| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dariusz Szczygieł, Małgorzata Szczygieł, Anna Łaś, Martyna Elas, Roxana Zuziak, Beata K Płonka, Przemysław M Płonk. Spin Trapping of Nitric Oxide by Hemoglobin and Ferrous Diethyldithiocarbamate in Model Tumors Differing in Vascularization. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673758. |
both human and animal tumors often reveal triplet epr signals of nitrosylhemoglobin (hbno) as an effect of nitric oxide formation in tumor tissue, where no is complexed by hb. |
2024-04-27 |
2024-04-29 |
mouse |
| Cezara Zagrean-Tuza, Galaba Pato, Grigore Damian, Radu Silaghi-Dumitrescu, Augustin C Mo. Redox Reactivity of Nonsymbiotic Phytoglobins towards Nitrite. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542837. |
class 1 hb are expressed under hypoxia, osmotic stress, and/or nitric oxide exposure, while class 2 hb are induced by cold stress and cytokinins. |
2024-03-28 |
2024-03-30 |
Not clear |
| Clayton Cuddington, Alisyn Greenfield, Yong Gyu Lee, Jung Lye Kim, Derek Lamb, Paul W Buehler, Sylvester M Black, Andre F Palmer, Bryan A Whitso. Polymerized Human Hemoglobin-Based Oxygen Carrier Preserves Lung Allograft Function During Normothermic Ex Vivo Lung Perfusion. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2024-01-24. PMID:38266069. |
as an o2 carrier, red blood cells (rbcs) are a scarce resource and are susceptible to hemolysis in perfusion circuits, thus releasing cell-free hemoglobin (hb), which can extravasate into the tissue space, thus promoting scavenging of nitric oxide (no) and oxidative tissue damage. |
2024-01-24 |
2024-01-27 |
human |
| Michele Samaja, Ashok Malavalli, Kim D Vandegrif. How Nitric Oxide Hindered the Search for Hemoglobin-Based Oxygen Carriers as Human Blood Substitutes. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834350. |
of the several bottlenecks encountered, the high reactivity of acellular hb with circulating nitric oxide (no) is particularly arduous to overcome because of the no-scavenging effect, which causes life-threatening side effects as vasoconstriction, inflammation, coagulopathies, and redox imbalance. |
2023-10-14 |
2023-10-15 |
human |
| Mamta P Sumi, Blair Tupta, Sanjoy Roychowdhury, Suzy Comhair, Kewal Asosingh, Dennis J Stuehr, Serpil C Erzurum, Arnab Ghos. Hemoglobin resident in the lung epithelium is protective for smooth muscle soluble guanylate cyclase function. Redox biology. vol 63. 2023-04-30. PMID:37120930. |
however hb being an nitric oxide (no) scavenger can bind to no and reduce its deleterious effects. |
2023-04-30 |
2023-08-14 |
mouse |
| Mamta P Sumi, Blair Tupta, Arnab Ghos. Nitric Oxide Trickle Drives Heme into Hemoglobin and Muscle Myoglobin. Cells. vol 11. issue 18. 2022-09-23. PMID:36139413. |
we show, by transwell co-culture of nitric oxide (no) generating, hek enos/nnos cells, and k562 erythroid or c2c12 muscle myoblasts, that low doses of no can effectively insert heme into hemoglobin (hb) and myoglobin (mb), making no not only a vasodilator, but also a globin heme trigger. |
2022-09-23 |
2023-08-14 |
Not clear |
| Kate Jones, Karen S Galea, Bernice Scholten, Marika Loikala, Simo P Porras, Radia Bousoumah, Sophie Ndaw, Elizabeth Leese, Henriqueta Louro, Maria João Silva, Susana Viegas, Lode Godderis, Jelle Verdonck, Katrien Poels, Thomas Gӧen, Radu-Corneliu Duca, Tiina Santonen, Hbm Eu Diisocyanates Study Tea. HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure. International journal of environmental research and public health. vol 19. issue 14. 2022-07-27. PMID:35886663. |
the study will collect urine samples (analysed for diisocyanate-derived diamines and acetyl-mdi-lysine), blood samples (analysed for diisocyanate-specific ige and igg antibodies, inflammatory markers, and diisocyanate-specific hb adducts for mdi), and buccal cells (micronucleus analysis) and measure fractional exhaled nitric oxide. |
2022-07-27 |
2023-08-14 |
human |
| Uddyalok Banerjee, Savannah Wolfe, Quintin O'Boyle, Clayton Cuddington, Andre F Palme. Scalable production and complete biophysical characterization of poly(ethylene glycol) surface conjugated liposome encapsulated hemoglobin (PEG-LEH). PloS one. vol 17. issue 7. 2022-07-08. PMID:35802716. |
hb encapsulation, methemoglobin (methb) level, o2-peg-leh equilibria, peg-leh gaseous (oxygen, carbon monoxide, nitric oxide) ligand binding/release kinetics, lipocrit, and long-term storage stability allowed us to examine their potential suitability and efficacy as an rbc replacement. |
2022-07-08 |
2023-08-14 |
Not clear |
| Edward N Calvo, Kaiea Vera, Ann Hashimoto, Scott K Ferguso. Impact of cell-free hemoglobin on oxygen pressure dynamics in muscles comprised primarily of fast-twitch fibers. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555063. |
cell free hemoglobin (hb), released due to hemolysis, reduces the bioavailability of nitric oxide (no) and the microvascular po |
