| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Yuxuan Song, Shuang Ren, Xingmei Chen, Xuhong Li, Lin Chen, Shijie Zhao, Yue Zhang, Xiangchun Shen, Yan Che. Inhibition of MFN1 restores tamoxifen-induced apoptosis in resistant cells by disrupting aberrant mitochondrial fusion dynamics. Cancer letters. 2024-04-07. PMID:38583647. |
the interaction of mfn1 and cristae-shaping protein optic atrophy 1 (opa1) and opa1 oligomerization were reduced due to augmented opa1 proteolytic cleavage, and their apoptosis-promoting function was reduced due to cristae remodeling. |
2024-04-07 |
2024-04-10 |
Not clear |
| Wataru Shimabukuro, Yasutsugu Chinen, Naoya Imanaga, Kumiko Yanagi, Tadashi Kaname, Koichi Nakanish. Renal coloboma syndrome/dominant optic atrophy with severe retinal atrophy and de novo digenic mutations in PAX2 and OPA1. Pediatric nephrology (Berlin, Germany). 2024-03-12. PMID:38467926. |
renal coloboma syndrome/dominant optic atrophy with severe retinal atrophy and de novo digenic mutations in pax2 and opa1. |
2024-03-12 |
2024-03-14 |
Not clear |
| Wataru Shimabukuro, Yasutsugu Chinen, Naoya Imanaga, Kumiko Yanagi, Tadashi Kaname, Koichi Nakanish. Renal coloboma syndrome/dominant optic atrophy with severe retinal atrophy and de novo digenic mutations in PAX2 and OPA1. Pediatric nephrology (Berlin, Germany). 2024-03-12. PMID:38467926. |
renal coloboma syndrome (rcs) and dominant optic atrophy are mainly caused by heterozygous mutations in pax2 and opa1, respectively. |
2024-03-12 |
2024-03-14 |
Not clear |
| Ying He, Ruicheng Li, Yuxi Yu, Chusheng Huang, Zhiran Xu, Tianbao Wang, Chen Ming, Hongri Huang, Zhongquan Q. Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models. Neurochemistry international. 2024-02-28. PMID:38417589. |
furthermore, nscs elevated proliferator-activated receptor gamma coactivator-1 alpha(pgc-1a), mitofusin 2(mfn2), and optic atrophy 1(opa1) expression, three genes mediating mitochondrial biogenesis, in the sn and striatum of pd monkeys. |
2024-02-28 |
2024-03-02 |
human |
| Su Han Lee, Duyen Pham, Edina Kosa, Abdulbaki Agba. Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases. Missouri medicine. vol 121. issue 1. 2024-02-26. PMID:38404440. |
optic atrophy 1(opa1) is a gtpase protein that controls mitochondrial fusion, cristae integrity, and mtdna maintenance. |
2024-02-26 |
2024-02-28 |
human |
| Corentin Affortit, Carolanne Coyat, Anissa Rym Saidia, Jean-Charles Ceccato, Majida Charif, Emmanuelle Sarzi, Frédéric Flamant, Romain Guyot, Chantal Cazevieille, Jean-Luc Puel, Guy Lenaers, Jing Wan. The human OPA1 Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-02-09. PMID:38334784. |
the human opa1 dominant optic atrophy (doa) is one of the most prevalent forms of hereditary optic neuropathies and is mainly caused by heterozygous variants in opa1, encoding a mitochondrial dynamin-related large gtpase. |
2024-02-09 |
2024-02-11 |
human |
| Jiali Weng, Qi Liu, Chenfei Li, Yi Feng, Qing Chang, Meiqin Xie, Xiaohui Wang, Mengnan Li, Hai Zhang, Ruolin Mao, Na Zhang, Xiaohua Yang, Kian Fan Chung, Ian M Adcock, Yan Huang, Feng L. TRPA1-PI3K/Akt-OPA1-ferroptosis axis in ozone-induced bronchial epithelial cell and lung injury. The Science of the total environment. vol 918. 2024-02-09. PMID:38320701. |
optic atrophy 1 (opa1) is one of the significant mitochondrial fusion proteins. |
2024-02-09 |
2024-02-14 |
Not clear |
