| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T M Axelsen, P Høgh, A R Bihlet, M A Karsdal, K Henriksen, S G Hasselbalch, A H Simonse. Serum Tau-A and Tau-C Levels and Their Association with Cognitive Impairment and Dementia Progression in a Memory Clinic Derived Cohort. The journal of prevention of Alzheimer's disease. vol 11. issue 3. 2024-05-06. PMID:38706289. |
serum-measured fragments of tau cleaved by adam-10 (tau-a) and caspase-3 (tau-c) have been found linked to change in cognitive function and risk of dementia. |
2024-05-06 |
2024-05-08 |
Not clear |
| Min Wang, Jiaying Lu, Ying Zhang, Qi Zhang, Luyao Wang, Ping Wu, Matthias Brendel, Axel Rominger, Kuangyu Shi, Qianhua Zhao, Jiehui Jiang, Chuantao Zu. Characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in Alzheimer's disease. Human brain mapping. vol 45. issue 7. 2024-05-04. PMID:38703095. |
tau pathology and its spatial propagation in alzheimer's disease (ad) play crucial roles in the neurodegenerative cascade leading to dementia. |
2024-05-04 |
2024-05-07 |
human |
| Walter Ángel Trujillo-Rangel, Sofía Acuña-Vaca, Danna Jocelyn Padilla-Ponce, Florencia Guillermina García-Mercado, Blanca Miriam Torres-Mendoza, Fermín P Pacheco-Moises, Martha Escoto-Delgadillo, Leonel García-Benavides, Daniela L C Delgado-Lar. Modulation of the Circadian Rhythm and Oxidative Stress as Molecular Targets to Improve Vascular Dementia: A Pharmacological Perspective. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673986. |
additionally, oxidative stress in vascular dementia can arise from ischemia-reperfusion injury, amyloid-beta production, the abnormal phosphorylation of tau protein, and alterations in neurotransmitters, among others. |
2024-04-27 |
2024-04-29 |
Not clear |
| Karly A Cody, Rebecca E Langhough, Matthew D Zammit, Lindsay Clark, Nathaniel Chin, Bradley T Christian, Tobey J Betthauser, Sterling C Johnso. Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer's disease. Brain : a journal of neurology. 2024-04-26. PMID:38667631. |
this cohort study included a total of 601 individuals from the wisconsin registry for alzheimer's prevention and wisconsin alzheimer's disease research center that underwent amyloid and tau pet, longitudinal neuropsychological assessments, and met clinical criteria for three clinical diagnosis groups: cognitively unimpaired (cu; n=537); mild cognitive impairment (mci; n=48); or dementia (n=16)). |
2024-04-26 |
2024-04-28 |
human |
| Hunter T Warren, Hannah N Saeger, Robert J Tombari, Milan Chytil, Kurt Rasmussen, David E Olso. Psychoplastogenic DYRK1A Inhibitors with Therapeutic Effects Relevant to Alzheimer's Disease. Journal of medicinal chemistry. 2024-04-22. PMID:38648167. |
using this approach, we discovered a nonhallucinogenic compound capable of promoting cortical neuron growth and suppressing tau hyperphosphorylation while also having the potential to mitigate the biological and psychological symptoms of dementia. |
2024-04-22 |
2024-04-26 |
Not clear |
| Daniel C Shippy, Sophia F Oliai, Tyler K Ullan. Zinc utilization by microglia in Alzheimer's disease. The Journal of biological chemistry. 2024-04-22. PMID:38648940. |
alzheimer's disease (ad) is the most common form of dementia defined by two key pathological characteristics in the brain, amyloid-β (aβ) plaques and neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. |
2024-04-22 |
2024-04-26 |
Not clear |
| Osama Al-Dalahmah, Matti Lam, Julie J McInvale, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A Jakubiak, Rebekka Kühn, Yoon A Kim, Maria Caterina De Rosa, Claudia A Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Angeliki Mela, Hong Lu, Michael A DeTure, Jean Paul Vonsattel, Zbigniew K Wszolek, Dennis W Dickson, Tanja Kuhlmann, Holm Zaehres, Hans R Schöler, Andrew A Sproul, Markus D Siegelin, Philip L De Jager, James E Goldman, Vilas Menon, Peter Canoll, Gunnar Hargu. Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons. Cell stem cell. 2024-04-16. PMID:38626772. |
frontotemporal dementia (ftd) is an incurable group of early-onset dementias that can be caused by the deposition of hyperphosphorylated tau in patient brains. |
2024-04-16 |
2024-04-19 |
mouse |
| Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617229. |
for the youngest individual with no documented dementia samples exhibited sparse tau deposits. |
2024-04-15 |
2024-04-17 |
Not clear |
| Irina Alafuzoff, Sylwia Libar. Ageing-Related Neurodegeneration and Cognitive Decline. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612875. |
age-related tau astrogliopathy (artag) was observed in 37% of the 1610 subjects and in 53% of those with dementia. |
2024-04-13 |
2024-04-15 |
human |
| Tomoyuki Ohara, Harutsugu Tatebe, Jun Hata, Takanori Honda, Mao Shibata, Sayo Matsuura, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Takahiko Tokuda, Toshiharu Ninomiy. Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population. Psychiatry and clinical neurosciences. 2024-04-12. PMID:38606661. |
to assess the association between plasma amyloid β (aβ) 42/40, phosphorylated tau (p-τ)181, glial fibrillary acidic protein (gfap), or neurofilament light chain (nfl) and the risk of dementia and to determine whether these plasma biomarkers could improve the ability to predict incident dementia in a general older population. |
2024-04-12 |
2024-04-14 |
