| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Chai Chen, Mei-Chou Lai, Tang-Yao Hong, I-Min Li. γ-Oryzanol from Rice Bran Antagonizes Glutamate-Induced Excitotoxicity in an In Vitro Model of Differentiated HT-22 Cells. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674927. |
the excessive activation of glutamate in the brain is a factor in the development of vascular dementia. |
2024-04-27 |
2024-04-29 |
Not clear |
| Li-Chai Chen, Mei-Chou Lai, Tang-Yao Hong, I-Min Li. γ-Oryzanol from Rice Bran Antagonizes Glutamate-Induced Excitotoxicity in an In Vitro Model of Differentiated HT-22 Cells. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674927. |
therefore, γ-oryzanol could be a promising candidate for the development of therapies for glutamate excitotoxicity-associated neurodegenerative diseases, including vascular dementia. |
2024-04-27 |
2024-04-29 |
Not clear |
| Lars Tatenhorst, Fabian Maass, Hannah Paul, Vivian Dambeck, Mathias Bähr, Rosanna Dono, Paul Lingo. Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-02-29. PMID:38424123. |
initially described as supporting functionality of synapses via glutamate receptors during cns development, glypican 4 (gpc-4) also plays a role in the context of dementia via tau hyperphosphorylation in alzheimer's disease, which is also a co-pathology in parkinson's disease dementia. |
2024-02-29 |
2024-03-03 |
human |
| Andrea Mastrangelo, Giulia Maria Scotti, Jose Garcia Manteiga, Magnus Gisslén, Richard W Price, Arabella Bestetti, Filippo Turrini, Roberta Caccia, Leonid Gorelik, Marco J Morelli, Antonella Castagna, Paola Cinqu. Alterations in glutamate, arginine, and energy metabolism characterize CSF and plasma metabolome of persons with HIV-associated dementia. AIDS (London, England). 2023-10-31. PMID:37905996. |
alterations in glutamate, arginine, and energy metabolism characterize csf and plasma metabolome of persons with hiv-associated dementia. |
2023-10-31 |
2023-11-08 |
Not clear |
| Niels Hansen, Bianca Teegen, Sina Hirschel, Jens Wiltfang, Björn H Schott, Claudia Bartels, Caroline Boute. Case report: Mixed dementia associated with autoantibodies targeting the vesicular glutamate transporter 2. Frontiers in psychiatry. vol 14. 2023-07-28. PMID:37502813. |
case report: mixed dementia associated with autoantibodies targeting the vesicular glutamate transporter 2. |
2023-07-28 |
2023-08-14 |
Not clear |
| Niels Hansen, Bianca Teegen, Sina Hirschel, Jens Wiltfang, Björn H Schott, Claudia Bartels, Caroline Boute. Case report: Mixed dementia associated with autoantibodies targeting the vesicular glutamate transporter 2. Frontiers in psychiatry. vol 14. 2023-07-28. PMID:37502813. |
autoantibodies against the vesicular glutamate transporter type 2 (vglut2) can trigger impaired synaptic signaling and are described here for the first time in association with mixed dementia. |
2023-07-28 |
2023-08-14 |
Not clear |
| Song Xue, Tengqun Shen, Mengfan Li, Bing Leng, Ran Yao, Yanling Gao, Hairong Sun, Zhenguang Li, Jinbiao Zhan. Neuronal glutamate transporters are associated with cognitive impairment in obstructive sleep apnea patients without dementia. Neuroscience letters. 2023-03-09. PMID:36894020. |
neuronal glutamate transporters are associated with cognitive impairment in obstructive sleep apnea patients without dementia. |
2023-03-09 |
2023-08-14 |
human |
| Alok Shiomurti Tripathi, Prajakta Bansod, K P Swath. Activation of 5-HT 1b/d receptor restores the cognitive function by reducing glutamate release, deposition of β-amyloid and TLR-4 pathway in the brain of scopolamine-induced dementia in rat. The Journal of pharmacy and pharmacology. vol 73. issue 12. 2021-12-08. PMID:34244776. |
activation of 5-ht 1b/d receptor restores the cognitive function by reducing glutamate release, deposition of β-amyloid and tlr-4 pathway in the brain of scopolamine-induced dementia in rat. |
2021-12-08 |
2023-08-13 |
rat |
| Magdalena Orzylowski, Esther Fujiwara, Darrell D Mousseau, Glen B Bake. An Overview of the Involvement of D-Serine in Cognitive Impairment in Normal Aging and Dementia. Frontiers in psychiatry. vol 12. 2021-10-30. PMID:34707525. |
the n-methyl-d-aspartate glutamate receptor (nmdar) and its co-agonist d-serine are currently of great interest as potential important contributors to cognitive function in normal aging and dementia. |
2021-10-30 |
2023-08-13 |
human |
| Tommaso Nuzzo, Andrea Mancini, Mattia Miroballo, Alessia Casamassa, Anna Di Maio, Giorgia Donati, Giulia Sansone, Lorenzo Gaetani, Federico Paolini Paoletti, Andrea Isidori, Paolo Calabresi, Francesco Errico, Lucilla Parnetti, Alessandro Usiell. High performance liquid chromatography determination of L-glutamate, L-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer's disease. Amino acids. vol 53. issue 3. 2021-10-28. PMID:33616735. |
in this study, we measured by high-performance liquid chromatography the amount of glutamate, glutamine and glycine in post-mortem brain samples of ad patients, as well as in csf and blood serum of drug-free subjects encompassing the whole ad clinical spectrum (pre-clinical ad, n = 18, mild cognitive impairment-ad, n = 29, dementia ad, n = 30). |
