| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gergely Keszler, Bálint Vékony, Zsuzsanna Elek, Zsófia Nemoda, Nóra Angyal, Zsófia Bánlaki, Réka Kovács-Nagy, Zsolt Rónai, János M Réthely. MicroRNA-Mediated Suppression of Glial Cell Line-Derived Neurotrophic Factor Expression Is Modulated by a Schizophrenia-Associated Non-Coding Polymorphism. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674063. |
plasma levels of glial cell line-derived neurotrophic factor (gdnf), a pivotal regulator of differentiation and survival of dopaminergic neurons, are reportedly decreased in schizophrenia. |
2024-04-27 |
2024-04-29 |
human |
| Guo Ge, Barath P Sivasubramanian, Bill D Geng, Shujie Zhao, Qing Zhou, Gang Huang, Jason C O'Connor, Robert A Clark, Senlin L. Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson's disease. Gene therapy. 2024-04-16. PMID:38627469. |
glial cell line-derived neurotrophic factor (gdnf) protects dopaminergic neurons in various models of parkinson's disease (pd). |
2024-04-16 |
2024-04-19 |
mouse |
| Guo Ge, Barath P Sivasubramanian, Bill D Geng, Shujie Zhao, Qing Zhou, Gang Huang, Jason C O'Connor, Robert A Clark, Senlin L. Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson's disease. Gene therapy. 2024-04-16. PMID:38627469. |
the results indicate that gdnf treatment effectively ameliorated mptp-induced motor deficits for up to 12 months, which coincided with the protection of nigral dopaminergic neurons and their striatal terminals. |
2024-04-16 |
2024-04-19 |
mouse |
| Raman Kumar Tripathi, Lav Goyal, Shamsher Sing. Potential Therapeutic Approach Using Aromatic l-amino Acid Decarboxylase and Glial-derived Neurotrophic Factor Therapy Targeting Putamen in Parkinson's Disease. Current gene therapy. 2024-02-04. PMID:38310455. |
targeting gdnf therapy specifically to the putaminal region is clinically sound and beneficial in protecting the dopaminergic neurons. |
2024-02-04 |
2024-02-06 |
Not clear |
| Suzita Mohd Noor, Chee Ern David Wong, Pooi-Fong Wong, Anwar Norazi. Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino. Methods in cell biology. vol 181. 2024-02-01. PMID:38302238. |
to gain a better understanding on the precise functional role of gdnf in dopaminergic neurons, our laboratory devised a targeted knockdown of gdnf in the zebrafish larval brain using vivo morpholino. |
2024-02-01 |
2024-02-04 |
human |
| Julieta Mendes-Oliveira, Filipa L Campos, Susana A Ferreira, Diogo Tomé, Carla P Fonseca, Graça Baltaza. Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation. Cells. vol 13. issue 1. 2024-01-11. PMID:38201277. |
endogenous gdnf is unable to halt dopaminergic injury triggered by microglial activation. |
2024-01-11 |
2024-01-13 |
Not clear |
| Julieta Mendes-Oliveira, Filipa L Campos, Susana A Ferreira, Diogo Tomé, Carla P Fonseca, Graça Baltaza. Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation. Cells. vol 13. issue 1. 2024-01-11. PMID:38201277. |
therefore, the present work aimed to disclose if the control of microglial responses mediated by astrocyte-derived factors, including gdnf, could be affected by the crosstalk with neurons, impacting gdnf's ability to protect dopaminergic neurons exposed to a pro-inflammatory environment. |
2024-01-11 |
2024-01-13 |
Not clear |
| Julieta Mendes-Oliveira, Filipa L Campos, Susana A Ferreira, Diogo Tomé, Carla P Fonseca, Graça Baltaza. Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation. Cells. vol 13. issue 1. 2024-01-11. PMID:38201277. |
also, we aimed to disclose if the protection of dopaminergic neurons by gdnf involves the modulation of microglial cells. |
2024-01-11 |
2024-01-13 |
Not clear |
| Julieta Mendes-Oliveira, Filipa L Campos, Susana A Ferreira, Diogo Tomé, Carla P Fonseca, Graça Baltaza. Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation. Cells. vol 13. issue 1. 2024-01-11. PMID:38201277. |
supplementation with exogenous gdnf was needed to afford protection of dopaminergic neurons exposed to the inflammatory environment. |
2024-01-11 |
2024-01-13 |
Not clear |
| Julieta Mendes-Oliveira, Filipa L Campos, Susana A Ferreira, Diogo Tomé, Carla P Fonseca, Graça Baltaza. Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation. Cells. vol 13. issue 1. 2024-01-11. PMID:38201277. |
in conclusion, our results revealed that dopaminergic protective effects promoted by gdnf involve the control of microglial reactivity. |
2024-01-11 |
2024-01-13 |
Not clear |
| Violina Kakoty, K C Sarathlal, Palwinder Kaur, Pankaj Wadhwa, Sukriti Vishwas, Farhan R Khan, Abdulfattah Yahya M Alhazmi, Hassan Hussain Almasoudi, Gaurav Gupta, Dinesh Kumar Chellappan, Keshav Raj Paudel, Dileep Kumar, Kamal Dua, Sachin Kumar Sing. Unraveling the role of glial cell line-derived neurotrophic factor in the treatment of Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-12-11. PMID:38082050. |
