| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wu Yingping, Lu Lizhi, Li Haiying, Chen Li, Gu Tiantian, Zhao Xiaoyu, Yao Yingying, Li Jiahu. The effect of LINC9137 targeting miR-140-3p-NKAIN3 signal axis on the development of goose testis sertoli cells. Poultry science. vol 103. issue 6. 2024-05-03. PMID:38701630. |
by measuring cell proliferation activity and apoptosis related gene expression, it was found that overexpression of linc9137 decreased cell proliferation activity (p > 0.05), while the expression level of apoptosis factor bcl2 associated x protein (bax)/b-cell lymphoma-2 (bcl2) increased (p > 0.05). |
2024-05-03 |
2024-05-06 |
Not clear |
| Jafar Shahraki, Kaveh Tabrizian, Ramin Rezaee, Behnam Tashakori, Zahra Dadrezaei, Vahideh Ghorani, Gholamreza Bagheri, Hosseinali Jahantigh, Mahmoud Hashemzae. Hesperidin neuroprotective effects against carbon monoxide-induced toxicity in male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2024-05-03. PMID:38700797. |
after evaluation of spatial learning and memory using a morris water maze (mwm), animals were sacrificed and oxidative stress status in blood samples, and akt, bax, bcl2, and brain-derived neurotrophic factor (bdnf) expression in brain samples were assessed. |
2024-05-03 |
2024-05-05 |
rat |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Qiulu Li, Kaixin Ping, Yannan Xiang, YingSun, Zunhan Hu, Shujuan Liu, Xinying Guan, Mian F. Ferulic acid alleviates avermectin induced renal injury in carp by inhibiting inflammation, oxidative stress and apoptosis. Fish & shellfish immunology. 2024-04-25. PMID:38663463. |
at the same time, fa inhibited the apoptosis of renal cells induced by avm by decreasing the transcription level and protein expression level of bax, and increasing the transcription level and protein expression level of bcl2, pi3k and akt. |
2024-04-25 |
2024-04-28 |
cat |
| Firas Khathayer, Mohammed Mikae. Mocetinostat as a novel selective histone deacetylase (HDAC) inhibitor in the promotion of apoptosis in glioblastoma cell line C6 and T98G. Research square. 2024-04-22. PMID:38645087. |
the high doses of mocetinostat drug significantly induce apoptosis and suppress cancer cell proliferation through increased pro-apoptotic proteins (bax) and a down level of anti-apoptotic proteins(bid, bcl2). |
2024-04-22 |
2024-04-24 |
Not clear |
| Lu Zhang, Ying Liu, Qiongyi Zhang, Weiyu Yao, Zenghui Zhao, Xiao Wang, Yongzhan Bao, Wanyu Sh. Salvia miltiorrhiza polysaccharide mitigates AFB1-induced liver injury in rabbits. Ecotoxicology and environmental safety. vol 276. 2024-04-18. PMID:38636259. |
moreover, smp upregulated the expression of nuclear factor e2 related factor 2 (nrf2), heme oxygenase 1 (ho-1), nadph quinone oxidoreductase 1 (nqo1) and b-cell lymphoma 2 (bcl2) while downregulating kelch like ech associated protein 1 (keap1), cytochrome c (cyt.c), caspase9, caspase3, and bcl-2-associated x protein (bax) expression, thereby inhibiting afb1-induced hepatocyte apoptosis. |
2024-04-18 |
2024-04-21 |
cat |
| Wenjie Xie, Juntao Chen, Xiaoqian Cao, Jiannan Zhang, Juanjuan Luo, Yajun Wan. Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells. Ecotoxicology and environmental safety. vol 276. 2024-04-16. PMID:38626605. |
concurrently, abnormal apoptosis in rox-exposed zebrafish embryos intensified alongside the upregulation of apoptosis-related genes (bax, bcl2, caspase-3a). |
2024-04-16 |
2024-04-19 |
human |
| Mohammad Yasin Zamanian, Maryam Golmohammadi, Bekhzod Abdullaev, María Olalla García, Adeeb Abdulally Abdulhussien Alazbjee, Abhinav Kumar, Sameer S Mohaamed, Beneen M Hussien, Fattaneh Khalaj, Seyede Mahsa Hodaei, Niyousha Shirsalimi, Gervason Morias. A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes. Cell biochemistry and function. vol 42. issue 3. 2024-04-08. PMID:38583080. |
