| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Sohair M Salem, Ahmed R Hamed, Rehab M Mosaa. MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-31. PMID:28802228. |
herein, we aimed to explore whether mir-375, mir-145, and mir-224 are involved in induction of apoptosis of crc cells by regulating apoptosis-mediating genes mtdh, map3k1, pdk1, bax, and bcl-xl. |
2018-05-31 |
2023-08-13 |
Not clear |
| Sohair M Salem, Ahmed R Hamed, Rehab M Mosaa. MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-31. PMID:28802228. |
the study concluded that the expression modulation of tumor suppressors mir-375 and mir-145, and oncomir mir-224 have the ability to induce apoptosis of crc cells through regulation of apoptosis mediating genes mtdh, map3k1, pdk1, bcl-xl and bax. |
2018-05-31 |
2023-08-13 |
Not clear |
| Fanjun Meng, Yuxia Zhang, Xing Li, Juan Wang, Zhiyu Wan. Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway. Oncology reports. vol 38. issue 3. 2018-04-25. PMID:28731179. |
ly294002, an inhibitor of pi3k, suppressed pi3k/akt/mtor signaling, induced apoptosis, inhibited cell proliferation, increased caspase-3 and bax protein expression, and decreased pdk1 protein expression in a2058 cells following mir-138 overexpression. |
2018-04-25 |
2023-08-13 |
human |