| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunmei Zhang, Yusi Zhang, Ran Zhuang, Kun Yang, Lihua Chen, Boquan Jin, Ying Ma, Yun Zhang, Kang Tan. Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674036. |
cx3cl1 signals are transmitted through its unique receptor, cx3cr1, primarily expressed in the microglia of the central nervous system (cns). |
2024-04-27 |
2024-04-29 |
human |
| Jonas Fritze, Chandramouli Muralidharan, Eleanor Stamp, Henrik Ahleniu. Microglia undergo disease-associated transcriptional activation and CX3C motif chemokine receptor 1 expression regulates neurogenesis in the aged brain. Developmental neurobiology. 2024-04-15. PMID:38616340. |
cx3c motif chemokine receptor 1 (cx3cr1) is characteristically expressed by brain microglia where it directs migration to targets for phagocytosis. |
2024-04-15 |
2024-04-17 |
mouse |
| Jonas Fritze, Chandramouli Muralidharan, Eleanor Stamp, Henrik Ahleniu. Microglia undergo disease-associated transcriptional activation and CX3C motif chemokine receptor 1 expression regulates neurogenesis in the aged brain. Developmental neurobiology. 2024-04-15. PMID:38616340. |
we show that cx3cr1 expression, as in dam, is downregulated in old svz microglia and that heterozygous cx3cr1 mice have increased proliferation and neuroblast number in the aged svz but not in the dentate gyrus, identifying cx3cr1 signaling as a novel age and brain region-specific regulator of neurogenesis. |
2024-04-15 |
2024-04-17 |
mouse |
| Elena Di Martino, Anoop Ambikan, Daniel Ramsköld, Takashi Umekawa, Sarantis Giatrellis, Davide Vacondio, Alejandro Lastra Romero, Marta Gómez Galán, Rickard Sandberg, Ulrika Ådén, Volker M Lauschke, Ujjwal Neogi, Klas Blomgren, Julianna Kel. Inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia. iScience. vol 27. issue 4. 2024-03-19. PMID:38500830. |
in the present study, we investigated the temporal dynamics of microglia (cx3cr1 |
2024-03-19 |
2024-03-21 |
Not clear |
| Derek Rodriguez, Kaira A Church, Chelsea T Smith, Difernando Vanegas, Sandra M Cardona, Isabel A Muzzio, Kevin R Nash, Astrid E Cardon. Therapeutic Delivery of Soluble Fractalkine Ameliorates Vascular Dysfunction in the Diabetic Retina. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339005. |
microglia exclusively bind to the neuronal-derived chemokine fractalkine (fkn) via the cx3cr1 receptor to ameliorate microglial activation. |
2024-02-10 |
2024-02-12 |
Not clear |
| Genaro E Olveda, Maryanne N Barasa, Robert A Hil. Microglial phagocytosis of single dying oligodendrocytes is mediated by CX3CR1 but not MERTK. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168326. |
deletion of the fractalkine receptor, cx3cr1, delayed microglia engagement with the cell soma but unexpectedly did not affect the clearance of myelin sheaths. |
2024-01-03 |
2024-01-06 |
mouse |
| Jingchun Pei, Yongwei Zou, Cheng Wan, Shuangshuang Liu, Bin Hu, Zhigao Li, Zhiwei Tan. CX3CR1 mediates Motor Dysfunction in Mice through 5-HTR2a. Behavioural brain research. 2023-12-25. PMID:38145872. |
cx3cr1 knockout could induce motor dysfunction in several neurological disease models mainly through regulating microglia's function. |
2023-12-25 |
2023-12-28 |
mouse |
| Anne-Kathrin Gellner, Janine Reis, Bernd L Fiebich, Brita Fritsc. Cx3cr1 deficiency interferes with learning- and direct current stimulation-mediated neuroplasticity of the motor cortex. The European journal of neuroscience. 2023-12-05. PMID:38049944. |
the role of microglia and their fractalkine receptor cx3cr1 in motor cortical neuroplasticity mediated by dcs or motor learning requires further elucidation. |
2023-12-05 |
2023-12-10 |
Not clear |
| Anne-Kathrin Gellner, Janine Reis, Bernd L Fiebich, Brita Fritsc. Cx3cr1 deficiency interferes with learning- and direct current stimulation-mediated neuroplasticity of the motor cortex. The European journal of neuroscience. 2023-12-05. PMID:38049944. |
we show that dcs-mediated neuroplasticity in the motor cortex depends on the presence of microglia and is driven in part by cx3cr1 signalling ex vivo and provide the first evidence of microglia interacting with neurons during dcs in vivo. |
2023-12-05 |
2023-12-10 |
Not clear |
| Anne-Kathrin Gellner, Janine Reis, Bernd L Fiebich, Brita Fritsc. Cx3cr1 deficiency interferes with learning- and direct current stimulation-mediated neuroplasticity of the motor cortex. The European journal of neuroscience. 2023-12-05. PMID:38049944. |
furthermore, cx3cr1 signalling is required for motor learning and underlying structural neuroplasticity in concert with microglia interaction. |
2023-12-05 |
2023-12-10 |
Not clear |
| Z W Huang, Y Y Liu, X M Chen, C L Yu, H Y He, Y H Den. Attenuating Neuronal Autophagy Alleviates Inflammatory Injury in OGDDeprived Co-culture of HT22 with BV2. Acta naturae. vol 15. issue 3. 2023-11-01. PMID:37908770. |