| Paola Zanfardino, Alessandro Amati, Stefano Doccini, Sharon N Cox, Apollonia Tullo, Giovanna Longo, Annamaria D'Erchia, Ernesto Picardi, Claudia Nesti, Filippo M Santorelli, Vittoria Petruzzell. OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts. Human molecular genetics. 2024-01-27. PMID:38280232. |
opa1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts. |
2024-01-27 |
2024-01-30 |
Not clear |
| Paola Zanfardino, Alessandro Amati, Stefano Doccini, Sharon N Cox, Apollonia Tullo, Giovanna Longo, Annamaria D'Erchia, Ernesto Picardi, Claudia Nesti, Filippo M Santorelli, Vittoria Petruzzell. OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts. Human molecular genetics. 2024-01-27. PMID:38280232. |
this study focused on fibroblasts from a patient with autosomal dominant optic atrophy (adoa) plus syndrome harboring a mutation in the optic atrophy 1 (opa1) gene. |
2024-01-27 |
2024-01-30 |
Not clear |
| Giulia Amore, Martina Romagnoli, Michele Carbonelli, Maria Lucia Cascavilla, Anna Maria De Negri, Arturo Carta, Vincenzo Parisi, Antonio Di Renzo, Costantino Schiavi, Chiara Lenzetti, Corrado Zenesini, Danara Ormanbekova, Flavia Palombo, Claudio Fiorini, Leonardo Caporali, Valerio Carelli, Piero Barboni, Chiara La Morgi. AFG3L2 and ACO2-linked Dominant Optic Atrophy: genotype-phenotype characterization compared to OPA1 patients. American journal of ophthalmology. 2024-01-26. PMID:38278202. |
afg3l2 and aco2-linked dominant optic atrophy: genotype-phenotype characterization compared to opa1 patients. |
2024-01-26 |
2024-01-29 |
Not clear |
| Giulia Amore, Martina Romagnoli, Michele Carbonelli, Maria Lucia Cascavilla, Anna Maria De Negri, Arturo Carta, Vincenzo Parisi, Antonio Di Renzo, Costantino Schiavi, Chiara Lenzetti, Corrado Zenesini, Danara Ormanbekova, Flavia Palombo, Claudio Fiorini, Leonardo Caporali, Valerio Carelli, Piero Barboni, Chiara La Morgi. AFG3L2 and ACO2-linked Dominant Optic Atrophy: genotype-phenotype characterization compared to OPA1 patients. American journal of ophthalmology. 2024-01-26. PMID:38278202. |
heterozygous mutations in afg3l2 gene (encoding a mitochondrial protease indirectly reflecting on opa1 cleavage) and aco2 gene (encoding the mitochondrial enzyme aconitase) are associated to isolated forms of dominant optic atrophy (doa). |
2024-01-26 |
2024-01-29 |
Not clear |
| Michelle Y Fry, Paula P Navarro, Pusparanee Hakim, Virly Y Ananda, Xingping Qin, Juan C Landoni, Sneha Rath, Zintis Inde, Camila Makhlouta Lugo, Bridget E Luce, Yifan Ge, Julie L McDonald, Ilzat Ali, Leillani L Ha, Benjamin P Kleinstiver, David C Chan, Kristopher A Sarosiek, Luke H Cha. In situ architecture of Opa1-dependent mitochondrial cristae remodeling. The EMBO journal. 2024-01-15. PMID:38225406. |
the protein optic atrophy 1 (opa1) is an important crista remodeler that exists as two forms in the mitochondrion, a membrane-anchored long form (l-opa1) and a processed short form (s-opa1). |
2024-01-15 |
2024-01-18 |
mouse |
| Xibing Yu, Hexiang Jiang, Jindou Li, Jiaxin Ding, Kainan Chen, Zhuang Ding, Xiaohong X. NDV inhibited IFN-β secretion through impeding CHCHD10-mediated mitochondrial fusion to promote viral proliferation. Veterinary microbiology. vol 290. 2024-01-11. PMID:38211361. |
the proteins involved in mitochondrial fusion, namely mitofusin 1 (mfn1) and optic atrophy 1 (opa1) are associated with interferon-beta (ifn-β) secretion during ndv infection. |
