| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raquel Ramos, Nuno Val. Dual Drug Repurposing: The Example of Saracatinib. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674150. |
in addition to alzheimer's disease, this src inhibitor has also been studied in relation to other health conditions such as pulmonary and liver fibrosis and even for analgesic and anti-allergic functions. |
2024-04-27 |
2024-04-29 |
Not clear |
| Ke-Zhen Cai, Qin Zheng, Xu-Dong Zhu, Shao-Feng Wei, Meng-Qi Wu, Hui Xiong, Hai-Ting Zha. [Mechanism of Sijunzi Decoction in treatment of Alzheimer's disease based on UPLC-Q-TOF-MS, network pharmacology, and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 6. 2023-04-03. PMID:37005850. |
hsp90aa1, ppara, src, ar, and esr1 were the main targets for sijunzi decoction to treat alzheimer's disease. |
2023-04-03 |
2023-08-14 |
mouse |
| Jiwen Zhu, Jiayao Zhang, Peng Hu, Mingxiang Fan, Dianwen Song, Huabin Yin, Penghui Yan, Shuyuan Xian, Zhenyu Li, Juanru Guo, Chunling Long, Runping Xu, Runzhi Huang, Tong Meng, Jie Zhang, Zongqiang Huan. Identification of Bone Metastatic and Prognostic Alternative Splicing Signatures in Prostate Adenocarcinoma. Biochemical genetics. 2023-04-03. PMID:37010714. |
moreover, a potential splicing regulatory network was established and after multiple-database validation, we supposed that the signaling axis of hspb1 up-regulating the pip5k1c - 46,721 - at (p < 0.001) might mediate the tumorigenesis, progression and metastasis of prad via the key members of alzheimer's disease pathway (src, egfr, mapt, app and prkca) (p < 0.001). |
2023-04-03 |
2023-08-14 |
Not clear |
| Camila C Portugal, Tiago O Almeida, Renato Socodato, João B Relva. Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases. The FEBS journal. 2021-10-04. PMID:34510775. |
src family kinases (sfks): critical regulators of microglial homeostatic functions and neurodegeneration in parkinson's and alzheimer's diseases. |
2021-10-04 |
2023-08-13 |
Not clear |
| Guanghao Liu, Kimberly L Fiock, Yona Levites, Todd E Golde, Marco M Hefti, Gloria Le. Fyn depletion ameliorates tau Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32665013. |
fyn depletion ameliorates tau the src family non-receptor tyrosine kinase fyn has been implicated in neurodegeneration of alzheimer's disease through interaction with amyloid β (aβ). |
2021-05-31 |
2023-08-13 |
Not clear |
| Christopher H van Dyck, Haakon B Nygaard, Kewei Chen, Michael C Donohue, Rema Raman, Robert A Rissman, James B Brewer, Robert A Koeppe, Tiffany W Chow, Michael S Rafii, Devon Gessert, Jiyoon Choi, R Scott Turner, Jeffrey A Kaye, Seth A Gale, Eric M Reiman, Paul S Aisen, Stephen M Strittmatte. Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial. JAMA neurology. vol 76. issue 10. 2021-05-03. PMID:31329216. |
azd0530 is an investigational kinase inhibitor specific for the src family, including fyn, that has been repurposed for the treatment of alzheimer disease. |
2021-05-03 |
2023-08-13 |
Not clear |
| Nadege Morisot, Anthony L Berger, Khanhky Phamluong, Alan Cross, Dorit Ro. The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking. Addiction biology. vol 24. issue 6. 2020-10-28. PMID:30536923. |
here, we used azd0530, a cns penetrable inhibitor of src ptks developed for the treatment of alzheimer disease and cancer and tested its efficacy to suppress alcohol-dependent molecular and behavioral effects. |
2020-10-28 |
2023-08-13 |
mouse |
| Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunie. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife. vol 8. 2020-02-24. PMID:31237563. |
the src kinase fyn plays critical roles in memory formation and alzheimer's disease. |
2020-02-24 |
2023-08-13 |
mouse |
| Meghan K Mattos, Marci L Nilsen, Jennifer H Lingle. Experiences Surrounding an Early-Stage Cognitive Diagnosis in Rural-Dwelling Older Adults. Research in gerontological nursing. vol 11. issue 4. 2018-12-11. PMID:30036404. |
the current study conducted semi-structured interviews to explore the experiences of rural-dwelling older adults (n = 9) and their caregivers (n = 10) surrounding diagnosis of mild cognitive impairment or early-stage alzheimer's disease at a specialty research center (src). |
2018-12-11 |
2023-08-13 |
human |
| Sandra I Mota, Ildete L Ferreira, Jorge Valero, Elisabete Ferreiro, Ana L Carvalho, Catarina R Oliveira, A Cristina Reg. Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus--linking NMDA receptors and the reelin pathway. Experimental neurology. vol 261. 2014-12-17. PMID:25128699. |
impaired src signaling and post-synaptic actin polymerization in alzheimer's disease mice hippocampus--linking nmda receptors and the reelin pathway. |
2014-12-17 |
2023-08-13 |
mouse |
| Cai-Ping Du, Ran Tan, Xiao-Yu Ho. Fyn kinases play a critical role in neuronal apoptosis induced by oxygen and glucose deprivation or amyloid-β peptide treatment. CNS neuroscience & therapeutics. vol 18. issue 9. 2013-02-12. PMID:22709448. |
src family protein tyrosine kinases (srcptks) have been implicated in the pathogenesis of brain ischemia and alzheimer's disease (ad). |
2013-02-12 |
2023-08-12 |
Not clear |
| Gunjan Dhawan, Colin K Comb. Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease. Journal of neuroinflammation. vol 9. 2013-01-17. PMID:22673542. |
inhibition of src kinase activity attenuates amyloid associated microgliosis in a murine model of alzheimer's disease. |
2013-01-17 |
2023-08-12 |
Not clear |