| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Ming Chao, Hon-Yen Wu, Sin-Huei Yeh, Ding-I Yang, Lu-Shiun Her, Yuh-Lin W. Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673797. |
this study aimed to elucidate the modulation of fgf21 production by gln and its impact on learning and memory functions. |
2024-04-27 |
2024-04-29 |
mouse |
| Xi Zhang, Hong Zheng, Zhitao Ni, Yuyin Shen, Die Wang, Wenqing Li, Liangcai Zhao, Chen Li, Hongchang Ga. Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline. Cerebral cortex (New York, N.Y. : 1991). 2024-01-14. PMID:38220573. |
results revealed that i.c.v fgf21 infusion effectively improved learning and memory performance of dicd mice; neuron loss and apoptosis in hippocampus and cortex were significantly blocked, suggesting a potential neuroprotective role of fgf21 in dicd. |
2024-01-14 |
2024-01-17 |
mouse |
| Bolu Zhou, Kristin E Claflin, Kyle H Flippo, Andrew I Sullivan, Arvand Asghari, Satya M Tadinada, Sharon O Jensen-Cody, Ted Abel, Matthew J Potthof. Central FGF21 production regulates memory but not peripheral metabolism. Cell reports. vol 40. issue 8. 2022-08-24. PMID:36001982. |
using a mouse model that drives cre recombinase in fgf21-expressing cells, we demonstrate that fgf21 is not expressed in the hypothalamus, but instead is produced from the retrosplenial cortex (rsc), an essential brain region for spatial learning and memory. |
2022-08-24 |
2023-08-14 |
mouse |
| Liangcai Zhao, Haowei Jiang, Jiaojiao Xie, Danjie Shen, Qingqing Yi, Jiapin Yan, Chen Li, Hong Zheng, Hongchang Ga. Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline. Molecular neurobiology. 2022-06-27. PMID:35761156. |
however, fgf21 treatment improved ldh-b activity, β-nicotinamide adenine dinucleotide, and atp levels, and increased mct2 expression and pi3k signaling pathway, which in turn improved the learning and memory defects. |
2022-06-27 |
2023-08-14 |
mouse |
| Liangcai Zhao, Haowei Jiang, Jiaojiao Xie, Danjie Shen, Qingqing Yi, Jiapin Yan, Chen Li, Hong Zheng, Hongchang Ga. Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline. Molecular neurobiology. 2022-06-27. PMID:35761156. |
at the end of the treatment period, learning and memory performance, nuclear magnetic resonance-based metabonomics, and expressions of various hippocampal protein were analyzed to determine the efficacy of fgf21. |
2022-06-27 |
2023-08-14 |
mouse |
| Rajeev Taliyan, Sarathlal K Chandran, Violina Kakot. Therapeutic Approaches to Alzheimer's Type of Dementia: A Focus on FGF21 Mediated Neuroprotection. Current pharmaceutical design. vol 25. issue 23. 2020-04-16. PMID:31333086. |
fgf21 receptors are present in certain areas of the brain involved in learning and memory. |
2020-04-16 |
2023-08-13 |
Not clear |