| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samuel Bridge, Sophia N Karagiannis, Alessandra Borsin. The complex role of the chemokine CX3CL1/Fractalkine in major depressive disorder: A narrative review of preclinical and clinical studies. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706575. |
our narrative review focuses on the role of the chemokine fractalkine (fkn) (also known as cx3cl1), which has gained increasing interest for its ability to induce changes to microglial phenotypes through interaction with its corresponding receptor (cx3cr1) that may impact neurophysiological processes relevant to mdd. |
2024-05-06 |
2024-05-08 |
mouse |
| Chunmei Zhang, Yusi Zhang, Ran Zhuang, Kun Yang, Lihua Chen, Boquan Jin, Ying Ma, Yun Zhang, Kang Tan. Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674036. |
cx3cl1 signals are transmitted through its unique receptor, cx3cr1, primarily expressed in the microglia of the central nervous system (cns). |
2024-04-27 |
2024-04-29 |
human |
| Ping Li, Yang Liu, Man-Shu Zou, Ting-Ting Wang, Hai-Peng Guo, Ting-Ting Ren, Ying He, Hua Wang, Yu-Hong Wan. [Neuroprotective effect and mechanism of Zuogui Jiangtang Jieyu Formula on diabetes mellitus complicated with depression model rats based on CX3CL1-CX3CR1 axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114178. |
based on the cx3c chemokine ligand 1(cx3cl1)-cx3c chemokine receptor 1(cx3cr1) axis, this study explored the potential mechanism by which zuogui jiangtang jieyu formula(zgjtjy) improved neuroinflammation and enhanced neuroprotective effect in a rat model of diabetes mellitus complicated with depression(dd). |
2023-12-19 |
2023-12-23 |
rat |
| Ping Li, Yang Liu, Man-Shu Zou, Ting-Ting Wang, Hai-Peng Guo, Ting-Ting Ren, Ying He, Hua Wang, Yu-Hong Wan. [Neuroprotective effect and mechanism of Zuogui Jiangtang Jieyu Formula on diabetes mellitus complicated with depression model rats based on CX3CL1-CX3CR1 axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114178. |
western blot was used to measure the expression levels of cx3cl1, cx3cr1, a2a adenosine receptor(a2ar), glutamate receptor 2a(nr2a), glutamate receptor 2b(nr2b), and brain-derived neurotrophic factor(bdnf) in the hippocampus. |
2023-12-19 |
2023-12-23 |
rat |
| Z W Huang, Y Y Liu, X M Chen, C L Yu, H Y He, Y H Den. Attenuating Neuronal Autophagy Alleviates Inflammatory Injury in OGDDeprived Co-culture of HT22 with BV2. Acta naturae. vol 15. issue 3. 2023-11-01. PMID:37908770. |
neuronal cx3cl1 suppressed microglial inflammation by binding to its receptor cx3cr1 expressed on microglia. |
2023-11-01 |
2023-11-08 |
Not clear |
| Matilda Iemmolo, Giulio Ghersi, Giulia Bivon. The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175729. |
cx3cl1, as an adhesion molecule, on the one hand, plays an inhibiting role in the pro-inflammatory response in the central nervous system (cns) and shows neuroprotective effects by binding its membrane receptor (cx3cr1) present into microglia cells and maintaining them in a quiescent state; on the other hand, the scx3cl1 isoform seems to promote neurodegeneration. |
2023-05-14 |
2023-08-14 |
Not clear |
| Zhihua Lu, Aihua Zhang, Yan Da. CX3CL1 deficiency ameliorates inflammation, apoptosis and accelerates osteogenic differentiation, mineralization in LPS-treated MC3T3-E1 cells via its receptor CX3CR1. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2022-11-27. PMID:36436718. |
