| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chanida Fongsaran, Krit Jirakanwisal, Bi-Hung Peng, Anna Fracassi, Giulio Taglialatela, Kelly T Dineley, Slobodan Paessler, Irma E Cisnero. Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706571. |
proteinopathies include synucleinopathies triggered by misfolded amyloid α-synuclein, tauopathies triggered by misfolded tau, and amyloidopathies triggered by misfolded amyloid of which alzheimer's disease (β-amyloid) is most prevalent. |
2024-05-06 |
2024-05-08 |
mouse |
| Min Wang, Jiaying Lu, Ying Zhang, Qi Zhang, Luyao Wang, Ping Wu, Matthias Brendel, Axel Rominger, Kuangyu Shi, Qianhua Zhao, Jiehui Jiang, Chuantao Zu. Characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in Alzheimer's disease. Human brain mapping. vol 45. issue 7. 2024-05-04. PMID:38703095. |
characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in alzheimer's disease. |
2024-05-04 |
2024-05-07 |
human |
| Min Wang, Jiaying Lu, Ying Zhang, Qi Zhang, Luyao Wang, Ping Wu, Matthias Brendel, Axel Rominger, Kuangyu Shi, Qianhua Zhao, Jiehui Jiang, Chuantao Zu. Characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in Alzheimer's disease. Human brain mapping. vol 45. issue 7. 2024-05-04. PMID:38703095. |
tau pathology and its spatial propagation in alzheimer's disease (ad) play crucial roles in the neurodegenerative cascade leading to dementia. |
2024-05-04 |
2024-05-07 |
human |
| Nianzhuang Qiu, Chenliang Qian, Tingting Guo, Yaling Wang, Hongwei Jin, Mingli Yao, Mei Li, Tianyang Guo, Yuli Lv, Xinxin Si, Song Wu, Hao Wang, Xuehui Zhang, Jie Xi. Discovery of a novel chemotype as DYRK1A inhibitors against Alzheimer's disease: Computational modeling and biological evaluation. International journal of biological macromolecules. 2024-05-04. PMID:38704072. |
dual-specificity tyrosine phosphorylation-regulated kinase 1 a (dyrk1a) plays an essential role in tau and aβ pathology closely related to alzheimer's disease (ad). |
2024-05-04 |
2024-05-07 |
mouse |
| Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Thomas K Karikari, Nicholas J Ashton, Andréa L Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C Kolb, Pedro Rosa-Neto, Yasser Iturria-Medin. Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer's disease. Communications biology. vol 7. issue 1. 2024-05-04. PMID:38704445. |
personalized whole-brain neural mass models reveal combined aβ and tau hyperexcitable influences in alzheimer's disease. |
2024-05-04 |
2024-05-07 |
Not clear |
| Yuta Katsumi, Inola A Howe, Ryan Eckbo, Bonnie Wong, Megan Quimby, Daisy Hochberg, Scott M McGinnis, Deepti Putcha, David A Wolk, Alexandra Touroutoglou, Bradford C Dickerso. Default mode network tau predicts future clinical decline in atypical early Alzheimer's disease. medRxiv : the preprint server for health sciences. 2024-05-03. PMID:38699357. |
default mode network tau predicts future clinical decline in atypical early alzheimer's disease. |
2024-05-03 |
2024-05-05 |
Not clear |
| Yuya Xu, Mengrong Xu, Chengyu Zhou, Ling Sun, Wenqiang Cai, Xuling L. Ferroptosis and its implications in treating cognitive impairment caused by aging: A study on the mechanism of repetitive transcranial magnetic stimulation. Experimental gerontology. 2024-05-02. PMID:38697556. |
research has established that alzheimer's disease (ad)-associated proteins, such as amyloid precursor protein (app) and phosphorylated tau, are involved in brain iron metabolism. |
