| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Hossein Fatemi, Elysabeth D Otte, Timothy D Folsom, Arthur C Eschenlauer, Randall J Roper, Justin W Aman, Paul D Thura. Early Chronic Fluoxetine Treatment of Ts65Dn Mice Rescues Synaptic Vesicular Deficits and Prevents Aberrant Proteomic Alterations. Genes. vol 15. issue 4. 2024-04-27. PMID:38674386. |
we hypothesized that investigation of the cerebral cortex of fluoxetine-treated trisomic mice may provide proteomic signatures that identify therapeutic targets for ds. |
2024-04-27 |
2024-04-29 |
mouse |
| Lei Tian, Shiyi Cheng, Shuaibin Chang, Yunzhe Li, Anna Novoseltseva, Sunni Lin, Yicun Wu, Jiahui Zhu, Ann Mckee, Douglas Rosene, Hui Wang, Irving Bigio, David Boa. Enhanced Multiscale Human Brain Imaging by Semi-supervised Digital Staining and Serial Sectioning Optical Coherence Tomography. Research square. 2024-04-02. PMID:38562721. |
we demonstrate ds on various human cerebral cortex samples with consistent staining quality. |
2024-04-02 |
2024-04-04 |
human |
| Rosa López-Hidalgo, Raúl Ballestín, Lorena Lorenzo, Sandra Sánchez, José Miguel Blasco-Ibáñez, Carlos Crespo, Juan Nacher, Emilio Vare. Early chronic fasudil treatment rescues hippocampal alterations in the Ts65Dn model for down syndrome. Neurochemistry international. 2024-02-03. PMID:38309665. |
ts65dn mice, as humans with ds, show defects in the structure, density, and distribution of dendritic spines in the cerebral cortex and hippocampus. |
2024-02-03 |
2024-02-06 |
mouse |
| Jayapriya Chandrasekaran, Kevin K Caldwell, Jonathan L Brigma. Dynamic regulation of corticostriatal glutamatergic synaptic expression during reversal learning in male mice. Neurobiology of learning and memory. 2024-01-19. PMID:38242226. |
following training to well-established stages of discrimination and reversal learning on a touchscreen visual task, lateral orbitofrontal cortex (ofc), dorsal striatum (ds) as well as medial prefrontal cortex (mpfc), basolateral amygdala (bla) and piriform cortex (pir) were micro dissected from male mouse brain and the expression of glutamatergic receptor subunits in the synaptic fraction were measured via immunoblotting. |
2024-01-19 |
2024-01-22 |
mouse |
| Giuliano Taccola, Roger Kissane, Stanislav Culaclii, Rosamaria Apicella, Wentai Liu, Parag Gad, Ronaldo M Ichiyama, Samit Chakrabarty, V Reggie Edgerto. Dynamic electrical stimulation enhances the recruitment of spinal interneurons by corticospinal input. Experimental neurology. 2023-10-31. PMID:37907125. |
apart from increased emgs, ds selectively increased excitability of the spinal interneurons that first process corticospinal input, without changing the magnitude of commands descending from the motor cortex, suggesting a novel correlation between muscle recruitment and components of cortically-evoked cdps. |
2023-10-31 |
2023-11-08 |
Not clear |
| Bianca Rusu, Bharti Kukreja, Taiyi Wu, Sophie J Dan, Min Yi Feng, Brian T Kalis. Single-nucleus profiling identifies accelerated oligodendrocyte precursor cell senescence in a mouse model of Down Syndrome. eNeuro. 2023-07-25. PMID:37491366. |
here, using the ts65dn mouse model of ds, we performed an integrated single-nucleus atac and rna-sequencing (snatac-seq and snrna-seq) analysis of the adult cortex. |
2023-07-25 |
2023-08-14 |
mouse |
| Giuliano Taccola, Roger Kissane, Stanislav Culaclii, Rosamaria Apicella, Wentai Liu, Parag Gad, Ronaldo M Ichiyama, Samit Chakrabarty, V Reggie Edgerto. Spinal facilitation of descending motor input. bioRxiv : the preprint server for biology. 2023-07-18. PMID:37461548. |
apart from increased emgs, ds selectively increased excitability of the spinal interneurons that first process corticospinal input, without changing the magnitude of commands descending from the motor cortex, suggesting a novel correlation between muscle recruitment and components of cortically-evoked cdps. |
2023-07-18 |
