| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Chai Chen, Mei-Chou Lai, Tang-Yao Hong, I-Min Li. γ-Oryzanol from Rice Bran Antagonizes Glutamate-Induced Excitotoxicity in an In Vitro Model of Differentiated HT-22 Cells. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674927. |
therefore, γ-oryzanol could be a promising candidate for the development of therapies for glutamate excitotoxicity-associated neurodegenerative diseases, including vascular dementia. |
2024-04-27 |
2024-04-29 |
Not clear |
| Maryam Rezaee Semnani, Zahra Mirzaasgari, Armin Ariaei, Bahram Haghi Ashtian. Evaluation of carotid Intima-Media Thickness (IMT) in amyotrophic lateral sclerosis disease using ultrasonography. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 124. 2024-04-24. PMID:38657488. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease with multi-mechanisms as; inflammation, oxidative stress, glutamate excitotoxicity, protein aggregation, etc. |
2024-04-24 |
2024-04-28 |
Not clear |
| Khaled S Abd-Elrahman, Jean-Martin Beaulieu, Stephen S G Ferguso. Editorial: Emerging insights in glutamate receptor signaling in psychiatric, neurodevelopmental, and neurodegenerative diseases. Frontiers in cell and developmental biology. vol 12. 2024-03-14. PMID:38481531. |
editorial: emerging insights in glutamate receptor signaling in psychiatric, neurodevelopmental, and neurodegenerative diseases. |
2024-03-14 |
2024-03-16 |
Not clear |
| Yangzhi Xie, Liang Chen, Jiacheng Chen, Yan Luo, Zhe Peng, Hao Zhang, Zhao Pan, Yongjun Che. Metabotropic Glutamate Receptor 8 Suppresses M1 Polarization in Microglia by Alleviating Endoplasmic Reticulum Stress and Mitochondrial Dysfunction. Journal of integrative neuroscience. vol 23. issue 2. 2024-02-29. PMID:38419440. |
metabotropic glutamate receptor 8 (grm8) has been reported to promote neuronal survival in neurodegenerative diseases, yet the effect of grm8 on neuroinflammation is still unclear. |
2024-02-29 |
2024-03-02 |
Not clear |
| Da Ma, Wenyu Deng, Zain Khera, Thajunnisa A Sajitha, Xinlei Wang, Gadi Wollstein, Joel S Schuman, Sieun Lee, Haolun Shi, Myeong Jin Ju, Joanne Matsubara, Mirza Faisal Beg, Marinko Sarunic, Rebecca M Sappington, Kevin C Cha. Early inner plexiform layer thinning and retinal nerve fiber layer thickening in excitotoxic retinal injury using deep learning-assisted optical coherence tomography. Acta neuropathologica communications. vol 12. issue 1. 2024-02-02. PMID:38303097. |
excitotoxicity from the impairment of glutamate uptake constitutes an important mechanism in neurodegenerative diseases such as alzheimer's, multiple sclerosis, and parkinson's disease. |
2024-02-02 |
2024-02-04 |
rat |
| Jiahui Chen, Wenqing Ran, Yiman Huang, Junjie Wei, Jian Rong, Huiyi Wei, Yinlong Li, Guocong Li, Zhen Chen, Lee Collier, Nehal H Elghazawy, Wolfgang Sippl, Ahmed Haider, Kai Liao, Chenchen Dong, Ying Li, Hao Xu, Wenpeng He, Lu Wang, Steven H Lian. Evaluation of thiadiazine-based PET radioligands for imaging the AMPA receptor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-11-05. PMID:37925936. |
as a subclass of ionotropic glutamate receptors (iglurs), α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (ampa) receptors have been implicated in various neurological disorders and neurodegenerative diseases. |
2023-11-05 |
2023-11-08 |
Not clear |
| Nadia Rabeh, Baraa Hajjar, Jude O Maraka, Ashwin F Sammanasunathan, Mohammed Khan, Saif M I Alkhaaldi, Samy Mansour, Rashed T Almheiri, Hamdan Hamdan, Khaled S Abd-Elrahma. Targeting mGluR group III for the treatment of neurodegenerative diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-20. PMID:37862967. |
developing disease-modifying treatments for neurodegenerative diseases targeting glutamate receptors is a promising avenue. |
2023-10-20 |
2023-11-08 |
Not clear |
| Mansi Singh, Siva Prasad Pand. The Role of monosodium glutamate (MSG) in Epilepsy and other Neurodegenerative Diseases: Phytochemical-based Therapeutic Approaches and Mechanisms. Current pharmaceutical biotechnology. 2023-07-27. PMID:37496245. |
the role of monosodium glutamate (msg) in epilepsy and other neurodegenerative diseases: phytochemical-based therapeutic approaches and mechanisms. |
2023-07-27 |
2023-08-14 |
Not clear |
| Ayşenur Akkulak, Emre Yeşilören, Abdullah Yalcin, Gizem Donmez Yalci. Kainic Acid-Induced Excitotoxicity Leads to the Activation of Heat Shock Response. Molecular neurobiology. 2023-07-13. PMID:37439958. |
excitotoxicity, which is the accumulation of excess glutamate in synaptic cleft, is observed in age-dependent neurodegenerative diseases and also in stroke, epilepsy, and brain trauma. |
2023-07-13 |
2023-08-14 |
human |
| Chuqiao Pan, Shijie Mao, Zeping Xiong, Zhao Chen, Ning X. Glutamate dehydrogenase: Potential therapeutic targets for neurodegenerative disease. European journal of pharmacology. 2023-04-28. PMID:37116563. |
glutamate dehydrogenase: potential therapeutic targets for neurodegenerative disease. |
