| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samaneh Vaziri-Amjad, Reza Rahgosha, Amir Taherkhan. Potential JAK2 Inhibitors from Selected Natural Compounds: A Promising Approach for Complementary Therapy in Cancer Patients. Evidence-based complementary and alternative medicine : eCAM. vol 2024. 2024-05-06. PMID:38706884. |
janus-activated kinase 2 (jak2) plays a pivotal role in numerous essential biological processes, including proliferation, apoptosis, and metastasis in human cells. |
2024-05-06 |
2024-05-08 |
human |
| Samaneh Vaziri-Amjad, Reza Rahgosha, Amir Taherkhan. Potential JAK2 Inhibitors from Selected Natural Compounds: A Promising Approach for Complementary Therapy in Cancer Patients. Evidence-based complementary and alternative medicine : eCAM. vol 2024. 2024-05-06. PMID:38706884. |
prior studies have indicated that inhibiting jak2 could be a promising strategy to mitigate cell proliferation and induce apoptosis in tumor cells. |
2024-05-06 |
2024-05-08 |
human |
| Rokeya Akter, Rackhyun Park, Soo Kyung Lee, Eun Ju Han, Kyu-Sang Park, Junsoo Park, Mee-Yon Ch. Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3 Signaling Pathway in Tumor Cells. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673975. |
jak2/stat3 inhibition decreased the levels of emr1, jak2, stat1, and stat3, significantly impeded the proliferation, migration, and mobility of cells, and increased the apoptosis of emr1 |
2024-04-27 |
2024-04-29 |
Not clear |
| Cui Fan, Yawei Zhang, Rui Yang, Xiaojie Wu, Jiadi Zhou, Jiangnan Xu. [leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) inhibits proliferation and promotes apoptosis of human HEL cells with JAK2 V617F mutation by blocking the JAK/STAT and PI3K/AKT signaling pathways]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 3. 2024-03-21. PMID:38512030. |
[leukocyte-associated immunoglobulin-like receptor 1 (lair-1) inhibits proliferation and promotes apoptosis of human hel cells with jak2 v617f mutation by blocking the jak/stat and pi3k/akt signaling pathways]. |
2024-03-21 |
2024-03-23 |
human |
| Cui Fan, Yawei Zhang, Rui Yang, Xiaojie Wu, Jiadi Zhou, Jiangnan Xu. [leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) inhibits proliferation and promotes apoptosis of human HEL cells with JAK2 V617F mutation by blocking the JAK/STAT and PI3K/AKT signaling pathways]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 3. 2024-03-21. PMID:38512030. |
objective to investigate the role of human leukocyte-associated immunoglobulin-like receptor-1 (lair-1) in the regulation of janus kinase/signal transducers and activators of transcription (jak/stat) and phosphatidylinositol 3 kinase/protein kinase b/mammalian target of rapamycin (pi3k/akt /mtor) signaling pathways in human acute myeloid leukemia hel cells carrying the jak2 v617f mutation, along with its effects on cell proliferation and apoptosis. |
2024-03-21 |
2024-03-23 |
human |
| Cui Fan, Yawei Zhang, Rui Yang, Xiaojie Wu, Jiadi Zhou, Jiangnan Xu. [leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) inhibits proliferation and promotes apoptosis of human HEL cells with JAK2 V617F mutation by blocking the JAK/STAT and PI3K/AKT signaling pathways]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 3. 2024-03-21. PMID:38512030. |
conclusion in hel cells with jak2 v617f mutation, lair-1 can inhibit the activation of jak/stat and pi3k/akt/mtor signaling pathways by recruiting shp-2, thereby inhibiting the proliferation of hel cells and promoting cell apoptosis. |
2024-03-21 |
2024-03-23 |
human |
| Garima Pandey, Lucia Mazzacurati, Tegan M Rowsell, Nathan P Horvat, Narmin E Amin, Guolin Zhang, Afua A Akuffo, Christelle M Colin-Leitzinger, Eric B Haura, Andrew T Kuykendall, Ling Zhang, Pearlie K Epling-Burnette, Gary W Reuthe. SHP2 inhibition displays efficacy as a monotherapy and in combination with JAK2 inhibition in preclinical models of myeloproliferative neoplasms. American journal of hematology. 2024-03-05. PMID:38440831. |
