| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petrilla Jayaprakash, Dmytro Isaev, Keun-Hang Susan Yang, Rami Beiram, Murat Oz, Bassem Sade. Apigenin Alleviates Autistic-like Stereotyped Repetitive Behaviors and Mitigates Brain Oxidative Stress in Mice. Pharmaceuticals (Basel, Switzerland). vol 17. issue 4. 2024-04-27. PMID:38675442. |
studying the involvement of nicotinic acetylcholine receptors (nachrs), specifically α7-nachrs, in neuropsychiatric brain disorders such as autism spectrum disorder (asd) has gained a growing interest. |
2024-04-27 |
2024-04-29 |
mouse |
| Toshiya Matsushima, Momoko Miura, Nina Patzke, Noriyuki Toji, Kazuhiro Wada, Yukiko Ogura, Koichi J Homma, Paola Sgadò, Giorgio Vallortigar. Fetal blockade of nicotinic acetylcholine transmission causes autism-like impairment of biological motion preference in the neonatal chick. Cerebral cortex communications. vol 3. issue 4. 2023-09-07. PMID:37674673. |
several environmental chemicals are suspected risk factors for autism spectrum disorder (asd), including valproic acid (vpa) and pesticides acting on nicotinic acetylcholine receptors (nachrs), if administered during pregnancy. |
2023-09-07 |
2023-10-07 |
chicken |
| Alexandra Ure, Georgina R Cox, Richard Haslam, Katrina William. Acetylcholinesterase inhibitors for autistic spectrum disorders. The Cochrane database of systematic reviews. vol 6. 2023-06-02. PMID:37267443. |
low levels of acetylcholine have been investigated as a potential contributor to autism symptomatology. |
2023-06-02 |
2023-08-14 |
Not clear |
| Ana Sofía Vallés, Francisco J Barrante. Dysregulation of Neuronal Nicotinic Acetylcholine Receptor-Cholesterol Crosstalk in Autism Spectrum Disorder. Frontiers in molecular neuroscience. vol 14. 2021-11-23. PMID:34803605. |
dysregulation of neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in autism spectrum disorder. |
2021-11-23 |
2023-08-13 |
Not clear |
| b' P Ballester, A L Richdale, E K Baker, A M Peir\\xc3\\xb. Sleep in autism: A biomolecular approach to aetiology and treatment. Sleep medicine reviews. vol 54. 2021-10-04. PMID:32759030.' |
this review approaches sleep in autism from several perspectives: sleep-wake mechanisms and problems, and brain areas and molecules controlling sleep (e.g., gaba and melatonin) and wake maintenance (e.g., serotonin, acetylcholine and glutamate). |
2021-10-04 |
2023-08-13 |
Not clear |
| Karthikkumar Venkatachalam, Nermin Eissa, Mohamed Al Awad, Petrilla Jayaprakash, Sicheng Zhong, Frauke Stölting, Holger Stark, Bassem Sade. The histamine H3R and dopamine D2R/D3R antagonist ST-713 ameliorates autism-like behavioral features in BTBR T+tf/J mice by multiple actions. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-07-23. PMID:33773463. |
several brain neurotransmitters, including histamine (ha), acetylcholine (ach), and dopamine (da) are suggested to be involved in several brain disorders including cognitive deficits, depression, schizophrenia, anxiety, and narcolepsy, all of which are comorbid with autism spectrum disorder (asd). |
2021-07-23 |
2023-08-13 |
mouse |
| Hafiz M Mahmood, Hesham M Aldhalaan, Tahani K Alshammari, Mashael A Alqasem, Musaad A Alshammari, Norah A Albekairi, Shakir D AlSharar. The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model. Autism research : official journal of the International Society for Autism Research. vol 13. issue 8. 2021-04-07. PMID:32691528. |
recent studies have demonstrated the importance of nicotinic acetylcholine receptors (nachrs) in the autistic behavior of btbr t + tf/j mouse model of autism. |
2021-04-07 |
2023-08-13 |
mouse |
| Rosa Marotta, Maria C Risoleo, Giovanni Messina, Lucia Parisi, Marco Carotenuto, Luigi Vetri, Michele Roccell. The Neurochemistry of Autism. Brain sciences. vol 10. issue 3. 2020-09-28. PMID:32182969. |
in this review, we aim to delineate the state-of-the-art main research findings about the neurochemical alterations in autism etiology, and focuses on gamma aminobutyric acid (gaba) and glutamate, serotonin, dopamine, n-acetyl aspartate, oxytocin and arginine-vasopressin, melatonin, vitamin d, orexin, endogenous opioids, and acetylcholine. |
2020-09-28 |
2023-08-13 |
Not clear |
| Nermin Eissa, Sheikh Azimullah, Petrilla Jayaprakash, Richard L Jayaraj, David Reiner, Shreesh K Ojha, Rami Beiram, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sade. The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice. Chemico-biological interactions. vol 312. 2019-10-07. PMID:31369746. |
the dual-active histamine h3 receptor antagonist and acetylcholine esterase inhibitor e100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice. |
2019-10-07 |
2023-08-13 |
mouse |
| Alan S Lewis, Gerrit Ian van Schalkwyk, Mayra Ortiz Lopez, Fred R Volkmar, Marina R Picciotto, Denis G Sukhodolsk. An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder. Journal of autism and developmental disorders. vol 48. issue 8. 2019-07-15. PMID:29536216. |
nicotinic acetylcholine receptors (nachrs), particularly the α7 nachr, are implicated in the pathophysiology of both autism spectrum disorder (asd) and aggressive behavior. |
2019-07-15 |
2023-08-13 |
human |
