| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sophia Nazir, Rabail Azhar Iqba. Recent Progress in the Application of Tau Protein Biosensors for Diagnosis of Neurodegenerative Diseases. Applied biochemistry and biotechnology. 2024-05-02. PMID:38696096. |
recent progress in the application of tau protein biosensors for diagnosis of neurodegenerative diseases. |
2024-05-02 |
2024-05-04 |
Not clear |
| Sophia Nazir, Rabail Azhar Iqba. Recent Progress in the Application of Tau Protein Biosensors for Diagnosis of Neurodegenerative Diseases. Applied biochemistry and biotechnology. 2024-05-02. PMID:38696096. |
neurodegenerative diseases have been linked to post-translational changes of tau, most notably phosphorylation. |
2024-05-02 |
2024-05-04 |
Not clear |
| Sophia Nazir, Rabail Azhar Iqba. Recent Progress in the Application of Tau Protein Biosensors for Diagnosis of Neurodegenerative Diseases. Applied biochemistry and biotechnology. 2024-05-02. PMID:38696096. |
this paper provides an overview of the most recent developments in the detection of neurodegenerative diseases employing biosensors built on nanotechnology and methods for imaging, electrochemical, and optical detection of the tau protein. |
2024-05-02 |
2024-05-04 |
Not clear |
| Dylan J Finneran, Taylor Desjarlais, Alayna Henry, Brianna M Jackman, Marcia N Gordon, David Morga. Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno-associated virus vectors expressing human P301L tau. Alzheimer's & dementia (New York, N. Y.). vol 10. issue 2. 2024-05-01. PMID:38689599. |
alzheimer's disease (ad) is a progressive neurodegenerative disease in which extracellular aggregates of the amyloid beta (aβ) peptide precede widespread intracellular inclusions of the microtubule-associated protein tau. |
2024-05-01 |
2024-05-03 |
mouse |
| Allwin Ebenezer Sahayaraj, Arshad Abdul Vahid, Asmita Dhara, Ann Teres Babu, Vinesh Vijaya. Role of G326 in Determining the Aggregation Propensity of R3 Tau Repeat: Insights from Studies on R1R3 Tau Construct. The journal of physical chemistry. B. 2024-04-27. PMID:38676652. |
the microtubule-binding repeat region (mtbr) of tau has been studied extensively due to its pathological implications in neurodegenerative diseases like alzheimer's disease. |
2024-04-27 |
2024-04-30 |
Not clear |
| Sachin P Patil, Bella R Kueh. Discovery of Small Molecule Glycolytic Stimulants for Enhanced ApoE Lipidation in Alzheimer's Disease Cell Model. Pharmaceuticals (Basel, Switzerland). vol 17. issue 4. 2024-04-27. PMID:38675451. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by pathophysiological deposits of extracellular amyloid beta (aβ) peptides and intracellular neurofibrillary tangles of tau. |
2024-04-27 |
2024-04-29 |
human |
| Francesca Orlandi, Arenn F Carlos, Farwa Ali, Heather M Clark, Joseph R Duffy, Rene L Utianski, Hugo Botha, Mary M Machulda, Yehkyoung C Stephens, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Federica Agosta, Massimo Filippi, Dennis W Dickson, Keith A Josephs, Jennifer L Whitwel. Histologic tau lesions and magnetic resonance imaging biomarkers differ across two progressive supranuclear palsy variants. Brain communications. vol 6. issue 2. 2024-04-26. PMID:38660629. |
progressive supranuclear palsy is a neurodegenerative disease characterized by the deposition of four-repeat tau in neuronal and glial lesions in the brainstem, cerebellar, subcortical and cortical brain regions. |
2024-04-26 |
2024-04-28 |
Not clear |
| Ethan D Smith, Robert McKenna, Mario Mietzsch, David R Borchelt, Stefan Prokop, Paramita Chakrabart. Hyperacetylation mimetics within the tau filament core inhibits prion-like propagation of misfolded tau. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659970. |
acetylation of key lysine residues characterizes aggregates of the microtubule-associated protein tau constituting the neuropathological hallmark of many neurodegenerative diseases, such as alzheimer's disease (ad) and progressive supranuclear palsy (psp). |
2024-04-25 |
2024-04-28 |
Not clear |
| Chenxi Qiu, Zhixiong Li, David A Leigh, Bingbing Duan, Joseph E Stucky, Nami Kim, George Xie, Kun Ping Lu, Xiao Zhen Zho. The role of the Pin1- Frontiers in cell and developmental biology. vol 12. 2024-04-17. PMID:38628595. |
