| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eunyeoung Kim, Wooin Yang, Dong Seok Cha, Young Taek Ha. Synthesis and dopaminergic neuroprotective activity of the proposed structure of bassiamide A, a caffeamide alkaloid derived from Bassia indica Wight. Chemistry & biodiversity. 2024-05-01. PMID:38693058. |
additionally, treatment with bassiamide a notably ameliorated the impaired food-sensing ability and locomotion of c. elegans, suggesting a protective effect on the functionality of dopaminergic neurons. |
2024-05-01 |
2024-05-04 |
caenorhabditis_elegans |
| Halina Falfushynska, Piotr Rychter, Anastasiia Boshtova, Yuliia Faidiuk, Nadiia Kasianchuk, Piotr Rzymsk. Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook. Pharmaceuticals (Basel, Switzerland). vol 17. issue 4. 2024-04-27. PMID:38675497. |
exposure to such xenobiotics can induce oxidative stress and dysfunction to mitochondrial and lysosomal function, distort locomotion activity by regulating the dopaminergic and glutamatergic systems, increase the predation risk, instigate neurological disorders, disbalance neurotransmission, and produce histopathological alterations in the brain and liver tissues, similar to those described in mammals. |
2024-04-27 |
2024-04-29 |
human |
| Wenwen Liu, Wenhui Zhou, Peiji Zhao, Tingting Wu, Huan Gu, Yixin Li, Chidi Zhong, Hua Bai, Ninghui Zhao, Xiaowei Huan. PD-Like Pathogenesis in Caenorhabditis elegans Intestinally Infected with Nocardia farcinica and the Underlying Molecular Mechanisms. Molecular neurobiology. 2024-03-28. PMID:38546929. |
here, we found that intestinal infection with nocardia farcinica induced a series of pd-like symptoms in caenorhabditis elegans, such as the accelerated degeneration of dopaminergic neurons, impaired locomotion capacity, and enhanced α-syn aggregation, through the disturbance of mitochondrial functions. |
2024-03-28 |
2024-03-31 |
caenorhabditis_elegans |
| Huanliang Liu, Xiaochao Tan, Yu Wu, Xiaona Li, Zhiyong Hu, Shuhan Lei, Wendong Fan, Zhenyu Wan. Long-term exposure to 6-PPD quinone at environmentally relevant concentrations causes neurotoxicity by affecting dopaminergic, serotonergic, glutamatergic, and GABAergic neuronal systems in Caenorhabditis elegans. The Science of the total environment. 2024-02-29. PMID:38423311. |
lastly, pearson's correlation analysis showed that locomotion behavior and sensory perception behavior were positively correlated with the dopaminergic, serotonergic, glutamatergic, and gabaergic neurotransmission. |
2024-02-29 |
2024-03-03 |
caenorhabditis_elegans |
| Sazan Ismael, Robert A Colvin, Daewoo Le. Activation of cyclic AMP signaling pathway in dopaminergic neurons rescues locomotion defects in a Drosophila larval model of Parkinson's disease. Brain research. 2023-10-22. PMID:37866407. |
activation of cyclic amp signaling pathway in dopaminergic neurons rescues locomotion defects in a drosophila larval model of parkinson's disease. |
2023-10-22 |
2023-11-08 |
drosophila_melanogaster |
| Shuanglong Yi, Linfang Wang, Margaret S Ho, Shiping Zhan. The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Neural regeneration research. vol 19. issue 5. 2023-10-20. PMID:37862221. |
importantly, loss of glial atg9 induces parkinsonian symptoms in drosophila including progressive loss of dopaminergic neurons, locomotion deficits, and glial activation. |
2023-10-20 |
2023-11-08 |
drosophila_melanogaster |
| İrem Akçalı, Simla Su Akkan, Mehmet Bülbü. The Regulatory Role of Central Neuropeptide-S in Locomotion. Peptides. 2023-10-13. PMID:37832875. |
nps receptor (npsr) is produced in locomotion-related brain regions including basal ganglia while nps mediates dopaminergic neurotransmission suggesting that endogenous brain nps is involved in the regulation of locomotion. |
2023-10-13 |
2023-10-15 |
rat |
