| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingjing Chen, Dan Wang, Zequn Wang, Mengyuan Han, Houqing Yin, Wenting Zhou, Ribai Yan, Yan Pa. Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome. Oncology research. vol 32. issue 5. 2024-04-30. PMID:38686054. |
dtp-pdt induced cell apoptosis together with upregulated bax and downregulated bcl-2, which could also be inhibited by nac or sb203580. |
2024-04-30 |
2024-05-03 |
Not clear |
| b' Martina Zigov\\xc3\\xa1, Vikt\\xc3\\xb3ria Mi\\xc5\\xa1kufov\\xc3\\xa1, Marianna Budovsk\\xc3\\xa1, Radka Michalkov\\xc3\\xa1, J\\xc3\\xa1n Moj\\xc5\\xbei\\xc5\\xa. Exploring the Antiproliferative and Modulatory Effects of 1-Methoxyisobrassinin on Ovarian Cancer Cells: Insights into Cell Cycle Regulation, Apoptosis, Autophagy, and Its Interactions with NAC. Molecules (Basel, Switzerland). vol 29. issue 8. 2024-04-27. PMID:38675591.' |
exploring the antiproliferative and modulatory effects of 1-methoxyisobrassinin on ovarian cancer cells: insights into cell cycle regulation, apoptosis, autophagy, and its interactions with nac. |
2024-04-27 |
2024-04-29 |
Not clear |
| Jiawei Cai, Yunpeng Li, Bohao Zhao, Zhiyuan Bao, Jiali Li, Shaoning Sun, Yang Chen, Xinsheng W. N-Acetylcysteine Alleviates D-Galactose-Induced Injury of Ovarian Granulosa Cells in Female Rabbits by Regulating the PI3K/Akt/mTOR Signaling Pathway. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671832. |
n-acetylcysteine (nac) is a prevalent and cell-permeable antioxidant molecule that effectively prevents apoptosis and promotes cellular survival. |
2024-04-27 |
2024-04-29 |
cat |
| Jiawei Cai, Yunpeng Li, Bohao Zhao, Zhiyuan Bao, Jiali Li, Shaoning Sun, Yang Chen, Xinsheng W. N-Acetylcysteine Alleviates D-Galactose-Induced Injury of Ovarian Granulosa Cells in Female Rabbits by Regulating the PI3K/Akt/mTOR Signaling Pathway. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671832. |
based on the results of the cell counting kit-8 assay, flow cytometry, and western blotting, it was found that 0.5 mg/ml of nac could significantly suppress cell apoptosis and promote proliferation. |
2024-04-27 |
2024-04-29 |
cat |
| Jiawei Cai, Yunpeng Li, Bohao Zhao, Zhiyuan Bao, Jiali Li, Shaoning Sun, Yang Chen, Xinsheng W. N-Acetylcysteine Alleviates D-Galactose-Induced Injury of Ovarian Granulosa Cells in Female Rabbits by Regulating the PI3K/Akt/mTOR Signaling Pathway. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671832. |
these findings demonstrated that nac could significantly influence gene expression within this pathway, thereby clarifying the exact relationship between the pi3k/akt/mtor signaling cascade and the underlying cellular processes controlling proliferation and apoptosis. |
2024-04-27 |
2024-04-29 |
cat |
| Jiawei Cai, Yunpeng Li, Bohao Zhao, Zhiyuan Bao, Jiali Li, Shaoning Sun, Yang Chen, Xinsheng W. N-Acetylcysteine Alleviates D-Galactose-Induced Injury of Ovarian Granulosa Cells in Female Rabbits by Regulating the PI3K/Akt/mTOR Signaling Pathway. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671832. |
in conclusion, nac can reduce the expression of bax, p53, and caspase-9 genes, inhibit the apoptosis of gcs, improve cell viability, and resist d-gal-induced oxidative stress by increasing the activity of cat, gsh, and sod. |
2024-04-27 |
2024-04-29 |
cat |
| Ronggang Yang, Feng Yan, Jiangyi Shen, Tiancai Wang, Menglong Li, Hongzao N. Geraniol attenuates oxygen-glucose deprivation/reoxygenation-induced ROS-dependent apoptosis and permeability of human brain microvascular endothelial cells by activating the Nrf-2/HO-1 pathway. Journal of bioenergetics and biomembranes. 2024-03-06. PMID:38446318. |
