| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cynthia Picard, Justin Miron, Judes Poirie. Association of TMEM106B with Cortical Genes. vol 15. issue 4. 2024-04-27. PMID:38674351. |
association of tmem106b with cortical the e4 allele of the apolipoprotein e gene is the strongest genetic risk factor for sporadic alzheimer's disease. |
2024-04-27 |
2024-04-29 |
Not clear |
| Quynh Nguyen, Caleb A Wood, Peter J Kim, Joanna L Jankowsk. The TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary hippocampal neurons. Frontiers in neuroscience. vol 17. 2023-10-30. PMID:37901434. |
the lysosomal protein tmem106b was identified as a risk modifier of multiple dementias including frontotemporal dementia and alzheimer's disease. |
2023-10-30 |
2023-11-08 |
mouse |
| Hideyuki Takahashi, Azucena Perez-Canamas, Hongping Ye, Xianlin Han, Stephen M Strittmatte. Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745346. |
tmem106b is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, alzheimer's disease, and hypomyelinating leukodystrophy but also potentially involved in covid-19. |
2023-09-25 |
2023-10-07 |
mouse |
| Bridget Shafit-Zagardo, Simone Sidoli, James E Goldman, Juwen C DuBois, John R Corboy, Stephen M Strittmatter, Hillary Guzik, Ukuemi Edema, Anita G Arackal, Yair M Botbol, Emilio Merheb, Rashed M Nagra, Sarah Graf. TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury. Cells. vol 12. issue 13. 2023-07-14. PMID:37443768. |
we determined that the transmembrane protein 106b (tmem106b), normally lysosome-associated, is insoluble in rrms plaques relative to normal-appearing white matter from individuals with alzheimer's disease and non-neurologic controls. |
2023-07-14 |
2023-08-14 |
mouse |
| Jolien Perneel, Manuela Neumann, Bavo Heeman, Simon Cheung, Marleen Van den Broeck, Sarah Wynants, Matt Baker, Cristina T Vicente, Júlia Faura, Rosa Rademakers, Ian R A Mackenzi. Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging. Acta neuropathologica. 2022-12-17. PMID:36527486. |
accumulation of tmem106b c-terminal immunoreactive (tmem-ir) material was a common finding in all the conditions evaluated, including frontotemporal lobar degeneration with tdp-43 pathology (ftld-tdp), alzheimer's disease, tauopathies, synucleinopathies and neurologically normal aging. |
2022-12-17 |
2023-08-14 |
human |
| Shengjun Hong, Valerija Dobricic, Olena Ohlei, Isabelle Bos, Stephanie J B Vos, Dmitry Prokopenko, Betty M Tijms, Ulf Andreasson, Kaj Blennow, Rik Vandenberghe, Silvy Gabel, Philip Scheltens, Charlotte E Teunissen, Sebastiaan Engelborghs, Giovanni Frisoni, Olivier Blin, Jill C Richardson, Regis Bordet, Alberto Lleó, Daniel Alcolea, Julius Popp, Christopher Clark, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Richard J B Dobson, Cristina Legido-Quigley, Kristel Sleegers, Christine Van Broeckhoven, Rudolph E Tanzi, Mara Ten Kate, Michael Wittig, Andre Franke, Christina M Lill, Frederik Barkhof, Simon Lovestone, Johannes Streffer, Henrik Zetterberg, Pieter Jelle Visser, Lars Bertra. TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 10. 2021-11-09. PMID:33991015. |
tmem106b and cpox are genetic determinants of cerebrospinal fluid alzheimer's disease biomarker levels. |
2021-11-09 |
2023-08-13 |
Not clear |
| Adam J Dugan, Peter T Nelson, Yuriko Katsumata, Lincoln M P Shade, Kevin L Boehme, Merilee A Teylan, Matthew D Cykowski, Shubhabrata Mukherjee, John S K Kauwe, Timothy J Hohman, Julie A Schneider, David W Fard. Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study. Acta neuropathologica communications. vol 9. issue 1. 2021-09-22. PMID:34526147. |
single nucleotide variants (snvs) within 10 kb of tmem106b, grn, abcc9, kcnmb2, and apoe were tested for association with hs and late-nc, and separately for alzheimer's pathologies, i.e. |
2021-09-22 |
2023-08-13 |
human |
| Yang Hu, Jing-Yi Sun, Yan Zhang, Haihua Zhang, Shan Gao, Tao Wang, Zhifa Han, Longcai Wang, Bao-Liang Sun, Guiyou Li. rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues. BMC medicine. vol 19. issue 1. 2021-06-23. PMID:33461566. |
rs1990622 variant associates with alzheimer's disease and regulates tmem106b expression in human brain tissues. |
2021-06-23 |
2023-08-13 |
human |
| Yang Hu, Jing-Yi Sun, Yan Zhang, Haihua Zhang, Shan Gao, Tao Wang, Zhifa Han, Longcai Wang, Bao-Liang Sun, Guiyou Li. rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues. BMC medicine. vol 19. issue 1. 2021-06-23. PMID:33461566. |
until recently, growing evidence highlights the role of tmem106b in alzheimer's disease (ad). |
2021-06-23 |
2023-08-13 |
human |