| Stephen Grossber. Acetylcholine Neuromodulation in Normal and Abnormal Learning and Memory: Vigilance Control in Waking, Sleep, Autism, Amnesia and Alzheimer's Disease. Frontiers in neural circuits. vol 11. 2018-07-09. PMID:29163063. |
acetylcholine neuromodulation in normal and abnormal learning and memory: vigilance control in waking, sleep, autism, amnesia and alzheimer's disease. |
2018-07-09 |
2023-08-13 |
Not clear |
| Yoshiaki Omura, Dominic Lu, Marilyn K Jones, Ahdallah Nihrane, Harsha Duvvi, Yasuhiro Shimotsuura, Motomu Ohk. Early Detection of Autism (ASD) by a Non-invasive Quick Measurement of Markedly Reduced Acetylcholine & DHEA and Increased β-Amyloid (1-42), Asbestos (Chrysotile), Titanium Dioxide, Al, Hg & often Coexisting Virus Infections (CMV, HPV 16 and 18), Bacterial Infections etc. in the Brain and Corresponding Safe Individualized Effective Treatment. Acupuncture & electro-therapeutics research. vol 40. issue 3. 2016-03-10. PMID:26829843. |
in addition the optimal doses of vitamin d3 and taurine may play an important role in the future treatment of autism, alzheimer's disease and memory disturbances by significantly increasing acetylcholine and dhea levels, enhancing the excretion of toxic substances in the urine, as well as having an anticancer effect. |
2016-03-10 |
2023-08-13 |
Not clear |
| Yoshiaki Omura, Dominic Lu, Marilyn K Jones, Ahdallah Nihrane, Harsha Duvvi, Yasuhiro Shimotsuura, Motomu Ohk. Early Detection of Autism (ASD) by a Non-invasive Quick Measurement of Markedly Reduced Acetylcholine & DHEA and Increased β-Amyloid (1-42), Asbestos (Chrysotile), Titanium Dioxide, Al, Hg & often Coexisting Virus Infections (CMV, HPV 16 and 18), Bacterial Infections etc. in the Brain and Corresponding Safe Individualized Effective Treatment. Acupuncture & electro-therapeutics research. vol 40. issue 3. 2016-03-10. PMID:26829843. |
early detection of autism (asd) by a non-invasive quick measurement of markedly reduced acetylcholine & dhea and increased β-amyloid (1-42), asbestos (chrysotile), titanium dioxide, al, hg & often coexisting virus infections (cmv, hpv 16 and 18), bacterial infections etc. |
2016-03-10 |
2023-08-13 |
Not clear |
| Yoshiaki Omura, Dominic Lu, Marilyn K Jones, Ahdallah Nihrane, Harsha Duvvi, Yasuhiro Shimotsuura, Motomu Ohk. Early Detection of Autism (ASD) by a Non-invasive Quick Measurement of Markedly Reduced Acetylcholine & DHEA and Increased β-Amyloid (1-42), Asbestos (Chrysotile), Titanium Dioxide, Al, Hg & often Coexisting Virus Infections (CMV, HPV 16 and 18), Bacterial Infections etc. in the Brain and Corresponding Safe Individualized Effective Treatment. Acupuncture & electro-therapeutics research. vol 40. issue 3. 2016-03-10. PMID:26829843. |
simple non- invasive measurement of various molecules through pupils & head of diagnosed or suspected autism patients indicated that in autism patients following changes were often found: 1) acetylcholine is markedly reduced; 2) alzheimer's disease markers (i.e. |
2016-03-10 |
2023-08-13 |
Not clear |
| Maegan M Weltzin, Marvin K Schult. Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit. The Journal of pharmacology and experimental therapeutics. vol 354. issue 2. 2015-09-15. PMID:26025967. |
alterations in expression patterns of α4β2 nicotinic acetylcholine receptors have been demonstrated to alter cholinergic neurotransmission and are implicated in neurologic disorders, including autism, nicotine addiction, alzheimer's disease, and parkinson's disease. |
2015-09-15 |
2023-08-13 |
xenopus_laevis |
| Golan Karvat, Tali Kimch. Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 4. 2014-10-10. PMID:24096295. |
acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism. |
2014-10-10 |
2023-08-12 |
mouse |
| Undurti N Da. Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids. Nutrition (Burbank, Los Angeles County, Calif.). vol 29. issue 10. 2014-04-14. PMID:23911220. |
autism has a strong genetic and environmental basis in which inflammatory markers and factors concerned with synapse formation, nerve transmission, and information processing such as brain-derived neurotrophic factor (bdnf), polyunsaturated fatty acids (pufas): arachidonic (aa), eicosapentaenoic (epa), and docosahexaenoic acids (dha) and their products and neurotransmitters: dopamine, serotonin, acetylcholine, γ-aminobutyric acid, and catecholamines and cytokines are altered. |
2014-04-14 |
2023-08-12 |
Not clear |
| P M Lippiell. Nicotinic cholinergic antagonists: a novel approach for the treatment of autism. Medical hypotheses. vol 66. issue 5. 2006-05-25. PMID:16406687. |
evidence supports the hypothesis that normalization of cholinergic tone by selective antagonism of neuronal nicotinic acetylcholine receptors (nnrs) may ameliorate the core symptoms of autism. |
2006-05-25 |
2023-08-12 |
Not clear |
| P M Lippiell. Nicotinic cholinergic antagonists: a novel approach for the treatment of autism. Medical hypotheses. vol 66. issue 5. 2006-05-25. PMID:16406687. |
this may also explain why stimulants (known to increase dopamine levels as do nnr agonists) appear to aggravate autistic symptoms and why studies with cholinesterase inhibitors that increase acetylcholine levels in the brain have yielded variable effects in autism. |
2006-05-25 |
2023-08-12 |
Not clear |