both shp2 and jak2 inhibition diminished cellular ras-gtp levels, and their concomitant inhibition enhanced erk inactivation and increased apoptosis. |
2024-03-05 |
2024-03-07 |
mouse |
| Q Ye, L Ren, Z M Jiang, X Y Li, G Y Wei, Y F Ren, L H Re. Cryptanshinone extract of Salvia miltiorrhiza stimulates pediatric acute myeloid leukemia stem cell apoptosis and the anti-inflammatory mechanism via accelerating microRNA-211-5p to supress Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway activation. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 6. 2024-02-13. PMID:38345448. |
this study was designed to explore cryptanshinone (cpt) extract of salvia miltiorrhiza stimulating pediatric acute myeloid leukemia (aml) stem cell (lsc) apoptosis and anti-inflammatory mechanism via accelerating microrna (mir)-211-5p to restrain janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway activation. |
2024-02-13 |
2024-02-15 |
human |
| Q Ye, L Ren, Z M Jiang, X Y Li, G Y Wei, Y F Ren, L H Re. Cryptanshinone extract of Salvia miltiorrhiza stimulates pediatric acute myeloid leukemia stem cell apoptosis and the anti-inflammatory mechanism via accelerating microRNA-211-5p to supress Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway activation. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 6. 2024-02-13. PMID:38345448. |
variation of mir-211-5p and jak2 in lscs was via plasmid transfection to explore their actions in cell advancement with apoptosis and inflammation. |
2024-02-13 |
2024-02-15 |
human |
| Q Ye, L Ren, Z M Jiang, X Y Li, G Y Wei, Y F Ren, L H Re. Cryptanshinone extract of Salvia miltiorrhiza stimulates pediatric acute myeloid leukemia stem cell apoptosis and the anti-inflammatory mechanism via accelerating microRNA-211-5p to supress Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway activation. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 6. 2024-02-13. PMID:38345448. |
in results: mir-211-5p was declined in endometrial cancer, while jak2 was elevated; cpt was available to boost lsc apoptosis and restrain the inflammation; elevated mir-211-5p or repressive jak2 was available to strengthen the acceleration of cpt on lscs apoptosis and the repression of inflammation; mir-211-5p targeted jak2; augmented jak2 was available to turn around the action of elevated mir-211-5p. |
2024-02-13 |
2024-02-15 |
human |
| Rajina Shakya, Mi Ran Byun, Sang Hoon Joo, Kyung-Soo Chun, Joon-Seok Cho. Domperidone Exerts Antitumor Activity in Triple-Negative Breast Cancer Cells by Modulating Reactive Oxygen Species and JAK/STAT3 Signaling. Biomolecules & therapeutics. vol 31. issue 6. 2023-10-30. PMID:37899746. |
immunoblot analysis showed that domperidone-induced apoptosis occurred through the down-regulation of the phosphorylation of jak2 and stat3. |
2023-10-30 |
2023-11-08 |
human |
| Gang Chen, Rui-Shi Wei, Jie Ma, Xin-Hua Li, Li Feng, Jian-Rong Y. FOXA1 prolongs S phase and promotes cancer progression in non-small cell lung cancer through upregulation of CDC5L and activation of the ERK1/2 and JAK2 pathways. The Kaohsiung journal of medical sciences. 2023-09-02. PMID:37658700. |
overexpression of cdc5l induced erk1/2 phosphorylation, induced jak2 phosphorylation, inhibited cell apoptosis, prolonged s phase, and significantly reversed the effects of foxa1 knockdown on the progression of nsclc. |
2023-09-02 |
2023-09-07 |
human |
| Shadia Hamoud Alshahrani, Nodir Rakhimov, Jitendra Gupta, Zahraa F Hassan, Ali Alsalamy, Ebraheem Abdu Musad Saleh, Hashem O Alsaab, Firas Kanawy Al-Aboudy, Ahmed Radhi Alawadi, Yasser Fakri Mustaf. The mechanisms, functions and clinical applications of miR-542-3p in human cancers. Pathology, research and practice. vol 248. 2023-08-05. PMID:37542861. |