2023-08-14 |
Not clear |
| Ana María Estrada-Sánchez, Claudia Rangel-Barajas, Andrew G Howe, Scott J Barton, Robert H Mach, Robert R Luedtke, George V Rebe. Selective Activation of D3 Dopamine Receptors Ameliorates DOI-Induced Head Twitching Accompanied by Changes in Corticostriatal Processing. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298250. |
moreover, the simultaneous recording of neuronal activity in the motor cortex (m1) and dorsal striatum (ds) indicated that d3 activation led to slight changes in a single unit activity, mainly in ds, and increased its correlated firing in ds or between presumed cortical pyramidal neurons (cpns) and striatal medium spiny neurons (msns). |
2023-06-11 |
2023-08-14 |
mouse |
| Natalia Barraza-Núñez, Ramón Pérez-Núñez, Belén Gaete-Ramírez, Alejandra Barrios-Garrido, Christian Arriagada, Karen Poksay, Varghese John, Jean-Vianney Barnier, Ana María Cárdenas, Pablo Caviede. Pharmacological Inhibition of p-21 Activated Kinase (PAK) Restores Impaired Neurite Outgrowth and Remodeling in a Cellular Model of Down Syndrome. Neurotoxicity research. 2023-03-03. PMID:36867391. |
in this work, using a neuronal cell line named ctb, which derived from the cerebral cortex of a trisomy 16 mouse, an animal model of human ds, we observed an overexpression of app, elevated caspase activity, augmented cleavage of the c-terminal fragment of app, and increased pak1 phosphorylation. |
2023-03-03 |
2023-08-14 |
mouse |
| André Luíz Teles E Silva, Bruno Yukio Yokota, Andrea Laurato Sertié, Bruna Lancia Zampier. Generation of Urine-Derived Induced Pluripotent Stem Cells and Cerebral Organoids for Modeling Down Syndrome. Stem cell reviews and reports. 2023-01-18. PMID:36652145. |
alterations in the complex process of cerebral cortex development contribute to the neurological deficits in ds, although the underlying molecular and cellular mechanisms are not completely understood. |
2023-01-18 |
2023-08-14 |
human |
| Fabrizio Vecchio, Lorenzo Nucci, Chiara Pappalettera, Francesca Miraglia, Daniela Iacoviello, Paolo Maria Rossin. Time-frequency analysis of brain activity in response to Directional and non-Directional visual stimuli: an Event Related Spectral Perturbations (ERSP) study. Journal of neural engineering. 2022-10-21. PMID:36270505. |
a large part of the cerebral cortex is dedicated to the processing of visual stimuli and there is still much to understand about such processing modalities and hierarchies. the main aim of the present study is to investigate the differences between directional (ds) and non-directional (n-ds) visual stimuli processing by time-frequency analysis of brain eeg activity during a visuo-motor task. |
2022-10-21 |
2023-08-14 |
Not clear |
| Ping Zhao, Qiuyang Li, Shuo Wang, Yiru Wang, Jianing Zhu, Lianhua Zhu, Jie Tang, Yukun Lu. Quantitative Analysis of Renal Perfusion in Rhabdomyolysis-Induced Acute Kidney Injury Using Contrast-Enhanced Ultrasound: An Experimental Study. Ultrasound in medicine & biology. 2022-08-01. PMID:35914992. |
with respect to the ceus quantitative parameters for the renal cortex, auc increased, and as and ds decreased. |
2022-08-01 |
2023-08-14 |
rat |
| Hu Zhou, Jingxin Zhang, Huaxiang Shi, Pengfei Li, Xin Sui, Yongan Wang, Liyun Wan. Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice. Molecular brain. vol 15. issue 1. 2022-06-14. PMID:35701839. |
notably, anterograde labeling showed that cdk5 kd in the ds disrupted long-range projections to the secondary motor cortex, dorsal and ventral thalamic nuclei, and basolateral amygdala, which are involved in the regulation of motor and circadian rhythms in the brain. |
2022-06-14 |
2023-08-14 |
mouse |
| Yathindar Giffin-Rao, Jie Sheng, Bennett Strand, Ke Xu, Leslie Huang, Margaret Medo, Kirstin A Risgaard, Samuel Dantinne, Sruti Mohan, Aratrika Keshan, Roger A Daley, Bradley Levesque, Lindsey Amundson, Rebecca Reese, André M M Sousa, Yunlong Tao, Daifeng Wang, Su-Chun Zhang, Anita Bhattacharyy. Altered patterning of trisomy 21 interneuron progenitors. Stem cell reports. 2022-05-27. PMID:35623352. |
