| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Zhe Wang, Xing-Chen Wang, Ya-Fei Chen, Chuan-Li Wang, Le Chen, Ming-Yue Jiang, Xi-Wei Liu, Xiao-Xuan Zhang, Yong-Zhen Feng, Jin-Hui X. Loss and recovery of myocardial mitochondria in mice under different tail suspension time: Apoptosis and mitochondrial fission, fusion and autophagy. Experimental physiology. 2023-08-11. PMID:37565298. |
the results showed: (1) mitochondrial swelling and disruption of cristae in ts2, but mitochondrial recovery and denser cristae in ts4; (2) an increase in the total number of mitochondria and number of sub-mitochondria in ts4; (3) no significant changes in the nuclear ultrastructure or dna fragmentation among the two ts groups and the control group; (4) an increase in the bax/bcl-2 protein levels in the two ts groups, indicating increased activation of the bax-mediated apoptosis pathway; (5) no change in the phosphorylation ratio of dynamin-related protein 1 in the two ts groups; (6) an increase in the protein levels of optic atrophy 1 and mitofusin 2 in the two ts groups; and (7) in comparison to the ts2 group, an increase in the phosphorylation ratio of parkin and the ratio of lc3ii to lc3i in ts4, suggesting an increase in autophagy. |
2023-08-11 |
2023-08-16 |
mouse |
| Ying Yuan, Xiao-Ming Zhan. Mechanistic study of optic atrophy 1 in ischemia-reperfusion disease. Journal of molecular medicine (Berlin, Germany). 2022-11-23. PMID:36418744. |
optic atrophy 1 (opa1) is a key protein that regulates mitochondrial inner membrane fusion and ensures normal mitochondrial function by balancing mitochondrial dynamics, participating in various processes such as mitochondrial fusion, oxidative stress, and apoptosis. |
2022-11-23 |
2023-08-14 |
Not clear |
| John Noone, Donal J O'Gorman, Helena C Kenn. OPA1 regulation of mitochondrial dynamics in skeletal and cardiac muscle. Trends in endocrinology and metabolism: TEM. 2022-08-09. PMID:35945104. |
optic atrophy 1 (opa1) regulates imm fusion, prevents apoptosis, and is a key regulator of morphological change in skeletal and cardiac muscle physiology and pathophysiology. |
2022-08-09 |
2023-08-14 |
Not clear |
| Maria Kalogerou, Sotiris Ioannou, Panagiotis Kolovos, Ekatherine Prokopiou, Louiza Potamiti, Kyriacos Kyriacou, Michail Panagiotidis, Maria Ioannou, Eleni Fella, Elena Panayiotou Worth, Tassos Georgio. Omega-3 fatty acids promote neuroprotection, decreased apoptosis and reduced glial cell activation in the retina of a mouse model of OPA1-related autosomal dominant optic atrophy. Experimental eye research. 2021-12-21. PMID:34933001. |
omega-3 fatty acids promote neuroprotection, decreased apoptosis and reduced glial cell activation in the retina of a mouse model of opa1-related autosomal dominant optic atrophy. |
2021-12-21 |
2023-08-13 |
mouse |
| Yulian Pang, Mengqi Qin, Piaopiao Hu, Kaibao Ji, Ruihan Xiao, Nan Sun, Xinghui Pan, Xu Zhan. Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression. International journal of molecular medicine. vol 46. issue 5. 2021-06-30. PMID:32901846. |
in the present study, the protective effects of resveratrol on rgc apoptosis, and the mechanisms underlying its effects were investigated, with a particular emphasis on the function of optic atrophy 1 (opa1). |
2021-06-30 |
2023-08-13 |
Not clear |
| Jia Zheng, Chengzhi L. Oxidized LDL Causes Endothelial Apoptosis by Inhibiting Mitochondrial Fusion and Mitochondria Autophagy. Frontiers in cell and developmental biology. vol 8. 2020-12-07. PMID:33262989. |