2021-10-28 |
2023-08-13 |
human |
| Anas Shamsi, Moyad Shahwan, Fahad A Alhumaydhi, Ameen S S Alwashmi, Mohammad Abdullah Aljasir, Suliman A Alsagaby, Waleed Al Abdulmonem, Md Imtaiyaz Hassan, Asimul Isla. Spectroscopic, calorimetric and in silico insight into the molecular interactions of Memantine with human transferrin: Implications of Alzheimer's drugs. International journal of biological macromolecules. vol 190. 2021-10-13. PMID:34508722. |
memantine is an orally administrative n-methyl-d-aspartate glutamate receptor antagonist used to slow the progression of moderate-to-severe alzheimer's disease (ad) and dementia. |
2021-10-13 |
2023-08-13 |
human |
| Daniela Enache, Joana B Pereira, Vesna Jelic, Bengt Winblad, Per Nilsson, Dag Aarsland, Erika Bereczk. Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 77. issue 3. 2021-09-09. PMID:32925049. |
postmortem studies suggest that zinc transporter protein 3 (znt3), ampa glutamate receptor 3 (glua3), and dynamin1 are associated with cognitive decline in ad and lewy body dementia patients. |
2021-09-09 |
2023-08-13 |
Not clear |
| Sara Ayuso-Dolado, Gema M Esteban-Ortega, Óscar G Vidaurre, Margarita Díaz-Guerr. A novel cell-penetrating peptide targeting calpain-cleavage of PSD-95 induced by excitotoxicity improves neurological outcome after stroke. Theranostics. vol 11. issue 14. 2021-08-04. PMID:34093851. |
however, calpain-processing challenges psd-95 function after overactivation of excitatory glutamate receptors (excitotoxicity) in stroke, a leading cause of death, disability and dementia in need of efficient pharmacological treatments. |
2021-08-04 |
2023-08-13 |
Not clear |
| Danfeng Tian, Yangyang Guo, Dandan Zhang, Qiang Gao, Ganlu Liu, Jingfeng Lin, Ze Chang, Yuchun Wang, Rui Su, Zhenyun Ha. Shenzhi Jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis. Chinese medicine. vol 16. issue 1. 2021-08-01. PMID:34321050. |
shenzhi jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis. |
2021-08-01 |
2023-08-13 |
Not clear |
| Danfeng Tian, Yangyang Guo, Dandan Zhang, Qiang Gao, Ganlu Liu, Jingfeng Lin, Ze Chang, Yuchun Wang, Rui Su, Zhenyun Ha. Shenzhi Jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis. Chinese medicine. vol 16. issue 1. 2021-08-01. PMID:34321050. |
synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (vd). |
2021-08-01 |
2023-08-13 |
Not clear |
| Xiaoqiong Li, Wen Wen, Ping Li, Ying Fu, Hao Chen, Fushun Wang, Yuan Dai, Shijun X. Mitochondrial Protection and Against Glutamate Neurotoxicity via Shh/Ptch1 Signaling Pathway to Ameliorate Cognitive Dysfunction by Kaixin San in Multi-Infarct Dementia Rats. Oxidative medicine and cellular longevity. vol 2021. 2021-07-27. PMID:34306310. |
mitochondrial protection and against glutamate neurotoxicity via shh/ptch1 signaling pathway to ameliorate cognitive dysfunction by kaixin san in multi-infarct dementia rats. |
2021-07-27 |
2023-08-13 |
rat |
| Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Franciane Cabral Pinheiro, Márcia Rósula Poetini, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Elize Aparecida Santos Musachio, Gustavo Petri Guerra, Marina Prigo. Modulation of glutamate levels and Na Physiology & behavior. vol 222. 2021-06-21. PMID:32302609. |
modulation of glutamate levels and na abnormalities in the thyroid hormones, like in hypothyroidism, are closely related to dementia and alzheimer's disease demonstrating the main symptom of these disorders: memory deficit. |
2021-06-21 |
2023-08-13 |
Not clear |
| Valerie Treyer, Anton F Gietl, Husam Suliman, Esmeralda Gruber, Rafael Meyer, Andreas Buchmann, Anass Johayem, Paul G Unschuld, Roger M Nitsch, Alfred Buck, Simon M Ametamey, Christoph Hoc. Reduced uptake of [11C]-ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer's dementia. Brain and behavior. vol 10. issue 6. 2021-06-21. PMID:32304284. |
reduced uptake of [11c]-abp688, a pet tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in alzheimer's dementia. |
2021-06-21 |
2023-08-13 |
Not clear |
| María Victoria Chacón-Quintero, Lina Gisela Pineda-López, Carlos Andrés Villegas-Lanau, Rafael Posada-Duque, Gloria Patricia Cardona-Góme. Beta-Secretase 1 Underlies Reactive Astrocytes and Endothelial Disruption in Neurodegeneration. Frontiers in cellular neuroscience. vol 15. 2021-05-26. PMID:34025357. |
in this study, we analyzed the relationship of bace1 with astrocytes and blood vessels in human brains with sporadic and familial dementia [autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil), sporadic alzheimer's disease (sad), and familial alzheimer's disease (fad)] and how bace1 inhibition affects astrocytes and endothelial cells under conditions of glutamate toxicity. |
2021-05-26 |
2023-08-13 |
human |
| Paula Garcia-Esparcia, Daniela Diaz-Lucena, Marina Ainciburu, Benjamin Torrejón-Escribano, Margarita Carmona, Franc Llorens, Isidro Ferre. Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29755340. |
glutamate transporter glt1 expression in alzheimer disease and dementia with lewy bodies. |
2020-10-01 |
2023-08-13 |
human |