| Dimitri Ryczko, Réjean Dubu. Dopamine control of downstream motor centers. Current opinion in neurobiology. vol 83. 2023-09-29. PMID:37774481. |
beyond locomotion, dopaminergic inputs modulate visuomotor transformations within the optic tectum (mammalian superior colliculus). |
2023-09-29 |
2023-10-07 |
Not clear |
| Dimitri Ryczko, Réjean Dubu. Dopamine control of downstream motor centers. Current opinion in neurobiology. vol 83. 2023-09-29. PMID:37774481. |
other descending dopaminergic projections have been shown to reach reticulospinal cells involved in the control of locomotion. |
2023-09-29 |
2023-10-07 |
Not clear |
| Heidy Jimenez, Joseph Carrion, Leslie Adrien, Adam Wolin, John Eun, Ezra Cinamon, Eric H Chang, Peter Davies, An Vo, Jeremy Koppe. The Impact of Muscarinic Antagonism on Psychosis-Relevant Behaviors and Striatal [ Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626588. |
in this report, we utilize a human-mutant-tau model (p301l/comtko) and an over-expressed non-mutant human tau model (htau) in order to compare the impact of antimuscarinic (scopolamine 10 mg/kg/day) treatment with dopaminergic (reboxetine 20 mg/kg/day) treatment, for 7 days, on locomotion and sensorimotor gating. |
2023-08-26 |
2023-09-07 |
human |
| Sandrine Bataille, Hadrien Jalaber, Ingrid Colin, Damien Remy, Pierre Affaticati, Cynthia Froc, Jean-Pierre Levraud, Philippe Vernier, Michaël Demarqu. Plasticity of dopaminergic phenotype and locomotion in larval zebrafish induced by brain excitability changes during the embryonic period. eNeuro. 2023-06-14. PMID:37316295. |
plasticity of dopaminergic phenotype and locomotion in larval zebrafish induced by brain excitability changes during the embryonic period. |
2023-06-14 |
2023-08-14 |
zebrafish |
| Siroshini K Thiagarajan, Siew Ying Mok, Satoshi Ogawa, Ishwar S Parhar, Pek Yee Tan. Integrative Roles of Dopamine Pathway and Calcium Channels Reveal a Link between Schizophrenia and Opioid Use Disorder. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835497. |
drug-induced locomotion and social preference were assessed, while the level of dopamine and the number of dopaminergic neurons were quantified. |
2023-02-25 |
2023-08-14 |
zebrafish |
| Eduard Dumitrescu, Jeffrey M Copeland, B Jill Vento. ACS chemical neuroscience. 2022-12-28. PMID:36576890. |
parkinson's disease (pd) is characterized by progressive degeneration of dopaminergic neurons leading to reduced locomotion. |
2022-12-28 |
2023-08-14 |
Not clear |
| Judit Oláh, Attila Lehotzky, Tibor Szénási, Tímea Berki, Judit Ovád. Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology. Cells. vol 11. issue 19. 2022-10-14. PMID:36230985. |
parkinson's disease is characterized by locomotion deficits, dopaminergic neuronal loss and alpha-synuclein (syn) aggregates; the tubulin polymerization promoting protein (tppp/p25 or tppp1) is also implicated in these processes. |
2022-10-14 |
2023-08-14 |
human |
| Inge Scharpf, Sylwia Cichocka, Dang Tri Le, Anna von Mikec. Peripheral neuropathy, protein aggregation and serotonergic neurotransmission: Distinctive bio-interactions of thiacloprid and thiamethoxam in the nematode Caenorhabditis elegans. Environmental pollution (Barking, Essex : 1987). 2022-09-26. PMID:36155223. |
thiacloprid caused a concentration-dependent delay of the transition between swimming and crawling locomotion that is controlled by dopaminergic and serotonergic neurotransmission. |
2022-09-26 |
2023-08-14 |
caenorhabditis_elegans |
| Joshua Fejeran, Frank Salazar, Cesia M Alvarez, Faisal R Jahangir. Deep Brain Stimulation and Microelectrode Recording for the Treatment of Parkinson's Disease. Cureus. vol 14. issue 8. 2022-09-16. PMID:36110462. |
