| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
the analysis identified higher levels of molecules associated with proliferation (erβ), glycolysis (mct2, pdk1, glut1, hex2, tgfβ and hif-1α), mitochondrial biogenesis (opa1, drp1) and autophagy (p38, beclin1 and bnip3) and decreased levels of apoptosis markers ( |
2024-04-27 |
2024-04-29 |
Not clear |
| Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kon. Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes. Cell death & disease. vol 14. issue 11. 2023-11-07. PMID:37935660. |
importantly, overexpression of pdk1 reduced hg-induced reactive oxygen species (ros) generation and neuronal apoptosis. |
2023-11-07 |
2023-11-20 |
mouse |
| Nana Zheng, Jiaqi Wei, Depei Wu, Yang Xu, Jianping Gu. Master kinase PDK1 in tumorigenesis. Biochimica et biophysica acta. Reviews on cancer. 2023-08-28. PMID:37640147. |
dysregulation of these upstream regulators or downstream signals involves in cancer development, as pdk1 regulating cell growth, metastasis, invasion, apoptosis and survival time. |
2023-08-28 |
2023-09-07 |
mouse |
| Chen Li, Yi Zhou, Yan Niu, Wenting He, Xinyi Wang, Xi Zhang, Yali Wu, Wenli Zhang, Liangcai Zhao, Hong Zheng, Weihong Song, Hongchang Ga. Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 9. 2023-08-10. PMID:37561545. |
here, we demonstrated that deficiency of pdk1 resulted in apoptosis, oxidative damage, and disturbed metabolism, both in vivo and in vitro. |
2023-08-10 |
2023-08-16 |
Not clear |
| Xian Yang, Qingsong Jiang, Tiankuo Luan, Chao Yu, Zhibo Liu, Ting Wang, Jingyuan Wan, Jiayu Huang, Ke L. Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative phosphorylation enhancement in cartilage promotes osteoarthritis progression. BMC musculoskeletal disorders. vol 24. issue 1. 2023-07-20. PMID:37474941. |
moreover, by inhibiting pdk1, cartilage loss is markedly accelerated in dmm-induced oa through extracellular matrix (ecm) degradation and apoptosis of chondrocytes. |
2023-07-20 |
2023-08-14 |
Not clear |
| Y Li, M Li, K Ahmed, J Yang, L Song, Z G Cui, Y Hirak. Mechanistic Study of Macranthoside B Effects on Apoptotic Cell Death in Human Cervical Adenocarcinoma Cells. Folia biologica. vol 68. issue 5-6. 2023-05-31. PMID:37256553. |
in hela cells, mb induced down-regulation of sod2 and gpx1, phosphorylation of akt and pdk1, and thus promoted ros-mediated apoptosis. |
2023-05-31 |
2023-08-14 |
human |
| Yulu Zhang, Hongling Chen, Renjie Yuan, Yange Wang, Dian Zhang, Qian Zeng, Weiqian Jiang, Ruiming Zhang, Tingmei Chen, Chengsen Chai, Bianqin Gu. PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway. Molecular carcinogenesis. 2023-04-12. PMID:37042573. |
in this study, we found that lncrna sprouty4-intron transcript 1 (spry4-it1) was regulated by pdk1 with correlation analysis, and pdk1 upregulated spry4-it1 remarkably in breast cancer cells, as pdk1 interacted with spry4-it1 in the nucleus and significantly enhanced the stability of srpy4-it1. furthermore, spry4-it1 was highly expressed in breast cancer, significantly promoted the proliferation and inhibited apoptosis of breast cancer cells. |
2023-04-12 |
2023-08-14 |
Not clear |
| Yingchao Ma, Xishen Zhang, Xiao Han, Zhizhong Hao, Rong Ji, Jianhui Li, Wenna Guo, Yanting Zhang, Fangxia Guan, Shanshan M. PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming. Molecular carcinogenesis. 2023-03-29. PMID:36988347. |
in this study, we found that pdk1 silence and dichloroacetic acid (dca) significantly inhibited the growth of escc cells and induced cell apoptosis. |
2023-03-29 |
2023-08-14 |
human |
| Xiao Xu, Yaqin Hou, Shumeng Lin, Kai Wang, Yanbei Ren, Tiansheng Zheng, Xi Zhang, Ming Li, Lihong Fa. Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 78. 2023-03-24. PMID:36963369. |
our further study demonstrated that the reduction of pdk1 activity inhibited lactate secretion, reduced mitochondrial membrane potential, caused the release of cytochrome c (cyto c), activated mitochondrial respiration, and promoted the apoptosis of lung cancer cells. |
2023-03-24 |
2023-08-14 |
human |
| Xiao Xu, Yaqin Hou, Shumeng Lin, Kai Wang, Yanbei Ren, Tiansheng Zheng, Xi Zhang, Ming Li, Lihong Fa. Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 78. 2023-03-24. PMID:36963369. |