we explored the role of optic atrophy 1 (opa1)-related mitochondrial fusion and mitophagy in ox-ldl-treated endothelial cells, focusing on mitochondrial damage and cell apoptosis. |
2020-12-07 |
2023-08-13 |
Not clear |
| Longyun Chen, Huimin Che. Effect of Mahuang Gancao Ganjiang Decoction on Fusion and Fission of Mitochondria and Apoptosis of Lymphocytes in Mice under Cold Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28191022. |
western blot analysis showed that these cells expressed decreased fusion-related proteins mitofusin 1 (mfn1), mitofusin 2 (mfn2), and optic atrophy protein-1 (opa-1) and increased fission-related proteins dynamin-related protein 1 (drp1) and fission 1 (fis-1); our results also show that decreased mitochondrial fusion induces cell apoptosis during cold stress. |
2020-09-30 |
2023-08-13 |
mouse |
| Qianbo Chen, Xiaoting Xi, Yong Zeng, Zhendan He, Jianfeng Zhao, Yan L. Acteoside inhibits autophagic apoptosis of retinal ganglion cells to rescue glaucoma-induced optic atrophy. Journal of cellular biochemistry. vol 120. issue 8. 2020-08-31. PMID:31021425. |
acteoside inhibits autophagic apoptosis of retinal ganglion cells to rescue glaucoma-induced optic atrophy. |
2020-08-31 |
2023-08-13 |
Not clear |
| Long-Long Xie, Feng Shi, Zheqiong Tan, Yueshuo Li, Ann M Bode, Ya Ca. Mitochondrial network structure homeostasis and cell death. Cancer science. vol 109. issue 12. 2019-01-02. PMID:30312515. |
recent advances revealed that a number of components of the fission and fusion machinery, including dynamin-related protein 1 (drp1), mitofusin1/2 (mfn1/2) and optic atrophy 1 (opa1), that have been implicated in mitochondrial shape changes are indispensible for autophagy, apoptosis and necroptosis. |
2019-01-02 |
2023-08-13 |
Not clear |
| Christina Glytsou, Enrique Calvo, Sara Cogliati, Arpit Mehrotra, Irene Anastasia, Giovanni Rigoni, Andrea Raimondi, Norihito Shintani, Marta Loureiro, Jesùs Vazquez, Luca Pellegrini, Jose Antonio Enriquez, Luca Scorrano, Maria Eugenia Sorian. Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control. Cell reports. vol 17. issue 11. 2017-11-28. PMID:27974214. |
the mitochondrial contact site and cristae organizing system (micos) and optic atrophy 1 (opa1) control cristae shape, thus affecting mitochondrial function and apoptosis. |
2017-11-28 |
2023-08-13 |
Not clear |
| Anna Signorile, Arcangela Santeramo, Grazia Tamma, Tommaso Pellegrino, Susanna D'Oria, Paolo Lattanzio, Domenico De Rasm. Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells. Biochimica et biophysica acta. Molecular cell research. vol 1864. issue 2. 2017-06-20. PMID:27890624. |
a number of mitochondrial proteins and pathways have been found to be involved in the mitochondrial dependent apoptosis mechanism, such as optic atrophy 1 (opa1), sirtuin 3 (sirt3), deacetylase enzyme and camp signal. |
2017-06-20 |
2023-08-13 |
rat |
| Patrizia Formichi, Elena Radi, Eleonora Giorgi, Gian Nicola Gallus, Jlenia Brunetti, Carla Battisti, Alessandra Rufa, Maria Teresa Dotti, Rossella Franceschini, Luisa Bracci, Antonio Federic. Analysis of opa1 isoforms expression and apoptosis regulation in autosomal dominant optic atrophy (ADOA) patients with mutations in the opa1 gene. Journal of the neurological sciences. vol 351. issue 1-2. 2016-01-11. PMID:25796301. |
adoa is associated to mutations in optic atrophy 1 gene (opa1), which encodes a mitochondrial protein involved in cristae remodeling, maintenance of mitochondrial membrane integrity, mitochondrial fusion and apoptosis regulation. |
2016-01-11 |
2023-08-13 |
Not clear |