| Alexandra M Nicholson, Rosa Rademaker. What we know about TMEM106B in neurodegeneration. Acta neuropathologica. vol 132. issue 5. 2017-09-20. PMID:27543298. |
in this manuscript, we review the initial discovery and replication studies describing tmem106b variants as disease risk factors and modifiers in tdp-43 proteinopathies, such as ftld-tdp caused by progranulin (grn) or chromosome 9 open reading frame 72 (c9orf72) mutations, as well as alzheimer's disease and hippocampal sclerosis. |
2017-09-20 |
2023-08-13 |
Not clear |
| Kwangsik Nho, Andrew J Saykin, Peter T Nelso. Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe. Journal of Alzheimer's disease : JAD. vol 52. issue 1. 2017-01-30. PMID:27003218. |
participants from the alzheimer's disease neuroimaging initiative cohort (adni; n = 1,239), with both mri scans and genotype data, were used to assess the association between brain atrophy and previously identified hs-aging risk snps in the following genes: grn, tmem106b, abcc9, and kcnmb2 (minor allele frequency for each is >30%). |
2017-01-30 |
2023-08-13 |
human |
| Maria Serpente, Chiara Fenoglio, Francesca Clerici, Rossana Bonsi, Beatrice Arosio, Sara M G Cioffi, Emanuela Rotondo, Massimo Franceschi, Filippo Martinelli Boneschi, Daniela Mari, Claudio Mariani, Elio Scarpini, Daniela Galimbert. Transmembrane protein 106B gene (TMEM106B) variability and influence on progranulin plasma levels in patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25114081. |
we carried out an association study of transmembrane protein 106b gene (tmem106b) rs1020004 a/g, rs6966915c/t, and rs1990622 a/g in a population of 656 patients with alzheimer's disease (ad) and 619 controls, and tested whether the rs1990622 influences plasma progranulin levels. |
2015-08-21 |
2023-08-13 |
Not clear |
| Maria Serpente, Chiara Fenoglio, Francesca Clerici, Rossana Bonsi, Beatrice Arosio, Sara M G Cioffi, Emanuela Rotondo, Massimo Franceschi, Filippo Martinelli Boneschi, Daniela Mari, Claudio Mariani, Elio Scarpini, Daniela Galimbert. Transmembrane protein 106B gene (TMEM106B) variability and influence on progranulin plasma levels in patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25114081. |
transmembrane protein 106b gene (tmem106b) variability and influence on progranulin plasma levels in patients with alzheimer's disease. |
2015-08-21 |
2023-08-13 |
Not clear |
| Rui-Chun Lu, Hao Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Ta. TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in Han Chinese. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 3. 2014-10-14. PMID:24166182. |
tmem106b and apoe polymorphisms interact to confer risk for late-onset alzheimer's disease in han chinese. |
2014-10-14 |
2023-08-12 |
Not clear |
| Rui-Chun Lu, Hao Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Ta. TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in Han Chinese. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 3. 2014-10-14. PMID:24166182. |
moreover, the tmem106b risk variant is also implicated in the pathologic presentation of alzheimer's disease (ad). |
2014-10-14 |
2023-08-12 |
Not clear |
| Jun-Ichi Satoh, Yoshihiro Kino, Natsuki Kawana, Yoji Yamamoto, Tsuyoshi Ishida, Yuko Saito, Kunimasa Arim. TMEM106B expression is reduced in Alzheimer's disease brains. Alzheimer's research & therapy. vol 6. issue 2. 2014-08-12. PMID:24684749. |
recent studies indicate that tmem106b plays a pathological role in various neurodegenerative diseases, including alzheimer's disease (ad). |
2014-08-12 |
2023-08-12 |
Not clear |
| Jun-Ichi Satoh, Yoshihiro Kino, Natsuki Kawana, Yoji Yamamoto, Tsuyoshi Ishida, Yuko Saito, Kunimasa Arim. TMEM106B expression is reduced in Alzheimer's disease brains. Alzheimer's research & therapy. vol 6. issue 2. 2014-08-12. PMID:24684749. |
tmem106b expression is reduced in alzheimer's disease brains. |
2014-08-12 |
2023-08-12 |
Not clear |
| Solène Debaisieux, Giampietro Schiav. TiME for TMEM106B. The EMBO journal. vol 33. issue 5. 2014-04-25. PMID:24497553. |
as tmem106b may be involved in other pathologies such as alzheimer's disease (ad) and amyotrophic lateral sclerosis (als), uncovering its cellular functions has become a priority. |
2014-04-25 |
2023-08-12 |
Not clear |
| Nicola J Rutherford, Minerva M Carrasquillo, Ma Li, Gina Bisceglio, Joshua Menke, Keith A Josephs, Joseph E Parisi, Ronald C Petersen, Neill R Graff-Radford, Steven G Younkin, Dennis W Dickson, Rosa Rademaker. TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease. Neurology. vol 79. issue 7. 2012-10-24. PMID:22855871. |
tmem106b risk variant is implicated in the pathologic presentation of alzheimer disease. |
2012-10-24 |
2023-08-12 |
Not clear |