geraniol and ros scavenger n-acetylcysteine (nac) both attenuated ogd/r-induced apoptosis and increase of caspase-3 activity and the permeability to fitc-dextran in hbmecs. |
2024-03-06 |
2024-03-08 |
human |
| Tareq Saleh, Sofian Al Shboul, Heyam Awad, Mohammed El-Sadoni, Ahmad Alhesa, Elham Alsharaiah, Nisreen Abu Shahin, Moureq R Alotaibi, AbdelKader Battah, Bilal Aza. Characterization of BCL-XL, MCL-1, and BAX Protein Expression in Response to Neoadjuvant Chemotherapy in Breast Cancer. Applied immunohistochemistry & molecular morphology : AIMM. 2024-03-01. PMID:38426376. |
apoptosis is an established cell stress response to nac in preclinical models; however, there is limited understanding of its role in clinical cancer, specifically, its contribution to favorable pathologic responses in breast cancer therapy. |
2024-03-01 |
2024-03-03 |
Not clear |
| Tareq Saleh, Sofian Al Shboul, Heyam Awad, Mohammed El-Sadoni, Ahmad Alhesa, Elham Alsharaiah, Nisreen Abu Shahin, Moureq R Alotaibi, AbdelKader Battah, Bilal Aza. Characterization of BCL-XL, MCL-1, and BAX Protein Expression in Response to Neoadjuvant Chemotherapy in Breast Cancer. Applied immunohistochemistry & molecular morphology : AIMM. 2024-03-01. PMID:38426376. |
collectively, our data indicate that the expression of apoptosis regulatory proteins changes following exposure to nac in breast cancer tissue, developing a partial pathologic response. |
2024-03-01 |
2024-03-03 |
Not clear |
| Weiwei Li, Zhonghou Han, Xiurong Yin, Rongjuan Zhou, Hongfeng Li. CDX2 alleviates hypoxia-induced apoptosis and oxidative stress in spermatogenic cells through suppression of reactive oxygen species-mediated Wnt/β-catenin pathway. Journal of applied toxicology : JAT. 2024-02-13. PMID:38295844. |
moreover, cdx2 knockdown restores the inhibitory effects of si-β-catenin or nac on hypoxia-induced activation of the wnt/β-catenin pathway, apoptosis, and oxidative stress. |
2024-02-13 |
2024-02-15 |
cat |
| Yang Yang, Liping Wang, Zelun Huang, Lingu Ge, Jianwei Sh. N-acetylcysteine as a novel methacrylate-based resin cement component: effect on cell apoptosis and genotoxicity in human gingival fibroblasts. BMC oral health. vol 24. issue 1. 2024-02-12. PMID:38347533. |
herein, we investigated the effects of methacrylate-based resin cement used in dental implant restoration on apoptosis and genotoxicity, as well as the antiapoptotic and antigenotoxic capabilities of its component, nac. |
2024-02-12 |
2024-02-15 |
human |
| Yan Tao, Jianzhong Lu, Lanlan Li, Lanpeng Lu, Beitang Fu, Jing Zhang, Shuni Zhang, Ruicong Ma, Jialong Ma, Jiaping Sun, Shengjun Fu, Shanhui Liu, Zhiping Wan. Raltitrexed induces apoptosis through activating ROS-mediated ER stress by impeding HSPA8 expression in prostate cancer cells. Biochimica et biophysica acta. Molecular cell research. 2024-02-01. PMID:38301906. |
pretreatment with n-acetyl-l-cysteine (nac) significantly prevented rtx-induced cell apoptosis and endoplasmic reticulum (er) stress signaling activation in prostate cancer cells. |
2024-02-01 |
2024-02-04 |
Not clear |
| Qianwei Zhao, Mengdan Yu, Jinxia Li, Yaoyu Guo, Zexuan Wang, Kefei Hu, Fang Xu, Yixian Liu, Lili Li, Didi Wan, Ying Zhao, Jian Shang, Jintao Zhan. GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis. Discover. Oncology. vol 15. issue 1. 2024-01-12. PMID:38216781. |
n-acetylcysteine (nac) treatment eliminated cellular ros and blocked p38/jnk mapk pathway activation, as well as cell apoptosis induced by glud1 overexpression. |
2024-01-12 |
2024-01-15 |
Not clear |
