| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikhail Paveliev, Anton A Egorchev, Foat Musin, Nikita Lipachev, Anastasiia Melnikova, Rustem M Gimadutdinov, Aidar R Kashipov, Dmitry Molotkov, Dmitry E Chickrin, Albert V Agano. Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673819. |
here, we review recent research implicating pnn microstructural changes in schizophrenia and other disorders. |
2024-04-27 |
2024-04-29 |
Not clear |
| Seungyeong Yu, Mincheol Park, Jiseung Kang, Eunkyung Lee, Jieun Jung, Tae Ki. Aberrant Gamma-Band Oscillations in Mice with Vitamin D Deficiency: Implications on Schizophrenia and its Cognitive Symptoms. Journal of personalized medicine. vol 12. issue 2. 2022-02-25. PMID:35207806. |
taken together, we suggest that vdd could result in decreased pnn and, consequently, increase the spontaneous gbo and decrease the evoked gbo, reminiscent of the aberrant gbo in schizophrenia. |
2022-02-25 |
2023-08-13 |
mouse |
| Rahul Kaushik, Nikita Lipachev, Gabriela Matuszko, Anastasia Kochneva, Anastasia Dvoeglazova, Axel Becker, Mikhail Paveliev, Alexander Dityate. Fine structure analysis of perineuronal nets in the ketamine model of schizophrenia. The European journal of neuroscience. vol 53. issue 12. 2021-08-13. PMID:32510674. |
in this study, we developed a novel open-source script for fiji (imagej) to semi-automatically quantify structural alterations of pnns such as the number of pnn units, area, mean intensity of pnn marker expression in 2d and 3d, shape parameters of pnn units in the ketamine-treated sprague-dawley rat model of schizophrenia using high-resolution confocal microscopic images. |
2021-08-13 |
2023-08-13 |
rat |
| Rahul Kaushik, Nikita Lipachev, Gabriela Matuszko, Anastasia Kochneva, Anastasia Dvoeglazova, Axel Becker, Mikhail Paveliev, Alexander Dityate. Fine structure analysis of perineuronal nets in the ketamine model of schizophrenia. The European journal of neuroscience. vol 53. issue 12. 2021-08-13. PMID:32510674. |
thus, the proposed multidimensional analysis of pnn units provided a robust and comprehensive morphometric fingerprinting of fine ecm structure abnormalities in the experimental model of schizophrenia. |
2021-08-13 |
2023-08-13 |
rat |
| Daniella Dwir, Basilio Giangreco, Lijing Xin, Liliane Tenenbaum, Jan-Harry Cabungcal, Pascal Steullet, Audrey Goupil, Martine Cleusix, Raoul Jenni, Abdelwahed Chtarto, Philipp S Baumann, Paul Klauser, Philippe Conus, Rabindra Tirouvanziam, Michel Cuenod, Kim Q D. MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients. Molecular psychiatry. vol 25. issue 11. 2021-03-15. PMID:30911107. |
various mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/nmda receptor dysfunction, neuroinflammation or redox imbalance, all appear to converge towards an oxidative stress "hub" affecting parvalbumine interneurones (pvi) and their perineuronal nets (pnn) (lancet psychiatry. |
2021-03-15 |
2023-08-13 |
mouse |
| Teresa H Wen, Devin K Binder, Iryna M Ethell, Khaleel A Raza. The Perineuronal 'Safety' Net? Perineuronal Net Abnormalities in Neurological Disorders. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30123106. |
indeed, pnn abnormalities have been observed in post-mortem brain tissues of patients with schizophrenia and alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zhoulong Yu, Na Chen, Die Hu, Wenxi Chen, Yi Yuan, Shiqiu Meng, Wen Zhang, Lin Lu, Ying Han, Jie Sh. Decreased Density of Perineuronal Net in Prelimbic Cortex Is Linked to Depressive-Like Behavior in Young-Aged Rats. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32116542. |
pnn abnormalities have been observed in various psychiatric disorders such as schizophrenia and bipolar disorder, but the relationship between pnn density and depression still remains unclear. |