the study's findings indicated that nar: (1) interacts with estrogen receptors, (2) regulates the expression of genes related to the p53 signaling pathway, (3) promotes apoptosis by increasing the expression of proapoptotic genes (bax, caspase9, and p53) and downregulation of the antiapoptotic gene bcl2, (4) inhibits the activity of enzymes involved in cell survival and proliferation, (5) decreases cyclin d1 levels, (6) reduces the expression of cyclin-dependent kinases (cdk4, cdk6, and cdk7) and antiapoptotic genes (bcl2, x-iap, and c-iap-2) in crc cells. |
2024-04-08 |
2024-04-10 |
human |
| Shatha M Alobaid, Rahaf M Alshahrani, Asma S Alonazi, Nawal M Alrasheed, Maha A Alamin, Tahani K Alshammari, Anfal F Bin Dayel, Doaa M Elnagar, Rana R Alotaibi, Lama A Almuthnabi, Dalia H Almasud, Shahad E Al-Ammar, Shahad O Almadhi, Reema A Almalke, Nouf T Aldamri, Hanan K Alghibiwi, Dalal A Alkhelb, Nouf M Alrashee. Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus. Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543160. |
western blotting and immunohistochemical studies revealed increased levels of ilk, p-pi3k, p-akt, and bcl2, as well as those of caspase 3, bax, and p-pten, indicating mitigation of cardiomyocyte apoptosis. |
2024-03-28 |
2024-03-30 |
rat |
| Gaiqin Dong, Qingfeng Li, Chun Yu, Qing Wang, Danhua Zuo, Xiaozhong L. n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats. Toxicological research. vol 40. issue 2. 2024-03-25. PMID:38525131. |
the mrna expressions of apoptosis, oxidative stress and inflammatory mediators, including b-cell lymphoma-2 (bcl2), bcl-2-associated x protein (bax), superoxide dismutase (sod), catalase (cat), interleukin 10 (il-10), tumor necrosis factor-α (tnf-α), caspase-3 and caspase-8 were analyzed in kidney tissues using real time pcr method. |
2024-03-25 |
2024-03-27 |
rat |
| Badrah Alghamdi, Emad H M Hassanein, Saif A Alharthy, Reem M Farsi, Steve Harake. Vinpocetine attenuates methotrexate-induced hippocampal intoxication via Keap-1/Nrf2, NF-κB/AP-1, and apoptotic pathways in rats. Drug and chemical toxicology. 2024-03-20. PMID:38508707. |
additionally, vnp attenuated apoptosis by reducing hippocampal bax levels while increasing bcl2 levels in mtx-intoxicated rats. |
2024-03-20 |
2024-03-23 |
rat |
| Prathapan Abeesh, Chandrasekharan Guruvayoorappa. Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 43. issue 2. 2024-03-20. PMID:38505911. |
also, lwa administration remarkably inhibited tumor cell proliferation by downregulating the expression of ki-67 and cyclin d1 and induced apoptosis by regulating the expression of bax, bcl2, and bcl xl levels. |
2024-03-20 |
2024-03-23 |
Not clear |
| Shucan Dong, Shengwei Jiang, Biwei Hou, Yaokun Li, Baoli Sun, Yongqing Guo, Ming Deng, Dewu Liu, Guangbin Li. miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473968. |
the results show that overexpression of mir-128-3p inhibited the proliferation of kgn cells, promoted cell apoptosis, and suppressed the expression of proliferating cell nuclear antigen (pcna) and b-cell lymphoma-2 (bcl2) while promoting that of bcl-2 associated x protein (bax). |
2024-03-13 |
2024-03-15 |
human |
| Xin Zhang, Yujie Huang, Lei Yang, Shuhuang Chen, Youlian Liu, Ni Tang, Zhiqiong Li, Xiaoli Zhang, Liangyu Li, Defang Che. Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces oxidative damage promoting cell apoptosis primarily via mitochondrial pathway in the hepatopancreas of carp, Cyprinus carpio. Ecotoxicology and environmental safety. vol 274. 2024-03-10. PMID:38461574. |
