| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rokeya Akter, Rackhyun Park, Soo Kyung Lee, Eun Ju Han, Kyu-Sang Park, Junsoo Park, Mee-Yon Ch. Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3 Signaling Pathway in Tumor Cells. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673975. |
jak2/stat3 inhibition decreased the levels of emr1, jak2, stat1, and stat3, significantly impeded the proliferation, migration, and mobility of cells, and increased the apoptosis of emr1 |
2024-04-27 |
2024-04-29 |
Not clear |
| Laura Dotta, Francesca Todaro, Manuela Baronio, Mauro Giacomelli, Marinella Pinelli, Martina Giambarda, Beatrice Brognoli, Silvia Greco, Francesca Rota, Manuela Cortesi, Annarosa Soresina, Daniele Moratto, Cesare Tomasi, Rosalba Monica Ferraro, Silvia Giliani, Raffaele Badolat. Patients with STAT1 Gain-of-function Mutations Display Increased Apoptosis which is Reversed by the JAK Inhibitor Ruxolitinib. Journal of clinical immunology. vol 44. issue 4. 2024-04-05. PMID:38578354. |
patients with stat1 gain-of-function mutations display increased apoptosis which is reversed by the jak inhibitor ruxolitinib. |
2024-04-05 |
2024-04-07 |
Not clear |
| Jingjing Ye, Wenqin Xu, Tianbing Che. [Knockdown of interferon-γ inducible protein 30 (IFI30) inhibits the proliferation, invasion and migration of human glioma U251 cells by activating STAT1 and promotes their apoptosis]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 1. 2024-01-21. PMID:38246175. |
[knockdown of interferon-γ inducible protein 30 (ifi30) inhibits the proliferation, invasion and migration of human glioma u251 cells by activating stat1 and promotes their apoptosis]. |
2024-01-21 |
2024-01-24 |
human |
| Chaoyang Wang, Yaowei Bai, Tongqiang Li, Jiacheng Liu, Yingliang Wang, Shuguang Ju, Wei Yao, Bin Xion. Ginkgetin exhibits antifibrotic effects by inducing hepatic stellate cell apoptosis via STAT1 activation. Phytotherapy research : PTR. 2024-01-13. PMID:38217097. |
ginkgetin exhibits antifibrotic effects by inducing hepatic stellate cell apoptosis via stat1 activation. |
2024-01-13 |
2024-01-16 |
mouse |
| Chaoyang Wang, Yaowei Bai, Tongqiang Li, Jiacheng Liu, Yingliang Wang, Shuguang Ju, Wei Yao, Bin Xion. Ginkgetin exhibits antifibrotic effects by inducing hepatic stellate cell apoptosis via STAT1 activation. Phytotherapy research : PTR. 2024-01-13. PMID:38217097. |
ginkgetin exhibits antifibrotic effects by inducing hsc apoptosis via stat1 activation and enhances hepatocyte proliferation secondary to hsc apoptosis via the il-6/stat3 pathway. |
2024-01-13 |
2024-01-16 |
mouse |
| Ling Dong, Xufu Wei, Le Yu, Yixin Li, Lixue Che. Inhibition of SIRT7 promotes STAT1 activation and STAT1-dependent signaling in hepatocellular carcinoma. Cellular signalling. 2023-12-09. PMID:38070755. |
notably, knockdown of stat1 in sirt7-deficient cells attenuates the increase in cell apoptosis induced by etoposide treatment. |
2023-12-09 |
2023-12-17 |
Not clear |
| Xiaoshuang Song, Mao Wang, Simeng Liu, Huimin Liu, Ailing Jiang, Yu Zou, Yuchuan Deng, Qin Qin, Yiran Song, Yu Zhen. A sequential scheme including PTT and 2'3'-cGAMP/CQ-LP reveals the antitumor immune function of PTT through the type I interferon pathway. Pharmacological research. vol 196. 2023-09-28. PMID:37758101. |
the sequential combination treatment caused a significant increase in tumor cell apoptosis, probably due to interferon stimulating gene products 15 and 54 (isg15 and isg 54), and achieved a more striking antitumor inhibition effect in the ct26 tumor model than the 4t1 model, likely due to higher stat1 expression and consequently more intense ifn signal transduction. |
