| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Izabela Jatczak-Pawlik, Alicja Ewiak-Paszyńska, Małgorzata Domowicz, Anna Jurewicz, Mariusz Stasiołe. Intracellular Accumulation and Secretion of YKL-40 (CHI3L1) in the Course of DMSO-Induced HL-60 Cell Differentiation. Pharmaceuticals (Basel, Switzerland). vol 17. issue 4. 2024-04-27. PMID:38675403. |
ykl-40 (chi3l1) is a matrix glycoprotein stored in human neutrophil-specific granules and released upon activation. |
2024-04-27 |
2024-04-29 |
human |
| Yu Xiao, Jieqi Qian, Xiaohui Deng, Huifeng Zhang, Jiancheng Wang, Zhijun Luo, Lingyan Zh. Macrophages regulate healing-associated fibroblasts in diabetic wound. Molecular biology reports. vol 51. issue 1. 2024-01-25. PMID:38270651. |
recently, a fibroblast subpopulation that expresses high matrix metalloproteinase 1 (mmp1), mmp3, mmp11 and chitinase-3-like protein 1 (chi3l1) was associated with a successful diabetic wound healing. |
2024-01-25 |
2024-01-27 |
Not clear |
| Ji Eun Yu, In Jun Yeo, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, Jin Tae Hon. Anti-Chi3L1 antibody suppresses lung tumor growth and metastasis through inhibition of M2 polarization. Molecular oncology. 2021-12-03. PMID:34861103. |
chitinase 3 like 1 (chi3l1) is associated with various biological processes, such as inflammation, tissue repair, proliferation, cell survival, invasion and extracellular matrix remodeling. |
2021-12-03 |
2023-08-13 |
mouse |
| Long Li, Kang Wei, Yifan Ding, Paerxiati Ahati, Haoran Xu, Huang Fang, Huan Wan. M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances Frontiers in immunology. vol 12. 2021-10-14. PMID:34168643. |
m2a macrophage-secreted chi3l1 promotes extracellular matrix metabolic imbalances the accumulation of macrophages in degenerated discs is a common phenomenon. |
2021-10-14 |
2023-08-13 |
human |
| Jeong-Sun Han, Sung Eun Kim, Jun-Qing Jin, Na Ri Park, Ji-Young Lee, Hong Lim Kim, Seong-Beom Lee, Suk-Woo Yang, Dong-Jun Li. Tear-Derived Exosome Proteins Are Increased in Patients with Thyroid Eye Disease. International journal of molecular sciences. vol 22. issue 3. 2021-09-03. PMID:33498689. |
the expression levels of exosomal proteins vitamin d-binding (vdb) protein, c-reactive protein (crp), chitinase 3-like 1 (chi3l1), matrix metalloproteinase-9 (mmp-9), and vascular adhesion molecule-1 (vcam-1) were significantly increased in patients with ted, compared to those of controls. |
2021-09-03 |
2023-08-13 |
human |
| Gustavo Ramos-Espinosa, Yuanyuan Wang, Johanna M Brandner, Stefan W Schneider, Christian Gorzelann. Melanoma Associated Chitinase 3-Like 1 Promoted Endothelial Cell Activation and Immune Cell Recruitment. International journal of molecular sciences. vol 22. issue 8. 2021-05-13. PMID:33920100. |
previous research indicated that chi3l1 is able to interact with different extracellular matrix components, such as heparan sulfate. |
2021-05-13 |
2023-08-13 |
Not clear |
| Gustavo Ramos-Espinosa, Yuanyuan Wang, Johanna M Brandner, Stefan W Schneider, Christian Gorzelann. Melanoma Associated Chitinase 3-Like 1 Promoted Endothelial Cell Activation and Immune Cell Recruitment. International journal of molecular sciences. vol 22. issue 8. 2021-05-13. PMID:33920100. |
in the present work, we investigated whether the interaction of chi3l1 with the extracellular matrix of melanoma cells can trigger an inflammatory activation of endothelial cells. |
2021-05-13 |
2023-08-13 |
Not clear |
