| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Saud A Alnaaim, Helal F Hetta, Hebatallah M Saad, Gaber El-Saber Batih. A Mutual Nexus Between Epilepsy and α-Synuclein: A Puzzle Pathway. Molecular neurobiology. 2024-05-04. PMID:38703341. |
in addition, accumulation of α-syn in epilepsy could be secondary to the different cellular alterations including oxidative stress, neuroinflammation, reduction of brain-derived neurotrophic factor (bdnf) and progranulin (pgn), and failure of the autophagy pathway. |
2024-05-04 |
2024-05-07 |
Not clear |
| Nimra Aziz, Chiara Ruzza, Chiara Falcicchia, Annunziata Guarino, Marie Soukupova, Laila Asth, Valentina Aleotti, Barbara Bettegazzi, Michele Simonato, Silvia Zucchin. Lack of Direct Effects of Neurotrophic Factors in an In Vitro Model of Neuroinflammation. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673746. |
our study suggests that the anti-inflammatory effect of bdnf and fgf-2 in vivo in the epilepsy model was indirect and likely due to a reduction in seizure frequency and severity. |
2024-04-27 |
2024-04-29 |
mouse |
| Retraction: "Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway". Journal of cellular physiology. 2024-04-09. PMID:38591623. |
retraction: "silencing lncrna pvt1 inhibits activation of astrocytes and increases bdnf expression in hippocampus tissues of rats with epilepsy by downregulating the wnt signaling pathway". |
2024-04-09 |
2024-04-11 |
rat |
| Retraction: "Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway". Journal of cellular physiology. 2024-04-09. PMID:38591623. |
retraction: "silencing lncrna pvt1 inhibits activation of astrocytes and increases bdnf expression in hippocampus tissues of rats with epilepsy by downregulating the wnt signaling pathway", by teng zhao, ying ding, min li, chunkui zhou, and weihong lin, j cell physiol. |
2024-04-09 |
2024-04-11 |
rat |
| Maria A Tikhonova, Anna A Shvaikovskaya, Svetlana Y Zhanaeva, Galina I Moysak, Anna A Akopyan, Jamil A Rzaev, Konstantin V Danilenko, Lyubomir I Aftana. Concordance between the In Vivo Content of Neurospecific Proteins (BDNF, NSE, VILIP-1, S100B) in the Hippocampus and Blood in Patients with Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203674. |
concordance between the in vivo content of neurospecific proteins (bdnf, nse, vilip-1, s100b) in the hippocampus and blood in patients with epilepsy. |
2024-01-11 |
2024-01-13 |
human |
| Maria A Tikhonova, Anna A Shvaikovskaya, Svetlana Y Zhanaeva, Galina I Moysak, Anna A Akopyan, Jamil A Rzaev, Konstantin V Danilenko, Lyubomir I Aftana. Concordance between the In Vivo Content of Neurospecific Proteins (BDNF, NSE, VILIP-1, S100B) in the Hippocampus and Blood in Patients with Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203674. |
the neurospecific proteins bdnf, nse, vilip-1, and s100b play an important role in the pathogenesis of neuropsychiatric disorders, including epilepsy. |
2024-01-11 |
2024-01-13 |
human |
| Maria A Tikhonova, Anna A Shvaikovskaya, Svetlana Y Zhanaeva, Galina I Moysak, Anna A Akopyan, Jamil A Rzaev, Konstantin V Danilenko, Lyubomir I Aftana. Concordance between the In Vivo Content of Neurospecific Proteins (BDNF, NSE, VILIP-1, S100B) in the Hippocampus and Blood in Patients with Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203674. |
this study aimed to assess the correspondence of the expression of bdnf, nse, vilip-1, and s100b in the blood (serum and peripheral blood mononuclear cells (pbmcs)) to the in vivo hippocampal levels of subjects with drug-resistant epilepsy who underwent neurosurgery (n = 44) using multiplex solid-phase analysis, elisa, and immunohistochemical methods, as well as to analyze the correlations and associations of the blood and hippocampal levels of these proteins with clinical parameters. |