| Rongli Sun, Manman Liu, Fei Xiong, Kai Xu, Jiawei Huang, Jinyan Liu, Daqin Wang, Yuepu P. Polystyrene micro- and nanoplastics induce gastric toxicity through ROS mediated oxidative stress and P62/Keap1/Nrf2 pathway. The Science of the total environment. 2023-12-15. PMID:38101634. |
furthermore, blocking ros (nac) partially alleviated ros and apoptosis caused by ps-mps. |
2023-12-15 |
2023-12-18 |
mouse |
| Qiumei Wu, Chao Liu, Dan Liu, Yougang Wang, Haomin Qi, Xudong Liu, Yuchao Zhang, Haiyu Chen, Yan Zeng, Jinquan L. Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress. The Science of the total environment. vol 912. 2023-12-14. PMID:38086481. |
collectively, nps-induced apoptosis and ferroptosis are attenuated by nac via inhibiting the ros-dependent er stress in vitro and in vivo. |
2023-12-14 |
2023-12-17 |
mouse |
| Rui Zhu, Guo-Jun Shang, Bao-Yuan Zhang, Hao-Tong Wang, Liang Li, Xiao-Fang Wei, Deng-Lai Li, Zhi-Yong Yang, Zi-Hui Qu, Ya-Nan Quan, Si-Ying Liu, Yin-Tao Wang, Si-Tong Meng, Li-Fang Wu, Gui-Xin Qi. Unlocking the potential of N-acetylcysteine: Improving hepatopancreas inflammation, antioxidant capacity and health in common carp (Cyprinus carpio) via the MAPK/NF-κB/Nrf2 signalling pathway. Fish & shellfish immunology. 2023-12-13. PMID:38092096. |
the results indicated that dietary 3.0-6.0 g/kg nac reduced hepatopancreas lipid vacuoles and nuclear translocation, and inhibited apoptosis in common carp. |
2023-12-13 |
2023-12-17 |
Not clear |
| Rui Zhu, Guo-Jun Shang, Bao-Yuan Zhang, Hao-Tong Wang, Liang Li, Xiao-Fang Wei, Deng-Lai Li, Zhi-Yong Yang, Zi-Hui Qu, Ya-Nan Quan, Si-Ying Liu, Yin-Tao Wang, Si-Tong Meng, Li-Fang Wu, Gui-Xin Qi. Unlocking the potential of N-acetylcysteine: Improving hepatopancreas inflammation, antioxidant capacity and health in common carp (Cyprinus carpio) via the MAPK/NF-κB/Nrf2 signalling pathway. Fish & shellfish immunology. 2023-12-13. PMID:38092096. |
in summary, nac has the potential to alleviate inflammation, mitigate oxidative stress and inhibit apoptosis via the mapk/nf-κb/nrf2 signaling pathway, thereby improving hepatopancreas function and health of common carp. |
2023-12-13 |
2023-12-17 |
Not clear |
| Jephte Y Akakpo, Anup Ramachandran, Barry H Rumack, Darren P Wallace, Hartmut Jaeschk. Lack of Mitochondrial Cyp2E1 Drives Acetaminophen-induced ER Stress-mediated Apoptosis in Mouse and Human Kidneys: Inhibition by 4-Methylpyrazole but not N-Acetylcysteine. Toxicology. 2023-12-02. PMID:38042273. |
while co-treatment with 4-methylpyrazole (4mp; fomepizole) or the caspase inhibitor ac-devd-cho prevented apap-induced cleavage of procaspase-12 and apoptosis in the kidney, treatment with nac had no effect. |
2023-12-02 |
2023-12-10 |
mouse |
| Jephte Y Akakpo, Anup Ramachandran, Barry H Rumack, Darren P Wallace, Hartmut Jaeschk. Lack of Mitochondrial Cyp2E1 Drives Acetaminophen-induced ER Stress-mediated Apoptosis in Mouse and Human Kidneys: Inhibition by 4-Methylpyrazole but not N-Acetylcysteine. Toxicology. 2023-12-02. PMID:38042273. |
we conclude that reactive metabolite formation by cyp2e1 in the er results in sustained er stress that causes activation of procaspase-12, triggering apoptosis of proximal tubular cells, and that 4mp but not nac may be an effective antidote against apap-induced kidney injury. |
2023-12-02 |
2023-12-10 |
mouse |
| Lele Wang, Yijie Xu, Xuyang Zhao, Xiaojing Zhu, Xiuyuan He, Aijun Sun, Guoqing Zhuan. Antagonistic effects of N-acetylcysteine on lead-induced apoptosis and oxidative stress in chicken embryo fibroblast cells. Heliyon. vol 9. issue 11. 2023-11-30. PMID:38034812. |
n-acetylcysteine (nac) has antioxidant activity, reducing lead-induced oxidative stress and apoptosis, but its role in chicken cells is unknown. |
2023-11-30 |
2023-12-10 |
cat |