discovered in 1993, gdnf is a neurotrophic factor identified from the glial cells which was found to have selective effects on promoting survival and regeneration of certain populations of neurons including the dopaminergic nigrostriatal pathway. |
2023-12-11 |
2023-12-17 |
Not clear |
| Jung-Eun Park, Yea-Hyun Leem, Jin-Sun Park, Seong-Eun Kim, Hee-Sun Ki. Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson's Disease Mouse Model. Antioxidants (Basel, Switzerland). vol 12. issue 11. 2023-11-25. PMID:38001852. |
nkt restored mptp-induced motor impairment and dopaminergic neuronal loss and increased the expression of neurotrophic factors like bdnf, gdnf, and pgc-1α. |
2023-11-25 |
2023-11-28 |
mouse |
| Laoise Casserly, Daniel R Garton, Ana Montaño-Rodriguez, Jaan-Olle Andresso. Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759827. |
glial cell line-derived neurotrophic factor (gdnf) is a strong dopaminergic factor, that recently was shown to correlate with scz in human csf and in striatal tissue. |
2023-09-28 |
2023-10-07 |
mouse |
| Laoise Casserly, Daniel R Garton, Ana Montaño-Rodriguez, Jaan-Olle Andresso. Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759827. |
a 2-3-fold increase in gdnf in the brain was sufficient to induce scz-like dopaminergic and behavioural changes in mice. |
2023-09-28 |
2023-10-07 |
mouse |
| Marcelo Duarte Azevedo, Naika Prince, Marie Humbert-Claude, Virginia Mesa-Infante, Cheryl Jeanneret, Valentine Golzne, Kevin De Matos, Benjamin Boury Jamot, Fulvio Magara, Tomas Gonzalez-Hernandez, Liliane Tenenbau. Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation. Molecular therapy. Methods & clinical development. vol 31. 2023-09-28. PMID:37766790. |
despite its established neuroprotective effect on dopaminergic neurons and encouraging phase i results, intraputaminal gdnf administration failed to demonstrate significant clinical benefits in parkinson's disease patients. |
2023-09-28 |
2023-10-07 |
human |
| Marcelo Duarte Azevedo, Naika Prince, Marie Humbert-Claude, Virginia Mesa-Infante, Cheryl Jeanneret, Valentine Golzne, Kevin De Matos, Benjamin Boury Jamot, Fulvio Magara, Tomas Gonzalez-Hernandez, Liliane Tenenbau. Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation. Molecular therapy. Methods & clinical development. vol 31. 2023-09-28. PMID:37766790. |
stable reduction of motor impairments as well as increased number of dopaminergic neurons and striatal innervation were obtained with a gdnf dose equivalent to 3- and 10-fold the rat endogenous level. |
2023-09-28 |
2023-10-07 |
human |
| Marcelo Duarte Azevedo, Naika Prince, Marie Humbert-Claude, Virginia Mesa-Infante, Cheryl Jeanneret, Valentine Golzne, Kevin De Matos, Benjamin Boury Jamot, Fulvio Magara, Tomas Gonzalez-Hernandez, Liliane Tenenbau. Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation. Molecular therapy. Methods & clinical development. vol 31. 2023-09-28. PMID:37766790. |
finally, aberrant dopaminergic fiber sprouting was observed with 20-fold gdnf but not at lower doses. |
2023-09-28 |
2023-10-07 |
human |
| Marcelo Duarte Azevedo, Naika Prince, Marie Humbert-Claude, Virginia Mesa-Infante, Cheryl Jeanneret, Valentine Golzne, Kevin De Matos, Benjamin Boury Jamot, Fulvio Magara, Tomas Gonzalez-Hernandez, Liliane Tenenbau. Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation. Molecular therapy. Methods & clinical development. vol 31. 2023-09-28. PMID:37766790. |
intermittent 20-fold gdnf treatment allowed to avoid toxicity and spare dopaminergic neurons but did not restore their cell size. |
2023-09-28 |
2023-10-07 |
human |
| Valerio Ricci, Domenico de Berardis, Giovanni Martinotti, Giuseppe Main. Neurotrophic Factors In Cannabis-Induced Psychosis: An Update. Current topics in medicinal chemistry. 2023-08-30. PMID:37644743. |
glial cell derived neurotrophic factor (gdnf) promotes the survival of midbrain dopaminergic neurons and neuregulin 1 (nrg-1) contributes to glutamatergic signals regulating the n-methyl-d-aspartate (nmda). |
2023-08-30 |
2023-09-07 |
Not clear |
| Pepin Marshal. Finding an Optimal Level of GDNF Overexpression: Insights from Dopamine Cycling. Cellular and molecular neurobiology. 2023-07-06. PMID:37410316. |
the application of glial cell line-derive neurotrophic factor (gdnf) to cell cultures and animal models has demonstrated positive effects upon dopaminergic neuronal survival and development, function, restoration, and protection. |
2023-07-06 |
2023-08-14 |
human |