| Shima Abed Kahnamouei, Kaveh Baghaei, Parviz Pakzad, Mehrdad Hashemi, Mohammad Reza Zal. The role of extracellular matrix proteins in gastric cancer development via epithelial-mesenchymal transition. Gastroenterology and hepatology from bed to bench. vol 13. issue Suppl1. 2021-02-16. PMID:33585016. |
to acquire a deeper perception of emt, we evaluated the expression of some candidate extra cellular matrix (ecm) proteins including thbs2, osmr and chi3l1 which were collected from rna-seq bioinformatic analyses. |
2021-02-16 |
2023-08-13 |
Not clear |
| Ruizhe Wang, Chen Xu, Huajian Zhong, Bo Hu, Leixin Wei, Ning Liu, Yizhi Zhang, Qianghui Shi, Chen Wang, Min Qi, Yifei Gu, Xiaolong Shen, Ye Tian, Yang Liu, Peng Cao, Huajiang Chen, Wen Yua. Inflammatory-sensitive CHI3L1 protects nucleus pulposus via AKT3 signaling during intervertebral disc degeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 3. 2021-01-25. PMID:31997395. |
overexpression of chi3l1 significantly decrease the catabolism, and increase the anabolism of extracellular matrix. |
2021-01-25 |
2023-08-13 |
mouse |
| b' R\\xc5\\xabta Urbanavi\\xc4\\x8di\\xc5\\xabt\\xc4\\x97, K\\xc4\\x99stutis Skauminas, Daina Skiriut\\xc4\\x9. The Evaluation of AREG, MMP-2, CHI3L1, GFAP, and OPN Serum Combined Value in Astrocytic Glioma Patients\' Diagnosis and Prognosis. Brain sciences. vol 10. issue 11. 2020-12-01. PMID:33227903.' |
the aim of this study was to select the most promising astrocytoma patient overall survival prediction variables from five secretory proteins-glial fibrillary acidic protein (gfap), matrix metalloproteinase-2 (mmp-2), chitinase 3-like 1 (chi3l1), osteopontin (opn), and amphiregulin (areg)-combining them with routinely used tumor markers to create a patient survival score calculation tool. |
2020-12-01 |
2023-08-13 |
Not clear |
| Tim Ruhl, Jan-Philipp Stromps, Lisa-Marie Maxi Depenau, Bong-Sung Kim, Norbert Pallu. Concentration of Chondrogenic Soluble Factors in Freshly Harvested Lipoaspirate. Annals of plastic surgery. vol 83. issue 3. 2020-10-13. PMID:30994491. |
bone morphogenetic protein 4 (bmp4), matrix metalloproteinase (mmp)-8, cartilage oligomeric matrix protein (comp), and chitinase-3-like protein 1 (chi3l1) have been shown to be involved in chondrogenic regeneration and represent potential therapeutic agents for cartilage repair. |
2020-10-13 |
2023-08-13 |
Not clear |
| Gerhard Hamilton, Barbara Rat. Circulating tumor cell interactions with macrophages: implications for biology and treatment. Translational lung cancer research. vol 6. issue 4. 2020-10-01. PMID:28904886. |
sclc ctcs recruit macrophages and elicit secretion of various cytokines and the six ctc lines express chitinase-3-like-1 (chi3l1), vascular endothelial growth factor (vegf) and matrix metalloproteinase-9 (mmp9) in abundance. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jaehwan Kim, Lewis Tomalin, Julie Lee, Lori J Fitz, Gabriel Berstein, Joel Correa-da Rosa, Sandra Garcet, Michelle A Lowes, Hernan Valdez, Robert Wolk, Mayte Suarez-Farinas, James G Kruege. Reduction of Inflammatory and Cardiovascular Proteins in the Blood of Patients with Psoriasis: Differential Responses between Tofacitinib and Etanercept after 4 Weeks of Treatment. The Journal of investigative dermatology. vol 138. issue 2. 2019-03-07. PMID:28927890. |
tumor necrosis factor receptor 1, e-selectin, hk11, tumor necrosis factor-related activation-induced cytokine, chi3l1, il-16, and matrix metalloproteinase-12 were cardiovascular proteins significantly reduced only in tofacitinib responders. |
2019-03-07 |
2023-08-13 |
Not clear |
