| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiayang Liu, Zhuang Li, Qiwei Zhao, Xinyue Zhou, Yu Wang, Gang Zhao, Xiaohong Gu. Capsaicin reverses cisplatin resistance in tongue squamous cell carcinoma by inhibiting the Warburg effect and facilitating mitochondrial-dependent apoptosis via the AMPK/AKT/mTOR axis. Cell biology international. 2024-05-06. PMID:38706122. |
moreover, this combined treatment induced cell apoptosis and significantly upregulated the levels of proapoptotic proteins, such as bax, cleaved caspase-3, -7, and -9, and apoptosis-inducing factor. |
2024-05-06 |
2024-05-08 |
Not clear |
| YuXin Feng, ZhengXinYu Liu, CaoYuan Han, JiaQian Chen, XinHao Lin, WangHao Du, Yu Zhang, BeiBei Dong, YiKai Zheng, KeXiang Lu, QingJian Lian. Ficus hirta Vahl. alleviate LPS induced apoptosis via down-regulating of MiR-411 in orange-spotted grouper (Epinephelus coioides) spleen cell. Developmental and comparative immunology. 2024-05-05. PMID:38705263. |
inhibition of mir-411 further decreased the inhibitory effect of fas on apoptosis, which reduced bcl-2 expression and mitochondrial membrane potential, enhanced the protein expression of bax and fas. |
2024-05-05 |
2024-05-08 |
Not clear |
| Wu Yingping, Lu Lizhi, Li Haiying, Chen Li, Gu Tiantian, Zhao Xiaoyu, Yao Yingying, Li Jiahu. The effect of LINC9137 targeting miR-140-3p-NKAIN3 signal axis on the development of goose testis sertoli cells. Poultry science. vol 103. issue 6. 2024-05-03. PMID:38701630. |
by measuring cell proliferation activity and apoptosis related gene expression, it was found that overexpression of linc9137 decreased cell proliferation activity (p > 0.05), while the expression level of apoptosis factor bcl2 associated x protein (bax)/b-cell lymphoma-2 (bcl2) increased (p > 0.05). |
2024-05-03 |
2024-05-06 |
Not clear |
| Sophie I Worsfold, Kristyn Carter, Moeed Akbar, Lisa Hackett, Neal L Millar, George A C Murrel. Rotator Cuff Tendinopathy: Pathways of Apoptosis. Sports medicine and arthroscopy review. vol 32. issue 1. 2024-05-02. PMID:38695498. |
a prospective cohort study was conducted with 28 patients-14 rotator cuff tear patients, 5 instability patients, and 9 anterior cruciate ligament reconstruction patients to determine whether there was any increase in several genes implicated in apoptosis, including fas receptor (fasr), fas ligand, aifm-1, bcl-2, fadd, bax, and caspase-3. |
2024-05-02 |
2024-05-04 |
Not clear |
| Zheng Yuan, Mark F van Delft, Mark Xiang Li, Fransisca Sumardy, Brian J Smith, David C S Huang, Guillaume Lessene, Yelena Khakam, Ruitao Jin, Sitong He, Nicholas A Smith, Richard W Birkinshaw, Peter E Czabotar, Grant Dewso. Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis. PLoS biology. vol 22. issue 5. 2024-05-02. PMID:38696533. |
bak and bax execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. |
2024-05-02 |
2024-05-05 |
Not clear |
| Yixin Rui, Xiumeng Zhang, Xinran Min, Hongxiao Xie, Xiuying Ma, Funeng Geng, Rong Li. Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury. International immunopharmacology. vol 133. 2024-05-01. PMID:38691919. |
furthermore, mesaconine inhibited the expression of renal pro-apoptotic proteins (bax, cytochrome c, cleaved-caspase 9, and cleaved-caspase 3) and induced the release of the anti-apoptotic protein bcl-2, further suppressing apoptosis. |
2024-05-01 |
2024-05-04 |
rat |