the results of apoptosis pathway genes showed that the mitochondrial pathway genes bax, casp3, and casp9 were significantly upregulated and bcl2 was significantly downregulated, while the transcription levels of fadd and perk were significantly enhanced. |
2024-03-10 |
2024-03-14 |
cat |
| Xiaoqi Ai, Rui Lin, Zeeshan Ali, Qingjun Zhu, Li Ding, Haitao Shi, Meiling Hon. Seasonal changes in hepatic lipid metabolism and apoptosis in Chinese soft-shelled turtle (Pelodiscus sinensis). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-03-04. PMID:38437998. |
also, the expression levels of genes (ask1, jnk1, and bax) associated with cell apoptosis increased in mid-h and ea, however, the expression of bcl2 was inhibited in mid-h. |
2024-03-04 |
2024-03-07 |
Not clear |
| Samyah T Alanazi, Samir A Salama, Ahmed Magdy El-Ebiary, Abdulelah K Altowairqi, Atheer T Alharthi, Shahad M Alzahrani, Shomokh H Althagafi, Reema A Alotaibi, Ahmed Abd-Eltawab Tamma. Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats. Toxicology. 2024-03-03. PMID:38432408. |
in addition, chrysin significantly ameliorated the iol-induced apoptosis as indicated by reduction in caspase-3 activity and modulation of bax and bcl2 protein abundance. |
2024-03-03 |
2024-03-06 |
rat |
| Wei Tan, Yanling Li, Lu Ma, Xinying Fu, Qingyin Long, Fanchen Yan, Wanyu Li, Xiaodan Liu, Huang Ding, Yang Wang, Wei Zhan. Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway. Scientific reports. vol 14. issue 1. 2024-02-23. PMID:38396011. |
notably, epc-exo can adhere to the injured vascular area, promoting enhanced endothelial function and inhibiting vascular endothelial hyperplasia moreover, they regulate the expression of proteins and genes associated with apoptosis, including b-cell lymphoma-2 (bcl2), bcl2-associated x (bax), and caspase-3. |
2024-02-23 |
2024-02-26 |
rat |
| Yilong Guo, Yang Che, Xuelin Zhang, Zongna Ren, Yinan Chen, Liliang Guo, Lin Mao, Ren Wei, Xiang Gao, Tao Zhang, Li Wang, Wei Gu. Cannabidiol protects against acute aortic dissection by inhibiting macrophage infiltration and PMAIP1-induced vascular smooth muscle cell apoptosis. Journal of molecular and cellular cardiology. 2024-02-22. PMID:38387723. |
pmaip1 potentially mediates havsmcs apoptosis by regulating bax and bcl2 expression. |
2024-02-22 |
2024-02-25 |
mouse |
| Stefano Pagano, Chiara Valenti, Paolo Negri, Monia Billi, Alessandro Di Michele, Stefano Bruscoli, Marta Febo, Maddalena Coniglio, Lorella Marinucc. Acute and chronic cannabidiol treatment: In vitro toxicological aspects on human oral cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-11. PMID:38342230. |
viability, morphology, migration, apoptosis and cell cycle, and expression of related genes (p53, bcl2, p21, and bax) and of endocannabinoid system receptors (cb1, cb2 and gpr55) with real-time pcr and dna damage with phospho-γ-h2ax immunofluorescence detection were analyzed. |
2024-02-11 |
2024-02-14 |
human |
| Ribrio Ivan Tavares Pereira Batista, Jenniffer Hauschildt Dias, Joedson Dantas Gonçalves, Gabriel Brun Vergani, Maria Emilia Franco Oliveira, Joanna Maria Gonçalves Souza-Fabjan, Jeferson Ferreira Fonsec. The presence of estradiol benzoate in the cervical relaxation treatment for non-surgical embryo collection does not impair embryonic morphological quality, cryosurvival, and gene expression profile. Theriogenology. vol 218. 2024-02-09. PMID:38335708. |
additionally, the presence of eb did not affect (p > 0.05) the embryo's morphological quality, the development dynamics, or the abundance of transcripts associated with embryonic quality (oct4 and nanog), cellular stress (hsp90 and prdx1), and apoptosis (bcl2 and bax). |
2024-02-09 |
2024-02-12 |
Not clear |