| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
the analysis identified higher levels of molecules associated with proliferation (erβ), glycolysis (mct2, pdk1, glut1, hex2, tgfβ and hif-1α), mitochondrial biogenesis (opa1, drp1) and autophagy (p38, beclin1 and bnip3) and decreased levels of apoptosis markers ( |
2024-04-27 |
2024-04-29 |
Not clear |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Débora Aparecida Oliveira Modena, Ana Paula Ferro, Everton Cazzo, Elaine Caldeira de Oliveira Guirro, Elinton Adami Chai. Effect of superficial adipose tissue mitochondrial and cellular functionality induced by extracorporeal shock wave therapy (ESWT). Lasers in medical science. vol 39. issue 1. 2024-02-09. PMID:38334845. |
the data demonstrated positivity in the expression of mitochondrial markers related to cell apoptosis, such as fis1 (p < 0.0203) and opa1 (p < 0.0283), in addition to the positivity of anti-mfn1, responsible for regulating mitochondrial cell proliferation (p < 0.0003). |
2024-02-09 |
2024-02-11 |
Not clear |
| Takeshi Tokuyama, Shigeru Yanag. Role of Mitochondrial Dynamics in Heart Diseases. Genes. vol 14. issue 10. 2023-10-30. PMID:37895224. |
mitochondrial fusion proteins, particularly mfn1/2 and opa1, play multiple roles beyond their pro-fusion effects, such as endoplasmic reticulum tethering, mitophagy, cristae remodeling, and apoptosis regulation. |
2023-10-30 |
2023-11-08 |
Not clear |
| W Chen, H DU, Y Sha, Y Zhou, J Liang, Y Chen, Q Ma, X Wu, G Qia. [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 43. issue 9. 2023-10-10. PMID:37814860. |
to investigate whether long noncoding rna h19 (lncrna h19) induces vascular calcification by promoting calcium deposition, osteogenic differentiation and apoptosis via inhibiting the bax inhibitor 1/optic atrophy 1 (bi-1/ opa1) pathway. |
2023-10-10 |
2023-10-15 |
Not clear |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Weiling Tu, Liang Li, Ming Yi, Junyu Chen, Xiaoqing Wang, Yan Su. Dapagliflozin attenuates high glucose-and hypoxia/reoxygenation-induced injury via activating AMPK/mTOR-OPA1-mediated mitochondrial autophagy in H9c2 cardiomyocytes. Archives of physiology and biochemistry. 2023-09-01. PMID:37655809. |
downregulation of opa1 expression increased mitochondrial intolerance in cardiomyocytes during hg-h/r injury and the ampk-mtor-autophagy signalling is a key mechanism for protecting mitochondrial function and reducing cardiomyocyte apoptosis. |
2023-09-01 |
2023-09-07 |
Not clear |
| Adrian Schwarzer, Matheus Oliveira, Marc-Jens Kleppa, Scott D Slattery, Andy Anantha, Alan Cooper, Mark Hannink, Axel Schambach, Anneke Doerrie, Alexey Kotylarov, Matthias Gaestel, Todd Hembrough, Jedd Levine, Michael Luther, Michael Stocum, Linsey Stiles, David M Weinstock, Marc Liesa, Matthew J Kostur. Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1. Molecular cancer therapeutics. 2023-08-29. PMID:37643767. |
treatment of tumor cells with compound leads to oma1-dependent cleavage of dele1 and opa1, mitochondrial fragmentation, activation of the eif2α-kinase hri, cell growth arrest and apoptosis. |
2023-08-29 |
2023-09-07 |
human |
| Jiaqi Chen, Jianan Shao, Yaoyao Wang, Kangxiang Wu, Mingyuan Huan. OPA1, a molecular regulator of dilated cardiomyopathy. Journal of cellular and molecular medicine. 2023-08-21. PMID:37603376. |
opa1 can be considered the missing link between dcmp53 and dcm apoptosis, mitochondrial dynamics imbalance and changes in cristae structure. |
2023-08-21 |
2023-09-07 |
Not clear |
| Jiaqi Chen, Jianan Shao, Yaoyao Wang, Kangxiang Wu, Mingyuan Huan. OPA1, a molecular regulator of dilated cardiomyopathy. Journal of cellular and molecular medicine. 2023-08-21. PMID:37603376. |
opa1 regulates apoptosis by regulating the release of cytochrome c from the mitochondrial matrix through cjs (crisp linkages, located in the inner mitochondrial membrane) and unbalances mitochondrial fusion and fission by affecting mitochondrial inner membrane (im) fusion. |
