| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomas Kukucka, Nikola Ferencova, Zuzana Visnovcova, Igor Ondrejka, Igor Hrtanek, Veronika Kovacova, Andrea Macejova, Zuzana Mlyncekova, Ingrid Tonhajzerov. Mechanisms Involved in the Link between Depression, Antidepressant Treatment, and Associated Weight Change. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674096. |
the suggested pathomechanisms include the abnormal functioning of the homeostatic (mostly humoral) and hedonic (mostly dopaminergic) circuits of appetite regulation, as well as causing neuromorphological and neurophysiological changes underlying the development of depressive disorder. |
2024-04-27 |
2024-04-29 |
Not clear |
| Antonio Maria D'Onofrio, Daniele Antonio Pizzuto, Rana Batir, Elisabetta Perrone, Fabrizio Cocciolillo, Federica Cavallo, Georgios Demetrios Kotzalidis, Alessio Simonetti, Giacomo d'Andrea, Mauro Pettorruso, Gabriele Sani, Daniela Di Giuda, Giovanni Camardes. Dopaminergic dysfunction in the left putamen of patients with major depressive disorder. Journal of affective disorders. 2024-04-18. PMID:38636713. |
dopaminergic dysfunction in the left putamen of patients with major depressive disorder. |
2024-04-18 |
2024-04-21 |
Not clear |
| Karl Goodkin, Teresa H Evering, Albert M Anderson, Ann Ragin, Cynthia L Monaco, Christina Gavegnano, Ryan J Avery, Sean B Rourke, Lucette A Cysique, Bruce J Bre. The comorbidity of depression and neurocognitive disorder in persons with HIV infection: call for investigation and treatment. Frontiers in cellular neuroscience. vol 17. 2023-05-19. PMID:37206666. |
we present a unified model for the comorbidity based upon deficits in dopaminergic transmission that occur in both major depressive disorder and hiv-associated neurocognitive disorder. |
2023-05-19 |
2023-08-14 |
human |
| Liang Gao, Qiang Xue, Shun Gong, Gaoyi Li, Wusong Tong, Mingxia Fan, Xianzhen Chen, Jia Yin, Yu Song, Songyu Chen, Jingrong Huang, Chengbin Wang, Yan Don. Structural and Functional Alterations of Substantia Nigra and Associations With Anxiety and Depressive Symptoms Following Traumatic Brain Injury. Frontiers in neurology. vol 13. 2022-04-22. PMID:35449518. |
although there are a certain number of studies dedicated to the disturbances of the dopaminergic system induced by traumatic brain injury (tbi), the associations of abnormal dopaminergic systems with post-traumatic anxiety and depressive disorders and their underlying mechanisms have not been clarified yet. |
2022-04-22 |
2023-08-13 |
Not clear |
| Xiaotong Song, Ning Sun, Aixia Zhang, Lei Lei, Xinrong Li, Zhifen Liu, Yanfang Wang, Chunxia Yang, Kerang Zhan. Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect. Neuropsychiatric disease and treatment. vol 17. 2021-08-20. PMID:34408421. |
although the pathogenesis of major depressive disorder (mdd) is still unclear, studies have shown that the dopaminergic system of depressed patients is defective, and that nr4a2 is an important transcription factor affecting the development and maintenance of dopaminergic neurons. |
2021-08-20 |
2023-08-13 |
Not clear |
| Hiroki Moriya, Mikael Tiger, Amane Tateno, Takeshi Sakayori, Takahiro Masuoka, WooChan Kim, Ryosuke Arakawa, Yoshiro Okub. Low dopamine transporter binding in the nucleus accumbens in geriatric patients with severe depression. Psychiatry and clinical neurosciences. vol 74. issue 8. 2021-06-09. PMID:32363761. |
dysfunction of dopaminergic neurons in the central nervous system is considered to be related to major depressive disorder (mdd). |
2021-06-09 |
2023-08-13 |
Not clear |
