| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriela Dumitrita Stanciu, Daniela-Carmen Ababei, Carmen Solcan, Cristina-Mariana Uritu, Vlad-Constantin Craciun, Cosmin-Vasilica Pricope, Andrei Szilagyi, Bogdan-Ionel Tamb. Exploring Cannabinoids with Enhanced Binding Affinity for Targeting the Expanded Endocannabinoid System: A Promising Therapeutic Strategy for Alzheimer's Disease Treatment. Pharmaceuticals (Basel, Switzerland). vol 17. issue 4. 2024-04-27. PMID:38675490. |
recently, the endocannabinoid system (ecs) has emerged as an essential therapeutic target due to its regulatory role in different physiological processes, such as neuroprotection, modulation of inflammation, and synaptic plasticity. |
2024-04-27 |
2024-04-29 |
Not clear |
| Joana Gonçalves-Ribeiro, Oksana K Savchak, Sara Costa-Pinto, Joana I Gomes, Rafael Rivas-Santisteban, Alejandro Lillo, Javier Sánchez Romero, Ana M Sebastião, Marta Navarrete, Gemma Navarro, Rafael Franco, Sandra H Va. Adenosine receptors are the on-and-off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex. Glia. 2024-03-14. PMID:38482984. |
adenosine receptors are the on-and-off switch of astrocytic cannabinoid type 1 (cb1) receptor effect upon synaptic plasticity in the medial prefrontal cortex. |
2024-03-14 |
2024-03-16 |
Not clear |
| Barna Dudok, Linlin Z Fan, Jordan S Farrell, Shreya Malhotra, Jesslyn Homidan, Doo Kyung Kim, Celestine Wenardy, Charu Ramakrishnan, Yulong Li, Karl Deisseroth, Ivan Soltes. Retrograde endocannabinoid signaling at inhibitory synapses in vivo. Science (New York, N.Y.). vol 383. issue 6686. 2024-02-29. PMID:38422134. |
endocannabinoid (ecb)-mediated suppression of inhibitory synapses has been hypothesized, but this has not yet been demonstrated to occur in vivo because of the difficulty in tracking ecb dynamics and synaptic plasticity during behavior. |
2024-02-29 |
2024-03-03 |
mouse |
| Luana Barreto Domingos, Heidi Kaastrup Müller, Nicole Rodrigues da Silva, Michaela D Filiou, Anders Lade Nielsen, Francisco Silveira Guimarães, Gregers Wegener, Sâmia Joc. Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression. Neuropharmacology. 2024-02-24. PMID:38401791. |
the pfc was analyzed by a) western blotting to assess markers of synaptic plasticity and cannabinoid signaling in synaptosome and cytosolic fractions; b) mass spectrometry-based lipidomics to investigate endocannabinoid levels (ecb). |
2024-02-24 |
2024-02-27 |
rat |
| Juan F Osuna-Ramos, Josué Camberos-Barraza, Laura E Torres-Mondragón, Ángel R Rábago-Monzón, Alejandro Camacho-Zamora, Marco A Valdez-Flores, Carla E Angulo-Rojo, Alma M Guadrón-Llanos, Verónica J Picos-Cárdenas, Loranda Calderón-Zamora, Javier A Magaña-Gómez, Claudia D Norzagaray-Valenzuela, Feliznando I Cárdenas-Torres, Alberto K De la Herrán-Arit. Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease. International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139290. |
conversely, the endocannabinoid system, a multifaceted signaling network, is intricately involved in diverse physiological processes and has been associated with modulating synaptic plasticity, nociception, affective states, appetite regulation, and immune responses. |
2023-12-23 |
2023-12-25 |
human |
| D Rapaka, P C Adiukwu, S R Challa, V R Bitr. Interplay Between Astroglial Endocannabinoid System and the Cognitive Dysfunction in Alzheimer's Disease. Physiological research. vol 72. issue 5. 2023-11-28. PMID:38015757. |
cannabinoid cb1 receptors have been shown to regulate wide array of functions ranging from homeostasis to the cognitive functioning but recent data support the hypothesis that astrocytes also operate as a mediator of synaptic plasticity and contribute to cognition and learning. |
2023-11-28 |
2023-12-07 |
Not clear |
