| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leonardo Sportelli, Daniel P Eisenberg, Roberta Passiatore, Enrico D'Ambrosio, Linda A Antonucci, Jasmine S Bettina, Qiang Chen, Aaron L Goldman, Michael D Gregory, Kira Griffiths, Thomas M Hyde, Joel E Kleinman, Antonio F Pardiñas, Madhur Parihar, Teresa Popolizio, Antonio Rampino, Joo Heon Shin, Mattia Veronese, William S Ulrich, Caroline F Zink, Alessandro Bertolino, Oliver D Howes, Karen F Berman, Daniel R Weinberger, Giulio Pergol. Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo. Nature communications. vol 15. issue 1. 2024-04-30. PMID:38688917. |
we identify a set of genes predominantly expressed in the caudate nucleus and associated with both clinical state and genetic risk for schizophrenia that shows dopaminergic selectivity. |
2024-04-30 |
2024-05-03 |
Not clear |
| Gergely Keszler, Bálint Vékony, Zsuzsanna Elek, Zsófia Nemoda, Nóra Angyal, Zsófia Bánlaki, Réka Kovács-Nagy, Zsolt Rónai, János M Réthely. MicroRNA-Mediated Suppression of Glial Cell Line-Derived Neurotrophic Factor Expression Is Modulated by a Schizophrenia-Associated Non-Coding Polymorphism. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674063. |
plasma levels of glial cell line-derived neurotrophic factor (gdnf), a pivotal regulator of differentiation and survival of dopaminergic neurons, are reportedly decreased in schizophrenia. |
2024-04-27 |
2024-04-29 |
human |
| Sophia C Gaynor-Gillett, Lijun Cheng, Manman Shi, Jason Liu, Gaoyuan Wang, Megan Spector, Mary Flaherty, Martha Wall, Ahyeon Hwang, Mengting Gu, Zhanlin Chen, Yuhang Chen, Jennifer R Moran, Jing Zhang, Donghoon Lee, Mark Gerstein, Daniel Geschwind, Kevin P Whit. Validation of Enhancer Regions in Primary Human Neural Progenitor Cells using Capture STARR-seq. bioRxiv : the preprint server for biology. 2024-04-02. PMID:38562832. |
these genes are involved in neuronal and psychiatric disease-associated pathways, including dopaminergic synapse, axon guidance, and schizophrenia. |
2024-04-02 |
2024-04-04 |
human |
| Lihong Deng, Wei Wei, Chunxia Qiao, Yubing Yin, Xiaojing Li, Hua Yu, Lingqi Jian, Xiaohong Ma, Liansheng Zhao, Qiang Wang, Wei Deng, Wanjun Guo, Tao L. Dynamic aberrances of substantia nigra-relevant coactivation patterns in first-episode treatment-naïve patients with schizophrenia. Psychological medicine. 2024-03-25. PMID:38523252. |
this study investigates the dynamic coactivation patterns (caps) associated with the substantia nigra (sn), a key dopaminergic nucleus, in first-episode treatment-naïve patients with schizophrenia (fes). |
2024-03-25 |
2024-03-27 |
Not clear |
| Giulia Spoto, Gabriella Di Rosa, Antonio Gennaro Nicoter. The Impact of Genetics on Cognition: Insights into Cognitive Disorders and Single Nucleotide Polymorphisms. Journal of personalized medicine. vol 14. issue 2. 2024-02-23. PMID:38392589. |
focusing on neurotransmitter regulation within the prefrontal cortex's dopaminergic circuits, this study emphasizes the role of genes like comt, prodh, and drd in shaping executive functions and influencing conditions such as adhd and schizophrenia. |
2024-02-23 |
2024-02-25 |
Not clear |
| Tomás Mouro Ferraz Lima, João Mauricio Castaldelli-Maia, Gisèle Apter, Kae Leopold. Neurobiological associations between smoking and internalizing disorders. International review of psychiatry (Abingdon, England). vol 35. issue 5-6. 2024-02-01. PMID:38299645. |
schizophrenia is associated with polymorphisms that result in an imbalance between glutamate and gaba release and abnormalities of dopaminergic pathways. |
2024-02-01 |
2024-02-03 |
Not clear |
| Xingyue Zeng, ChengYan Wu, Yongkai Cao, Huijun Li, Xiaohan Zhan. Mdm2-mediated ubiquitination of PKCβII is responsible for insulin-induced heterologous desensitization of dopamine D FEBS letters. 2024-02-01. PMID:38302840. |
