| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingya Ruan, Zhongwei Shi, Xiaoyan Cao, Zhunan Dang, Qianqian Zhang, Wei Zhang, Lijie Wu, Yi Zhang, Tao Wan. Research Progress on Anti-Inflammatory Effects and Related Mechanisms of Astragalin. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674061. |
in vivo studies have shown that ast effectively alleviates neuroinflammation and brain damage while also exhibiting potential for treating moderate diseases such as depression and stroke; it also demonstrates significant anti-inflammatory effects on both large and small intestinal epithelial cells. |
2024-04-27 |
2024-04-29 |
mouse |
| Yi-Fan Peng, Lin-Lin Wang, Juan-Hua Gu, Yue-Qin Zen. Effects of astaxanthin on depressive and sleep symptoms: A narrative mini-review. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539097. |
this mini-review highlights the potential mechanisms by which ast can prevent depression, providing novel insights into drug research for depression treatment. |
2023-08-04 |
2023-08-14 |
Not clear |
| Jing-Ze Yu, Jing Wen, Yi Ying, Wen Yin, Si-Qi Zhang, Wen-Ling Pang, Cui Wang, Yao Bian, Jia-Li Yuan, Jin-Yuan Yan, Zhong-Shan Yan. Astragaloside trigger autophagy: Implication a potential therapeutic strategy for pulmonary fibrosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 154. 2023-03-21. PMID:36942596. |
these findings suggest that ast might treat pulmonary fibrosis by modulating the ras/raf/mek/erk signaling pathway mediated by depression. |
2023-03-21 |
2023-08-14 |
mouse |
| b' Gavin R Stewart, Anne Corbett, Clive Ballard, Byron Creese, Dag Aarsland, Adam Hampshire, Helen Brooker, Rebecca A Charlton, Francesca Happ\\xc3\\xa. The cognitive profile of middle-aged and older adults with high vs. low autistic traits. Autism research : official journal of the International Society for Autism Research. 2022-12-01. PMID:36454212.' |
in addition, ast self-reported more cognitive decline than coa, but this difference was not significant when controlling for current depression symptoms, or when using informant-report. |
2022-12-01 |
2023-08-14 |
human |
| Guangda Yao, Zijun Bai, Jianguo Niu, Rui Zhang, Youyuan Lu, Tiantian Gao, Hanqing Wan. Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression. Psychopharmacology. 2022-04-12. PMID:35411464. |
however, the effects of ast on perimenopausal depression and the molecular mechanism in regulating microglia polarization remained unknown. |
2022-04-12 |
2023-08-13 |
Not clear |
| Faezeh Darabi, Majid Keshavarzi, Media N Abdullah, Fatemeh Dehghani, Narges Khanjani, Saeed Yousefinejad, Farahnaz Khajehnasiri, Zahra Zamania. Evaluation of oxidative stress and biochemical biomarkers, and psychological parameters in cement plant workers. Toxicology and industrial health. vol 38. issue 1. 2022-02-01. PMID:35100896. |
the levels of alkaline phosphatase (alp), aspartate transaminase (ast), and the scores of depression and stress were also significantly higher in the exposed group. |
2022-02-01 |
2023-08-13 |
human |
| Bum Ju Le. Association of depressive disorder with biochemical and anthropometric indices in adult men and women. Scientific reports. vol 11. issue 1. 2021-11-05. PMID:34193938. |
among women, the depression group was more likely to have higher triglyceride, aspartate aminotransferase (ast), bun, and creatinine levels and lower high-density lipoprotein cholesterol (hdl-c), hematocrit, and red blood cell counts. |
2021-11-05 |
2023-08-13 |
human |
| Anca Sfärlea, Christina Buhl, Johanna Loechner, Jakob Neumüller, Laura Asperud Thomsen, Kornelija Starman, Elske Salemink, Gerd Schulte-Körne, Belinda Plat. "I Am a Total…Loser" - The Role of Interpretation Biases in Youth Depression. Journal of abnormal child psychology. vol 48. issue 10. 2021-10-22. PMID:32654075. |
after a negative mood induction interpretation biases were assessed with two experimental tasks: ambiguous scenarios task (ast) and scrambled sentences task (sst) in three groups of 9-14-year-olds: children and adolescents with a diagnosis of major depression (n = 32), children and adolescents with a high risk for depression (children of depressed parents; n = 48), as well as low-risk children and adolescents (n = 42). |
2021-10-22 |
2023-08-13 |
Not clear |
| Anca Sfärlea, Christina Buhl, Johanna Loechner, Jakob Neumüller, Laura Asperud Thomsen, Kornelija Starman, Elske Salemink, Gerd Schulte-Körne, Belinda Plat. "I Am a Total…Loser" - The Role of Interpretation Biases in Youth Depression. Journal of abnormal child psychology. vol 48. issue 10. 2021-10-22. PMID:32654075. |
the different findings for the two tasks suggest that more implicit interpretation biases (assessed with the sst) might represent cognitive vulnerabilities for depression whereas more explicit interpretation biases (assessed with the ast) may arise as a consequence of depressive symptomatology. |
2021-10-22 |
2023-08-13 |
Not clear |
| Zhen Lin, Fangping Li, Yu Zhang, Xiaohui Tan, Ping Luo, Huazhong Li. Analysis of astaxanthin molecular targets based on network pharmacological strategies. Journal of food biochemistry. vol 45. issue 5. 2021-07-09. PMID:33844306. |