the role of the pin1- tauopathies are neurodegenerative diseases characterized by deposits of abnormal tau protein in the brain. |
2024-04-17 |
2024-04-19 |
Not clear |
| Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan L. Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-04-13. PMID:38615036. |
parkinson's disease (pd) is the second most frequently diagnosed neurodegenerative disease, and it is characterized by the intracellular and extracellular accumulation of α-synuclein (α-syn) and tau, which are major components of cytosolic protein inclusions called lewy bodies, in the brain. |
2024-04-13 |
2024-04-16 |
mouse |
| Michael Anekson Widjaya, Shin-Da Lee, Wei-Chung Cheng, Bor-Tsang W. Effects of Exercise Training on Immune-Related Genes and Pathways in the Cortex of Animal Models of Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease : JAD. 2024-04-05. PMID:38578886. |
alzheimer's disease (ad) is a chronic neurodegenerative disease that affects the immune system due to the accumulation of amyloid-β (aβ) and tau associated molecular pathology and other pathogenic processes. |
2024-04-05 |
2024-04-10 |
Not clear |
| Nikki McArthur, Bokyung Kang, Felix G Rivera Moctezuma, Akber T Shaikh, Kathryn Loeffler, Nemil N Bhatt, Madison Kidd, Jennifer M Zupancic, Alec A Desai, Naima Djeddar, Anton Bryksin, Peter M Tessier, Rakez Kayed, Levi B Wood, Ravi S Kan. Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates. Biotechnology progress. 2024-04-03. PMID:38568030. |
antibodies against tau play an increasingly important role in studying these neurodegenerative diseases and the generation of tools to diagnose and treat them. |
2024-04-03 |
2024-04-05 |
mouse |
| Ashish Raj, Justin Toro. Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559176. |
the interaction of amyloid and tau in neurodegenerative diseases is a central feature and key to understanding ad pathophysiology. |
2024-04-01 |
2024-04-04 |
human |
| Sarah Buchholz, Hans Zempe. The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-01. PMID:38556838. |
imbalances in the tau isoform ratio can lead to neurodegenerative diseases, underscoring the need for precise control over tau isoform balance. |
2024-04-01 |
2024-04-03 |
human |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
a neurodegenerative disease is considered a primary tauopathy when mapt mutations/haplotypes are its primary cause and/or tau is the main pathological feature. |
2024-03-30 |
2024-04-02 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
neurodegenerative diseases, like alzheimer's, are associated with the presence of neurofibrillary lesions formed by tau protein filaments in the cerebral cortex. |
2024-03-30 |
2024-04-02 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
while it is known that different morphologies of tau filaments characterize different neurodegenerative diseases, there are few metrics of global and local structure complexity that enable to quantify their structural diversity rigorously. |
2024-03-30 |
2024-04-02 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
in this manuscript, we employ for the first time mathematical topology and geometry to classify neurodegenerative diseases by using cryo-electron microscopy structures of tau filaments that are available in the protein data bank. |
2024-03-30 |
2024-04-02 |
Not clear |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
alzheimer's disease (ad) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (aβ) aggregates and intraneuronal hyperphosphorylated tau. |
2024-03-22 |
2024-03-24 |
mouse |
| Tabassum Khair Barbhuiya, Dulari K Jayarathna, Raechelle Gilmour, Caroline Smet-Nocca, Neha S Gandh. Characterization of Posttranslationally Modified PHF-1 Tau Peptides Using Gaussian Accelerated Molecular Dynamics Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512658. |
the microtubule-associated protein, tau, is an intrinsically disordered protein that plays a crucial role in neurodegenerative diseases like alzheimer's disease. |
2024-03-21 |
2024-03-24 |
Not clear |