2024-01-11 |
2024-01-14 |
human |
| Li Wang, Rafael Rivas, Angelo Wilson, Yu Min Park, Shannon Walls, Tianzheng Yu, Alexandra C Mille. Dose-Dependent Effects of Radiation on Mitochondrial Morphology and Clonogenic Cell Survival in Human Microvascular Endothelial Cells. Cells. vol 13. issue 1. 2024-01-11. PMID:38201243. |
the study further revealed that low doses induced mitochondrial elongation, likely via an increase in mitochondrial fusion protein 1 (mfn1), while high doses caused mitochondrial fragmentation via a decrease in optic atrophy protein 1 (opa1). |
2024-01-11 |
2024-01-13 |
human |
| Mengliu Luo, Qianhua Yuan, Yutong Xie, Meiqing Mai, Wanhan Song, Ya Wang, Haimei Shi, Enqin Xia, Honghui Gu. Yo-yo Dieting Delays Male Drosophila melanogaster Aging Through Enhanced Mitochondrial Function, Relative to Sustained High-Calorie Diet Feeding. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-01-10. PMID:38198696. |
importantly, it improved mitochondrial function and upregulated the expression of essential mitochondrial fusion proteins, namely mitofusin 1 and mitofusin 2, optic atrophy 1 (opa1), and peroxisome proliferator-activated receptor-γ coactivator-1α (pgc-1α). |
2024-01-10 |
2024-01-13 |
drosophila_melanogaster |
| Da Huo, Xin-Yu Bi, Jun-Ling Zeng, Da-Mao Dai, Xiang-Lin Don. Drugs targeting TGF-β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion. Molecular and cellular biochemistry. 2023-12-29. PMID:38158493. |
in addition, optic atrophy 1 (opa1)-mediated mitochondrial fusion contributes to fibroblast proliferation, and tgf-β/smad3 axis and the notch1 pathway facilitate opa1-mediated mitochondrial fusion. |
2023-12-29 |
2024-01-05 |
human |
| Chenfei Li, Qi Liu, Qing Chang, Meiqin Xie, Jiali Weng, Xiaohui Wang, Mengnan Li, Jiani Chen, Yan Huang, Xiaohua Yang, Kai Wang, Na Zhang, Kian Fan Chung, Ian M Adcock, Hai Zhang, Feng L. Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease. Respiratory research. vol 24. issue 1. 2023-12-19. PMID:38110986. |
this study examined mitochondrial dynamics, mitophagy and lung cellular senescence in copd patients and investigated the effects of modulation of mitochondrial fusion [mitofusin2 (mfn2) and optic atrophy 1 (opa1)] on cs extract (cse)-induced lung cellular senescence. |
2023-12-19 |
2023-12-21 |
Not clear |
| Qiannan Lei, Kangjian Xiang, Lin Cheng, Mengqing Xian. Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function. Stem cell reports. 2023-12-15. PMID:38101398. |
autosomal dominant optic atrophy (adoa), mostly caused by heterozygous opa1 mutations and characterized by retinal ganglion cell (rgc) loss and optic nerve degeneration, is one of the most common types of inherited optic neuropathies. |
2023-12-15 |
2023-12-18 |
human |
| Jiaqi Zeng, Jianing Liu, Haiya Ni, Ling Zhang, Jun Wang, Yazhou Li, Wentao Jiang, Ziyu Wu, Min Zho. Mitochondrial transplantation reduces lower limb ischemia-reperfusion injury by increasing skeletal muscle energy and adipocyte browning. Molecular therapy. Methods & clinical development. vol 31. 2023-12-01. PMID:38027061. |
in this study, we found that in addition to being taken up by skeletal muscle cells, human umbilical cord mesenchymal stem cells (hmscs)-derived mitochondria were also taken up by adipocytes, which was accompanied by an increase in optic atrophy 1 (opa1) and uncoupling protein 1. |
2023-12-01 |
2023-12-10 |
human |