the results suggest that ast is involved in steroid hormone metabolism, and the regulation of glucocorticoids may be one of the potential mechanisms of its known therapeutic effects on depression and insulin resistance. |
2021-07-09 |
2023-08-13 |
Not clear |
| Ting Linghu, Yao Gao, Aiping Li, Biyun Shi, Junsheng Tian, Xuemei Qi. A unique insight for energy metabolism disorders in depression based on chronic unpredictable mild stress rats using stable isotope-resolved metabolomics. Journal of pharmaceutical and biomedical analysis. vol 191. 2021-06-17. PMID:32927418. |
pyruvate carboxylase (pc), pyruvate dehydrogenase (pdh), aspartate aminotransferase (ast) and phosphoenolpyruvate carboxykinase (pepc) may be the new targets for depression. |
2021-06-17 |
2023-08-13 |
human |
| Yuting Ke, Shizhong Bu, Hong Ma, Lei Gao, Yujia Cai, Yisheng Zhang, Wenhua Zho. Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats. Frontiers in pharmacology. vol 10. 2020-09-28. PMID:32082151. |
this study indicates that ast may be used as a preventive or therapeutic approach for co-morbidity of diabetes and depression. |
2020-09-28 |
2023-08-13 |
rat |
| Yuting Ke, Shizhong Bu, Hong Ma, Lei Gao, Yujia Cai, Yisheng Zhang, Wenhua Zho. Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats. Frontiers in pharmacology. vol 10. 2020-09-28. PMID:32082151. |
astaxanthin (ast) has been demonstrated to improve glucose metabolism and has antidepressant-like effects, but it is not clear whether ast has potential for preventing depression in diabetes. |
2020-09-28 |
2023-08-13 |
rat |
| Anca Sfärlea, Johanna Löchner, Jakob Neumüller, Laura Asperud Thomsen, Kornelija Starman, Elske Salemink, Gerd Schulte-Körne, Belinda Plat. Passing on the half-empty glass: A transgenerational study of interpretation biases in children at risk for depression and their parents with depression. Journal of abnormal psychology. vol 128. issue 2. 2019-11-25. PMID:30714796. |
interpretation biases were assessed with two experimental tasks: ambiguous scenarios task (ast) and scrambled sentences task (sst) in 9-14-year-old children of parents with a history of depression (high risk; n = 43) in comparison to children of parents with no history of mental disorders (low risk; n = 35). |
2019-11-25 |
2023-08-13 |
Not clear |
| Anca Sfärlea, Johanna Löchner, Jakob Neumüller, Laura Asperud Thomsen, Kornelija Starman, Elske Salemink, Gerd Schulte-Körne, Belinda Plat. Passing on the half-empty glass: A transgenerational study of interpretation biases in children at risk for depression and their parents with depression. Journal of abnormal psychology. vol 128. issue 2. 2019-11-25. PMID:30714796. |
as expected, we found more negative interpretation biases in high-risk children compared to low-risk children as well as in parents with a history of depression compared to never-depressed parents (assessed via the sst but not the ast). |
2019-11-25 |
2023-08-13 |
Not clear |
| Qiong-Qiong Lv, Wen-Jie Wu, Xiao-Liang Guo, Rui-Li Liu, Yu-Ping Yang, Du-Shuang Zhou, Ji-Xia Zhang, Ju-Yuan Li. Antidepressant activity of astilbin: involvement of monoaminergic neurotransmitters and BDNF signal pathway. Biological & pharmaceutical bulletin. vol 37. issue 6. 2015-01-20. PMID:24681540. |
in this study, the antidepressant-like effect of ast was investigated using chronic unpredictable mild stress (cums) model of depression in mice. |
2015-01-20 |
2023-08-12 |
mouse |
| Kale J Naegeli, Joann A O'Connor, Pradeep Banerjee, David A Morila. Effects of milnacipran on cognitive flexibility following chronic stress in rats. European journal of pharmacology. vol 703. issue 1-3. 2013-09-23. PMID:23422875. |
deficits of cognitive flexibility, measured by extra-dimensional set-shifting on the attentional set-shifting test (ast), are consistent with dysregulation of prefrontal cortical function, also characteristic of depression. |
2013-09-23 |
2023-08-12 |
rat |
| Yueh-Ching Chou, Anthony D Harman, Chwen-Jen Lin, Wan-Ping Lee, Shu-Chuan Chang, Mei-Ling Li. Outcome evaluation of active support training in Taiwan. Research in developmental disabilities. vol 32. issue 3. 2011-07-19. PMID:21295439. |
within the group, analyses showed that the residents whose staff received ast showed increased levels of choice and adaptive behavior and decreased levels of depression in the post-test and follow up in addition the residents' engagement in domestic activities improved in the follow up. |
2011-07-19 |
2023-08-12 |
human |
| Cedomir Todorovic, Tessi Sherrin, Matthew Pitts, Cathrin Hippel, Martin Rayner, Joachim Spies. Suppression of the MEK/ERK signaling pathway reverses depression-like behaviors of CRF2-deficient mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 6. 2009-06-17. PMID:18843268. |
similarly, treatment with [glu(11,16)]ast reversed depression phenotype of crf2-/- mice without affecting the phenotype of wild-type littermates. |
2009-06-17 |
2023-08-12 |
mouse |
| Henry Older. Average sunrise time predicts depression prevalence. Journal of psychosomatic research. vol 55. issue 2. 2004-01-06. PMID:12932507. |
published depression prevalence research does not use arising time, but average sunrise time (ast) for cities might serve as an analogue for arising time. |
2004-01-06 |
2023-08-12 |
Not clear |