| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Predescu, Tudor Vaidean, Andreea-Marlena Rapciuc, Roxana Sipo. Metabolomic Markers in Attention-Deficit/Hyperactivity Disorder (ADHD) among Children and Adolescents-A Systematic Review. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673970. |
synthesis revealed intricate links between adhd and altered amino acid metabolism, neurotransmitter dysregulation (especially dopamine and serotonin), oxidative stress, and the kynurenine pathway impacting neurotransmitter homeostasis. |
2024-04-27 |
2024-04-29 |
human |
| Lina Bukowski, Markus Emanuel Strøm, Jens Lindengren Andersen, Jannick Bang Maesen, Lin Tian, Steffen Sinnin. 5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release. Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38504103. |
5ht_fastr accelerates and democratizes functional characterization and pharmacological studies of serotonin transporters and genetic variants thereof in disease states such as depression, anxiety and adhd. |
2024-03-20 |
2024-03-23 |
Not clear |
| Sampath Madhyastha, Muddanna S Rao, Waleed M Renn. Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396978. |
of late, the emerging results point out the serotonergic (5-ht) system, which indirectly modulates the da activity in reducing the core symptoms of adhd. |
2024-02-24 |
2024-02-26 |
rat |
| Sampath Madhyastha, Muddanna S Rao, Waleed M Renn. Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396978. |
on this basis, second-generation antipsychotics, which utilize 5-ht receptors, were prescribed to children with adhd. |
2024-02-24 |
2024-02-26 |
rat |
| Lorissa Lamoureux, Joel Beverley, Heinz Steiner, Michela Marinell. Methylphenidate with or without fluoxetine triggers reinstatement of cocaine seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-12-12. PMID:38086900. |
combined exposure to mp and selective serotonin reuptake inhibitors such as fluoxetine (flx) can also occur, such as in the treatment of adhd with depression comorbidity or when patients taking flx use mp for non-medical purposes. |
2023-12-12 |
2023-12-17 |
rat |
| Larisa M Dinu, Samriddhi N Singh, Neo S Baker, Alexandra L Georgescu, Paul G Overton, Eleanor J Dommet. The effects of tryptophan loading on Attention Deficit Hyperactivity in adults: A remote double blind randomised controlled trial. PloS one. vol 18. issue 11. 2023-11-30. PMID:38033150. |
despite the impact and prevalence of attention deficit hyperactivity disorder (adhd), current treatment options remain limited and there is a drive for alternative approaches, including those building on evidence of a role for tryptophan (trp) and serotonin (5-ht). |
2023-11-30 |
2023-12-10 |
Not clear |
| Ángela González-Martínez, Susana Muñiz de Miguel, Noemi Graña, Xiana Costas, Francisco Javier Diégue. Serotonin and Dopamine Blood Levels in ADHD-Like Dogs. Animals : an open access journal from MDPI. vol 13. issue 6. 2023-03-29. PMID:36978578. |
adhd has a very complex pathophysiology in which many neurotransmitters are involved, such as serotonin and dopamine. |
2023-03-29 |
2023-08-14 |
dog |
| Jong-In Park, In-Ho Lee, Seung-Jea Lee, Ryeo-Won Kwon, Eon-Ah Choo, Hyun-Woo Nam, Jeong-Beom Le. Effects of music therapy as an alternative treatment on depression in children and adolescents with ADHD by activating serotonin and improving stress coping ability. BMC complementary medicine and therapies. vol 23. issue 1. 2023-03-06. PMID:36879223. |
effects of music therapy as an alternative treatment on depression in children and adolescents with adhd by activating serotonin and improving stress coping ability. |
2023-03-06 |
2023-08-14 |
Not clear |
| Jong-In Park, In-Ho Lee, Seung-Jea Lee, Ryeo-Won Kwon, Eon-Ah Choo, Hyun-Woo Nam, Jeong-Beom Le. Effects of music therapy as an alternative treatment on depression in children and adolescents with ADHD by activating serotonin and improving stress coping ability. BMC complementary medicine and therapies. vol 23. issue 1. 2023-03-06. PMID:36879223. |
the objective of this study was to determine the effect of music therapy as an alternative treatment on depression in children and adolescents with attention-deficit hyperactivity disorder (adhd) by activating serotonin (5-ht) and improving stress coping ability. |
2023-03-06 |
2023-08-14 |
Not clear |
| Chungsoo Kim, Dong Yun Lee, Jimyung Park, Su-Jin Yang, Eng Hooi Tan, Daniel-Prieto Alhambra, Yo Han Lee, Sangha Lee, Seong-Ju Kim, Jeewon Lee, Rae Woong Park, Yunmi Shi. Safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression: Psychological medicine. 2023-02-21. PMID:36803587. |
safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression: attention deficit-hyperactivity disorder (adhd) is related to depressive disorder, and adolescents with both present poor outcomes. |
2023-02-21 |
2023-08-14 |
Not clear |
| Chungsoo Kim, Dong Yun Lee, Jimyung Park, Su-Jin Yang, Eng Hooi Tan, Daniel-Prieto Alhambra, Yo Han Lee, Sangha Lee, Seong-Ju Kim, Jeewon Lee, Rae Woong Park, Yunmi Shi. Safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression: Psychological medicine. 2023-02-21. PMID:36803587. |