mir-542-3p is engaged in various cancer-related behaviors like glycolysis, metastasis, epithelial-to-mesenchymal transition (emt), cell cycle, apoptosis, and proliferation via targeting at least 18 genes and some important signaling pathways like wnt/β-catenin, extracellular signal-regulated protein kinases 1 and 2 (erk1/2) and janus kinase 2 (jak2) signaling, and phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling. |
2023-08-05 |
2023-08-14 |
human |
| Kadirvel Devi, Thukani Sathanantham Shanmugaraja. Therapeutic Potential of Plant Metabolites in Bone Apoptosis: A Review. Current drug targets. 2023-08-01. PMID:37526458. |
osteoblast apoptosis is governed by the factors like b cell lymphoma 2 (bcl-2) family proteins, extracellular signal-regulated kinase (erk), mitogen-activated protein kinases (mapk), phosphoinositide-3-kinase/ protein kinase b (pi3-k/akt), janus kinase 2 (jak2), bone morphogenetic protein (bmp), and bone matrix protein. |
2023-08-01 |
2023-08-14 |
Not clear |
| Computational And Mathematical Methods In Medicin. Retracted: Effects of mir-195 Targeted Regulation of JAK2 on Proliferation, Invasion, and Apoptosis of Gastric Cancer Cells. Computational and mathematical methods in medicine. vol 2023. 2023-07-07. PMID:37416272. |
retracted: effects of mir-195 targeted regulation of jak2 on proliferation, invasion, and apoptosis of gastric cancer cells. |
2023-07-07 |
2023-08-14 |
Not clear |
| Jing-Ru Weng, Balraj Gopula, Po-Chen Chu, Jing-Lan Hu, Chia-Hsien Fen. A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells. Chemico-biological interactions. 2023-05-10. PMID:37164279. |
a pkm2 inhibitor induces apoptosis and autophagy through jak2 in human oral squamous cell carcinoma cells. |
2023-05-10 |
2023-08-14 |
human |
| Yongmei Zhao, Mao Ding, Feng Yan, Jie Yin, Wenjuan Shi, Nan Yang, Haiping Zhao, Yalan Fang, Yuyou Huang, Yangmin Zheng, Xueqi Yang, Wei Li, Xunming Ji, Yumin Lu. Inhibition of the JAK2/STAT3 pathway and cell cycle re-entry contribute to the protective effect of remote ischemic pre-conditioning of rat hindlimbs on cerebral ischemia/reperfusion injury. CNS neuroscience & therapeutics. 2022-11-24. PMID:36419252. |
in the present study, we investigated the role of janus-activated kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway and cell cycle arrest, and their relationship with neuronal apoptosis following ripc. |
2022-11-24 |
2023-08-14 |
rat |
| Rajina Shakya, Gyu Hwan Park, Sang Hoon Joo, Jung-Hyun Shim, Joon-Seok Cho. Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling. Biomolecules & therapeutics. vol 30. issue 6. 2022-10-28. PMID:36305293. |
western blot analysis showed that hydroxyzine-induced apoptosis was through down-regulation of the phosphorylation of jak2 and stat3 by hydroxyzine treatment. |
2022-10-28 |
2023-08-14 |
human |
| Jun-Ren Chen, Xiao-Fang Xie, Xiao-Yu Cao, Gang-Min Li, Yan-Peng Yin, Cheng Pen. [Research progress on mechanism of Carthamus tinctorius in ischemic stroke therapy]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164862. |
furthermore, mediating the activation of janus kinase 2(jak2)/stat3/suppressor of cytokine signaling 3(socs3) signaling pathway and phosphoinositide 3-kinase(pi3 k)/protein kinase b(akt)/glycogen synthase kinase-3β(gsk3β) signaling pathway and regulating the release of matrix metalloproteinase(mmp) inhibitor/mmp are main ways that c. tinctorius inhibits neuronal apoptosis. |
2022-09-27 |
2023-08-14 |
Not clear |
| Shuzhen Liu, Dongmei Yu, Peng Wei, Jiansheng Cai, Min Xu, Haoyu He, Xu Tang, Chuntao Nong, Yi Wei, Xia Xu, Xiaoting Mo, Zhiyong Zhang, Jian Qi. JAK2/STAT3 Signaling Pathway and Klotho Gene in Cadmium-induced Neurotoxicity In Vitro and In Vivo. Biological trace element research. 2022-09-27. PMID:36166115. |
in comparison with the high-dose cd exposure group, after adding tyrphostin ag490 (ag490), the apoptosis rate of pc12 cells increased, whereas the phosphorylation levels of jak2 and stat3 in the cells decreased significantly (p < 0.05). |
2022-09-27 |
2023-08-14 |
rat |