2024-01-11 |
2024-01-13 |
human |
| Maria A Tikhonova, Anna A Shvaikovskaya, Svetlana Y Zhanaeva, Galina I Moysak, Anna A Akopyan, Jamil A Rzaev, Konstantin V Danilenko, Lyubomir I Aftana. Concordance between the In Vivo Content of Neurospecific Proteins (BDNF, NSE, VILIP-1, S100B) in the Hippocampus and Blood in Patients with Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203674. |
significant correlations between the levels of the neurospecific proteins studied herein suggest interactions between bdnf, nse, vilip-1, and s100b in the pathophysiology of epilepsy. |
2024-01-11 |
2024-01-13 |
human |
| Alexander A Shpak, Flora K Rider, Tatiana A Druzhkova, Marina Y Zhanina, Sofya B Popova, Alla B Guekht, Natalia V Gulyaev. Reduced Levels of Lacrimal Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Patients with Focal Epilepsy and Focal Epilepsy with Comorbid Depression: A Biomarker Candidate. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069144. |
since glial cell line-derived neurotrophic factor (gdnf) is involved in the control of neuronal networks in an epileptic brain, we aimed to assess the gdnf levels in lf and bs as well as the bdnf and the hypothalamic-pituitary-adrenocortical and inflammation indices in bs of patients with focal epilepsy (fe) and epilepsy and comorbid depression (fe + mdd) and to compare them with those of patients with major depressive disorder (mdd) and healthy controls (hc). |
2023-12-09 |
2023-12-17 |
Not clear |
| Alexander A Shpak, Flora K Rider, Tatiana A Druzhkova, Marina Y Zhanina, Sofya B Popova, Alla B Guekht, Natalia V Gulyaev. Reduced Levels of Lacrimal Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Patients with Focal Epilepsy and Focal Epilepsy with Comorbid Depression: A Biomarker Candidate. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069144. |
logistic regression models demonstrated that the probability of fe can be evaluated using gdnf in lf and bdnf in bs; that of mdd using gdnf in lf and cortisol and tnf-α in bs; and that of epilepsy with mdd using gdnf in lf and tnf-α and bdnf in bs. |
2023-12-09 |
2023-12-17 |
Not clear |
| Raed AlRuwaili, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Naif H Ali, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy. Neurochemical research. 2023-11-25. PMID:38006577. |
despite of that the brain-derived neurotrophic factor (bdnf) is implicated in the pathogenesis of epileptogenesis and epilepsy, bdnf may have a neuroprotective effect against epilepsy. |
2023-11-25 |
2023-11-28 |
Not clear |
| Raed AlRuwaili, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Naif H Ali, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy. Neurochemical research. 2023-11-25. PMID:38006577. |
thus, the goal of the present review was to highlight the protective and detrimental roles of bdnf in epilepsy. |
2023-11-25 |
2023-11-28 |
Not clear |
| Raed AlRuwaili, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Naif H Ali, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy. Neurochemical research. 2023-11-25. PMID:38006577. |
therefore, the assessment of bdnf levels in epilepsy should be related to other neuronal signaling pathways and types of epilepsy in both preclinical and clinical studies. |
2023-11-25 |
2023-11-28 |
Not clear |
| Raed AlRuwaili, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Naif H Ali, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy. Neurochemical research. 2023-11-25. PMID:38006577. |
in conclusion, there is a strong controversy concerning the potential role of bdnf in epilepsy. |
2023-11-25 |
2023-11-28 |
