| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simon J Schreiner, Jiri M G Van Bergen, Anton F Gietl, Alfred Buck, Christoph Hock, Klaas P Pruessmann, Anke Henning, Paul G Unschul. Gray matter gamma-hydroxy-butyric acid and glutamate reflect beta-amyloid burden at old age. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 2. 2024-05-01. PMID:38690510. |
here, we investigate relationships between gaba, glutamate, and brain ß-amyloid (aß) burden before clinical manifestation of alzheimer's disease (ad). |
2024-05-01 |
2024-05-03 |
Not clear |
| Rifat Jabeen, Nusrat Jan, Bazila Naseer, Prakash Kumar Sarangi, Kandi Sridhar, Praveen Kumar Dikkala, Maharshi Bhaswant, Syed Zameer Hussain, Baskaran Stephen Inbara. Development of Germinated-Brown-Rice-Based Novel Functional Beverage Enriched with γ-Aminobutyric Acid: Nutritional and Bio-Functional Characterization. Foods (Basel, Switzerland). vol 13. issue 8. 2024-04-27. PMID:38672954. |
γ-aminobutyric acid (gaba), recognized as a primary inhibitory neurotransmitter within the brain, serves a crucial role in the aging process and in neurodegenerative conditions such as alzheimer's disease. |
2024-04-27 |
2024-04-29 |
Not clear |
| Bhupender Sharma, Melissa M Torres, Sheryl Rodriguez, Laxman Gangwani, Subodh Kuma. MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons. Neural regeneration research. vol 19. issue 12. 2024-04-10. PMID:38595288. |
journal/nrgr/04.03/01300535-202412000-00026/figure1/v/2024-04-08t165401z/r/image-tiff gamma-aminobutyric acid (gaba)ergic neurons, the most abundant inhibitory neurons in the human brain, have been found to be reduced in many neurological disorders, including alzheimer's disease and alzheimer's disease-related dementia. |
2024-04-10 |
2024-04-12 |
mouse |
| Bhupender Sharma, Melissa M Torres, Sheryl Rodriguez, Laxman Gangwani, Subodh Kuma. MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons. Neural regeneration research. vol 19. issue 12. 2024-04-10. PMID:38595288. |
our previous study identified the upregulation of microrna-502-3p (mir-502-3p) and downregulation of gaba type a receptor subunit α-1 in alzheimer's disease synapses. |
2024-04-10 |
2024-04-12 |
mouse |
| Dong Yuan, Zheng Zhou, Meihui Song, Yunfan Zhang, Yunbin Zhang, Ping Ren, Zhuangfei Chen, Yu F. Role of GABA Neurochemistry international. 2024-03-15. PMID:38490487. |
role of gaba alzheimer's disease (ad) is the most common cause of dementia in the elderly. |
2024-03-15 |
2024-03-18 |
Not clear |
| Alena O Burnyasheva, Natalia A Stefanova, Nataliya G Kolosova, Darya V Telegin. Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer's Disease Signs Development. Biochemistry. Biokhimiia. vol 88. issue 12. 2024-03-10. PMID:38462444. |
glutamate and gaba homeostasis is important for healthy aging and reducing the risk of various neurological diseases, while long-term imbalance can contribute to the development of neurodegenerative disorders, including alzheimer's disease (ad). |
2024-03-10 |
2024-03-14 |
rat |
| Yanyan Kong, Lei Cao, Fang Xie, Xiuzhe Wang, Chuantao Zuo, Kuangyu Shi, Axel Rominger, Qi Huang, Jianfei Xiao, Donglang Jiang, Yihui Guan, Ruiqing N. Reduced SV2A and GABA Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-07. PMID:38325265. |
reduced sv2a and gaba type 2 diabetes mellitus (t2dm) is associated with a greater risk of alzheimer's disease. |
2024-02-07 |
2024-02-10 |
Not clear |
| Mridula Bhalla, C Justin Le. Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state. Molecular brain. vol 17. issue 1. 2024-01-12. PMID:38216963. |
alzheimer's disease (ad) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyloid beta (aβ) plaques in the brain, elevated release of inhibitory neurotransmitter gamma-aminobutyric acid (gaba) and reactive oxygen species from astrocytes, and subsequent neurodegeneration. |
2024-01-12 |
2024-01-15 |
mouse |
| Paula Zaręba, Kamil Łątka, Gabriela Mazur, Beata Gryzło, Anna Pasieka, Justyna Godyń, Dawid Panek, Anna Skrzypczak-Wiercioch, Georg C Höfner, Gniewomir Latacz, Maciej Maj, Alba Espargaró, Raimon Sabaté, Krzysztof Jóźwiak, Klaus T Wanner, Kinga Sałat, Barbara Malawska, Katarzyna Kulig, Marek Bajd. Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 261. 2023-10-14. PMID:37837674. |
discovery of novel multifunctional ligands targeting gaba transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of alzheimer's disease. |
2023-10-14 |
2023-11-08 |
Not clear |
| Jens V Andersen, Arne Schousboe, Petrine Wellendorp. Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling. Essays in biochemistry. 2023-02-22. PMID:36806927. |
disrupted inhibitory signaling and dysfunctional astrocyte gaba handling are implicated in several diseases including epilepsy and alzheimer's disease. |
2023-02-22 |
2023-08-14 |
Not clear |
| Ankita Rajput, Palvi Sharma, Nitish Kumar, Sarabjit Kaur, Saroj Aror. Neuroprotective activity of novel phenanthrene derivative from Grewia tiliaefolia by in vitro and in silico studies. Scientific reports. vol 13. issue 1. 2023-02-10. PMID:36765125. |
