| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Ehsan Arabzadeh, Mirzahossein Norouzi Kamareh, Rodrigo Ramirez-Campillo, Reza Mirnejad, Yousef Masti, Hossein Shirvan. Twelve weeks of treadmill exercise training with green tea extract reduces myocardial oxidative stress and alleviates cardiomyocyte apoptosis in aging rat: The emerging role of BNIP3 and HIF-1α/IGFBP3 pathway. Journal of food biochemistry. 2022-09-07. PMID:36069470. |
in this study, we consider the effect of treadmill exercise training, green tea extract, and combination of exercise training with green tea extract, in aging rat cardiac myocytes apoptosis markers (i.e., hif-1α, bnip3, bax, igfbp3, bcl-2, caspase-3, mda, gpx, bax/bcl-2 ratio, and hematoxylin and eosin). |
2022-09-07 |
2023-08-14 |
rat |
| Wei Sun, Xiuyun Li, Zhaohu Chu, Tingting Huang, Wenqian W. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Central-European journal of immunology. vol 46. issue 4. 2022-02-07. PMID:35125942. |
homogenized hippocampal fractions were determined for the levels of beclin-1, lc3, p53, bax, caspase-3, bnip3, drp1 and nrf2. |
2022-02-07 |
2023-08-13 |
mouse |
| María-Aránzazu Martínez, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, Jorge-Enrique Maximiliano, Jose-Luis Rodríguez, María-Rosa Martínez-Larrañaga, Arturo Anadón, Cesar Peteiro, Susana Rubiño, María Horto. Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 156. 2021-09-14. PMID:34348126. |
moreover, g. baccata extract caused up-regulation of gstm2, nrf2, and akt1 gene expressions, as well as g. baccata extract reduced significantly bax, bnip3, apaf1, erk1, jnk1, mapk1, p38, p53, nfκb1, tnfα, il-6, il-1β and ho-1 gene expressions related to apoptosis, proinflammation and oxidative stress induced by tert-booh. |
2021-09-14 |
2023-08-13 |
Not clear |
| Hongyan Ma, Ying Liu, Zhengtian Li, Lu Yu, Yang Gao, Xiangmei Ye, Baoyi Yang, Hulun Li, Jinghui Sh. Propofol Protects Against Hepatic Ischemia Reperfusion Injury via Inhibiting Bnip3-Mediated Oxidative Stress. Inflammation. vol 44. issue 4. 2021-07-19. PMID:33496895. |
pro ameliorated the abnormal histopathology, reduced cell apoptosis and the levels of ast, alt, bnip3, cleaved caspase-3, and bax, but upregulated the bcl-2 level in the liver tissues of i/r mice. |
2021-07-19 |
2023-08-13 |
mouse |
| María-Aránzazu Martínez, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, Jose-Luis Rodríguez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, Jose-Manuel de la Rosa, Mercedes Cuet. Protective effects of culture extracts (CB08035-SCA and CB08035-SYP) from Marinobacter hydrocarbonoclasticus (strain CB08035) against oxidant-induced stress in human colon carcinoma Caco-2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 145. 2021-05-10. PMID:32784000. |
moreover, cb08035-sca and cb08035-syp treatments reduced significantly bax, bnip3, apaf1, erk1, jnk1, mapk1, nfκb1, tnfα, il-6, il-1β and ho-1 gene expressions of apoptosis, proinflammation and oxidative stress induced by t-booh. |
2021-05-10 |
2023-08-13 |
human |
| Ke Peng, Wei-Rong Chen, Fan Xia, Hong Liu, Xiao-Wen Meng, Juan Zhang, Hua-Yue Liu, Zheng-Yuan Xia, Fu-Hai J. Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-03. PMID:31680420. |
dexmedetomidine administration at the beginning of reperfusion or reoxygenation attenuated i/r-induced myocardial injury or h/r-induced cell death, alleviated mitochondrial dysfunction, reduced the number of apoptotic cardiomyocytes, inhibited the activation of hif-1α and modulated the expressions of apoptosis-related proteins including bcl-2, bax, bnip3, cleaved caspase-3 and cleaved parp. |
2021-05-03 |
2023-08-13 |
rat |