2023-04-28 |
2023-08-14 |
Not clear |
| Chuqiao Pan, Shijie Mao, Zeping Xiong, Zhao Chen, Ning X. Glutamate dehydrogenase: Potential therapeutic targets for neurodegenerative disease. European journal of pharmacology. 2023-04-28. PMID:37116563. |
gdh activators and gene therapy have been found to protect neurons and improve motor disorders in neurodegenerative diseases caused by glutamate metabolism disorders. |
2023-04-28 |
2023-08-14 |
Not clear |
| Kuljira Mongkolpobsin, Chanin Sillapachaiyaporn, Sunita Nilkhet, Tewin Tencomnao, Seung Joon Bae. Stigmasterol isolated from Azadirachta indica flowers attenuated glutamate-induced neurotoxicity via downregulation of the Cdk5/p35/p25 signaling pathway in the HT-22 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 113. 2023-03-10. PMID:36898255. |
glutamate, an excitatory neurotransmitter, was elevated in the brain of neurodegenerative disease (nd) patients. |
2023-03-10 |
2023-08-14 |
Not clear |
| Shao-Peng Lin, Jingyi Bu, Shan Ye, Qiangda Xie, Jue-Xian Wei, Xiaofang Yin, Fen Mei, Pei-Yi Lin, Xiao-Hui Che. Activated AMPK-mediated glucose uptake and mitochondrial dysfunction is critically involved in the glutamate-induced oxidative injury in HT22 cell. Tissue & cell. vol 81. 2023-02-22. PMID:36805774. |
accumulation of glutamate damages neurons via the reactive oxygen species (ros) injury, which was involved in the development of neurodegenerative diseases. |
2023-02-22 |
2023-08-14 |
Not clear |
| José Luis Castañeda-Cabral, Sandra A Orozco-Suárez, Carlos Beas-Zárate, Blanca F Fajardo-Fregoso, Mario E Flores-Soto, Mónica E Ureña-Guerrer. Inhibition of VEGFR-2 by SU5416 increases neonatally glutamate-induced neuronal damage in the cerebral motor cortex and hippocampus. Journal of biochemical and molecular toxicology. 2023-02-03. PMID:36732937. |
neonatal monosodium glutamate (msg) treatment triggers neuronal death by excitotoxicity, which is commonly involved in different neurological disorders, including neurodegenerative diseases. |
2023-02-03 |
2023-08-14 |
Not clear |
| Pasquale Linciano, Claudia Sorbi, Giacomo Rossino, Daniela Rossi, Andrea Marsala, Nunzio Denora, Martina Bedeschi, Noemi Marino, Giacomo Miserocchi, Giulio Dondio, Marco Peviani, Anna Tesei, Simona Collina, Silvia Franchin. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. European journal of medicinal chemistry. vol 249. 2023-01-30. PMID:36716640. |
sigma-1 receptor (s1r) has been considered a promising therapeutic target for several neurodegenerative diseases and s1r agonists have shown neuroprotective activity against glutamate excitotoxicity and oxidative stress. |
2023-01-30 |
2023-08-14 |
human |
| Ki Beom Jeon, Seong Hun Lee, Yong Seong Kwon, Jin Hong Beak, Hyeon Lee, Choong Je M. Protective effect of fermented aloe extract on glutamate-induced cytotoxicity in HT22 cells. Animal cells and systems. vol 26. issue 6. 2023-01-06. PMID:36605589. |
excessive glutamate can cause oxidative stress in neuronal cells and this can significantly contribute to the etiology of neurodegenerative disease. |
2023-01-06 |
2023-08-14 |
Not clear |
| Chimere Nnatubeugo, Erica Johnson, Sarah Gisondi, Felicia Roland, Werner J Geldenhuys, Michael A Menze, Mary E Konkl. The Mitochondrial Protein MitoNEET as a Probe for the Allostery of Glutamate Dehydrogenase. Molecules (Basel, Switzerland). vol 27. issue 23. 2022-12-11. PMID:36500407. |
the proteins glutamate dehydrogenase (gdh) and mitoneet are both targets of drug development efforts to treat metabolic disorders, cancer, and neurodegenerative diseases. |
2022-12-11 |
2023-08-14 |
Not clear |
| Eui-Jeong Han, Chunying Zhang, Hyun-Soo Kim, Ji-Yul Kim, Sang-Muyn Park, Won-Kyo Jung, Ginnae Ahn, Seon-Heui Ch. Sargachromenol Isolated from Marine drugs. vol 20. issue 11. 2022-11-24. PMID:36421988. |
sargachromenol isolated from oxidative stress-induced neuronal cell loss is considered to be the major mechanism underlying the pathogenesis of neurodegenerative diseases, which could be induced by a high concentration of glutamate. |
2022-11-24 |
2023-08-14 |
Not clear |
| Arina Zgodova, Svetlana Pavlova, Anastasia Nekrasova, Dmitriy Boyarkin, Vsevolod Pinelis, Alexander Surin, Zanda Bakaev. Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity. Membranes. vol 12. issue 11. 2022-11-11. PMID:36363608. |
it is considered that glutamate excitotoxicity may be a major factor in the pathological death of neurons and mediate the development of neurodegenerative diseases in humans. |
2022-11-11 |
2023-08-14 |
Not clear |
| Kade Riche, Natalie R Lenar. Quercetin's Effects on Glutamate Cytotoxicity. Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364448. |
the clinical importance for the attenuation of glutamate excitotoxicity arises from the need to deter the continuous formation of tissue infarction caused by various neurological diseases, such as ischemic stroke, seizures, neurodegenerative diseases, and trauma. |
2022-11-11 |
2023-08-14 |
Not clear |