| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingya Ruan, Zhongwei Shi, Xiaoyan Cao, Zhunan Dang, Qianqian Zhang, Wei Zhang, Lijie Wu, Yi Zhang, Tao Wan. Research Progress on Anti-Inflammatory Effects and Related Mechanisms of Astragalin. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674061. |
specifically, ast is believed to possess inhibitory effects on inflammation-related factors and protein levels in various in vitro cell models, such as macrophages, microglia, and epithelial cells. |
2024-04-27 |
2024-04-29 |
mouse |
| Guangyuan Han, Lijuan Song, Zhibin Ding, Qing Wang, Yuqing Yan, Jianjun Huang, Cungen M. The Important Double-Edged Role of Astrocytes in Neurovascular Unit After Ischemic Stroke. Frontiers in aging neuroscience. vol 14. 2022-04-25. PMID:35462697. |
in recent years, neurovascular unit (nvu) which is composed of neurons, astrocytes (ast), microglia (mg), vascular cells and extracellular matrix (ecm), has become an attractive field in ischemic stroke. |
2022-04-25 |
2023-08-13 |
Not clear |
| Guangda Yao, Zijun Bai, Jianguo Niu, Rui Zhang, Youyuan Lu, Tiantian Gao, Hanqing Wan. Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression. Psychopharmacology. 2022-04-12. PMID:35411464. |
however, the effects of ast on perimenopausal depression and the molecular mechanism in regulating microglia polarization remained unknown. |
2022-04-12 |
2023-08-13 |
Not clear |
| V S B Wies Mancini, A A Di Pietro, S de Olmos, P R Silva, M Vence, M Marder, L M Igaz, M S Marcora, J M Pasquini, J D Correale, L A Pasquin. Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model. Journal of neurochemistry. 2021-12-22. PMID:34935149. |
active demyelination and neurodegeneration have also been linked to microglia (mg) and astrocyte (ast)-activation in early lesions. |
2021-12-22 |
2023-08-13 |
mouse |
| Yue Tong, Huiling Fu, Changbo Xia, Wen Song, Yuanjie Li, Jianjun Zhao, Xia Zhang, Xiaojuan Gao, Jingjiao Yong, Quanxia Liu, Caiyan Yang, Hanqing Wan. Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation. ACS chemical neuroscience. vol 11. issue 10. 2021-06-18. PMID:32364698. |
immunohistochemistry revealed ast mitigated cums-induced microglia overactivation. |
2021-06-18 |
2023-08-13 |
Not clear |
| Yukari Shigemoto-Mogami, Kazue Hoshikawa, Kaoru Sat. Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30618641. |
in this study, we investigated this interaction by adding lps-activated microglia (lps-mg) to the abluminal side of a bbb model composed of endothelial cells (ec), pericytes (peri) and astrocytes (ast). |
2020-10-01 |
2023-08-13 |
rat |
| Ying-Li Zhu, Meng-Fei Sun, Xue-Bing Jia, Kun Cheng, Yi-Da Xu, Zhi-Lan Zhou, Pei-Hao Zhang, Chen-Meng Qiao, Chun Cui, Xue Chen, Xu-Sheng Yang, Yan-Qin She. Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress. International immunopharmacology. vol 66. 2019-05-14. PMID:30419450. |
immunofluorescence assays showed that ast reduced the loss of dopaminergic neurons and the activation of microglia and astrocytes in the substantia nigra. |
2019-05-14 |
2023-08-13 |
mouse |
| Praneeti Pathipati, Donna M Ferrier. The Differential Effects of Erythropoietin Exposure to Oxidative Stress on Microglia and Astrocytes in vitro. Developmental neuroscience. vol 39. issue 1-4. 2018-02-13. PMID:28511187. |
despite this, there is a lack of clear understanding of how epo modulates glial cell activity following oxidative injury, specifically, whether it affects microglia (mg) and astrocytes (ast) differently. |
2018-02-13 |
2023-08-13 |
Not clear |
| Chung-Ching Chio, Mao-Tsun Lin, Ching-Ping Chang, Hung-Jung Li. A positive correlation exists between neurotrauma and TGF-β1-containing microglia in rats. European journal of clinical investigation. vol 46. issue 12. 2017-05-03. PMID:27759956. |
both neuro aid™ (mlc601) and astragaloside (ast) attenuate microglia activation in rats with tbi. |
2017-05-03 |
2023-08-13 |
rat |
| Shun-Tai Yang, Jia-Wei Lin, Bi-Ying Chiu, Yao-Chin Hsu, Ching-Ping Chang, Cheng-Kuei Chan. Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation. The American journal of Chinese medicine. vol 42. issue 6. 2015-08-27. PMID:25384449. |
our results indicate that ast may protect against brain contusion and neuronal apoptosis after tbi by attenuating microglia activation in male rats. |
2015-08-27 |
2023-08-13 |
rat |
| Shun-Tai Yang, Jia-Wei Lin, Bi-Ying Chiu, Yao-Chin Hsu, Ching-Ping Chang, Cheng-Kuei Chan. Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation. The American journal of Chinese medicine. vol 42. issue 6. 2015-08-27. PMID:25384449. |
tbi-induced microglial activation evidenced by the morphological transformation of microglia (or ameboid microglia) and the microglial overexpression of tumor necrosis factor-alpha was reduced by ast. |
2015-08-27 |
2023-08-13 |
rat |
| Marios Politis, Nicola Pavese, Yen F Tai, Lorenzo Kiferle, Sarah L Mason, David J Brooks, Sarah J Tabrizi, Roger A Barker, Paola Piccin. Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study. Human brain mapping. vol 32. issue 2. 2011-04-27. PMID:21229614. |
these data suggest that pathologically activated microglia in ast and other areas related to cognitive function, maybe better predictors of clinical onset and stresses the importance of early cognitive assessment in hd. |
2011-04-27 |
2023-08-12 |
Not clear |
| David P Stirling, Kourosh Khodarahmi, Jie Liu, Lowell T McPhail, Christopher B McBride, John D Steeves, Matt S Ramer, Wolfram Tetzlaf. Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 9. 2004-05-14. PMID:14999069. |
minocycline or vehicle control was injected into the intraperitoneal cavity 30 min and 8 hr after sci and thereafter twice daily for 2 d. we report a reduction of apoptotic oligodendrocytes and microglia within both proximal and distal segments of the ast after minocycline treatment, using immunostaining for active caspase-3 and hoechst 33258 staining in combination with cell-specific markers. |
2004-05-14 |
2023-08-12 |
rat |