in silico study was conducted to predict its action on proteins playing crucial role in neurological and neurodegenerative disorders such as gamma amino butyric acid (gaba) receptor and glutamate α amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (glu ampa) receptor in epilepsy and ache enzyme in alzheimer's diseases. |
2023-02-10 |
2023-08-14 |
Not clear |
| Hongzhu Li, Lanfeng Lai, Xin Li, Runyi Wang, Xiaoling Fang, Nenggui Xu, Jiaying Zha. Electroacupuncture Ameliorates Cognitive Impairment by Regulating γ-Amino Butyric Acidergic Interneurons in the Hippocampus of 5 Familial Alzheimer's Disease Mice. Neuromodulation : journal of the International Neuromodulation Society. 2023-01-05. PMID:36604241. |
γ-amino butyric acid (gaba)-ergic dysfunction in excitatory and inhibitory (e/i) imbalance drives the pathogenesis of alzheimer's disease (ad). |
2023-01-05 |
2023-08-14 |
mouse |
| James Auta, Andrea Locci, Alessandro Guidotti, John M Davis, Hongxin Don. Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation. Current research in neurobiology. vol 3. 2022-12-15. PMID:36518344. |
sex-dependent sensitivity to positive allosteric modulation of gaba action in an app knock-in mouse model of alzheimer's disease: potential epigenetic regulation. |
2022-12-15 |
2023-08-14 |
mouse |
| Afia B Ali, Anam Islam, Andrew Constant. The fate of interneurons, GABA Brain pathology (Zurich, Switzerland). 2022-11-21. PMID:36409151. |
the fate of interneurons, gaba alzheimer's disease (ad) is the most common neurological disease, which is associated with gradual memory loss and correlated with synaptic hyperactivity and abnormal oscillatory rhythmic brain activity that precedes phenotypic alterations and is partly responsible for the spread of the disease pathology. |
2022-11-21 |
2023-08-14 |
Not clear |
| Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Luis de la Ossa, Ester Aso, Laura Gómez-Acero, Ryuichi Shigemoto, Yugo Fukazawa, Francisco Ciruela, Rafael Lujá. Nanoscale alterations in GABA Alzheimer's research & therapy. vol 14. issue 1. 2022-09-21. PMID:36131327. |
nanoscale alterations in gaba alzheimer's disease (ad) is characterized by a reorganization of brain activity determining network hyperexcitability and loss of synaptic plasticity. |
2022-09-21 |
2023-08-14 |
Not clear |
| Hugo R Arias, Allison L Germann, Spencer R Pierce, Seiji Sakamoto, Marcelo O Ortells, Itaru Hamachi, Gustav Ak. Modulation of the mammalian GABA British journal of pharmacology. 2022-09-09. PMID:36082615. |
modulation of the mammalian gaba positive allosteric modulators of the α7 nachr (α7-pams) possess promnesic and procognitive properties, and have potential in the treatment of cognitive and psychiatric disorders including alzheimer's disease and schizophrenia. |
2022-09-09 |
2023-08-14 |
Not clear |
| Xi Gu, Junhao Wang, Xiaodan Jian. miR-124- and let-7-Mediated Reprogram of Human Fibroblasts into SST Interneurons. ACS chemical neuroscience. 2022-09-08. PMID:36074953. |
dysfunction of γ-aminobutyric acid (gaba)ergic interneurons may cause a variety of neurological and psychiatric disorders such as epilepsy, autism, alzheimer's disease, and depression. |
2022-09-08 |
2023-08-14 |
human |
| Sanjeev Billa, Yaswanthi Yanamadala, Imran Hossain, Shabnam Siddiqui, Nicolaie Moldovan, Teresa A Murray, Prabhu U Arumuga. Brain-Implantable Multifunctional Probe for Simultaneous Detection of Glutamate and GABA Neurotransmitters: Optimization and In Vivo Studies. Micromachines. vol 13. issue 7. 2022-07-27. PMID:35888825. |
imbalances in levels of glutamate (glu) and gamma-aminobutyric acid (gaba) and their sub-second signaling dynamics occur in several brain disorders including traumatic brain injury, epilepsy, and alzheimer's disease. |
2022-07-27 |
2023-08-14 |
Not clear |
| b' Jovana Aran\\xc4\\x91elovi\\xc4\\x87, Anja Santra\\xc4\\x8d, Bojan Batini\\xc4\\x87, Lidija Todorovi\\xc4\\x87, Vladimir Stevanovi\\xc4\\x87, Veera Venkata Naga Phani Babu Tiruveedhula, Dishary Sharmin, Farjana Rashid, Boban Stanojevi\\xc4\\x87, James M Cook, Miroslav M Savi\\xc4\\x8. Effects of \\xce\\xb15 GABA CNS neuroscience & therapeutics. 2022-07-13. PMID:35822698.' |
effects of α5 gaba gabaergic modulation involved in cognitive processing appears to be substantially changed in alzheimer's disease (ad). |
2022-07-13 |
2023-08-14 |
Not clear |
| Jinfei Mei, Huijuan Yang, Sajjad Ahmad, Xiaohong Ma, Wen Xu, Wenqi Gao, Ye Li, Chuanbo Wang, Hongqi A. Toxicity Mechanism of Aβ42 Oligomer in the Binding between the GABA ACS chemical neuroscience. 2022-06-23. PMID:35737468. |
toxicity mechanism of aβ42 oligomer in the binding between the gaba amyloid-β peptide (aβ), characterized by its abnormal folding into neurotoxic aggregates, impairs synaptic plasticity and causes synaptic loss associated with alzheimer's disease (ad). |
2022-06-23 |
2023-08-14 |
Not clear |