| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| W Chen, H DU, Y Sha, Y Zhou, J Liang, Y Chen, Q Ma, X Wu, G Qia. [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 43. issue 9. 2023-10-10. PMID:37814860. |
to investigate whether long noncoding rna h19 (lncrna h19) induces vascular calcification by promoting calcium deposition, osteogenic differentiation and apoptosis via inhibiting the bax inhibitor 1/optic atrophy 1 (bi-1/ opa1) pathway. |
2023-10-10 |
2023-10-15 |
Not clear |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
results compared with ad group mice, the expression of rock2 in shrock2 group mice was significantly reduced; the cognitive function was significantly improved with the number of neurons in the hippocampal ca3 and dg areas increasing, and nissl bodies were deeply stained; the expression of c-caspase-3 and bax was decreased, while the expression of bcl2 was increased; the expression of mitochondrial division related proteins p-drp1 and fis1 were decreased, while the expression of mitochondrial fusion-related proteins opa1, mfn1 and mfn2 were increased. |
2023-07-29 |
2023-08-14 |
mouse |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
western blot analysis was used to detect the expression rock2, cleaved-caspase-3 (c-caspase-3), b-cell lymphoma 2 (bcl2), bcl2-related protein x (bax), p-drp1, mitochondrial fission 1 (fis1), optic atrophy 1 (opa1), mfn1 and mfn2. |
2023-07-29 |
2023-08-14 |
mouse |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Xiaxia Xiong, Weiping Xiong, Linyuan Li, Juan DU, Daozhuang Wang, Xu Wan. [Down-regulation of miR-29a inhibits mitochondrial fusion and fission in rat H9c2 cardiomyocytes induced by oxygen and glucose deprivation/reoxygenation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 11. 2022-11-03. PMID:36328430. |
western blot analysis was employed to test the levels of bcl2-associated x protein (bax), bcl2 antagonist/killer (bak), caspase-9, mitochondrial fission protein 1(fis1), mitofusin 1 (mfn1), mfn2, optic atrophy 1(opa1), phosphoryerated extracellular signal-regulated kinase (p-erk) and phosphoryerated dynamin related protein-1(p-drp1). |
2022-11-03 |
2023-08-14 |
rat |
| Rachel J Carter, Mateus Milani, Alison J Beckett, Shiyu Liu, Ian A Prior, Gerald M Cohen, Shankar Varadaraja. Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis. Cell death & disease. vol 13. issue 5. 2022-05-04. PMID:35508606. |
further mechanistic studies reveal that climp-63 is required for cristae remodeling (opa1 proteolysis) and drp1-mediated mitochondrial fission, whereas both rtn4 and climp-63 regulate the recruitment of bax to er and mitochondrial membranes to enable cytochrome c release and apoptosis, thereby performing novel and distinct roles in the regulation of mitochondrial structure and function. |
2022-05-04 |
2023-08-13 |
Not clear |
| W Chen, H DU, G Qian, Y Zhou, Y Chen, Q Ma, X Wu, Y Sh. [Bax inhibitor 1 inhibits vascular calcification in mice by activating optic atrophy 1 expression]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 42. issue 3. 2022-04-15. PMID:35426795. |
to investigate the effects of bax inhibitor 1 (bi- 1) and optic atrophy protein 1 (opa1) on vascular calcification (vc). |
2022-04-15 |
2023-08-13 |
mouse |
| Nancy P Gómez-Crisóstomo, Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Erick N De la Cruz-Hernández, Corazón de María Márquez Álvarez, Pablo Alexis Estrada Caraveo, Noemí Gelista Herrera, Marlen Valdés-Fuentes, Eduardo Martínez-Abundi. Chronic exposition to ozone induces cardiac antioxidant response and overexpression of either mitochondrial fision protein DRP1 and hipertrophyc-related proteins. Journal of bioenergetics and biomembranes. 2022-03-29. PMID:35347511. |
oxidative stress was evaluated by tbars and protein nitrosylation in addition to superoxide dismutase 1 (sod1) and catalase levels; the apoptosis related-proteins caspase 3, caspase 9, bax, bcl-2, and the mitochondrial dynamic-associated proteins fis1, drp1, opa1, and mfn1 were quantified by western blot among the cardiac hypertrophy indicator alpha-actin (cardiac actin). |
2022-03-29 |
2023-08-13 |
rat |
| Siwen Li, Hongjing Zhao, Yu Wang, Yizhi Shao, Juanjuan Liu, Mingwei Xin. Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens. Poultry science. vol 98. issue 2. 2019-03-06. PMID:30339249. |
further quantitative real-time pcr demonstrated that b cell lymphoma/leukemia 2 (bcl2) were significantly decreased and dynamin-related protein 1 (drp1), optic atrophy 1 (opa1), mitochondrial fission factor 1 (mfn1), mfn2, p53, caspase-8, bcl-2 associated x protein (bax), caspase-3, caspase-9 and cytochrome c were significantly increased in all as2o3 group. |
2019-03-06 |
2023-08-13 |
chicken |
| Luis Bonet-Ponce, Sara Saez-Atienzar, Carmen da Casa, Miguel Flores-Bellver, Jorge M Barcia, Javier Sancho-Pelluz, Francisco J Romero, Joaquín Jordan, María F Galind. On the mechanism underlying ethanol-induced mitochondrial dynamic disruption and autophagy response. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25779081. |
these findings suggest that cells respond to ethanol activating mitochondrial fission machinery by drp1 and opa1 rather than bax, in a manner that stimulates cytoprotective autophagy through mitochondrial ros. |
2015-08-27 |
2023-08-13 |
mouse |
| Ryuji Yamaguchi, Lydia Lartigue, Guy Perkins, Ray T Scott, Amruta Dixit, Yulia Kushnareva, Tomomi Kuwana, Mark H Ellisman, Donald D Newmeye. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Molecular cell. vol 31. issue 4. 2008-09-16. PMID:18691924. |
pharmacological blockade of momp did not prevent opa1 disassembly and cjo; moreover, expression of a disassembly-resistant mutant opa1 (q297v) blocked cytochrome c release and apoptosis but not bax activation. |
2008-09-16 |
2023-08-12 |
Not clear |
| Christian Frezza, Sara Cipolat, Olga Martins de Brito, Massimo Micaroni, Galina V Beznoussenko, Tomasz Rudka, Davide Bartoli, Roman S Polishuck, Nika N Danial, Bart De Strooper, Luca Scorran. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell. vol 126. issue 1. 2006-08-28. PMID:16839885. |
opa1 does not interfere with activation of the mitochondrial "gatekeepers" bax and bak, but it controls the shape of mitochondrial cristae, keeping their junctions tight during apoptosis. |
2006-08-28 |
2023-08-12 |
Not clear |