| Minkyung Park, Mark J Niciu, Carlos A Zarat. Novel Glutamatergic Treatments for Severe Mood Disorders. Current behavioral neuroscience reports. vol 2. issue 4. 2021-01-09. PMID:26824031. |
all currently approved antidepressant medications for major depressive disorder (mdd) and bipolar disorder act primarily on the monoaminergic system and have varying affinities for serotonergic, norepinephrine-ergic, and/or dopaminergic receptors. |
2021-01-09 |
2023-08-13 |
Not clear |
| Wenhai Zhang, Caizhi Liao, Fanggui Tang, Shirui Liu, Jing Chen, Lulu Zheng, Ping Zhang, Qiang Ding, Hong L. Emotional Contexts Modulate Anticipatory Late Positive Component and Reward Feedback Negativity in Adolescents With Major Depressive Disorder. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32411033. |
neuroimaging research has determined deficits in the dopaminergic circuit of major depressive disorder (mdd) during adolescence. |
2020-09-28 |
2023-08-13 |
Not clear |
| Helia Ghanean, Amanda K Ceniti, Sidney H Kenned. Fatigue in Patients with Major Depressive Disorder: Prevalence, Burden and Pharmacological Approaches to Management. CNS drugs. vol 32. issue 1. 2019-02-28. PMID:29383573. |
our review of the effects of pharmacological treatments on fatigue in major depressive disorder found that medications with dopaminergic and/or noradrenergic action such as modafinil, flupenthixol and atomoxetine were most effective in improving symptoms of fatigue and low energy. |
2019-02-28 |
2023-08-13 |
Not clear |
| Roee Admon, Roselinde H Kaiser, Daniel G Dillon, Miranda Beltzer, Franziska Goer, David P Olson, Gordana Vitaliano, Diego A Pizzagall. Dopaminergic Enhancement of Striatal Response to Reward in Major Depression. The American journal of psychiatry. vol 174. issue 4. 2017-05-01. PMID:27771973. |
major depressive disorder is characterized by reduced reward-related striatal activation and dysfunctional reward learning, putatively reflecting decreased dopaminergic signaling. |
2017-05-01 |
2023-08-13 |
Not clear |
| Soumava Santra, Horrick Sharma, Seenuvasan Vedachalam, Tamara Antonio, Maarten Reith, Aloke Dutt. Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template. Bioorganic & medicinal chemistry. vol 23. issue 4. 2015-10-05. PMID:25593099. |
it has been hypothesized that a dysfunctional dopaminergic system in the mesocorticolimbic pathway in depressive disorder may lead to development of anhedonia associated with loss of pleasure and interest along with loss of motivation. |
2015-10-05 |
2023-08-13 |
Not clear |
| Daniel G Dillon, Ian G Dobbins, Diego A Pizzagall. Weak reward source memory in depression reflects blunted activation of VTA/SN and parahippocampus. Social cognitive and affective neuroscience. vol 9. issue 10. 2015-06-03. PMID:24078019. |
reward responses in the medial temporal lobes and dopaminergic midbrain boost episodic memory formation in healthy adults, and weak memory for emotionally positive material in depression suggests this mechanism may be dysfunctional in major depressive disorder (mdd). |
2015-06-03 |
2023-08-12 |
human |
| Kyoung-Shim Kim, Young-Mi Kang, Young Kang, Tae-Shin Park, Hye-Yeon Park, Yoon-Jung Kim, Baek-Soo Han, Chun-Hyung Kim, Chul-Ho Lee, Paul A Ardayfio, Pyung-Lim Han, Bong-Hyun Jung, Kwang-Soo Ki. Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism. Brain research. vol 1552. 2014-10-16. PMID:24480473. |
using pit3x-deficient mice, a model for selective nigrostriatal dopaminergic neurodegeneration, we tested depression-related behaviors and acute stress responses to better understand how a nigrostriatal dopaminergic deficit increases the prevalence of depressive disorders in pd patients. |