| Patrizia Formichi, Elena Radi, Eleonora Giorgi, Gian Nicola Gallus, Jlenia Brunetti, Carla Battisti, Alessandra Rufa, Maria Teresa Dotti, Rossella Franceschini, Luisa Bracci, Antonio Federic. Analysis of opa1 isoforms expression and apoptosis regulation in autosomal dominant optic atrophy (ADOA) patients with mutations in the opa1 gene. Journal of the neurological sciences. vol 351. issue 1-2. 2016-01-11. PMID:25796301. |
analysis of opa1 isoforms expression and apoptosis regulation in autosomal dominant optic atrophy (adoa) patients with mutations in the opa1 gene. |
2016-01-11 |
2023-08-13 |
Not clear |
| Maki Sumida, Kent Doi, Emi Ogasawara, Tetsushi Yamashita, Yoshifumi Hamasaki, Taro Kariya, Eiki Takimoto, Naoki Yahagi, Masaomi Nangaku, Eisei Noir. Regulation of Mitochondrial Dynamics by Dynamin-Related Protein-1 in Acute Cardiorenal Syndrome. Journal of the American Society of Nephrology : JASN. vol 26. issue 10. 2015-12-31. PMID:25644112. |
electron microscopy showed a significant increase of mitochondrial fragmentation in the heart at 24 h. cardiomyocyte apoptosis and cardiac dysfunction, evaluated by echocardiography, were observed at 72 h. among the mitochondrial dynamics regulating molecules, dynamin-related protein 1 (drp1), which regulates fission, and mitofusin 1, mitofusin 2, and optic atrophy 1, which regulate fusion, only drp1 was increased in the mitochondrial fraction of the heart. |
2015-12-31 |
2023-08-13 |
mouse |
| Fabrizia Stavru, Amy E Palmer, Chunxin Wang, Richard J Youle, Pascale Cossar. Atypical mitochondrial fission upon bacterial infection. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 40. 2013-12-03. PMID:24043775. |
llo does not cause processing of the fusion protein optic atrophy protein 1 (opa1), despite inducing a decrease in the mitochondrial membrane potential, suggesting a unique drp1- and opa1-independent fission mechanism distinct from that triggered by uncouplers or the apoptosis inducer staurosporine. |
2013-12-03 |
2023-08-12 |
Not clear |
| Luiza K Sanjuán Szklarz, Luca Scorran. The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock. Biochimica et biophysica acta. vol 1817. issue 10. 2013-05-03. PMID:22579715. |
the mitochondria-shaping protein optic atrophy 1 (opa1) has genetically distinguishable roles in mitochondrial morphology and apoptosis. |
2013-05-03 |
2023-08-12 |
Not clear |
| Sandra Noble, Abid Ismail, Rafael Godoy, Yanwei Xi, Marc Ekke. Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival. Journal of neurochemistry. vol 122. issue 1. 2012-08-27. PMID:22506991. |
the parl gene product is found in the inner mitochondrial membrane and cleaves the optic atrophy 1 protein, involved in mitochondrial morphology and apoptosis. |
2012-08-27 |
2023-08-12 |
human |
| Hsin-Yuan Fang, Chih-Yi Chen, Shiow-Her Chiou, Yu-Ting Wang, Tze-Yi Lin, Hui-Wen Chang, I-Ping Chiang, Kuo-Jung Lan, Kuan-Chih Cho. Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells. Human pathology. vol 43. issue 1. 2012-01-31. PMID:21798574. |
overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells. |
2012-01-31 |
2023-08-12 |
Not clear |
| Shin-ichi Sato, Asako Murata, Tsubasa Orihara, Takashi Shirakawa, Kiyotake Suenaga, Hideo Kigoshi, Motonari Uesug. Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chemistry & biology. vol 18. issue 1. 2011-04-28. PMID:21276946. |
results of the present study showed that aurilide selectively binds to prohibitin 1 (phb1) in the mitochondria, activating the proteolytic processing of optic atrophy 1 (opa1) and resulting in mitochondria-induced apoptosis. |
2011-04-28 |
2023-08-12 |
human |