cx3cl1 deficiency ameliorates inflammation, apoptosis and accelerates osteogenic differentiation, mineralization in lps-treated mc3t3-e1 cells via its receptor cx3cr1. |
2022-11-27 |
2023-08-14 |
Not clear |
| Anna Bagó-Mas, Andrea Korimová, Meritxell Deulofeu, Enrique Verdú, Núria Fiol, Viktorie Svobodová, Petr Dubový, Pere Boadas-Vaell. Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury-induced neuropathic pain development in ICR-CD1 female mice. Scientific reports. vol 12. issue 1. 2022-09-02. PMID:36056079. |
then, gliosis, erk phosphorylation and the expression of ccl2 and cx3cl1 chemokines and their receptors, ccr2 and cx3cr1, were analyzed in the spinal cord. |
2022-09-02 |
2023-08-14 |
mouse |
| Yangyang Ge, Li Wang, Chenchen Wang, Jiayi Chen, Maosha Dai, Shanglong Yao, Yun Li. CX3CL1 inhibits NLRP3 inflammasome-induced microglial pyroptosis and improves neuronal function in mice with experimentally-induced ischemic stroke. Life sciences. 2022-04-24. PMID:35461837. |
the chemokine cx3cl1 and its receptor cx3cr1 play a fundamental role in the pathophysiology of ischemic stroke. |
2022-04-24 |
2023-08-13 |
mouse |
| Cankun Zheng, Wanling Xuan, Zhenhuan Chen, Rui Zhang, Xiaoxia Huang, Yingqi Zhu, Siyuan Ma, Kaitong Chen, Lu Chen, Mingyuan He, Hairuo Lin, Wangjun Liao, Jianping Bin, Yulin Lia. CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome. Frontiers in pharmacology. vol 13. 2022-04-04. PMID:35370759. |
in the two diabetic mouse models, knockout of cx3cl1 receptor cx3cr1 or treatment with an cx3cl1 neutralizing antibody significantly improved cardiorenal dysfunction by inhibiting apoptosis, mitochondrial dysfunction, and fibrosis. |
2022-04-04 |
2023-08-13 |
mouse |
| Lu Zheng, Yi Wang, Bin Shao, Huijuan Zhou, Xing Li, Cai Zhang, Ning Sun, Jing Sh. Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice. Neuroscience bulletin. 2022-03-30. PMID:35352285. |
tia promoted the interaction of anxa1 and cx3cr1, increased the membrane distribution of cx3cr1 in microglia, and thus enhanced the cx3cr1 and cx3cl1 interaction. |
2022-03-30 |
2023-08-13 |
mouse |
| Jing Cao, Hui Gan, Han Xiao, Hui Chen, Dan Jian, Dan Jian, Xuan Zha. Key protein-coding genes related to microglia in immune regulation and inflammatory response induced by epilepsy. Mathematical biosciences and engineering : MBE. vol 18. issue 6. 2021-12-09. PMID:34814358. |
meanwhile, several genes, including cx3cr1, cx3cl1, gpr183, fpr1, p2ry13, p2ry12 and lpar5, were associated with microglial activation and migration, providing novel candidate targets for immunotherapy in epilepsy and laying the foundation for further research. |
2021-12-09 |
2023-08-13 |
mouse |
| Qingxiu Zhang, Lei He, Mo Chen, Hui Yang, Xiaowei Cao, Xiaomei Liu, Qi Hao, Zhengwei Chen, Tengfei Liu, Xiu-E Wei, Liangqun Ron. PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:33599284. |
cx3 chemokine ligand 1 (cx3cl1) is a chemokine specifically expressed in neurons while its receptor cx3cr1 is highly expressed in microglia. |
2021-08-24 |
2023-08-13 |
mouse |
| Katharina Sessler, Vivian Blechschmidt, Ulrich Hoheisel, Siegfried Mense, Lucas Schirmer, Rolf-Detlef Treed. Spinal cord fractalkine (CX3CL1) signaling is critical for neuronal sensitization in experimental nonspecific, myofascial low back pain. Journal of neurophysiology. vol 125. issue 5. 2021-08-17. PMID:33596743. |