| María-Aránzazu Martínez, Bernardo Lopez-Torres, José-Luis Rodríguez, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, Irma Are. Toxicologic evidence of developmental neurotoxicity of Type II pyrethroids cyfluthrin and alpha-cypermethrin in SH-SY5Y cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 137. 2020-11-30. PMID:32028016. |
we examine, in sh-sy5y cells, whether apoptosis and oxidative stress via reactive oxygen species (ros) generation, caspase 3/7 activation, gene expression (bax, bcl-2, casp-3, bnip3, p53 and nrf2) alterations and necrosis by release of cytosolic adenylate kinase (ak), underlie direct effects of the pyrethroids cyfluthrin and alpha-cypermethrin. |
2020-11-30 |
2023-08-13 |
Not clear |
| Bingru Xu, Liyang Zhu, Jin Chu, Zhanqiang Ma, Qiang Fu, Wei Wei, Xueyang Deng, Shiping M. Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy. Behavioural brain research. vol 372. 2020-08-19. PMID:31238056. |
moreover, mitophagy and mitochondrial apoptosis were stimulated in response to the mitochondrial oxidative stress in the hippocampus of tbccao-treated mice, and esc treatment regulated the expression of mitophagy-related factors, including bnip3, beclin1, pink1, and parkin, the lc-3 ii/i ratio, and apoptosis-related factors, including p53, bax, and caspase 3. |
2020-08-19 |
2023-08-13 |
mouse |
| Jie-Qiong Peng, Shu-Mei Han, Ze-Hao Chen, Jing Yang, Yan-Qing Pei, Cong Bao, Lei Qiao, Wen-Qiang Chen, Bo Li. Chaperone-mediated autophagy regulates apoptosis and the proliferation of colon carcinoma cells. Biochemical and biophysical research communications. vol 522. issue 2. 2020-08-12. PMID:31761324. |
inhibition of cma in ct26 cells facilitated apoptosis, as evidenced by increased tunel immunolabeling, increased expression of bax and bnip3, and decreased expression of bcl-2. |
2020-08-12 |
2023-08-13 |
mouse |
| Ye Li, Xu Zhang, Jian Yang, Yi Zhang, Dongming Zhu, Lifeng Zhang, Yanbo Zhu, Dechun Li, Jian Zho. Methylation of BNIP3 in pancreatic cancer inhibits the induction of mitochondrial-mediated tumor cell apoptosis. Oncotarget. vol 8. issue 38. 2019-11-20. PMID:28968982. |
the expression of bnip3 correlated positively to the proapoptotic protein bax and negatively to the antiapoptotic protein bcl-2, whereas the induction of apoptosis by bnip3 was independent of caspase 3 and 9 activation. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yan Du, Lan-Lan Li, Hao Chen, Cong Wang, Xue-Wen Qian, Yu-Bin Feng, Lei Zhang, Fei-Hu Che. A novel all-trans retinoic acid derivative inhibits proliferation and induces apoptosis of myelodysplastic syndromes cell line SKM-1 cells via up-regulating p53. International immunopharmacology. vol 65. 2019-04-08. PMID:30415163. |
in addition, real-time quantitative rt-pcr (qrt-pcr) and western blotting were used to analyzed the expression of p53, as well as the levels of bnip3, apoptosis proteins of caspase-3, bax and bcl-2. |
2019-04-08 |
2023-08-13 |
Not clear |
| Ulrike B Hendgen-Cotta, Sonja Esfeld, Katharina Rudi, Ilkka Miinalainen, Johann P Klare, Tienush Rassa. Cytosolic BNIP3 Dimer Interacts with Mitochondrial BAX Forming Heterodimers in the Mitochondrial Outer Membrane under Basal Conditions. International journal of molecular sciences. vol 18. issue 4. 2017-04-28. PMID:28333095. |
we investigated the basal distribution of cardiac bnip3 in vivo and its physical interaction with the pro-death protein bcl2 associated x, apoptosis regulator (bax) and with mitochondria using immunoblot analysis, co-immunoprecipitation, and continuous wave and pulsed electron paramagnetic resonance spectroscopy techniques. |
2017-04-28 |
2023-08-13 |
Not clear |