| Jingjing Chen, Dan Wang, Zequn Wang, Mengyuan Han, Houqing Yin, Wenting Zhou, Ribai Yan, Yan Pa. Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome. Oncology research. vol 32. issue 5. 2024-04-30. PMID:38686054. |
dtp-pdt induced cell apoptosis together with upregulated bax and downregulated bcl-2, which could also be inhibited by nac or sb203580. |
2024-04-30 |
2024-05-03 |
Not clear |
| Xiaoyun Shi, Yundie Li, Shibiao Chen, Huaping Xu, Xiuhong Wan. Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis. Immunologic research. 2024-04-27. PMID:38676899. |
des treatment improved lps-induced cell viability, reduced inflammatory cytokine (tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), and interleukin-6 (il-6)) levels, decreased cell apoptosis, down-regulated the pro-apoptotic proteins (bcl-2-associated x protein (bax) and cleaved caspase 3) expression, and up-regulated the anti-apoptotic protein b-cell-lymphoma-2 (bcl-2) expression in lps-induced beas-2b cells. |
2024-04-27 |
2024-04-30 |
Not clear |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Seong Min Lee, Sang Mok Lee, Jungbin Son. Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674879. |
additionally, the th extract modulated the protein expressions of bax and bcl-2, which are key regulators of apoptosis in prostate cells. |
2024-04-27 |
2024-04-29 |
rat |
| Jiawei Cai, Yunpeng Li, Bohao Zhao, Zhiyuan Bao, Jiali Li, Shaoning Sun, Yang Chen, Xinsheng W. N-Acetylcysteine Alleviates D-Galactose-Induced Injury of Ovarian Granulosa Cells in Female Rabbits by Regulating the PI3K/Akt/mTOR Signaling Pathway. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671832. |
in conclusion, nac can reduce the expression of bax, p53, and caspase-9 genes, inhibit the apoptosis of gcs, improve cell viability, and resist d-gal-induced oxidative stress by increasing the activity of cat, gsh, and sod. |
2024-04-27 |
2024-04-29 |
cat |
| Wei-Zhe Liang, Yuan-Yi Chia, Huai-Jhih Sun, Gwo-Ching Su. Exploration of beauvericin's toxic effects and mechanisms in human astrocytes and N-acetylcysteine's protective role. Toxicon : official journal of the International Society on Toxinology. 2024-04-26. PMID:38670497. |
western blot analysis of cells treated with bea revealed altered protein levels of bax, cleaved caspase-9, and caspase-3, along with an increased bax/bcl-2 ratio, indicating the induction of apoptosis. |
2024-04-26 |
2024-04-29 |
human |
| Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang, Changjiang Wen. Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity. PLoS pathogens. vol 20. issue 4. 2024-04-26. PMID:38669242. |
mechanistically, gm competitively combines with bcl-xl to disrupt the bcl-xl-bak complex, resulting in bcl-2-antagonistic killer (bak) oligomerization and bcl-2-associated x (bax) activation, which destroys the mitochondrial membrane potential and activates caspase-3/7 to trigger apoptosis. |
2024-04-26 |
2024-04-29 |
mouse |
| Yun Xing, Tian Tian, Xue Zhang, Duomeng Yang, Chanjuan Zhang, Miao Wang, Yiyang Wang, Tao Luo, Zhi Wang, Huadong Wang, Hongmei L. Endogenous β3-adrenergic receptor activation alleviates sepsis-induced cardiomyocyte apoptosis via PI3K/Akt signaling pathway. Shock (Augusta, Ga.). 2024-04-25. PMID:38662592. |