mdm2-mediated ubiquitination of pkcβii is responsible for insulin-induced heterologous desensitization of dopamine d the insulin and dopaminergic systems in the brain are associated with schizophrenia and parkinson's disease with respect to etiology and treatment. |
2024-02-01 |
2024-02-04 |
Not clear |
| Sung M Yang, Ayan Ghoshal, Jeffrey M Hubbard, Florian Gackière, Romain Teyssié, Stuart A Neale, Seth C Hopkins, Kenneth S Koblan, Linda J Bristow, Nina Dedi. TAAR1 agonist ulotaront modulates striatal and hippocampal glutamate function in a state-dependent manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-12-19. PMID:38110609. |
aberrant dopaminergic and glutamatergic function, particularly within the striatum and hippocampus, has repeatedly been associated with the pathophysiology of schizophrenia. |
2023-12-19 |
2023-12-21 |
mouse |
| Sung M Yang, Ayan Ghoshal, Jeffrey M Hubbard, Florian Gackière, Romain Teyssié, Stuart A Neale, Seth C Hopkins, Kenneth S Koblan, Linda J Bristow, Nina Dedi. TAAR1 agonist ulotaront modulates striatal and hippocampal glutamate function in a state-dependent manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-12-19. PMID:38110609. |
these findings expand the mechanistic circuit hypothesis of ulotaront and taar1 agonists, which may be uniquely positioned to normalize both the excessive dopaminergic tone and regulate abnormal glutamatergic function associated with schizophrenia. |
2023-12-19 |
2023-12-21 |
mouse |
| Chao Xie, Shitong Xiang, Yueyuan Zheng, Chun Shen, Xuerui Peng, Yuzhu Li, Wei Cheng, Xiao Chang, Jingliang Cheng, Long-Biao Cui, Chu-Chung Huang, Nanyu Kuang, Chunbo Li, Ching-Po Lin, Cheng Luo, Yingying Tang, Jijun Wang, Xinran Wu, Dezhong Yao, Jie Zhang, Tianhong Zhang, Andreas Heinz, Trevor W Robbins, Oliver D Howes, Gunter Schumann, Tianye Jia, Jianfeng Fen. Dopaminergic-related Anatomical Pattern of Dorsal Striatum in Schizophrenia. medRxiv : the preprint server for health sciences. 2023-12-11. PMID:38077063. |
striatal dopaminergic overactivity was hypothesized as the core pathophysiology of schizophrenia. |
2023-12-11 |
2023-12-17 |
Not clear |
| Przemysław J Danek, Władysława A Danie. The Novel Atypical Antipsychotic Lurasidone Affects Cytochrome P450 Expression in the Liver and Peripheral Blood Lymphocytes. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069119. |
lurasidone is a novel atypical antipsychotic drug acting on dopaminergic, serotonergic and noradrenergic receptors; it is applied for the long-term treatment of schizophrenia and depression in patients with bipolar disorders. |
2023-12-09 |
2023-12-17 |
rat |
| Xun Yang, Yuan Song, Yuhan Zou, Yilin Li, Jianguang Zen. Neural correlates of prediction error in patients with schizophrenia: evidence from an fMRI meta-analysis. Cerebral cortex (New York, N.Y. : 1991). 2023-12-07. PMID:38061699. |
although dopaminergic abnormalities in the mesocorticolimbic reward circuit have been found in patients with schizophrenia, the pathway through which prediction error signals are processed in schizophrenia has yet to be elucidated. |
2023-12-07 |
2023-12-17 |
Not clear |
| Laoise Casserly, Daniel R Garton, Ana Montaño-Rodriguez, Jaan-Olle Andresso. Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759827. |
the increase in presynaptic striatal dopamine is the main dopaminergic abnormality in schizophrenia (scz). |
2023-09-28 |
2023-10-07 |
mouse |
| Lorenzo Moccia, Michelangelo di Luzio, Eliana Conte, Marco Modica, Marianna Ambrosecchia, Martina Ardizzi, Pierluigi Lanzotti, Georgios D Kotzalidis, Delfina Janiri, Marco Di Nicola, Luigi Janiri, Vittorio Gallese, Gabriele San. Sense of Agency and Its Disturbances: a Systematic Review Targeting the Intentional Binding Effect in Neuropsychiatric Disorders. Psychiatry and clinical neurosciences. 2023-09-27. PMID:37755315. |