Not clear |
| Zsolt Huszár, Marie Anne Engh, Márk Pavlekovics, Tomoya Sato, Yalea Steenkamp, Bernard Hanseeuw, Tamás Terebessy, Zsolt Molnár, Péter Hegyi, Gábor Csukl. Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology: a systematic review and meta-analysis. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-12. PMID:38610055. |
risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology: a systematic review and meta-analysis. |
2024-04-12 |
2024-04-15 |
human |
| Geert Mayer, Helmut Frohnhofen, Martha Jokisch, Dirk M Hermann, Janine Gronewol. Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review. Frontiers in neuroscience. vol 18. 2024-04-08. PMID:38586191. |
aging is accompanied by changes of sleep structure, deposition of beta-amyloid (aß) and tau proteins and vascular changes and can turn into mild cognitive impairment (mci) as well as dementia. |
2024-04-08 |
2024-04-10 |
Not clear |
| Elijah Mak, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Christopher G Schwarz, Matthew L Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R Jack, Hoon Ki Min, Manoj K Jain, Toji Miyagawa, Leah K Forsberg, Julie A Fields, Rodolfo Savica, Jonathan Graff-Radford, David T Jones, Hugo Botha, Erik K St Louis, David S Knopman, Vijay K Ramanan, Dennis W Dickson, Neill R Graff-Radford, Tanis J Ferman, Ronald C Petersen, Val J Lowe, Bradley F Boeve, John T O'Brien, Kejal Kantarc. Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies. NPJ Parkinson's disease. vol 10. issue 1. 2024-04-03. PMID:38570511. |
influences of amyloid-β and tau on white matter neurite alterations in dementia with lewy bodies. |
2024-04-03 |
2024-04-06 |
Not clear |
| Elijah Mak, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Christopher G Schwarz, Matthew L Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R Jack, Hoon Ki Min, Manoj K Jain, Toji Miyagawa, Leah K Forsberg, Julie A Fields, Rodolfo Savica, Jonathan Graff-Radford, David T Jones, Hugo Botha, Erik K St Louis, David S Knopman, Vijay K Ramanan, Dennis W Dickson, Neill R Graff-Radford, Tanis J Ferman, Ronald C Petersen, Val J Lowe, Bradley F Boeve, John T O'Brien, Kejal Kantarc. Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies. NPJ Parkinson's disease. vol 10. issue 1. 2024-04-03. PMID:38570511. |
we evaluated the associations of tau and amyloid-β with dti and noddi parameters and examined the correlations of ad-related white matter injury with clinical dementia rating (cdr). |
2024-04-03 |
2024-04-06 |
Not clear |
| Dennis C Chan, ChaeMin Kim, Rachel Y Kang, Madison K Kuhn, Lynne M Beidler, Nanyin Zhang, Elizabeth A Procto. Cytokine expression patterns predict suppression of vulnerable neural circuits in a mouse model of Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559177. |
alzheimer's disease is a neurodegenerative disorder characterized by progressive amyloid plaque accumulation, tau tangle formation, neuroimmune dysregulation, synapse an neuron loss, and changes in neural circuit activation that lead to cognitive decline and dementia. |
2024-04-01 |
2024-04-04 |
mouse |
| Po-Chung Yu, Ching-Min Kuo, I-Chun Che. Tau and delirium superimposed on dementia: A case report. SAGE open medical case reports. vol 12. 2024-04-01. PMID:38559407. |
tau and delirium superimposed on dementia: a case report. |
2024-04-01 |
2024-04-04 |
Not clear |
| Sarah Buchholz, Hans Zempe. The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-01. PMID:38556838. |
the six brain-specific tau isoforms and their role in alzheimer's disease and related neurodegenerative dementia syndromes. |
2024-04-01 |
2024-04-03 |
human |
| Lisa Bransby, Nawaf Yassi, Emily Rosenich, Rachel Buckley, Qiao-Xin Li, Paul Maruff, Matthew Pase, Yen Ying Li. Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults. Neurobiology of aging. vol 138. 2024-03-27. PMID:38537555. |
this study aimed to determine associations between modifiable dementia risk factors (mdrf), across domains mood symptomatology, lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology, with cognition, beta-amyloid (aβ) and tau, and brain volume. |
2024-03-27 |
2024-03-30 |
Not clear |
| Martin Tolar, John A Hey, Aidan Power, Susan Abushakr. The Single Toxin Origin of Alzheimer's Disease and Other Neurodegenerative Disorders Enables Targeted Approach to Treatment and Prevention. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473975. |
amyloid oligomers appear to be the primary factor causing the synaptic impairment, neuronal stress, spreading of tau pathology, and eventual cell death that lead to the clinical syndrome of ad dementia. |
2024-03-13 |
2024-03-15 |
Not clear |
| Daniel Pirici, Laurentiu Mogoanta, Daniela Adriana Ion, Samir Kumar-Sing. Fractal Analysis in Neurodegenerative Diseases. Advances in neurobiology. vol 36. 2024-03-12. PMID:38468042. |
the abnormal conformation and assembly of proteins is suggested to be the most probable cause for many of these neurodegenerative disorders, leading to the accumulation of abnormally aggregated proteins, for example, amyloid β (aβ) (alzheimer's disease and vascular dementia), tau protein (alzheimer's disease and frontotemporal lobar degeneration), α-synuclein (parkinson's disease and lewy body dementia), polyglutamine expansion diseases (huntington disease), or prion proteins (creutzfeldt-jakob disease). |
2024-03-12 |
2024-03-14 |
Not clear |