| Yonggang Xu, Jie Wang, Yanbin Xu, Hong Xiao, Jianhua Li, Zhi Wan. Screening critical genes associated with malignant glioma using bioinformatics analysis. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901452. |
functional enrichment analyses showed that matrix metalloproteinase 9 (mmp9) and chitinase 3‑like 1 (chi3l1) were enriched in the extracellular matrix and extracellular matrix structural constituent, respectively. |
2018-06-04 |
2023-08-13 |
Not clear |
| Gerhard Hamilton, Barbara Rath, Ernst Ulsperge. How to target small cell lung cancer. Oncoscience. vol 2. issue 8. 2015-10-01. PMID:26425658. |
most important, expression of chitinase-3-like-1/ykl-40 (chi3l1) which controls expression of vascular epithelial growth factor (vegf) and matrix metalloproteinase-9 (mmp9) was newly described in these cells. |
2015-10-01 |
2023-08-13 |
Not clear |
| Yang Zhou, Hong Peng, Huanxing Sun, Xueyan Peng, Chuyan Tang, Ye Gan, Xiaosong Chen, Aditi Mathur, Buqu Hu, Martin D Slade, Ruth R Montgomery, Albert C Shaw, Robert J Homer, Eric S White, Chang-Min Lee, Meagan W Moore, Mridu Gulati, Chun Geun Lee, Jack A Elias, Erica L Herzo. Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis. Science translational medicine. vol 6. issue 240. 2015-01-23. PMID:24920662. |
in this model, chi3l1 played a protective role in injury by ameliorating inflammation and cell death, and a profibrotic role in the repair phase by augmenting alternative macrophage activation, fibroblast proliferation, and matrix deposition. |
2015-01-23 |
2023-08-13 |
mouse |
| Stephania Libreros, Ramon Garcia-Areas, Yoshimi Shibata, Roberto Carrio, Marta Torroella-Kouri, Vijaya Iragavarapu-Charyul. Induction of proinflammatory mediators by CHI3L1 is reduced by chitin treatment: decreased tumor metastasis in a breast cancer model. International journal of cancer. vol 131. issue 2. 2012-07-30. PMID:21866546. |
we demonstrate that while chi3l1 has an inhibitory role in the expression of interferon-gamma (ifn-γ), chi3l1 up-regulates pro-inflammatory mediators, c-chemokine ligand 2 (ccl2), chemokine cx motif ligand 2 (cxcl2) and matrix metalloproteinase-9 (mmp-9) all of which contribute to tumor growth and metastasis. |
2012-07-30 |
2023-08-12 |
mouse |
| Bo Mi Ku, Yeon Kyung Lee, Jinhyun Ryu, Joo Yeon Jeong, Jungil Choi, Keyoung Mi Eun, Hye Young Shin, Dong Gyu Kim, Eun Mi Hwang, Jae Cheal Yoo, Jae-Yong Park, Gu Seob Roh, Hyun Joon Kim, Gyeong Jae Cho, Wan Sung Choi, Sun Ha Paek, Sang Soo Kan. CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells. International journal of cancer. vol 128. issue 6. 2011-03-24. PMID:20506295. |
furthermore, the expression and activity of matrix metalloproteinase-2 was also decreased in glioma cells in which chi3l1 was knocked down. |
2011-03-24 |
2023-08-12 |
human |
| Katrin Eurich, Mayuko Segawa, Satoko Toei-Shimizu, Emiko Mizoguch. Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells. World journal of gastroenterology. vol 15. issue 42. 2010-02-25. PMID:19908331. |
although the exact function of chi3l1 in inflammation and cancer is still largely unknown, chi3l1 plays a pivotal role in exacerbating the inflammatory processes and in promoting angiogenesis and remodeling of the extracellular matrix. |
2010-02-25 |
2023-08-12 |
Not clear |
| Kimi C Nishikawa, Albert J T Milli. gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Experimental cell research. vol 287. issue 1. 2003-07-31. PMID:12799184. |
gp38k (chi3l1) is a secreted heparin-binding glycoprotein whose expression, in vitro, is associated with vascular smooth muscle cell (vsmc) migration and invasion into the underlying gelatinous matrix. |
2003-07-31 |
2023-08-12 |
Not clear |