2023-09-28 |
2023-10-07 |
Not clear |
| Nguyen Thanh Huyen, Nguyen Thy Ngoc, Nguyen Hoang Giang, Do Thi Trang, Ha Hong Hanh, Vu Duc Binh, Nguyen Van Giang, Nguyen Xuan Canh, Nguyen Thi Xua. CYLD stimulates macrophage phagocytosis of leukemic cells through STAT1 signalling in acute myeloid leukemia. PloS one. vol 18. issue 8. 2023-08-07. PMID:37549179. |
moreover, treatment of normal macrophages with cyld sirna enhanced activation of stat-1, leading to increases in expressions of maturation markers and il-6 production as well as suppression in cell apoptosis and phagocytosis, while macrophage phagocytosis from aml m4/m5b was higher than that from healthy controls upon cyld sirna transfection through stat1 signalling. |
2023-08-07 |
2023-08-14 |
human |
| Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yan. Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3. Archives of toxicology. 2023-07-03. PMID:37395757. |
apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating stat1 and stat3. |
2023-07-03 |
2023-08-14 |
mouse |
| Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yan. Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3. Archives of toxicology. 2023-07-03. PMID:37395757. |
in conclusion, our results indicate that apelin-13 could be a potential otoprotective agent to prevent cisplatin-induced ototoxicity by inhibiting apoptosis, ros production, tnf-α and il-6 expression, and regulating phosphorylation of stat1 and stat3 transcription factors. |
2023-07-03 |
2023-08-14 |
mouse |
| Kai Qian, Jinqian Zhang, Jingbo Lu, Wenjun Liu, Xingxing Yao, Qing Chen, Shun Lu, Guoan Xiang, Hao Li. [Retracted] FAM172A modulates apoptosis and proliferation of colon cancer cells via STAT1 binding to its promoter. Oncology reports. vol 49. issue 5. 2023-04-13. PMID:37052264. |
[retracted] fam172a modulates apoptosis and proliferation of colon cancer cells via stat1 binding to its promoter. |
2023-04-13 |
2023-08-14 |
Not clear |
| Leonie Meyer-Heemsoth, Katja Mitschke, Jasmina Bier, Konstantin Schütz, Andreas Villunger, Tobias J Legler, Martin S Weber, Fred Lühder, Holger M Reichard. T Cell Energy Metabolism Is a Target of Glucocorticoids in Mice, Healthy Humans, and MS Patients. Cells. vol 12. issue 3. 2023-02-11. PMID:36766792. |
this effect was mediated by the gc receptor and unrelated to both apoptosis induction and stat1 activity. |
2023-02-11 |
2023-08-14 |
mouse |
| Shigekazu Tanaka, Hajime Orita, Taro Kataoka, Masahiro Miyazaki, Harumi Saeki, Ryo Wada, Malcolm V Brock, Tetsu Fukunaga, Takanori Amano, Toshihiko Shiroish. Gasdermin D Represses Inflammation-Induced Colon Cancer Development by Regulating Apoptosis. Carcinogenesis. 2023-02-08. PMID:36753047. |
results show that gsdmd deficiency enhances crc development, probably due to decreased apoptosis caused by down-regulation of interferon-gamma (ifnγ) - signal transducer and activator 1 (stat1) signaling. |
2023-02-08 |
2023-08-14 |
human |
| Yong Zeng, Hong-Qiang Chen, Zhe Zhang, Jun Fan, Jing-Zhi Li, Shi-Meng Zhou, Na Wang, Su-Peng Yan, Jia Cao, Jin-Yi Liu, Zi-Yuan Zhou, Wen-Bin Li. IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis. Environmental pollution (Barking, Essex : 1987). 2022-12-30. PMID:36584854. |
results proved that ifi44l promoted stat1 phosphorylation and activated the jak/stat1 signaling pathway by directly binding to stat1 protein, thereby leading to cell apoptosis. |
2022-12-30 |
2023-08-14 |
Not clear |
