| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rifat Jabeen, Nusrat Jan, Bazila Naseer, Prakash Kumar Sarangi, Kandi Sridhar, Praveen Kumar Dikkala, Maharshi Bhaswant, Syed Zameer Hussain, Baskaran Stephen Inbara. Development of Germinated-Brown-Rice-Based Novel Functional Beverage Enriched with γ-Aminobutyric Acid: Nutritional and Bio-Functional Characterization. Foods (Basel, Switzerland). vol 13. issue 8. 2024-04-27. PMID:38672954. |
γ-aminobutyric acid (gaba), recognized as a primary inhibitory neurotransmitter within the brain, serves a crucial role in the aging process and in neurodegenerative conditions such as alzheimer's disease. |
2024-04-27 |
2024-04-29 |
Not clear |
| Arubala P Reddy, Priyanka Rawat, Nicholas Rohr, Razelle Alvir, Jasbir Bisht, Mst Anika Bushra, Jennifer Luong, Aananya P Redd. Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis. Aging and disease. 2024-04-12. PMID:38607731. |
the neurotransmitter serotonin (5-hydroxytryptamine, 5-ht) is implicated mainly in alzheimer's disease (ad) and reported to be responsible for several processes and roles in the human body, such as regulating sleep, food intake, sexual behavior, anxiety, and drug abuse. |
2024-04-12 |
2024-04-15 |
human |
| A Saud, V Krishnaraju, A Taha, K Kalpana, V Malarkodi, S Durgaramani, V Vinoth Prabhu, F A Saleh, S Ezhilarasa. Potential acetylcholinesterase inhibitors to treat Alzheimer's disease. European review for medical and pharmacological sciences. vol 28. issue 6. 2024-04-03. PMID:38567612. |
a lack of the brain neurotransmitter acetylcholine has been related to the etiology of alzheimer's disease. |
2024-04-03 |
2024-04-05 |
Not clear |
| Jason D Braga, Masubon Thongngam, Thanutchaporn Kumrungse. Gamma-aminobutyric acid as a potential postbiotic mediator in the gut-brain axis. NPJ science of food. vol 8. issue 1. 2024-04-02. PMID:38565567. |
imbalances of this neurotransmitter are associated with neurological diseases, such as alzheimer's and parkinson's disease, and psychological disorders, including anxiety, depression, and stress. |
2024-04-02 |
2024-04-05 |
human |
| Arash Salehi, Behzad Zolfaghari, Mahmoud Aghaei, Hajar Sirous, Morteza Sadeghi, Mohammad Reza Gholami, Parham Reisi, Mustafa Ghanadia. New amide and diterpene alkaloids with anticholinesterase activity from Delphinium cyphoplectrum roots. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2024-03-18. PMID:38498253. |
the cholinergic hypothesis posits a robust correlation between the onset of alzheimer's disease and a pronounced deficit in acetylcholine, a pivotal neurotransmitter crucial for the central cholinergic nervous system's function, pivotal for memory and learning. |
2024-03-18 |
2024-03-21 |
Not clear |
| Hyun Lee, Hyeongmin Lee, Jinhyung Choi, Gyujeong Hwang, Hyemin Lee, Hyunmin Lee, Sujeong Kim, Minjeong Kim, Huiju Nam, Jaeyoon Shim, Hatem Jaber, Jongeun Yi. Investigation of the Approaches to Optimal Exercise Interventions Based on Dementia Type: A Theoretical Review. Healthcare (Basel, Switzerland). vol 12. issue 5. 2024-03-12. PMID:38470687. |
for alzheimer's, a combination of drug therapies and exercises is recommended to enhance cerebral blood flow and neurotransmitter activity. |
2024-03-12 |
2024-03-15 |
Not clear |
| Monika Sharma, Pankaj Pal, Sukesh Kumar Gupt. The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons. Brain research. 2024-02-11. PMID:38342422. |
the neurotransmitter puzzle of alzheimer's: dissecting mechanisms and exploring therapeutic horizons. |
2024-02-11 |
2024-02-14 |
Not clear |
| Ayman Bou Ghanem, Yaman Hussayni, Raghid Kadbey, Yara Ratel, Shereen Yehya, Lara Khouzami, Hilda E Ghadieh, Amjad Kanaan, Sami Azar, Frederic Har. Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases. Frontiers in aging neuroscience. vol 15. 2024-01-19. PMID:38239489. |
in neurodegenerative disorders like alzheimer's and parkinson's, perturbations in ocm pathways are implicated in the dysregulation of neurotransmitter synthesis and mitochondrial dysfunction, contributing to disease pathophysiology. |
2024-01-19 |
2024-01-21 |
Not clear |
| Camila W Adarvez-Feresin, Javier E Ortiz, Mauricio D Piñeiro, Oscar Parravicini, Ricardo D Enriz, Adriana D Garro, Gabriela E Feresi. Inhibitory effect of galantamine and donepezil combination against cholinesterase: An in silico and in vitro study. Archiv der Pharmazie. 2024-01-16. PMID:38229212. |
these combinations might be a possible therapy to improved efficacy, reduced doses, minor side effects, and high levels of the neurotransmitter in the synaptic space for alzheimer's disease. |
2024-01-16 |
2024-01-19 |
Not clear |
| Mridula Bhalla, C Justin Le. Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state. Molecular brain. vol 17. issue 1. 2024-01-12. PMID:38216963. |
