| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Khalilimeybodi, Jeffrey J Saucerman, P Rangaman. Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy. Computers in biology and medicine. vol 175. 2024-04-27. PMID:38677172. |
we predicted that the transcription factors stat, srf, gata4, tp53, and foxo are the key regulators of cardiomyocyte hypertrophy and apoptosis in hcm in alignment with experiments. |
2024-04-27 |
2024-04-30 |
mouse |
| Juan Andrés García-Loredo, Michelle G Santoyo-Suarez, Oscar Rodríguez-Nuñez, Diego Francisco Benitez Chao, Elsa N Garza-Treviño, Patricio Adrián Zapata-Morin, Gerardo R Padilla-Rivas, Jose Francisco Isla. Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors. Life (Basel, Switzerland). vol 14. issue 4. 2024-04-27. PMID:38672763. |
our analysis reveals klf's interactions with gata4, mef2c, nkx2.5 and other ~90 potential genes that participate in the regulation of the hypertrophic environment (or cvds' environment). |
2024-04-27 |
2024-04-29 |
Not clear |
| Mikael Jumppanen, Sini M Kinnunen, Matej Zore, Mika J Välimäki, Virpi Talman, Gustav Boije Af Gennäs, Heikki J Ruskoaho, Jari Yli-Kauhaluom. Affinity chromatography reveals direct binding of the GATA4-NKX2-5 interaction inhibitor (3i-1000) with GATA4. Scientific reports. vol 14. issue 1. 2024-04-18. PMID:38637629. |
transcription factors are in a central role in various cellular processes, and in the heart, gata4 and nkx2-5 transcription factors mediate hypertrophic responses and remodeling. |
2024-04-18 |
2024-04-21 |
Not clear |
| Kelian Zhang, Huilin Zhuo, Jingyi Guo, Wei Wang, Ruozhu Da. Astaxanthin Alleviates the Process of Cardiac Hypertrophy by Targeting the METTL3/Circ_0078450/MiR-338-3p/GATA4 Pathway. International heart journal. vol 65. issue 1. 2024-02-06. PMID:38296564. |
the protein levels of hypertrophy genes, gata4, and methyltransferase-like 3 (mettl3) were determined by western blot analysis. |
2024-02-06 |
2024-02-09 |
human |
| Kelian Zhang, Huilin Zhuo, Jingyi Guo, Wei Wang, Ruozhu Da. Astaxanthin Alleviates the Process of Cardiac Hypertrophy by Targeting the METTL3/Circ_0078450/MiR-338-3p/GATA4 Pathway. International heart journal. vol 65. issue 1. 2024-02-06. PMID:38296564. |
also, the interaction between mir-338-3p and circ_0078450 or gata4 was confirmed by dual-luciferase reporter and rip assays, and the regulation of mettl3 on circ_0078450 was verified by merip and rip assays.asx reduced the hypertrophy gene protein expression and cell size in ang-ii-induced ac16 cells. |
2024-02-06 |
2024-02-09 |
human |
| Kelian Zhang, Huilin Zhuo, Jingyi Guo, Wei Wang, Ruozhu Da. Astaxanthin Alleviates the Process of Cardiac Hypertrophy by Targeting the METTL3/Circ_0078450/MiR-338-3p/GATA4 Pathway. International heart journal. vol 65. issue 1. 2024-02-06. PMID:38296564. |
circ_0078450 could sponge mir-338-3p to positively regulate gata4 expression, and gata4 overexpression overturned the suppressive effect of circ_0078450 knockdown on ang-ii-induced cardiomyocyte hypertrophy. |
2024-02-06 |
2024-02-09 |
human |
| Kelian Zhang, Huilin Zhuo, Jingyi Guo, Wei Wang, Ruozhu Da. Astaxanthin Alleviates the Process of Cardiac Hypertrophy by Targeting the METTL3/Circ_0078450/MiR-338-3p/GATA4 Pathway. International heart journal. vol 65. issue 1. 2024-02-06. PMID:38296564. |
also, the inhibitory effect of asx on ang-ii-induced cardiomyocyte hypertrophy could be reversed by circ_0078450 or gata4 overexpression. |
2024-02-06 |
2024-02-09 |
human |
| Omar M Hedaya, Kadiam C Venkata Subbaiah, Feng Jiang, Li Huitong Xie, Jiangbin Wu, Eng-Soon Khor, Mingyi Zhu, David H Mathews, Chris Proschel, Peng Ya. Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy. Nature communications. vol 14. issue 1. 2023-10-03. PMID:37789015. |
human cardiomyocytes and mice treated with a uorf-enhancing aso showed reduced cardiac gata4 protein levels and increased resistance to cardiomyocyte hypertrophy. |
2023-10-03 |
2023-10-07 |
mouse |
| Lin Cheng, Chengsheng Xu, Yue Chen, Jian Li, Jing Wang, Jiewen Xiao, Mingjia Ma, Xin Feng, Xiang Wei, Jing Fan. DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4. Journal of molecular and cellular cardiology. vol 169. 2022-06-06. PMID:35659652. |
dec1 represses cardiomyocyte hypertrophy by recruiting prp19 as an e3 ligase to promote ubiquitination-proteasome-mediated degradation of gata4. |
2022-06-06 |
2023-08-14 |
rat |
| Lin Cheng, Chengsheng Xu, Yue Chen, Jian Li, Jing Wang, Jiewen Xiao, Mingjia Ma, Xin Feng, Xiang Wei, Jing Fan. DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4. Journal of molecular and cellular cardiology. vol 169. 2022-06-06. PMID:35659652. |
although the pro-hypertrophic role of gata binding protein 4 (gata4) during cardiac hypertrophy has been well established, the negative regulatory mechanism to counteract its hyperactivation remains elusive. |
2022-06-06 |
2023-08-14 |
rat |