| Andrii Slonchak, Xiaohui Wang, Julio Aguado, Julian D J Sng, Harman Chaggar, Morgan E Freney, Kexin Yan, Francisco J Torres, Alberto A Amarilla, Rickyle Balea, Yin Xiang Setoh, Nias Peng, Daniel Watterson, Ernst Wolvetang, Andreas Suhrbier, Alexander A Khromyk. Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis. Science advances. vol 8. issue 48. 2022-11-30. PMID:36449607. |
in infected human placental cells, sfrna inhibits multiple antiviral pathways and promotes apoptosis, with signal transducer and activator of transcription 1 (stat1) identified as a key shared factor. |
2022-11-30 |
2023-08-14 |
mouse |
| Min Zhou, Ping Zhang, Mengting Da, Rui Yang, Yulian Ma, Jiuda Zhao, Tao Ma, Jiazeng Xia, Guoshuang Shen, Yu Chen, Daozhen Che. A pan-cancer analysis of the expression of STAT family genes in tumors and their relationship to the tumor microenvironment. Frontiers in oncology. vol 12. 2022-09-30. PMID:36176415. |
the signal transducer and activator of transcription (stat) protein family, a group of seven members (stat1, stat2, stat3, stat4, stat5a, stat5b, and stat6), has been widely used to investigate numerous biological functions including cell proliferation, differentiation, apoptosis, and immune regulation. |
2022-09-30 |
2023-08-14 |
Not clear |
| Lena Blümel, Nan Qin, Johannes Berlandi, Eunice Paisana, Rita Cascão, Carlos Custódia, David Pauck, Daniel Picard, Maike Langini, Kai Stühler, Frauke-Dorothee Meyer, Sarah Göbbels, Bastian Malzkorn, Max C Liebau, João T Barata, Astrid Jeibmann, Kornelius Kerl, Serap Erkek, Marcel Kool, Stefan M Pfister, Pascal D Johann, Michael C Frühwald, Arndt Borkhardt, Guido Reifenberger, Claudia C Faria, Ute Fischer, Martin Hasselblatt, Jasmin Bartl, Marc Remk. Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors. Cell death & disease. vol 13. issue 9. 2022-09-20. PMID:36127323. |
additionally, apoptosis was significantly increased via the induction of stat1 and dr5 signaling, as detected by proteogenomic profiling. |
2022-09-20 |
2023-08-14 |
mouse |
| Jie Zhang, Shufeng Xia, Xiaoyu Liu, Deguang Qi, Xiaodong He, Daqin Che. STAT1 Mediates the Transcription of CircIFI30 and Promotes the Progression of Triple-Negative Breast Cancer by Up-Regulating CDCA4. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 41. issue 1. 2022-04-04. PMID:35378000. |
signal transducers and activators of transcription 1 (stat1) is an important transcription factor that regulates the growth, survival, differentiation and apoptosis of various tumor cells. |
2022-04-04 |
2023-08-13 |
Not clear |
| Jie Zhang, Shufeng Xia, Xiaoyu Liu, Deguang Qi, Xiaodong He, Daqin Che. STAT1 Mediates the Transcription of CircIFI30 and Promotes the Progression of Triple-Negative Breast Cancer by Up-Regulating CDCA4. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 41. issue 1. 2022-04-04. PMID:35378000. |
up-regulated stat1 could promote the proliferation, invasion, migration, emt and inhibit the apoptosis of tnbc cells. |
2022-04-04 |
2023-08-13 |
Not clear |
| Keshan Zhang, Bo Yang, Chaochao Shen, Ting Zhang, Yu Hao, Dajun Zhang, Huanan Liu, Xijuan Shi, Guoli Li, Jinke Yang, Dan Li, Zixiang Zhu, Hong Tian, Fan Yang, Yi Ru, Wei Jun Cao, Jianhong Guo, Jijun He, Haixue Zheng, Xiangtao Li. MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway. mBio. 2022-01-25. PMID:35076286. |
further evidence showed that mgf360-9l interacts with signal transducer and activator of transcription (stat) 1 and stat2 and degrades stat1 and stat2 through apoptosis and ubiquitin-proteasome pathways, respectively. |
2022-01-25 |
2023-08-13 |
Not clear |