alzheimer's disease (ad) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyloid beta (aβ) plaques in the brain, elevated release of inhibitory neurotransmitter gamma-aminobutyric acid (gaba) and reactive oxygen species from astrocytes, and subsequent neurodegeneration. |
2024-01-12 |
2024-01-15 |
mouse |
| Jingxuan Guo, Jia Sun, Donghui Liu, Ji Liu, Lijuan Gui, Man Luo, Dexin Kong, Sainaiwaiergul Wusiman, Chang Yang, Ting Liu, Zhenwei Yuan, Ruixi L. Developing a Two-Photon "AND" Logic Probe and Its Application in Alzheimer's Disease Differentiation. Analytical chemistry. 2023-11-10. PMID:37947381. |
in alzheimer's disease, hypochlorous acid involved in the clearance of invading bacteria or pathogens and butyrylcholinesterase engaged in the hydrolysis of the neurotransmitter acetylcholine are relatively significantly altered. |
2023-11-10 |
2023-11-20 |
mouse |
| Filippo Basagni, Jose A Ortega, Sine M Bertozzi, Andrea Armirotti, Maria Summa, Rosalia Bertorelli, Manuela Bartolini, Ian R Mellor, Martina Bedeschi, Giovanni Bottegoni, Vittorio Lembo, Anna Minarini, Andrea Cavalli, Michela Rosin. Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties. European journal of medicinal chemistry. vol 261. 2023-09-21. PMID:37734258. |
neurodegenerative processes characterizing alzheimer's disease (ad) are strictly related to the impairment of cholinergic and glutamatergic neurotransmitter systems which provoke synaptic loss. |
2023-09-21 |
2023-10-07 |
Not clear |
| Ann-Kathrin Weishaupt, Laura Kubens, Lysann Ruecker, Tanja Schwerdtle, Michael Aschner, Julia Bornhors. A Reliable Method Based on Liquid Chromatography-Tandem Mass Spectrometry for the Simultaneous Quantification of Neurotransmitters in Molecules (Basel, Switzerland). vol 28. issue 14. 2023-07-29. PMID:37513246. |
balance in neurotransmitter homeostasis is essential, and altered neurotransmitter levels are associated with various neurological disorders, e.g., loss of dopaminergic neurons (parkinson's disease) or altered ach synthesis (alzheimer's disease). |
2023-07-29 |
2023-08-14 |
Not clear |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
the depletion of the neurotransmitter acetylcholine has been suggested to contribute to the reduced cognitive function observed in individuals suffering from neurodegenerative diseases such as alzheimer's disease (ad). |
2023-06-26 |
2023-08-14 |
Not clear |
| Yihuai Peng, Zhen Du, Jianxiu Duan, Yaqin Shao, Shengdan Ni. MiR-107 Activates NF- κ B versus A β Analysis of the regulatory effect of 1-42 induced apoptosis in Alzheimer's disease cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 3. 2023-06-11. PMID:37300691. |
research in recent years has shown that micrornas play an effective role in alzheimer's disease and neurotransmitter factors. |
2023-06-11 |
2023-08-14 |
Not clear |
| Yihuai Peng, Zhen Du, Jianxiu Duan, Yaqin Shao, Shengdan Ni. MiR-107 Activates NF- κ B versus A β Analysis of the regulatory effect of 1-42 induced apoptosis in Alzheimer's disease cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 3. 2023-06-11. PMID:37300691. |
experiments conducted using the dual luciferase method and western blot analysis also showed that mir-107 in primary neurons affects neurotransmitter factors in alzheimer's disease through the regulation of the nf-κb signaling pathway. |
2023-06-11 |
2023-08-14 |
Not clear |
| Meng Zhang, Li-Yuan Liu, Yong Xu, Wen-Zhi Wang, Nian-Zhuang Qiu, Fang-Fang Zhang, Feng Zhang, Xiao-Dan Wang, Wei Chen, Xiao-Yan Xu, Yong-Feng Gao, Mei-Hua Chen, Yu-Qin Li, Han-Ting Zhang, Hao Wan. Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer disease. Metabolic brain disease. 2023-05-31. PMID:37256468. |
imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of alzheimer disease. |
2023-05-31 |
2023-08-14 |
mouse |
| Joanna Grzelczyk, Dominik Szwajgier, Ewa Baranowska-Wójcik, Horacio Pérez-Sánchez, Miguel Carmena-Bargueño, Bożena Sosnowska, Grażyna Budry. Effect of Inhibiting Butyrylcholinesterase Activity Using Fractionated Coffee Extracts Digested In Vitro in Gastrointestinal Tract: Docking Simulation and Calorimetric and Studies. Nutrients. vol 15. issue 10. 2023-05-27. PMID:37242249. |
butyrylcholinesterase (bche) is a major enzyme from the alpha-glycoprotein family that catalyzes the hydrolysis of neurotransmitter acetylcholine (ach), lowering the concentration of ach in the nervous system, which could cause aggravation of alzheimer's disease (ad). |
2023-05-27 |
2023-08-14 |
Not clear |
| Yongheum Choi, Chang Su Jeon, Kwang Bok Kim, Hyun-Jong Kim, Sung Hyun Pyun, Young Min Par. Quantitative detection of dopamine in human serum with surface-enhanced Raman scattering (SERS) of constrained vibrational mode. Talanta. vol 260. 2023-05-05. PMID:37146455. |
dopamine (da) is a crucial neurotransmitter involved in the hormonal, nervous, and vascular systems being considered as an index to diagnose neurodegenerative diseases, including parkinson's and alzheimer's disease. |
2023-05-05 |
2023-08-14 |
human |