| Priyanka D Pinky, Jenna Bloemer, Warren D Smith, Yifeng Du, Ryan T Heslin, Sharay E Setti, Jeremiah C Pfitzer, Kawsar Chowdhury, Hao Hong, Subhrajit Bhattacharya, Muralikrishnan Dhanasekaran, Alexander Dityatev, Miranda N Reed, Vishnu Suppiramania. Prenatal Cannabinoid Exposure Elicits Memory Deficits Associated with Reduced PSA-NCAM Expression, Altered Glutamatergic Signaling, and Adaptations in Hippocampal Synaptic Plasticity. Cells. vol 12. issue 21. 2023-11-10. PMID:37947603. |
prenatal cannabinoid exposure elicits memory deficits associated with reduced psa-ncam expression, altered glutamatergic signaling, and adaptations in hippocampal synaptic plasticity. |
2023-11-10 |
2023-11-20 |
rat |
| Samah Shahen-Zoabi, Reem Smoum, Alexey Bingor, Etty Grad, Alina Nemirovski, Tawfeeq Shekh-Ahmad, Raphael Mechoulam, Rami Yak. N-oleoyl glycine and N-oleoyl alanine attenuate alcohol self-administration and preference in mice. Translational psychiatry. vol 13. issue 1. 2023-07-31. PMID:37524707. |
the endocannabinoid system (ecs) plays a key modulatory role during synaptic plasticity and homeostatic processes in the brain and has an important role in the neurobiological processes underlying drug addiction. |
2023-07-31 |
2023-08-14 |
mouse |
| Laia Alegre-Zurano, Alba García-Baos, Adriana Castro-Zavala, Mireia Medrano, Ines Gallego-Landin, Olga Valverd. The FAAH inhibitor URB597 reduces cocaine intake during conditioned punishment and mitigates cocaine seeking during withdrawal. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-27. PMID:37499453. |
the endocannabinoid system is prominently implicated in the control of cocaine reinforcement due to its relevant role in synaptic plasticity and neurotransmitter modulation in the mesocorticolimbic system. |
2023-07-27 |
2023-08-14 |
mouse |
| Zhiwei Xue, Lei Ye, Jianwei Ge, Zhen Lan, Xinxin Zou, Chenglu Mao, Xinyu Bao, Linjie Yu, Yun Xu, Xiaolei Zh. Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe/PS1dE9 mice. Pharmacological research. 2023-07-22. PMID:37480972. |
in addition, intraperitoneal injection of wwl70, a specific inhibitor of abhd6, improved synaptic plasticity and memory function in app/ps1 mice, which might attribute to the activation of endogenous cannabinoid signaling. |
2023-07-22 |
2023-08-14 |
mouse |
| Axel Bernabeu, Anissa Bara, Michelle N Murphy Green, Antonia Manduca, Jim Wager-Miller, Milene Borsoi, Olivier Lassalle, Anne-Laure Pelissier-Alicot, Pascale Chavis, Ken Mackie, Olivier J J Manzon. Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression. Cannabis and cannabinoid research. 2023-04-04. PMID:37015060. |
sexually dimorphic adolescent trajectories of prefrontal endocannabinoid synaptic plasticity equalize in adulthood, reflected by endocannabinoid system gene expression. |
2023-04-04 |
2023-08-14 |
Not clear |
| Masayasu Ukai, Stephanie McGrath, Joseph Wakshla. The clinical use of cannabidiol and cannabidiolic acid-rich hemp in veterinary medicine and lessons from human medicine. Journal of the American Veterinary Medical Association. 2023-03-25. PMID:36965472. |
the endocannabinoid system (ecs) is an integral neuromodulatory system involved in neuronal development, synaptic plasticity, and homeostasis regarding immunity, as well as brain and other physiological functions such as anxiety, pain, metabolic regulation, and bone growth. |
2023-03-25 |
2023-08-14 |
human |
| Antonio Figueiredo, Joseph F Chee. Endocannabinoid regulation of hippocampus-dependent memory. Experimental neurology. 2023-03-19. PMID:36934867. |
additionally, we examine the impact of cannabinoids on synaptic plasticity and intracellular signaling within the hippocampus related to these processes. |
2023-03-19 |
2023-08-14 |
Not clear |