an important feedback loop mechanism is via release of fractalkine (cx3cl1) from primary afferent terminals and dorsal horn neurons and binding to cx3cr1 receptors on microglial cells. |
2021-08-17 |
2023-08-13 |
Not clear |
| Bingjie Qin, Ni Luo, Yuxing Li, Denghui Gong, Jun Zheng, Xiao Tan, Weihong Zhen. Protective effect of gastrodin on peripheral neuropathy induced by anti-tumor treatment with vincristine in rat models. Drug and chemical toxicology. vol 44. issue 1. 2021-08-03. PMID:30554535. |
gastrodin relieved cipn by inhibiting activation of spinal microglia through fractalkine (cx3cl1) and its receptor cx3cr1, then inhibited p38/mitogen-activated protein kinase (mapk) signaling pathway and reduced the expression of inflammatory factor tnf-α and interleukin-1β (il-1β). |
2021-08-03 |
2023-08-13 |
human |
| Marta González-Prieto, Irene L Gutiérrez, Borja García-Bueno, Javier R Caso, Juan C Leza, Adriana Ortega-Hernández, Dulcenombre Gómez-Garre, José L M Madriga. Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline. Glia. vol 69. issue 1. 2021-07-28. PMID:32662924. |
the activation of microglial cx3cr1, sole receptor for cx3cl1, reduces the activation of microglia, which is known to largely contribute to the neuronal damage characteristic of ad. |
2021-07-28 |
2023-08-13 |
mouse |
| Marta González-Prieto, Irene L Gutiérrez, Borja García-Bueno, Javier R Caso, Juan C Leza, Adriana Ortega-Hernández, Dulcenombre Gómez-Garre, José L M Madriga. Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline. Glia. vol 69. issue 1. 2021-07-28. PMID:32662924. |
therefore, alterations of cx3cr1 production in microglia could translate into the enhancement or inhibition of cx3cl1 anti-inflammatory effects. |
2021-07-28 |
2023-08-13 |
mouse |
| Efthalia Angelopoulou, Yam Nath Paudel, Mohd Farooq Shaikh, Christina Piper. Fractalkine (CX3CL1) signaling and neuroinflammation in Parkinson's disease: Potential clinical and therapeutic implications. Pharmacological research. vol 158. 2021-06-03. PMID:32445958. |
fractalkine (cx3cl1), a chemokine mainly expressed by neurons, can modulate microglial activity through binding to its sole g-protein-coupled receptor (cx3cr1), expressed by microglia. |
2021-06-03 |
2023-08-13 |
mouse |
| Ye Liu, Tianxiang Zhang, Dewang Meng, Li Sun, Guili Yang, Yating He, Chao Zhan. Involvement of CX3CL1/CX3CR1 in depression and cognitive impairment induced by chronic unpredictable stress and relevant underlying mechanism. Behavioural brain research. vol 381. 2021-05-26. PMID:31765724. |
a major participant in neuroinflammation is microglia, and fractalkine signaling (which comprises the chemokine cx3cl1, mainly expressed by neurons, and its receptor cx3cr1, almost exclusively present on microglia in healthy brains) has been reported to critically regulate microglial activity. |
2021-05-26 |
2023-08-13 |
human |
| Qin Wu, Yuping Chen, Wenying Zhang, Siyuan Song, Ziyang Xu, Hong Zhang, Liping Liu, Jihu Su. Upregulation of Chemokines in the Paraventricular Nucleus of the Hypothalamus in Rats with Stress-Induced Hypertension. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-21. PMID:33199674. |
the numbers of cx3cr1 (receptor of cx3cl1)-immunostained cells and oxycocin-42 (ox-42, marker of microglia)-positive cells increased in pvn of the sih rats. |
2021-05-21 |
2023-08-13 |
rat |