2020-09-28 |
2023-08-13 |
rat |
| John F Enwright, Sowmya Sanapala, Aaron Foglio, Raissa Berry, Kenneth N Fish, David A Lewi. Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:26868058. |
using confocal microscopy, we quantified the densities and fluorescence intensities of pv neurons and pnns labeled with wfa or immunoreactive for the major pnn protein, aggrecan, in the dlpfc from schizophrenia and matched comparison subjects. |
2018-01-09 |
2023-08-13 |
human |
| Byron K Y Bitanihirwe, Sarah A Mauney, Tsung-Ung W Wo. Weaving a Net of Neurobiological Mechanisms in Schizophrenia and Unraveling the Underlying Pathophysiology. Biological psychiatry. vol 80. issue 8. 2017-08-07. PMID:27113498. |
an integrated understanding of these neurobiological processes should provide a better basis to elucidate how pnn abnormalities influence brain function and contribute to the pathogenesis of neurodevelopmental disorders such as schizophrenia. |
2017-08-07 |
2023-08-13 |
Not clear |
| Byron K Y Bitanihirwe, Sarah A Mauney, Tsung-Ung W Wo. Weaving a Net of Neurobiological Mechanisms in Schizophrenia and Unraveling the Underlying Pathophysiology. Biological psychiatry. vol 80. issue 8. 2017-08-07. PMID:27113498. |
also, an increasing body of evidence links pnn abnormalities to schizophrenia. |
2017-08-07 |
2023-08-13 |
Not clear |
| Byron K Y Bitanihirwe, Sarah A Mauney, Tsung-Ung W Wo. Weaving a Net of Neurobiological Mechanisms in Schizophrenia and Unraveling the Underlying Pathophysiology. Biological psychiatry. vol 80. issue 8. 2017-08-07. PMID:27113498. |
given the established role of pnns in modulating developmental plasticity, the pnn represents a possible candidate for altering the onset and progression of schizophrenia. |
2017-08-07 |
2023-08-13 |
Not clear |
| Sabina Berretta, Harry Pantazopoulos, Matej Markota, Christopher Brown, Eleni T Batzianoul. Losing the sugar coating: potential impact of perineuronal net abnormalities on interneurons in schizophrenia. Schizophrenia research. vol 167. issue 1-3. 2016-06-27. PMID:25601362. |
we integrate these considerations with results from recent genetic studies showing genetic susceptibility for schizophrenia associated with genes encoding for pnn components, matrix-regulating molecules and immune system factors. |
2016-06-27 |
2023-08-13 |
human |
| Sabina Berretta, Harry Pantazopoulos, Matej Markota, Christopher Brown, Eleni T Batzianoul. Losing the sugar coating: potential impact of perineuronal net abnormalities on interneurons in schizophrenia. Schizophrenia research. vol 167. issue 1-3. 2016-06-27. PMID:25601362. |
we speculate that the physiological process of pnn remodeling may be disrupted in schizophrenia as a result of interactions between matrix remodeling processes and immune system dysregulation. |
2016-06-27 |
2023-08-13 |
human |
| H Pantazopoulos, M Markota, F Jaquet, D Ghosh, A Wallin, A Santos, B Caterson, S Berrett. Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala. Translational psychiatry. vol 5. 2015-09-09. PMID:25603412. |
previous findings showed robust pnn decreases in amygdala, entorhinal cortex and prefrontal cortex of subjects with schizophrenia (sz), but not bipolar disorder (bd). |
2015-09-09 |
2023-08-13 |
human |
| Byron K Y Bitanihirwe, Tsung-Ung W Wo. Perineuronal nets and schizophrenia: the importance of neuronal coatings. Neuroscience and biobehavioral reviews. vol 45. 2015-04-16. PMID:24709070. |
until recently, the functions of the pnn had remained enigmatic, but are now considered to be important in development of the central nervous system, neuronal protection and synaptic plasticity, all elements which have been associated with schizophrenia. |
2015-04-16 |
2023-08-13 |
Not clear |