| Michele Santoni, Claudia Sagheddu, Valeria Serra, Rafaela Mostallino, Maria Paola Castelli, Francesco Pisano, Maria Scherma, Paola Fadda, Anna Lisa Muntoni, Erica Zamberletti, Tiziana Rubino, Miriam Melis, Marco Pisti. Maternal immune activation impairs endocannabinoid signaling in the mesolimbic system of adolescent male offspring. Brain, behavior, and immunity. 2023-02-06. PMID:36746342. |
experiments were performed during adolescence to assess i) the behavioral endophenotype (locomotor activity, plus maze, prepulse inhibition of startle reflex); ii) the locomotor activity in response to Δ9-tetrahydrocannabinol (thc) and iii) the properties of ventral tegmental area (vta) dopamine neurons in vivo and their response to thc; iv) endocannabinoid-mediated synaptic plasticity in vta dopamine neurons; v) the expression of cannabinoid receptors and enzymes involved in endocannabinoid synthesis and catabolism in mesolimbic structures and vi) mia-induced neuroinflammatory scenario evaluated by measurements of levels of cytokine and neuroinflammation markers. |
2023-02-06 |
2023-08-14 |
rat |
| Isaac Ostlund, Michael Von Gunten, Calvin Smith, Jeffrey G Edward. Chronic Δ9-tetrahydrocannabinol impact on plasticity, and differential activation requirement for CB1-dependent long-term depression in ventral tegmental area GABA neurons in adult versus young mice. Frontiers in neuroscience. vol 16. 2023-01-26. PMID:36699526. |
in young mice, vta gaba cells exhibit a form of synaptic plasticity known as long-term depression (ltd) that is dependent on cannabinoid 1 (cb1) receptors preceded by metabotropic glutamate receptor 5 (mglur5) signaling to induce endocannabinoid production. |
2023-01-26 |
2023-08-14 |
mouse |
| Mylène Potier, Marlène Maitre, Thierry Leste-Lasserre, Giovanni Marsicano, Francis Chaouloff, Aline Marighett. Age-dependent effects of estradiol on temporal memory: A role for the type 1 cannabinoid receptor? Psychoneuroendocrinology. vol 148. 2022-12-15. PMID:36521252. |
in keeping with the key role of the endocannabinoid system in memory processes and ca3 to dca1 synaptic plasticity, we next examined the role of cannabinoid type 1 receptors (cb |
2022-12-15 |
2023-08-14 |
mouse |
| Charles F Yates, Jin Y Huang, Dario A Prott. Tonic Endocannabinoid Levels Modulate Retinal Signaling. International journal of environmental research and public health. vol 19. issue 19. 2022-10-14. PMID:36231760. |
the endocannabinoid (ecb) system is critically involved in the modulation of synaptic transmission in the central nervous system, playing an important role in the control of emotional responses, neurodevelopment and synaptic plasticity among other functions. |
2022-10-14 |
2023-08-14 |
mouse |
| Fouad Lemtiri-Chlieh, Eric S Levin. 2-AG and anandamide enhance hippocampal long-term potentiation Frontiers in cellular neuroscience. vol 16. 2022-10-10. PMID:36212685. |
this is likely related to the inhibition of long-term potentiation (ltp), a form of synaptic plasticity, by the global and sustained activation of cb1 cannabinoid receptors in the presence of exogenous agonists. |
2022-10-10 |
2023-08-14 |
mouse |
| Fouad Lemtiri-Chlieh, Eric S Levin. 2-AG and anandamide enhance hippocampal long-term potentiation Frontiers in cellular neuroscience. vol 16. 2022-10-10. PMID:36212685. |
conversely, the temporally and spatially restricted release of endogenous cannabinoid (ecb) ligands may enhance synaptic plasticity in a synapse-specific manner. |
2022-10-10 |
2023-08-14 |
mouse |
| Alexander P Young, Eileen M Denovan-Wrigh. The microglial endocannabinoid system is similarly regulated by lipopolysaccharide and interferon gamma. Journal of neuroimmunology. vol 372. 2022-09-23. PMID:36150252. |
perturbation of the endocannabinoid system can have profound effects on immune function and synaptic plasticity. |
2022-09-23 |
2023-08-14 |
Not clear |