2024-05-02 |
2024-05-05 |
Not clear |
| Zexin Zhu, Xiaofang Zhong, Bin Wang, Haiyan Lu, Lingjun L. Probing Protein Structural Changes in Alzheimer's Disease via Quantitative Cross-linking Mass Spectrometry. Analytical chemistry. 2024-05-01. PMID:38690851. |
alzheimer's disease (ad) is a progressive neurological disorder featuring abnormal protein aggregation in the brain, including the pathological hallmarks of amyloid plaques and hyperphosphorylated tau. |
2024-05-01 |
2024-05-04 |
Not clear |
| Masahiro Furuta, Suguru Arii, Hiroki Umeda, Ryota Matsukawa, Katsuyuki Shizu, Hironori Kaji, Shigehiro A Kawashima, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Harunobu Mitsunuma, Motomu Kana. Leuco Ethyl Violet as Self-Activating Prodrug Photocatalyst for In Vivo Amyloid-Selective Oxygenation. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-05-01. PMID:38689504. |
aberrant aggregates of amyloid-β (aβ) and tau protein (tau), called amyloid, are related to the etiology of alzheimer disease (ad). |
2024-05-01 |
2024-05-03 |
mouse |
| Dylan J Finneran, Taylor Desjarlais, Alayna Henry, Brianna M Jackman, Marcia N Gordon, David Morga. Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno-associated virus vectors expressing human P301L tau. Alzheimer's & dementia (New York, N. Y.). vol 10. issue 2. 2024-05-01. PMID:38689599. |
alzheimer's disease (ad) is a progressive neurodegenerative disease in which extracellular aggregates of the amyloid beta (aβ) peptide precede widespread intracellular inclusions of the microtubule-associated protein tau. |
2024-05-01 |
2024-05-03 |
mouse |
| Ke Hou, Hope Pan, Hedieh Shahpasand-Kroner, Carolyn Hu, Romany Abskharon, Paul Seidler, Marisa Mekkittikul, Melinda Balbirnie, Carter Lantz, Michael R Sawaya, Joshua L Dolinsky, Mychica Jones, Xiaohong Zuo, Joseph A Loo, Sally Frautschy, Greg Cole, David S Eisenber. D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease. Science advances. vol 10. issue 18. 2024-05-01. PMID:38691615. |
d-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of alzheimer's disease. |
2024-05-01 |
2024-05-04 |
mouse |
| Ke Hou, Hope Pan, Hedieh Shahpasand-Kroner, Carolyn Hu, Romany Abskharon, Paul Seidler, Marisa Mekkittikul, Melinda Balbirnie, Carter Lantz, Michael R Sawaya, Joshua L Dolinsky, Mychica Jones, Xiaohong Zuo, Joseph A Loo, Sally Frautschy, Greg Cole, David S Eisenber. D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease. Science advances. vol 10. issue 18. 2024-05-01. PMID:38691615. |
amyloid fibrils of tau are increasingly accepted as a cause of neuronal death and brain atrophy in alzheimer's disease (ad). |
2024-05-01 |
2024-05-04 |
mouse |
| Madia Lozupone, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Roberta Stallone, Mario Altamura, Antonello Bellomo, Antonio Daniele, Vincenzo Solfrizzi, Francesco Panz. Lessons learned from the failure of solanezumab as a prospective treatment strategy for Alzheimer's disease. Expert opinion on drug discovery. 2024-04-30. PMID:38685682. |
in the last decade, the efforts conducted for discovering alzheimer's disease (ad) treatments targeting the best-known pathogenic factors [amyloid-β (aβ), tau protein, and neuroinflammation] were mostly unsuccessful. |
2024-04-30 |
2024-05-03 |
Not clear |
| Deepak Kumar, Govind Singh, Tarun, Meenakshi Dhanawat, Sumeet Gupta, Mohamed A Morsy, Anroop B Nair, Asmaa I Matou. Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats. Endocrine, metabolic & immune disorders drug targets. 2024-04-30. PMID:38685761. |
