| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunmei Zhang, Yusi Zhang, Ran Zhuang, Kun Yang, Lihua Chen, Boquan Jin, Ying Ma, Yun Zhang, Kang Tan. Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674036. |
cx3cl1 signals are transmitted through its unique receptor, cx3cr1, primarily expressed in the microglia of the central nervous system (cns). |
2024-04-27 |
2024-04-29 |
human |
| Chunmei Zhang, Yusi Zhang, Ran Zhuang, Kun Yang, Lihua Chen, Boquan Jin, Ying Ma, Yun Zhang, Kang Tan. Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674036. |
in the cns, cx3cl1 acts as a regulator of microglia activation in response to brain disorders or inflammation. |
2024-04-27 |
2024-04-29 |
human |
| Z W Huang, Y Y Liu, X M Chen, C L Yu, H Y He, Y H Den. Attenuating Neuronal Autophagy Alleviates Inflammatory Injury in OGDDeprived Co-culture of HT22 with BV2. Acta naturae. vol 15. issue 3. 2023-11-01. PMID:37908770. |
neuronal cx3cl1 suppressed microglial inflammation by binding to its receptor cx3cr1 expressed on microglia. |
2023-11-01 |
2023-11-08 |
Not clear |
| Matilda Iemmolo, Giulio Ghersi, Giulia Bivon. The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175729. |
cx3cl1, as an adhesion molecule, on the one hand, plays an inhibiting role in the pro-inflammatory response in the central nervous system (cns) and shows neuroprotective effects by binding its membrane receptor (cx3cr1) present into microglia cells and maintaining them in a quiescent state; on the other hand, the scx3cl1 isoform seems to promote neurodegeneration. |
2023-05-14 |
2023-08-14 |
Not clear |
| Giulia Bivona, Matilda Iemmolo, Giulio Ghers. CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175935. |
among the molecules known to influence the baseline status of microglia, c-x3-chemokine ligand 1 (cx3cl1), also known as fractalkine (fkn), is one of the most investigated. |
2023-05-14 |
2023-08-14 |
Not clear |
| Giulia Bivona, Matilda Iemmolo, Giulio Ghers. CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175935. |
cx3cl1 has an effect on aβ clearance and tau phosphorylation, as well as in microglia activation and priming. |
2023-05-14 |
2023-08-14 |
Not clear |
| Xiao-Wei Cao, Hui Yang, Xiao-Mei Liu, Shi-Ying Lou, Li-Ping Kong, Liang-Qun Rong, Jun-Jun Shan, Yun Xu, Qing-Xiu Zhan. Blocking postsynaptic density-93 binding to C-X3-C motif chemokine ligand 1 promotes microglial phenotypic transformation during acute ischemic stroke. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254989. |
we previously reported that postsynaptic density-93 mediates neuron-microglia crosstalk by interacting with amino acids 357-395 of c x3 c motif chemokine ligand 1 (cx3cl1) to induce microglia polarization. |
2022-10-18 |
2023-08-14 |
Not clear |
| Jineta Banerjee, Mauricio D Dorfman, Rachael Fasnacht, John D Douglass, Alice C Wyse-Jackson, Andres Barria, Joshua P Thale. CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742824. |
cx3cl1 action on microglia protects from diet-induced obesity by restoring pomc neuronal excitability and melanocortin system activity impaired by high-fat diet feeding. |
2022-06-24 |
2023-08-14 |
mouse |
| Lu Zheng, Yi Wang, Bin Shao, Huijuan Zhou, Xing Li, Cai Zhang, Ning Sun, Jing Sh. Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice. Neuroscience bulletin. 2022-03-30. PMID:35352285. |
tia promoted the interaction of anxa1 and cx3cr1, increased the membrane distribution of cx3cr1 in microglia, and thus enhanced the cx3cr1 and cx3cl1 interaction. |
2022-03-30 |
2023-08-13 |
mouse |
| Koichi Inou. Potential significance of CX3CR1 dynamics in stress resilience against neuronal disorders. Neural regeneration research. vol 17. issue 10. 2022-03-09. PMID:35259822. |
fractalkine (fkn or cx3cl1) signaling is an important factor that influences the inflammatory response of microglia. |
2022-03-09 |
2023-08-13 |
human |
| Cooper A Brett, Julianne B Carroll, Mark L Gabriel. Compromised fractalkine signaling delays microglial occupancy of emerging modules in the multisensory midbrain. Glia. vol 70. issue 4. 2022-02-08. PMID:35132709. |
cx3cl1 expression becomes distinctly modular at p12, in keeping with the notion of fractalkine-mediated recruitment of microglia to modular centers. |