Not clear |
| Aileen McGonigal, Christel Becker, Julia Fath, Kahina Hammam, Karine Baumstarck, Sara Fernandes, Bernard Giusiano, Stéphane Dufau, Sylvain Rheims, Louis Maillard, Arnaud Biraben, Jean-Jacques Benoliel, Christophe Bernard, Fabrice Bartolome. BDNF as potential biomarker of epilepsy severity and psychiatric comorbidity: pitfalls in the clinical population. Epilepsy research. vol 195. 2023-08-05. PMID:37542747. |
bdnf as potential biomarker of epilepsy severity and psychiatric comorbidity: pitfalls in the clinical population. |
2023-08-05 |
2023-08-14 |
Not clear |
| Aileen McGonigal, Christel Becker, Julia Fath, Kahina Hammam, Karine Baumstarck, Sara Fernandes, Bernard Giusiano, Stéphane Dufau, Sylvain Rheims, Louis Maillard, Arnaud Biraben, Jean-Jacques Benoliel, Christophe Bernard, Fabrice Bartolome. BDNF as potential biomarker of epilepsy severity and psychiatric comorbidity: pitfalls in the clinical population. Epilepsy research. vol 195. 2023-08-05. PMID:37542747. |
several studies implicate brain-derived neurotrophic factor (bdnf) in the pathophysiology of epilepsy. |
2023-08-05 |
2023-08-14 |
Not clear |
| Aileen McGonigal, Christel Becker, Julia Fath, Kahina Hammam, Karine Baumstarck, Sara Fernandes, Bernard Giusiano, Stéphane Dufau, Sylvain Rheims, Louis Maillard, Arnaud Biraben, Jean-Jacques Benoliel, Christophe Bernard, Fabrice Bartolome. BDNF as potential biomarker of epilepsy severity and psychiatric comorbidity: pitfalls in the clinical population. Epilepsy research. vol 195. 2023-08-05. PMID:37542747. |
in particular, preclinical data suggest that lower serum bdnf is a biomarker of epilepsy severity and psychiatric comorbidities. |
2023-08-05 |
2023-08-14 |
Not clear |
| Elena A Filimonova, Anton A Pashkov, Galina I Moysak, Anastasia Y Tropynina, Svetlana Y Zhanaeva, Anna A Shvaikovskaya, Anna A Akopyan, Konstantin V Danilenko, Lyubomir I Aftanas, Maria A Tikhonova, Jamil A Rzae. Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy. Frontiers in neuroscience. vol 17. 2023-08-04. PMID:37539386. |
to narrow this gap, in this study, we aimed to estimate the relationship between hippocampal and serum levels of brain-derived neurotrophic factor (bdnf), one of the main and most widely studied neurotrophins, and hippocampal subfield volumes in patients with drug-resistant mesial temporal epilepsy undergoing neurosurgical treatment. |
2023-08-04 |
2023-08-14 |
human |
| Jeremy M Van Raamsdonk, Hilal H Al-Shekaili, Laura Wagner, Tim W Bredy, Laura Chan, Jacqueline Pearson, Claudia Schwab, Zoe Murphy, Rebecca S Devon, Ge Lu, Michael S Kobor, Michael R Hayden, Blair R Leavit. Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice. Aging and disease. 2023-05-18. PMID:37199581. |
these abnormal fvb/n mice demonstrate the cardinal features of mouse models of epilepsy including spontaneous seizures, astrocytosis, neuronal hypertrophy, upregulation of brain-derived neurotrophic factor (bdnf), and sudden seizure-related death. |
2023-05-18 |
2023-08-14 |
mouse |
| Aya A Zayed, Mae M Seleem, Hebatallah A Darwish, Amira A Shahee. Role of long noncoding RNAs; BDNF-AS and 17A and their relation to GABAergic dysfunction in Egyptian epileptic patients. Metabolic brain disease. 2023-02-22. PMID:36807083. |
this study investigated the expression levels of lncrnas; bdnf-as and 17a in the sera of egyptian patients with idiopathic generalized and symptomatic focal epilepsy and correlated their levels with brain-derived neurotrophic factor (bdnf), phosphorylated camp reaction element -binding protein (p-creb), gamma- aminobutyric acid (gaba) and glutamate, to underline their related molecular mechanism. |
2023-02-22 |
2023-08-14 |
Not clear |