some viruses, such as herpes viruses, hsv-1, and hsv-2, are causative agents of alzheimer's disease and result in β-amyloid peptide and tau protein accumulation in the brain. |
2024-04-30 |
2024-05-03 |
rat |
| Linlin Xu, Xiaohui Wu, Shuyue Zhao, Haodong Hu, Silei Wang, Yongxin Zhang, Jiajing Chen, Xiaochen Zhang, Yu Zhao, Rujiang Ma, Fan Huang, Linqi Sh. Harnessing Nanochaperone-Mediated Autophagy for Selective Clearance of Pathogenic Tau Protein in Alzheimer's Disease. Advanced materials (Deerfield Beach, Fla.). 2024-04-30. PMID:38688523. |
harnessing nanochaperone-mediated autophagy for selective clearance of pathogenic tau protein in alzheimer's disease. |
2024-04-30 |
2024-05-03 |
mouse |
| Linlin Xu, Xiaohui Wu, Shuyue Zhao, Haodong Hu, Silei Wang, Yongxin Zhang, Jiajing Chen, Xiaochen Zhang, Yu Zhao, Rujiang Ma, Fan Huang, Linqi Sh. Harnessing Nanochaperone-Mediated Autophagy for Selective Clearance of Pathogenic Tau Protein in Alzheimer's Disease. Advanced materials (Deerfield Beach, Fla.). 2024-04-30. PMID:38688523. |
accumulation of pathological tau is a hallmark of alzheimer's disease (ad), which correlates more closely with cognitive impairment than does the amyloid-β (aβ) burden. |
2024-04-30 |
2024-05-03 |
mouse |
| Ganzhong Tian, John Hanfelt, James Lah, Benjamin B Ris. Mixture of regressions with multivariate responses for discovering subtypes in Alzheimer's biomarkers with detection limits. Data science in science. vol 3. issue 1. 2024-04-29. PMID:38680829. |
we apply a mixture of regressions with a multivariate truncated gaussian distribution (also called a censored multivariate gaussian mixture of regressions or a mixture of multivariate tobit regressions) to over 3,000 participants from the emory goizueta alzheimer's disease research center and emory healthy brain study to examine amyloid-beta peptide 1-42 (abeta42), total tau protein and phosphorylated tau protein in csf with known detection limits. |
2024-04-29 |
2024-05-01 |
human |
| You-Yue Li, Dan-Dan Guo, Ruo-Nan Duan, Yi L. Interactions between Beta-Amyloid and Pericytes in Alzheimer's Disease. Frontiers in bioscience (Landmark edition). vol 29. issue 4. 2024-04-29. PMID:38682184. |
alzheimer's disease (ad) is an age-related progressive neurodegenerative disorder characterized by aberrant amyloid precursor protein (app) cleavage, pathological aggregations of beta-amyloid (aβ) that make up aβ plaques and hyperphosphorylation of tau that makes up neurofibrillary tangles (nfts). |
2024-04-29 |
2024-05-01 |
Not clear |
| Tom Earnest, Abdalla Bani, Sung Min Ha, Diana A Hobbs, Deydeep Kothapalli, Braden Yang, John J Lee, Tammie L S Benzinger, Brian A Gordon, Aristeidis Sotira. Data-driven decomposition and staging of flortaucipir uptake in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-29. PMID:38683905. |
previous approaches pursuing in vivo staging of tau pathology in alzheimer's disease (ad) have typically relied on neuropathologically defined criteria. |
2024-04-29 |
2024-05-03 |
Not clear |
| Pu Duan, Nadia El Mammeri, Mei Hon. Milligram-Scale Assembly and NMR Fingerprint of Tau Fibrils Adopting the Alzheimer's Disease Fold. The Journal of biological chemistry. 2024-04-28. PMID:38679331. |
milligram-scale assembly and nmr fingerprint of tau fibrils adopting the alzheimer's disease fold. |
2024-04-28 |
2024-05-01 |
Not clear |