our stereological analysis of adult ds cortex indicates a reduction of calretinin-expressing interneurons. |
2022-05-27 |
2023-08-13 |
human |
| Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Jarek Wegiel, Shuang Yong Ma, Nanbert Zhong, Teresa Wierzba Bobrowicz, Mony de Leon, Florence Lai, Wayne P Silverman, Thomas Wisniewsk. Developmental deficits and staging of dynamics of age associated Alzheimer's disease neurodegeneration and neuronal loss in subjects with Down syndrome. Acta neuropathologica communications. vol 10. issue 1. 2022-01-05. PMID:34983655. |
the aims of this study of 14 brain regions including the entorhinal cortex, hippocampus, basal ganglia, and cerebellum in 33 adults with ds 26-72 years of age were to identify the magnitude of brain region-specific developmental neuronal deficits contributing to intellectual deficits, to apply this baseline to identification of the topography and magnitude of neurodegeneration and neuronal and volume losses caused by eoad, and to establish age-based staging of the pattern of genetically driven neuropathology in ds. |
2022-01-05 |
2023-08-13 |
human |
| Logan Chariker, Robert Shapley, Michael Hawken, Lai-Sang Youn. A theory of direction selectivity for macaque primary visual cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 32. 2021-12-01. PMID:34353906. |
we hypothesize that ds is initiated in feed-forward lgn input, in the summed responses of lgn cells afferent to a cortical cell, and it is achieved through the interplay of 1) different visual response dynamics of on and off lgn cells and 2) the wiring of on and off lgn neurons to cortex. |
2021-12-01 |
2023-08-13 |
monkey |
| Julia A C Case, Matthew Mattoni, Thomas M Olin. Examining the Neurobiology of Non-Suicidal Self-Injury in Children and Adolescents: The Role of Reward Responsivity. Journal of clinical medicine. vol 10. issue 16. 2021-08-31. PMID:34441857. |
exploratory connectivity analyses found that nssi was associated with differential connectivity between regions including the ds, vmpfc, insula, and parietal operculum cortex when controlling for depressive symptoms. |
2021-08-31 |
2023-08-13 |
Not clear |
| Michael S C Thomas, Olatz Ojinaga Alfageme, Hana D'Souza, Prachi A Patkee, Mary A Rutherford, Kin Y Mok, John Hardy, Annette Karmiloff-Smit. A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment. Research in developmental disabilities. vol 104. 2021-07-28. PMID:32653761. |
we describe new magnetic resonance imaging methods for measuring prenatal and neonatal brain structure in ds (e.g., volumes of supratentorial brain, cortex, cerebellar volume; patkee et al., 2019). |
2021-07-28 |
2023-08-13 |
Not clear |
| Seiko Yamakoshi, Osamu Ito, Rong Rong, Yusuke Ohsaki, Takahiro Nakamura, Takuo Hirose, Kazuhiro Takahashi, Takefumi Mori, Kazuhito Totsune, Masahiro Kohzuk. High Salt Intake-Increased (Pro)renin Receptor Expression Is Exaggerated in the Kidney of Dahl Salt-Sensitive Rats. Hypertension (Dallas, Tex. : 1979). vol 75. issue 6. 2021-04-08. PMID:32336231. |
additionally, deoxycorticosterone acetate increased (p)rr expression in the renal cortex and distal tubules but not in the proximal tubules of ds rats fed the normal salt diet. |
2021-04-08 |
2023-08-13 |
rat |
| Seiko Yamakoshi, Osamu Ito, Rong Rong, Yusuke Ohsaki, Takahiro Nakamura, Takuo Hirose, Kazuhiro Takahashi, Takefumi Mori, Kazuhito Totsune, Masahiro Kohzuk. High Salt Intake-Increased (Pro)renin Receptor Expression Is Exaggerated in the Kidney of Dahl Salt-Sensitive Rats. Hypertension (Dallas, Tex. : 1979). vol 75. issue 6. 2021-04-08. PMID:32336231. |
these results indicate that hs intake greatly increases (p)rr expression in the renal cortex of ds rats. |
2021-04-08 |
2023-08-13 |
rat |