| Lin Cheng, Chengsheng Xu, Yue Chen, Jian Li, Jing Wang, Jiewen Xiao, Mingjia Ma, Xin Feng, Xiang Wei, Jing Fan. DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4. Journal of molecular and cellular cardiology. vol 169. 2022-06-06. PMID:35659652. |
using high throughput mass spectrometry technology, we carried out a proteomic screen for endogenous suppressor of gata4, which disassociated with gata4 during the hypertrophic response in a cultured cardiac myoblast cell line (h9c2 cells). |
2022-06-06 |
2023-08-14 |
rat |
| Lin Cheng, Chengsheng Xu, Yue Chen, Jian Li, Jing Wang, Jiewen Xiao, Mingjia Ma, Xin Feng, Xiang Wei, Jing Fan. DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4. Journal of molecular and cellular cardiology. vol 169. 2022-06-06. PMID:35659652. |
we identified differentiated embryo chondrocyte 1 (dec1) negatively regulated the function of gata4 through physical interaction and negatively regulated cardiac hypertrophy both in vivo and in vitro. |
2022-06-06 |
2023-08-14 |
rat |
| Lin Cheng, Chengsheng Xu, Yue Chen, Jian Li, Jing Wang, Jiewen Xiao, Mingjia Ma, Xin Feng, Xiang Wei, Jing Fan. DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4. Journal of molecular and cellular cardiology. vol 169. 2022-06-06. PMID:35659652. |
furthermore, rescue experiments performed in these cells revealed that dec1 and prp19 suppressed cardiomyocyte hypertrophy by inhibiting the function of gata4. |
2022-06-06 |
2023-08-14 |
rat |
| Lin Cheng, Chengsheng Xu, Yue Chen, Jian Li, Jing Wang, Jiewen Xiao, Mingjia Ma, Xin Feng, Xiang Wei, Jing Fan. DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4. Journal of molecular and cellular cardiology. vol 169. 2022-06-06. PMID:35659652. |
although gata4 is indispensable for normal cardiac function, harnessing dec1- or prp19-mediated negative regulation to counteract the hyperactivation of gata4 might serve as a novel therapeutic strategy for pathological cardiac hypertrophy. |
2022-06-06 |
2023-08-14 |
rat |
| Haiyun Chen, Jiawen Zhou, Hongjie Chen, Jialong Liang, Chunfeng Xie, Xin Gu, Rong Wang, Zhiyuan Mao, Yongjie Zhang, Qing Li, Guoping Zuo, Dengshun Miao, Jianliang Ji. Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4. Clinical and translational medicine. vol 12. issue 4. 2022-04-07. PMID:35390228. |
bmi-1-ring1b prevents gata4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of gata4. |
2022-04-07 |
2023-08-13 |
Not clear |
| Satoshi Shimizu, Yoichi Sunagawa, Naruto Hajika, Natsumi Yorimitsu, Yasufumi Katanasaka, Masafumi Funamoto, Yusuke Miyazaki, Nurmila Sari, Kana Shimizu, Koji Hasegawa, Tatsuya Morimot. Multimerization of the GATA4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response. International journal of biological sciences. vol 18. issue 3. 2022-02-17. PMID:35173540. |
multimerization of the gata4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response. |
2022-02-17 |
2023-08-13 |
Not clear |
| Satoshi Shimizu, Yoichi Sunagawa, Naruto Hajika, Natsumi Yorimitsu, Yasufumi Katanasaka, Masafumi Funamoto, Yusuke Miyazaki, Nurmila Sari, Kana Shimizu, Koji Hasegawa, Tatsuya Morimot. Multimerization of the GATA4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response. International journal of biological sciences. vol 18. issue 3. 2022-02-17. PMID:35173540. |
the activation of the gata-binding factor 4 (gata4) transcription factor induces cardiac hypertrophy and heart failure. |
2022-02-17 |
2023-08-13 |
Not clear |
| Satoshi Shimizu, Yoichi Sunagawa, Naruto Hajika, Natsumi Yorimitsu, Yasufumi Katanasaka, Masafumi Funamoto, Yusuke Miyazaki, Nurmila Sari, Kana Shimizu, Koji Hasegawa, Tatsuya Morimot. Multimerization of the GATA4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response. International journal of biological sciences. vol 18. issue 3. 2022-02-17. PMID:35173540. |
furthermore, the inhibition of gata4 multimerization suppressed phenylephrine (pe)-induced hypertrophic response in cardiomyocytes. |
2022-02-17 |
2023-08-13 |
Not clear |
| Satoshi Shimizu, Yoichi Sunagawa, Naruto Hajika, Natsumi Yorimitsu, Yasufumi Katanasaka, Masafumi Funamoto, Yusuke Miyazaki, Nurmila Sari, Kana Shimizu, Koji Hasegawa, Tatsuya Morimot. Multimerization of the GATA4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response. International journal of biological sciences. vol 18. issue 3. 2022-02-17. PMID:35173540. |
this study demonstrates that the multimerization of gata4 during the p300-induced acetylation of gata4 activates the transcription of hypertrophic response genes, which leads to cardiomyocyte hypertrophy. |
2022-02-17 |
2023-08-13 |
Not clear |
| Rui Song, Han Lei, Li Feng, Wanwen Cheng, Ying Li, Ling Ling Yao, Jie Li. TFEB insufficiency promotes cardiac hypertrophy by blocking autophagic degradation of GATA4. The Journal of biological chemistry. vol 297. issue 4. 2021-11-25. PMID:34517007. |
tfeb insufficiency promotes cardiac hypertrophy by blocking autophagic degradation of gata4. |
2021-11-25 |
2023-08-13 |
Not clear |