sr59230a not only increased myocardial apoptosis, reduced p-aktser473 and bcl-2 contents, but also increased mitochondrial bax, cytoplasm cytochrome c, cleaved caspase-9 and cleaved caspase-3 levels of the myocardium in septic rats. |
2024-04-25 |
2024-04-28 |
rat |
| Qiulu Li, Kaixin Ping, Yannan Xiang, YingSun, Zunhan Hu, Shujuan Liu, Xinying Guan, Mian F. Ferulic acid alleviates avermectin induced renal injury in carp by inhibiting inflammation, oxidative stress and apoptosis. Fish & shellfish immunology. 2024-04-25. PMID:38663463. |
at the same time, fa inhibited the apoptosis of renal cells induced by avm by decreasing the transcription level and protein expression level of bax, and increasing the transcription level and protein expression level of bcl2, pi3k and akt. |
2024-04-25 |
2024-04-28 |
cat |
| Julia Saravia, Daniela Nualart, Kurt Paschke, Juan Pablo Pontigo, Jorge M Navarro, Luis Vargas-Chacof. Temperature and immune challenges modulate the transcription of genes of the ubiquitin and apoptosis pathways in two high-latitude Notothenioid fish across the Antarctic Polar Front. Fish physiology and biochemistry. 2024-04-24. PMID:38658493. |
after 1 week, samples of gills, liver and spleen were taken to evaluate the expression by real-time pcr of specific genes involved in ubiquitination (e3-ligase enzyme) and apoptosis (bax and smac/diablo). |
2024-04-24 |
2024-04-28 |
Not clear |
| Firas Khathayer, Mohammed Mikae. Mocetinostat as a novel selective histone deacetylase (HDAC) inhibitor in the promotion of apoptosis in glioblastoma cell line C6 and T98G. Research square. 2024-04-22. PMID:38645087. |
the high doses of mocetinostat drug significantly induce apoptosis and suppress cancer cell proliferation through increased pro-apoptotic proteins (bax) and a down level of anti-apoptotic proteins(bid, bcl2). |
2024-04-22 |
2024-04-24 |
Not clear |
| Lu Zhang, Ying Liu, Qiongyi Zhang, Weiyu Yao, Zenghui Zhao, Xiao Wang, Yongzhan Bao, Wanyu Sh. Salvia miltiorrhiza polysaccharide mitigates AFB1-induced liver injury in rabbits. Ecotoxicology and environmental safety. vol 276. 2024-04-18. PMID:38636259. |
moreover, smp upregulated the expression of nuclear factor e2 related factor 2 (nrf2), heme oxygenase 1 (ho-1), nadph quinone oxidoreductase 1 (nqo1) and b-cell lymphoma 2 (bcl2) while downregulating kelch like ech associated protein 1 (keap1), cytochrome c (cyt.c), caspase9, caspase3, and bcl-2-associated x protein (bax) expression, thereby inhibiting afb1-induced hepatocyte apoptosis. |
2024-04-18 |
2024-04-21 |
cat |
| Qianshi Zhang, Jing Li, Fubing Liu, Jiarui Hu, Fusheng Liu, Jianfei Zou, Xiaobin Wan. Ephrin B2 (EFNB2) potentially protects against intervertebral disc degeneration through inhibiting nucleus pulposus cell apoptosis. Archives of biochemistry and biophysics. 2024-04-18. PMID:38636690. |
in degenerative np cells stimulated by il-1β, efnb2 knockdown significantly increased the rate of apoptosis as well as the apoptosis-related molecules cleaved-caspase-3 and the bax to bcl-2 ratio. |
2024-04-18 |
2024-04-21 |
Not clear |
| Tianchun Wu, Han Yang, Jinjin Li, Hongbo Fang, Xiaoyi Shi, Jie Li, Liushun Fen. Jolkinolide B inhibits the progression of hepatocellular carcinoma by regulating Musashi-2 protein. PloS one. vol 19. issue 4. 2024-04-17. PMID:38630658. |
in addition, jolkinolide b induced hcc cell apoptosis by upregulating bax and downregulating bcl-2 expressions. |
2024-04-17 |
2024-04-20 |
Not clear |