the in vivo experiment revealed that sse inhibited the activation of nf-κb signaling pathway, decreased the expression of pdk1, and induced lung cancer cell proliferation and apoptosis. |
2023-03-24 |
2023-08-14 |
human |
| Xiao Xu, Yaqin Hou, Shumeng Lin, Kai Wang, Yanbei Ren, Tiansheng Zheng, Xi Zhang, Ming Li, Lihong Fa. Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 78. 2023-03-24. PMID:36963369. |
all these findings indicated that sse promoted lung cancer cell apoptosis by inhibiting the activation of nf-κb signaling pathway, down-regulating pdk1 and activating mitochondrial apoptosis pathway. |
2023-03-24 |
2023-08-14 |
human |
| Yi Li, Wenyan She, Xiaoran Xu, Yixin Liu, Xinyu Wang, Sheng Tian, Shiyi Li, Miao Wang, Chaochao Yu, Pan Liu, Tianhe Huang, Yongchang We. AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer. Journal of Zhejiang University. Science. B. vol 24. issue 3. 2023-03-14. PMID:36915999. |
aaz2 induces mitochondrial-dependent apoptosis by targeting pdk1 in gastric cancer. |
2023-03-14 |
2023-08-14 |
Not clear |
| Fen Zhu, Qing Li, Jun Li, Benlei Li, Dongsheng L. Long noncoding Mirt2 reduces apoptosis to alleviate myocardial infarction through regulation of the miR-764/PDK1 axis. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 2. 2023-02-12. PMID:36775483. |
further mechanistic analysis showed that mirt2 could protect mi and apoptosis in ami rats by competitively adsorbing mir-764 and reducing the inhibitory effect of mir-764 on 3-phosphoinositide-dependent kinase 1 (pdk1). |
2023-02-12 |
2023-08-14 |
rat |
| Hongyan Lin, Hongwei Han, Minkai Yang, Zhongling Wen, Qingqing Chen, Yudi Ma, Xuan Wang, Changyi Wang, Tongming Yin, Xiaoming Wang, Guihua Lu, Hongyuan Chen, Jinliang Qi, Yonghua Yan. PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism. European journal of medicinal chemistry. vol 249. 2023-02-02. PMID:36731272. |
firstly, we found that the combination of ml265 (pkm2 activator) and azd7545 (pdk1 inhibitor) could synergistically inhibit proliferation and induce apoptosis in h1299 cells. |
2023-02-02 |
2023-08-14 |
Not clear |
| Jinzhi Meng, Huawei Du, Haiyuan Lv, Jinfeng Lu, Jia Li, Jun Ya. Identification of the osteoarthritis signature gene PDK1 by machine learning and its regulatory mechanisms on chondrocyte autophagy and apoptosis. Frontiers in immunology. vol 13. 2023-01-23. PMID:36685513. |
identification of the osteoarthritis signature gene pdk1 by machine learning and its regulatory mechanisms on chondrocyte autophagy and apoptosis. |
2023-01-23 |
2023-08-14 |
Not clear |
| Rong Wang, Ke-Liang Huang, Lian-Xiang Xin. TRIM35 functions as a novel tumor suppressor in breast cancer by inducing cell apoptosis through ubiquitination of PDK1. Neoplasma. 2022-01-27. PMID:35081724. |
trim35 functions as a novel tumor suppressor in breast cancer by inducing cell apoptosis through ubiquitination of pdk1. |
2022-01-27 |
2023-08-13 |
Not clear |
| Rong Wang, Ke-Liang Huang, Lian-Xiang Xin. TRIM35 functions as a novel tumor suppressor in breast cancer by inducing cell apoptosis through ubiquitination of PDK1. Neoplasma. 2022-01-27. PMID:35081724. |
in conclusion, trim35 functions as a tumor suppressor to suppress breast cancer proliferation by inactivating akt signaling through the increased ubiquitination of pdk1, resulting in the promotion of apoptosis. |
2022-01-27 |
2023-08-13 |
Not clear |
| Yawara Kawano, Takayuki Sasano, Yuichiro Arima, Saki Kushima, Kenichi Tsujita, Masao Matsuoka, Hiroyuki Hat. A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells. Biochemical and biophysical research communications. vol 587. 2021-12-09. PMID:34875534. |
a novel pdk1 inhibitor, jx06, inhibits glycolysis and induces apoptosis in multiple myeloma cells. |
2021-12-09 |
2023-08-13 |
Not clear |
| Yawara Kawano, Takayuki Sasano, Yuichiro Arima, Saki Kushima, Kenichi Tsujita, Masao Matsuoka, Hiroyuki Hat. A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells. Biochemical and biophysical research communications. vol 587. 2021-12-09. PMID:34875534. |
jx06 suppressed cell growth and induced apoptosis against mm cells from approximately 0.5 μm jx06 treatment reduced pdh phosphorylation, suggesting that jx06 is indeed inhibiting pdk1. |
2021-12-09 |
2023-08-13 |
Not clear |