parkinson's disease (pd) is a neurological disorder in which nigrostriatal pathways involving the basal ganglia experience a decrease in neural activity regarding dopaminergic neurons. pd symptoms, such as muscle stiffness and involuntary tremors, have an adverse impact on the daily lives of those affected. current medical treatments seek to decrease the severity of these symptoms. deep brain stimulation (dbs) has become the preferred safe, and reliable treatment approach. dbs involves implanting microelectrodes into subcortical areas that produce electrical impulses directly to high populations of dopaminergic neurons. the most common targets are the subthalamic nucleus (stn), and the basal ganglia's globus pallidus pars interna (gpi). research studies suggest that dbs of the stn may cause a significant reduction in the daily dose of l-dopa compared to dbs of the gpi. dbs of the stn has suggested that there may be sweet spots within the stn that provide hyper-direct cortical connectivity pathways to the primary motor cortex (m1), supplementary motor area (sma), and prefrontal cortex (pfc). in addition, the pedunculopontine nucleus (ppn) may be a new target for dbs that helps treat locomotion problems associated with gait and posture. both microelectrode recording (mer) and magnetic resonance imaging (mri) are used to ensure electrode placement accuracy. using mer, stimulation of the stn at high frequencies (140<) decreased oscillatory neuronal firing by 67%. this paper investigates methods of intraoperative neuromonitoring during dbs as a form of pd treatment. |
2022-09-16 |
2023-08-14 |
Not clear |
| Dandan Qian, Wei Li, Jinwen Xue, Yi Wu, Ziling Wang, Tao Shi, Songting Li, Jingxuan Yang, Shi Qiu, Shaoli Wang, Yousheng Shu, Liang Chen, Qiao Wang, Ti-Fei Yuan, Douglas Zhou, Wei L. A striatal SOM-driven ChAT-iMSN loop generates beta oscillations and produces motor deficits. Cell reports. vol 40. issue 3. 2022-07-20. PMID:35858550. |
here, we show that optogenetic suppression of dopaminergic control over the dorsal striatum (ds) elevates the power of local field potentials (lfps) selectively at beta band (12-25 hz), accompanied by impairments in locomotion. |
2022-07-20 |
2023-08-14 |
Not clear |
| Tao Ke, Alexey A Tinkov, Anatoly V Skalny, Abel Santamaria, Marcelo Farina, João B T Rocha, Aaron B Bowman, Michael Aschne. The Human LRRK2 Modulates the Age-Dependent Effects of Developmental Methylmercury Exposure in Caenorhabditis elegans. Neurotoxicity research. 2022-07-15. PMID:35838907. |
worms exposed to mehg (10 or 50 nm) at the larval stage (l1 stage) were compared at adult stages (young age: day 1 adult; middle age: day 5 adult; old age: day 10 adult) for the swimming speeds in m9 buffer, moving speeds during locomotion on an op50-seeded plate, and the numbers of cep dopaminergic pre-vesicles, vesicular structures originating from the dendrites of cep for exportation of cellular content. |
2022-07-15 |
2023-08-14 |
human |
| Shan Dongjie, R Samuel Rajendran, Qing Xia, Gaimei She, Pengfei Tu, Yun Zhang, Kechun Li. Neuroprotective effects of Tongtian oral liquid, a Traditional Chinese Medicine in the Parkinson's disease-induced zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 148. 2022-02-13. PMID:35152046. |
mptp-treated zebrafish larvae showed degeneration of dopaminergic neurons, locomotion dysfunction, diminished activities of antioxidant enzymes, mda accumulation, and altered gene expression of dopamine pathway. |
2022-02-13 |
2023-08-13 |
cat |
| Chitrakshi Pant, Moumita Chakrabarti, Jolly Janette Mendonza, Bogonda Ganganna, Srihari Pabbaraja, Manika Pal Bhadr. ACS chemical neuroscience. vol 12. issue 23. 2021-12-01. PMID:34763419. |
parkinson's disease is a chronic and progressive neurodegenerative disease, induced by slow and progressive death of the dopaminergic (da) neurons from the midbrain region called substantia nigra (snc) leading to difficulty in locomotion. |
2021-12-01 |
2023-08-13 |
Not clear |