neuronal cx3cl1 suppressed microglial inflammation by binding to its receptor cx3cr1 expressed on microglia. |
2023-11-01 |
2023-11-08 |
Not clear |
| Derek Power, Jesse Schalle. Poster Session: Deep retinal laser lesions recruit resident microglia without involvement of labeled neutrophils. Journal of vision. vol 23. issue 11. 2023-09-21. PMID:37733513. |
using fluorescence aoslo, we tracked microglia (cx3cr1, gfp transgenic mice) and neutrophils (ly-6g-647 nm antibody). |
2023-09-21 |
2023-10-07 |
mouse |
| Lu Wang, Hanyi Ling, Hui He, Nan Hu, Lin Xiao, Yue Zhang, Lei Xie, Zili Yo. Dysfunctional synaptic pruning by microglia correlates with cognitive impairment in sleep-deprived mice: Involvement of CX3CR1 signaling. Neurobiology of stress. vol 25. 2023-08-07. PMID:37547773. |
dysfunctional synaptic pruning by microglia correlates with cognitive impairment in sleep-deprived mice: involvement of cx3cr1 signaling. |
2023-08-07 |
2023-08-14 |
mouse |
| Shunyi Zhao, Jiaying Zheng, Lingxiao Wang, Anthony D Umpierre, Sebastian Parusel, Manling Xie, Aastha Dheer, Katayoun Ayasoufi, Aaron J Johnson, Jason R Richardson, Long-Jun W. Chemogenetic manipulation of CX3CR1 Molecular psychiatry. 2023-06-26. PMID:37365239. |
chemogenetic manipulation of cx3cr1 chemogenetic approaches using designer receptors exclusively activated by designer drugs (dreadd, a family of engineered gpcrs) were recently employed in microglia. |
2023-06-26 |
2023-08-14 |
Not clear |
| Matilda Iemmolo, Giulio Ghersi, Giulia Bivon. The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175729. |
cx3cl1, as an adhesion molecule, on the one hand, plays an inhibiting role in the pro-inflammatory response in the central nervous system (cns) and shows neuroprotective effects by binding its membrane receptor (cx3cr1) present into microglia cells and maintaining them in a quiescent state; on the other hand, the scx3cl1 isoform seems to promote neurodegeneration. |
2023-05-14 |
2023-08-14 |
Not clear |
| Giulia Bivona, Matilda Iemmolo, Giulio Ghers. CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175935. |
fkn and its microglial receptor cx3cr1 are crucial players in the interplay between neurons and microglia, modulating the operation of some neural circuits and the efficacy and persistence of immune response against injury. |
2023-05-14 |
2023-08-14 |
Not clear |
| Michela Perrone, Martina Pagano, Carmela Belardo, Flavia Ricciardi, Federica Ricciardi, Antimo Fusco, Maria Consiglia Trotta, Rosmara Infantino, Francesca Gargano, Andrea Parente, Rosa Giacca, Gorizio Pieretti, Livio Luongo, Sabatino Maione, Serena Boccella, Francesca Guid. Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1). Neuropharmacology. 2023-02-16. PMID:36796675. |
likewise, hcar2 stimulation reduced the proinflammatory mediators mrna expression induced by neuronal chemokine fractalkine (fkn), a neuronal derived chemokine activating its unique receptor, chemokine receptor 1 (cx3cr1) on microglia surface. |
2023-02-16 |
2023-08-14 |
rat |
| Yong Chen, Dan Li, Ningcen Li, PeiYong Loh, Yi Guo, Xiyou Hu, Jingyu Zhang, Baomin Dou, Lifen Wang, Chaobo Yang, Tao Guo, Shuangli Chen, Zhen Liu, Bo Chen, Zelin Che. Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain. Frontiers in neurology. vol 14. 2023-02-09. PMID:36756246. |
moreover, neuroinflammation in pain can be inhibited by acupuncture through inhibiting jak2/stat3, pi3k/mtor pathways, down regulating chemokine receptor cx3cr1 on microglia and up regulating adenosine receptor a1rs on astrocytes, inhibiting the activation of glia and reducing tnf-α and other inflammatory substances. |
2023-02-09 |
2023-08-14 |
Not clear |
| N P Camacho-Hernández, F Peña-Orteg. Fractalkine/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease. Neural plasticity. vol 2023. 2023-01-16. PMID:36644710. |
cx3cr1 is a g protein-coupled receptor that is expressed exclusively by microglia within the brain parenchyma. |
2023-01-16 |
2023-08-14 |
Not clear |
| Monique M A de Almeida, Adrianne E S Watson, Sana Bibi, Nicole L Dittmann, Kara Goodkey, Pedram Sharafodinzadeh, Danny Galleguillos, Maryam Nakhaei-Nejad, Jayasankar Kosaraju, Noam Steinberg, Beatrix S Wang, Tim Footz, Fabrizio Giuliani, Jing Wang, Simonetta Sipione, Julia M Edgar, Anastassia Voronov. Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model. Stem cell reports. 2023-01-07. PMID:36608690. |
finally, we show that activated opcs and microglia/macrophages express fractalkine receptor cx3cr1 in vivo, and that in opc-microglia co-cultures fractalkine increases in vitro oligodendrocyte differentiation by modulating both opc and microglia biology. |
2023-01-07 |
2023-08-14 |
mouse |