2014-10-16 |
2023-08-12 |
mouse |
| M Elizabeth Sublette, Hanga C Galfalvy, Joseph R Hibbeln, John G Keilp, Kevin M Malone, Maria A Oquendo, J John Man. Polyunsaturated fatty acid associations with dopaminergic indices in major depressive disorder. The international journal of neuropsychopharmacology. vol 17. issue 3. 2014-09-17. PMID:24300434. |
polyunsaturated fatty acid associations with dopaminergic indices in major depressive disorder. |
2014-09-17 |
2023-08-12 |
Not clear |
| Gian Marco Leggio, Salvatore Salomone, Claudio Bucolo, Chiara Platania, Vincenzo Micale, Filippo Caraci, Filippo Drag. Dopamine D(3) receptor as a new pharmacological target for the treatment of depression. European journal of pharmacology. vol 719. issue 1-3. 2014-07-02. PMID:23872400. |
dysfunction of dopaminergic neurotransmission within the mesolimbic system may contribute to anhedonia, loss of motivation and psychomotor retardation in severe depressive disorders. |
2014-07-02 |
2023-08-12 |
Not clear |
| Oliver D Howes, Matthew Williams, Kemal Ibrahim, Garret Leung, Alice Egerton, Philip K McGuire, Federico Turkheime. Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study. Brain : a journal of neurology. vol 136. issue Pt 11. 2013-12-31. PMID:24097339. |
in a post-mortem study, a semi-quantitative analysis of tyrosine hydroxylase staining was conducted in nigral dopaminergic cells from post-mortem tissue from patients with schizophrenia (n = 12), major depressive disorder (n = 13) and matched control subjects (n = 13). |
2013-12-31 |
2023-08-12 |
human |
| Oliver D Howes, Matthew Williams, Kemal Ibrahim, Garret Leung, Alice Egerton, Philip K McGuire, Federico Turkheime. Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study. Brain : a journal of neurology. vol 136. issue Pt 11. 2013-12-31. PMID:24097339. |
in the post-mortem study we found that tyrosine hydroxylase staining was significantly increased in nigral dopaminergic neurons in schizophrenia compared with both control subjects (p < 0.001) and major depressive disorder (p < 0.001). |
2013-12-31 |
2023-08-12 |
human |
| Quentin Jm Huys, Diego A Pizzagalli, Ryan Bogdan, Peter Daya. Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis. Biology of mood & anxiety disorders. vol 3. issue 1. 2013-07-08. PMID:23782813. |
we attempted to disentangle these factors with respect to anhedonia in the context of stress, major depressive disorder (mdd), bipolar disorder (bpd) and a dopaminergic challenge. |
2013-07-08 |
2023-08-12 |
Not clear |
| M Martínez-Vázquez, R Estrada-Reyes, A G Araujo Escalona, I Ledesma Velázquez, L Martínez-Mota, J Moreno, G Heinz. Antidepressant-like effects of an alkaloid extract of the aerial parts of Annona cherimolia in mice. Journal of ethnopharmacology. vol 139. issue 1. 2012-04-27. PMID:22101086. |
it has been reported that the alkaloids isolated from some species of the annona have affinity to serotonergic 5-ht(1a) receptors and modulate dopaminergic transmission, which is involved in depressive disorders. |
2012-04-27 |
2023-08-12 |
mouse |
| Paul S Foster, Raegan C Yung, Kaylei K Branch, Kristi Stringer, Brad J Ferguson, William Sullivan, Valeria Drag. Increased spreading activation in depression. Brain and cognition. vol 77. issue 2. 2012-02-09. PMID:21889248. |
the dopaminergic system is implicated in depressive disorders and research has also shown that dopamine constricts lexical/semantic networks by reducing spreading activation. |
2012-02-09 |
2023-08-12 |
Not clear |