however, evidence for the safety of concomitantly using a methylphenidate (mph) and a selective serotonin reuptake inhibitor (ssri) among adolescent adhd patients is limited, a literature gap aimed to address through this investigation. |
2023-02-21 |
2023-08-14 |
Not clear |
| Maeri Yamamoto, Toshiya Inad. Positron emission tomography studies in adult patients with attention-deficit/hyperactivity disorder. Japanese journal of radiology. 2022-12-08. PMID:36480104. |
we found that, although, disturbances of dopamine, serotonin, and norepinephrine functions have been implicated in adhd, no characteristic findings have been identified from pet studies in patients with adhd. |
2022-12-08 |
2023-08-14 |
Not clear |
| Panayotis K Thanos, Madison McCarthy, Daniela Senior, Samantha Watts, Carly Connor, Nikki Hammond, Kenneth Blum, Michael Hadjiargyrou, David Komatsu, Heinz Steine. Combined chronic oral methylphenidate and fluoxetine treatment during adolescence: Effects on behavior. Current pharmaceutical biotechnology. 2022-10-28. PMID:36306463. |
attention deficit hyperactivity disorder (adhd) can be comorbid with depression, often leading to prescription of both methylphenidate (mp) and selective serotonin reuptake inhibitor (ssri) antidepressants, such as fluoxetine (flx). |
2022-10-28 |
2023-08-14 |
Not clear |
| Ramkripa Raghavan, Neha S Anand, Guoying Wang, Xiumei Hong, Colleen Pearson, Barry Zuckerman, Hehuang Xie, Xiaobin Wan. Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder. Translational psychiatry. vol 12. issue 1. 2022-07-09. PMID:35810183. |
alterations in tryptophan and serotonin have been implicated in various mental disorders; but studies are limited on child neurodevelopmental disabilities such as autism spectrum disorder (asd) and attention-deficit hyperactivity disorder (adhd). |
2022-07-09 |
2023-08-14 |
human |
| Ramkripa Raghavan, Neha S Anand, Guoying Wang, Xiumei Hong, Colleen Pearson, Barry Zuckerman, Hehuang Xie, Xiaobin Wan. Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder. Translational psychiatry. vol 12. issue 1. 2022-07-09. PMID:35810183. |
this prospective cohort study examined the associations between levels of tryptophan and select metabolites (5-methoxytryptophol (5-mtx), 5-hydroxytryptophan (5-htp), serotonin, n-acetyltrytophan) in cord plasma (collected at birth) and physician-diagnosed asd, adhd and other developmental disabilities (dd) in childhood. |
2022-07-09 |
2023-08-14 |
human |
| Ramkripa Raghavan, Neha S Anand, Guoying Wang, Xiumei Hong, Colleen Pearson, Barry Zuckerman, Hehuang Xie, Xiaobin Wan. Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder. Translational psychiatry. vol 12. issue 1. 2022-07-09. PMID:35810183. |
cord serotonin was not associated with asd, adhd, and other dd. |
2022-07-09 |
2023-08-14 |
human |
| Lenard A Adler, Julie Adams, Jessica Madera-McDonough, Eva Kohegyi, Mary Hobart, Denise Chang, Mark Angelicola, Robert McQuade, Michael Liebowit. Efficacy, Safety, and Tolerability of Centanafadine Sustained-Release Tablets in Adults With Attention-Deficit/Hyperactivity Disorder: Results of 2 Phase 3, Randomized, Double-blind, Multicenter, Placebo-Controlled Trials. Journal of clinical psychopharmacology. 2022-06-02. PMID:35652746. |
centanafadine is an inhibitor of norepinephrine, dopamine, and serotonin reuptake transporters under investigation for the treatment of attention-deficit/hyperactivity disorder (adhd). |
2022-06-02 |
2023-08-14 |
Not clear |
| Nikhil M Urs, Sharonda Harris, Sara M Green, Mayank M Kuma. A Role for Cortical Dopamine in the Paradoxical Calming Effects of Psychostimulants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554609. |
studies using the dopamine (da) transporter (dat) knockout mice, which have elevated striatal da levels and are considered an animal model of adhd, have suggested that the paradoxical calming effect of psychostimulants might be through the actions on serotonin neurotransmission. |
2022-05-13 |
2023-08-13 |
mouse |
| Nikhil M Urs, Sharonda Harris, Sara M Green, Mayank M Kuma. A Role for Cortical Dopamine in the Paradoxical Calming Effects of Psychostimulants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554609. |
together, these data suggest that elevation of pfc dopamine and not norepinephrine or serotonin as a convergent mechanism for the paradoxical psychostimulant effects observed in adhd therapy. |
2022-05-13 |
2023-08-13 |
mouse |
| Larisa Maria Dinu, Nachaphol Phattharakulnij, Eleanor Jane Dommet. Tryptophan modulation in individuals with attention deficit hyperactivity disorder: a systematic review. Journal of neural transmission (Vienna, Austria : 1996). 2022-03-14. PMID:35286460. |
the serotonergic system is implicated in adhd, but the impact of serotonin's precursor molecule, tryptophan, on adhd symptomology remains unclear. |
2022-03-14 |
2023-08-13 |
Not clear |