2023-08-21 |
2023-09-07 |
Not clear |
| Jiaqi Chen, Jianan Shao, Yaoyao Wang, Kangxiang Wu, Mingyuan Huan. OPA1, a molecular regulator of dilated cardiomyopathy. Journal of cellular and molecular medicine. 2023-08-21. PMID:37603376. |
this review discusses the implication of opa1 for dcm from three aspects: apoptosis, mitochondrial dynamics and ridge structure. |
2023-08-21 |
2023-09-07 |
Not clear |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Xiaoru Chang, Shuyan Niu, Mengting Shang, Jiangyan Li, Menghao Guo, Wenli Zhang, Zuoyi Sun, Yunjing Li, Rui Zhang, Xin Shen, Meng Tang, Yuying Xu. ROS-Drp1-mediated mitochondria fission contributes to hippocampal HT22 cell apoptosis induced by silver nanoparticles. Redox biology. vol 63. 2023-05-15. PMID:37187014. |
furthermore drp1-mediated mitochondrial fission contributed to mitochondria-dependent apoptosis induced by agnps, all aforementioned changes were significantly rescued by n-acetyl-l-cysteine (nac) and mdivi-1 except for opa1 protein expression. |
2023-05-15 |
2023-08-14 |
mouse |
| Masafumi Noguchi, Susumu Kohno, Anna Pellattiero, Yukino Machida, Keitaro Shibata, Norihito Shintani, Takashi Kohno, Noriko Gotoh, Chiaki Takahashi, Atsushi Hirao, Luca Scorrano, Atsuko Kasahar. Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line. Cell death & disease. vol 14. issue 4. 2023-04-05. PMID:37019897. |
in the resistant cells, levels of opa1 were increased and its genetic or pharmacological inhibition reverted the mitochondrial morphology changes and sensitized them to gefitinib-induced cytochrome c release and apoptosis. |
2023-04-05 |
2023-08-14 |
Not clear |
| Seung-Il Choi, Ga-Hyun Lee, Jong-Hwan Woo, Ikhyun Jun, Eung Kweon Ki. Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts. Genes. vol 14. issue 3. 2023-03-29. PMID:36980838. |
reduced opa1, mitochondrial fragmentation and increased susceptibility to apoptosis in granular corneal dystrophy type 2 corneal fibroblasts. |
2023-03-29 |
2023-08-14 |
Not clear |
| Seung-Il Choi, Ga-Hyun Lee, Jong-Hwan Woo, Ikhyun Jun, Eung Kweon Ki. Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts. Genes. vol 14. issue 3. 2023-03-29. PMID:36980838. |
opa1 reduction by short hairpin rna (shrna) resulted in fragmented mitochondrial tubular networks and increased susceptibility to mitochondrial stress-induced apoptosis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Hongyu Li, Joseph C K Leung, Wai Han Yiu, Loretta Y Y Chan, Bin Li, Sarah W Y Lok, Rui Xue, Yixin Zou, Kar Neng Lai, Sydney C W Tan. Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury. Cell death & disease. vol 13. issue 12. 2022-12-20. PMID:36539406. |
in both aki models, tubular β-catenin stabilization in tubcat animals significantly reduced bun/serum creatinine, tubular damage (ngal-positive tubules), apoptosis (tunel-positive cells) and necroptosis (phosphorylation of mlkl and rip3) through activating akt phosphorylation and p53 suppression; enhanced mitochondrial biogenesis (increased pgc-1α and nrf1) and restored mitochondrial mass (increased tim23) to re-establish mitochondrial homeostasis (increased fusion markers opa1, mfn2, and decreased fission protein drp1) through the foxo3/pgc-1α signaling cascade. |
2022-12-20 |
2023-08-14 |
mouse |
| Yonghong Jian, Yifei Yang, Lingli Cheng, Xueyan Yang, Hongyan Liu, Wei Li, Yuhan Wan, Dingping Yan. Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1. Cell proliferation. 2022-11-26. PMID:36433732. |
functional studies revealed that sirt3 overexpression alleviated lps-induced mitochondrial damage and apoptosis in tecs by promoting opa1-mediated mitochondrial fusion through the deacetylation of i-aaa protease (yme1l1), an upstream regulatory molecule of opa1. |
2022-11-26 |
2023-08-14 |
mouse |