| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikhail Paveliev, Anton A Egorchev, Foat Musin, Nikita Lipachev, Anastasiia Melnikova, Rustem M Gimadutdinov, Aidar R Kashipov, Dmitry Molotkov, Dmitry E Chickrin, Albert V Agano. Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673819. |
pnn undergo structural changes in schizophrenia, epilepsy, alzheimer's disease, stroke, post-traumatic conditions, and some other brain disorders. |
2024-04-27 |
2024-04-29 |
Not clear |
| Yixiao Dong, Kunkun Zhao, Xuemei Qin, Guanhua Du, Li Ga. The mechanisms of perineuronal net abnormalities in contributing aging and neurological diseases. Ageing research reviews. 2023-10-15. PMID:37839757. |
pnn undergoes abnormal changes during aging and in various neurological diseases, such as alzheimer's disease, parkinson's disease, schizophrenia, autism spectrum disorder, and multiple sclerosis. |
2023-10-15 |
2023-11-08 |
Not clear |
| Matthieu Lépine, Sara Douceau, Gabrielle Devienne, Paul Prunotto, Sophie Lenoir, Caroline Regnauld, Elsa Pouettre, Juliette Piquet, Laurent Lebouvier, Yannick Hommet, Eric Maubert, Véronique Agin, Bertrand Lambolez, Bruno Cauli, Carine Ali, Denis Vivie. Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure. BMC biology. vol 20. issue 1. 2022-10-05. PMID:36199089. |
in the adult, their degradation alters fs-pv-driven functions, such as brain plasticity and memory, and altered pnn structures have been found in neurodevelopmental and central nervous system disorders such as alzheimer's disease, leading to interest in identifying targets able to modify or participate in pnn metabolism. |
2022-10-05 |
2023-08-14 |
Not clear |
| Jarrad M Scarlett, Shannon J Hu, Kimberly M Along. The "Loss" of Perineuronal Nets in Alzheimer's Disease: Missing or Hiding in Plain Sight? Frontiers in integrative neuroscience. vol 16. 2022-06-13. PMID:35694184. |
in this hypothesis and theory article, we begin by highlighting pnn changes observed in human postmortem brain tissue associated with alzheimer's disease (ad) and corresponding changes reported in rodent models of ad neuropathology. |
2022-06-13 |
2023-08-14 |
human |
| Christophe Clément Rey, Vincent Robert, Guillaume Bouisset, Maïthé Loisy, Sébastien Lopez, Vanessa Cattaud, Camille Lejards, Rebecca Ann Piskorowski, Claire Rampon, Vivien Chevaleyre, Laure Verre. Altered inhibitory function in hippocampal CA2 contributes in social memory deficits in Alzheimer's mouse model. iScience. vol 25. issue 3. 2022-03-04. PMID:35243253. |
parvalbumin (pv)-expressing interneurons which are often associated with the specific extracellular matrix perineuronal net (pnn) play a critical role in the alteration of brain activity and memory performance in alzheimer's disease (ad). |
2022-03-04 |
2023-08-13 |
mouse |
| Aric F Logsdon, Kendra L Francis, Nicole E Richardson, Shannon J Hu, Chelsea L Faber, Bao Anh Phan, Vy Nguyen, Naly Setthavongsack, William A Banks, Randy L Woltjer, C Dirk Keene, Caitlin S Latimer, Michael W Schwartz, Jarrad M Scarlett, Kimberly M Along. Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-08. PMID:34482642. |
perineuronal nets (pnns) are chondroitin sulfate-glycosaminoglycan (cs-gag) containing matrices that enmesh neural networks involved in memory and cognition, and loss of pnn matrices is reported in patients with neurocognitive and neuropsychiatric disorders including alzheimer's disease (ad). |
2021-09-08 |
2023-08-13 |
Not clear |
| Bhanu P Tewari, Harald Sontheime. Protocol to quantitatively assess the structural integrity of Perineuronal Nets Bio-protocol. vol 9. issue 10. 2021-03-05. PMID:33654764. |
various central nervous system diseases including schizophrenia, alzheimer disease and epilepsy present with qualitative alteration in pnns, however prior studies failed to quantitatively assess such changes at single pnn level and correlate them with functional changes in disease. |
2021-03-05 |
2023-08-13 |
Not clear |
| Teresa H Wen, Devin K Binder, Iryna M Ethell, Khaleel A Raza. The Perineuronal 'Safety' Net? Perineuronal Net Abnormalities in Neurological Disorders. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30123106. |
indeed, pnn abnormalities have been observed in post-mortem brain tissues of patients with schizophrenia and alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Nikita Arnst, Svetlana Kuznetsova, Nikita Lipachev, Nurislam Shaikhutdinov, Anastasiya Melnikova, Mikhail Mavlikeev, Pavel Uvarov, Tatyana V Baltina, Heikki Rauvala, Yuriy N Osin, Andrey P Kiyasov, Mikhail Pavelie. Spatial patterns and cell surface clusters in perineuronal nets. Brain research. vol 1648. issue Pt A. 2017-07-26. PMID:27425428. |
perineuronal nets (pnn) ensheath gabaergic and glutamatergic synapses on neuronal cell surface in the central nervous system (cns), have neuroprotective effect in animal models of alzheimer disease and regulate synaptic plasticity during development and regeneration. |
2017-07-26 |
2023-08-13 |
mouse |
| Qing-Long Miao, Qian Ye, Xiao-Hui Zhan. Perineuronal net, CSPG receptor and their regulation of neural plasticity. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 4. 2015-05-16. PMID:25131780. |
aberrant pnn signaling can lead to cns dysfunctions like epilepsy, stroke and alzheimer's disease. |
2015-05-16 |
2023-08-13 |
Not clear |
| Bao-Ming Nie, Li-Min Yang, Sai-Li Fu, Xiao-Yan Jiang, Pei-Hua Lu, Yang L. Protective effect of panaxydol and panaxynol on sodium nitroprusside-induced apoptosis in cortical neurons. Chemico-biological interactions. vol 160. issue 3. 2006-06-08. PMID:16530744. |
the results raise the possibility that pnd and pnn reduce neurodegeneration in the alzheimer's brain. |
2006-06-08 |
2023-08-12 |
rat |