S Souza, Imane G El Idrissi, Nicola A Colabufo, Ana Diniz, Filipa Marcelo, M Conceição Oliveira, Óscar López, José G Fernandez-Bolaños, Philipp Dätwyler, Beat Ernst, Ke Ning, Claire Garwood, Beining Chen, Amélia P Raute. Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease. Journal of medicinal chemistry. vol 63. issue 20. 2020-12-28. PMID:32959649. |
moreover, with the premise of fyn kinase as a paradigm-shifting target in alzheimer's drug discovery, we explore glucosylpolyphenols as blockers of aβ-induced fyn kinase activation while looking into downstream effects leading to tau hyperphosphorylation. |
2020-12-28 |
2023-08-13 |
Not clear |
| Dharani Nedunchezhian, Kulanthaivel Langeswaran, Sundar Santhoshkuma. Identification of novel inhibitor targeting Fyn kinase using molecular docking analysis. Bioinformation. vol 15. issue 6. 2020-10-01. PMID:31312079. |
identification of tyrosine fyn kinase inhibitor is recognized as an effective and feasible therapeutic measure in reducing consequences of memory loss disorder alzheimer's. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiaoguang Yao, Xiaohui Xian, Mingxing Fang, Shujuan Fan, Wenbin L. Loss of miR-369 Promotes Tau Phosphorylation by Targeting the Fyn and Serine/Threonine-Protein Kinase 2 Signaling Pathways in Alzheimer's Disease Mice. Frontiers in aging neuroscience. vol 11. 2020-09-28. PMID:32082134. |
loss of mir-369 promotes tau phosphorylation by targeting the fyn and serine/threonine-protein kinase 2 signaling pathways in alzheimer's disease mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunie. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife. vol 8. 2020-02-24. PMID:31237563. |
the src kinase fyn plays critical roles in memory formation and alzheimer's disease. |
2020-02-24 |
2023-08-13 |
mouse |