| Decui Shao, Jun Ni, Yang Shen, Jia Liu, Li Zhou, Hong Xue, Yu Huang, Wei Zhang, Limin L. CHOP mediates XBP1S-induced renal mesangial cell necrosis following high glucose treatment. European journal of pharmacology. vol 758. 2016-04-26. PMID:25857226. |
apoptosis and necrosis were quantified by flow cytometry; protein levels of xbp1s, caspase3, bax, bcl2, bnip3, and chop were analyzed by western blotting. |
2016-04-26 |
2023-08-13 |
Not clear |
| Zhouqing Huang, Bozhi Ye, Zhenyu Dai, Xinlei Wu, Zhongqiu Lu, Peiren Shan, Weijian Huan. Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes. Molecular medicine reports. vol 11. issue 6. 2015-12-15. PMID:25673156. |
these findings suggested that the protective effect of curcumin against h/r injury in the h9c2 myocytes was through the inhibition of apoptosis and autophagy by inducing the expression of bcl‑2 and inhibiting the expression levels of bax, beclin‑1, bnip3 and sirt1. |
2015-12-15 |
2023-08-13 |
Not clear |
| Na Li, Yangyan He, Ling Wang, Chunfen Mo, Jie Zhang, Wei Zhang, Junhong Li, Zhiyong Liao, Xiaoqiang Tang, Hengyi Xia. D-galactose induces necroptotic cell death in neuroblastoma cell lines. Journal of cellular biochemistry. vol 112. issue 12. 2012-04-06. PMID:21826710. |
d-gal treatment can transcriptionally up-regulate the genes relevant to necroptosis (bmf, bnip3) and autophagy (atg5, tigar) but not the genes related to apoptosis (caspase3, bax, and p53). |
2012-04-06 |
2023-08-12 |
Not clear |
| Chih-Yang Huang, Yi-Fan Liou, Shu-Ying Chung, Wen-Yuan Lin, Gwo-Ping Jong, Chia-Hua Kuo, Fuu-Jen Tsai, Yi-Chang Cheng, Fu-Chou Cheng, Jing-Ying Li. Role of ERK signaling in the neuroprotective efficacy of magnesium sulfate treatment during focal cerebral ischemia in the gerbil cortex. The Chinese journal of physiology. vol 53. issue 5. 2011-08-18. PMID:21793341. |
in the ipsilateral cortex, a significant increase in the level of the proapoptotic proteins bax, bad, bnip3 and activated caspase 3 were detected at the end of focal ischemia compared to the non-ischemic cortex. |
2011-08-18 |
2023-08-12 |
rat |
| Lu Zhang, Li Li, Heather W Leavesley, Xun Zhang, Joseph L Borowitz, Gary E Iso. Cyanide-induced apoptosis of dopaminergic cells is promoted by BNIP3 and Bax modulation of endoplasmic reticulum-mitochondrial Ca2+ levels. The Journal of pharmacology and experimental therapeutics. vol 332. issue 1. 2010-01-26. PMID:19841471. |
treatment of mice with cyanide up-regulated bnip3 and bax expression in tyrosine hydroxylase (th)-positive cells of the substantia nigra, and progressive loss of th-positive neurons was observed over a 9-day period. |
2010-01-26 |
2023-08-12 |
mouse |
| Lu Zhang, Li Li, Heather W Leavesley, Xun Zhang, Joseph L Borowitz, Gary E Iso. Cyanide-induced apoptosis of dopaminergic cells is promoted by BNIP3 and Bax modulation of endoplasmic reticulum-mitochondrial Ca2+ levels. The Journal of pharmacology and experimental therapeutics. vol 332. issue 1. 2010-01-26. PMID:19841471. |
cyanide-induced apoptosis of dopaminergic cells is promoted by bnip3 and bax modulation of endoplasmic reticulum-mitochondrial ca2+ levels. |
2010-01-26 |
2023-08-12 |
mouse |
| Noömi Lombaert, Dominique Lison, Paul Van Hummelen, Micheline Kirsch-Volder. In vitro expression of hard metal dust (WC-Co)--responsive genes in human peripheral blood mononucleated cells. Toxicology and applied pharmacology. vol 227. issue 2. 2008-03-31. PMID:18078969. |
quantitative rt-pcr data for a selection of the most strongly modulated genes (hmox1, hspa1a, hspa1l, bnip3, bnip3l, adora2b, mt3, pla2g7, tnfaip6), and some additionally chosen apoptosis related genes (bcl2, bax, fas, fasl, tnfalpha), confirmed the microarray data after wc-co exposure and demonstrated limited differences between the co-containing compounds. |
2008-03-31 |
2023-08-12 |
human |