abnormally increased action-outcome binding was found in schizophrenia and in patients with parkinson's disease taking dopaminergic medications or reporting impulsive-compulsive behaviours. |
2023-09-27 |
2023-10-07 |
Not clear |
| Aisha Nasir Hashmi, Merlyn Sabin Raja, Rizwan Taj, Raees Ahmed Dharejo, Zehra Agha, Raheel Qamar, Maleeha Aza. Association of 11 variants of the dopaminergic and cognitive pathways genes with major depression, schizophrenia and bipolar disorder in the Pakistani population. The International journal of neuroscience. 2023-08-29. PMID:37642370. |
association of 11 variants of the dopaminergic and cognitive pathways genes with major depression, schizophrenia and bipolar disorder in the pakistani population. |
2023-08-29 |
2023-09-07 |
human |
| Aisha Nasir Hashmi, Merlyn Sabin Raja, Rizwan Taj, Raees Ahmed Dharejo, Zehra Agha, Raheel Qamar, Maleeha Aza. Association of 11 variants of the dopaminergic and cognitive pathways genes with major depression, schizophrenia and bipolar disorder in the Pakistani population. The International journal of neuroscience. 2023-08-29. PMID:37642370. |
the dopaminergic pathways control neural signals that modulate mood and behaviour along and have a vital role in the aetiology of major depression (mdd), schizophrenia (shz) and bipolar disorder (bd). |
2023-08-29 |
2023-09-07 |
human |
| Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D'Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomei. The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. Biomolecules. vol 13. issue 8. 2023-08-26. PMID:37627285. |
an integrative view exploring this topic should take into account the following aspects: (i) the implication for glutamate, dopamine, and serotonin neurotransmission as demonstrated by genetic findings; (ii) the growing neuroimaging evidence of the common brain regions and dysfunctional circuits involved in both diseases; (iii) the pharmacological modulation of dopaminergic, serotoninergic, and glutamatergic systems as current therapeutic strategies in schizophrenia ocs; (iv) the recent discovery of midbrain dopamine neurons and dopamine d1- and d2-like receptors as orchestrating hubs in repetitive and psychotic behaviors; (v) the contribution of n-methyl-d-aspartate receptor subunits to both psychosis and ocd neurobiology. |
2023-08-26 |
2023-09-07 |
Not clear |
| Samuel K Powell, Will Liao, Callan O'Shea, Sarah Kammourh, Sadaf Ghorbani, Raymond Rigat, Rahat Elahi, Pj Michael Deans, Derek J Le, Poonam Agarwal, Wei Qiang Seow, Kevin C Wang, Schahram Akbarian, Kristen J Brennan. Schizophrenia Risk Mapping and Functional Engineering of the 3D Genome in Three Neuronal Subtypes. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502907. |
here, we map long-range chromosomal conformations in isogenic human dopaminergic, gabaergic, and glutamatergic neurons to track developmentally programmed shifts in the regulatory activity of schizophrenia risk loci. |
2023-07-28 |
2023-08-14 |
human |
| K K Xue, J L Chen, Y R Wei, Y Chen, S S Han, C H Wang, Y Zhang, X Q Song, J L Chen. [Abnormal changes of static and dynamic functional connectivity of dopaminergic midbrain in patients with first-episode schizophrenia and their correlations with clinical symptoms]. Zhonghua yi xue za zhi. vol 103. issue 21. 2023-05-29. PMID:37248062. |
[abnormal changes of static and dynamic functional connectivity of dopaminergic midbrain in patients with first-episode schizophrenia and their correlations with clinical symptoms]. |
2023-05-29 |
2023-08-14 |
Not clear |
| Fabrice Duva. Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia. Healthcare (Basel, Switzerland). vol 11. issue 10. 2023-05-27. PMID:37239772. |
systematic review of the apomorphine challenge test in the assessment of dopaminergic activity in schizophrenia. |
2023-05-27 |
2023-08-14 |
Not clear |