2022-02-08 |
2023-08-13 |
mouse |
| Xiu-Juan Bai, Lei Hao, Yan-E Guo, Xiao-Bing Shi, Wei-Ping W. Bone marrow stromal cells reverse the microglia type from pro-inflammatory tumour necrosis factor a microglia to anti-inflammatory CD206 microglia of middle cerebral artery occlusion rats through triggering secretion of CX3CL1. Folia neuropathologica. vol 59. issue 1. 2021-11-25. PMID:33969675. |
bone marrow stromal cells reverse the microglia type from pro-inflammatory tumour necrosis factor a microglia to anti-inflammatory cd206 microglia of middle cerebral artery occlusion rats through triggering secretion of cx3cl1. |
2021-11-25 |
2023-08-13 |
rat |
| Xiu-Juan Bai, Lei Hao, Yan-E Guo, Xiao-Bing Shi, Wei-Ping W. Bone marrow stromal cells reverse the microglia type from pro-inflammatory tumour necrosis factor a microglia to anti-inflammatory CD206 microglia of middle cerebral artery occlusion rats through triggering secretion of CX3CL1. Folia neuropathologica. vol 59. issue 1. 2021-11-25. PMID:33969675. |
in conclusion, bmscs reverse microglia from pro-inflammatory type tnf-a microglia to anti-inflammatory type cd206 microglia in the infarct region of mcao rats (3rd to 7th days post bmsc transplantation), through triggering of cx3cl1 secretion. |
2021-11-25 |
2023-08-13 |
rat |
| Koichi Inoue, Hiroyuki Morimoto, Masahiro Ohgidani, Takatoshi Uek. Modulation of inflammatory responses by fractalkine signaling in microglia. PloS one. vol 16. issue 5. 2021-10-26. PMID:34019594. |
microglia produce immunological responses to various stimuli, which include fractalkine (fkn or cx3cl1). |
2021-10-26 |
2023-08-13 |
Not clear |
| Qingxiu Zhang, Lei He, Mo Chen, Hui Yang, Xiaowei Cao, Xiaomei Liu, Qi Hao, Zhengwei Chen, Tengfei Liu, Xiu-E Wei, Liangqun Ron. PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:33599284. |
psd-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to cx3cl1. |
2021-08-24 |
2023-08-13 |
mouse |
| Qingxiu Zhang, Lei He, Mo Chen, Hui Yang, Xiaowei Cao, Xiaomei Liu, Qi Hao, Zhengwei Chen, Tengfei Liu, Xiu-E Wei, Liangqun Ron. PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:33599284. |
cx3 chemokine ligand 1 (cx3cl1) is a chemokine specifically expressed in neurons while its receptor cx3cr1 is highly expressed in microglia. |
2021-08-24 |
2023-08-13 |
mouse |
| Qingxiu Zhang, Lei He, Mo Chen, Hui Yang, Xiaowei Cao, Xiaomei Liu, Qi Hao, Zhengwei Chen, Tengfei Liu, Xiu-E Wei, Liangqun Ron. PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:33599284. |
in this study, we examined the interaction of psd-93 and cx3cl1 in the crosstalk between neurons and microglia in acute ischemic stroke. |
2021-08-24 |
2023-08-13 |
mouse |
| Qingxiu Zhang, Lei He, Mo Chen, Hui Yang, Xiaowei Cao, Xiaomei Liu, Qi Hao, Zhengwei Chen, Tengfei Liu, Xiu-E Wei, Liangqun Ron. PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:33599284. |
together, these data suggest that psd-93 binds cx3cl1 to activate microglia and initiate neuroinflammation. |
2021-08-24 |
2023-08-13 |
mouse |
| Bingjie Qin, Ni Luo, Yuxing Li, Denghui Gong, Jun Zheng, Xiao Tan, Weihong Zhen. Protective effect of gastrodin on peripheral neuropathy induced by anti-tumor treatment with vincristine in rat models. Drug and chemical toxicology. vol 44. issue 1. 2021-08-03. PMID:30554535. |
gastrodin relieved cipn by inhibiting activation of spinal microglia through fractalkine (cx3cl1) and its receptor cx3cr1, then inhibited p38/mitogen-activated protein kinase (mapk) signaling pathway and reduced the expression of inflammatory factor tnf-α and interleukin-1β (il-1β). |
2021-08-03 |
2023-08-13 |
human |
| Marta González-Prieto, Irene L Gutiérrez, Borja García-Bueno, Javier R Caso, Juan C Leza, Adriana Ortega-Hernández, Dulcenombre Gómez-Garre, José L M Madriga. Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline. Glia. vol 69. issue 1. 2021-07-28. PMID:32662924. |
the activation of microglial cx3cr1, sole receptor for cx3cl1, reduces the activation of microglia, which is known to largely contribute to the neuronal damage characteristic of ad. |
2021-07-28 |
2023-08-13 |
mouse |