2022-05-13 |
2023-08-13 |
Not clear |
| Xiangming Gu, Richard Hickey, Antara Rath, Andre F Palme. Scalable manufacturing platform for the production of methemoglobin as a non-oxygen carrying control material in studies of cell-free hemoglobin solutions. PloS one. vol 17. issue 2. 2022-02-16. PMID:35171971. |
methemoglobin (methb) arises from the oxidation of ferrous hemoglobin (hbfe2+, hb) to ferric hemoglobin (hbfe3+, methb), which is unable to bind gaseous ligands such as oxygen (o2) and carbon monoxide (co), and binds to nitric oxide (no) significantly slower compared to hb. |
2022-02-16 |
2023-08-13 |
human |
| Krianthan Govender, Vinay P Jani, Pedro Cabrale. The Disconnect Between Extracorporeal Circulation and the Microcirculation: A Review. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2022-01-24. PMID:35067580. |
the effects of hemolysis are especially pronounced in the microcirculation, where plasma hb leads to nitric oxide scavenging, oxidization, formation of reactive oxygen species, and inflammatory responses. |
2022-01-24 |
2023-08-13 |
Not clear |
| Yung-Chih Chen, Kuang-Nan Hsu, Jerry Cheng-Yen Lai, Li-Yang Chen, Mei-Shin Kuo, Chiu-Chu Liao, Kate Hs. Influence of hemoglobin on blood pressure among people with GP.Mur blood type Journal of the Formosan Medical Association = Taiwan yi zhi. 2022-01-10. PMID:35000824. |
because band 3 and hb comodulate nitric oxide (no)-dependent vasodilation and hemoglobin (hb) is positively associated with bp, we aimed to test whether these could contribute to higher bp in gp.mur+ people. |
2022-01-10 |
2023-08-13 |
Not clear |
| Shahid Rameez, Uddyalok Banerjee, Jorge Fontes, Alexander Roth, Andre F Palme. The Reactivity of Polymersome Encapsulated Hemoglobin with Physiologically Important Gaseous Ligands: Oxygen, Carbon Monoxide and Nitric Oxide. Macromolecules. vol 45. issue 5. 2021-10-21. PMID:22865934. |
key biophysical properties as well as the kinetics of polymersome encapsulated hb (peh) interaction with physiologically important gaseous ligands (o(2), carbon monoxide and nitric oxide) were measured as a function of the hydrophobic membrane thickness of the peh particle. |
2021-10-21 |
2023-08-12 |
Not clear |
| Raphael M Buzzi, Catherine M Owczarek, Kevin Akeret, Andrea Tester, Natasha Pereira, Rebecca Butcher, Valérie Brügger-Verdon, Matthew P Hardy, Marlies Illi, Andreas Wassmer, Florence Vallelian, Rok Humar, Michael Hugelshofer, Paul W Buehler, Thomas Gentinetta, Dominik J Schae. Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics. Molecular pharmaceutics. vol 18. issue 8. 2021-08-27. PMID:34292741. |
haptoglobin (hp) captures hb in an irreversible protein complex and prevents its pathophysiological contributions to vascular nitric oxide depletion and tissue oxidation. |
2021-08-27 |
2023-08-13 |
human |
| Raphael M Buzzi, Catherine M Owczarek, Kevin Akeret, Andrea Tester, Natasha Pereira, Rebecca Butcher, Valérie Brügger-Verdon, Matthew P Hardy, Marlies Illi, Andreas Wassmer, Florence Vallelian, Rok Humar, Michael Hugelshofer, Paul W Buehler, Thomas Gentinetta, Dominik J Schae. Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics. Molecular pharmaceutics. vol 18. issue 8. 2021-08-27. PMID:34292741. |
the functions of these proteins were then characterized for hb and heme-binding, binding of the hp-hb complexes with the clearance receptor cd163, antioxidant properties, and vascular nitric oxide sparing capacity. |
2021-08-27 |
2023-08-13 |
human |
| Yu-Jung Lin, Chun-Chieh Chen, Dang Nguyen, Huei-Rou Su, Kun-Ju Lin, Hsin-Lung Chen, Yu-Jung Hu, Po-Liang Lai, Hsing-Wen Sun. Biomimetic Engineering of a Scavenger-Free Nitric Oxide-Generating/Delivering System to Enhance Radiation Therapy. Small (Weinheim an der Bergstrasse, Germany). vol 16. issue 23. 2021-06-23. PMID:32363753. |
nitric oxide (no) is a potent tumor-cell radiosensitizer but it can be readily scavenged by hemoglobin (hb) in vivo. |
2021-06-23 |
2023-08-13 |
Not clear |
| Ryan L Hoiland, Joshua C Tremblay, Benjamin S Stacey, Geoff B Coombs, Daniela Nowak-Flück, Michael M Tymko, Alexander Patrician, Mike Stembridge, Connor A Howe, Damian M Bailey, Daniel J Green, David B MacLeod, Philip N Ainsli. Acute reductions in haematocrit increase flow-mediated dilatation independent of resting nitric oxide bioavailability in humans. The Journal of physiology. vol 598. issue 19. 2021-02-15. PMID:32639605. |
changes in haematocrit influence nitric oxide signalling through alterations in shear stress stimuli and haemoglobin scavenging of nitric oxide; these two regulatory factors have not been assessed simultaneously isovolumic haemodilution led to a marked increase in brachial artery flow-mediated dilatation in humans the increase in flow-mediated dilatation occurred in the face of an unaltered shear stress stimulus for vasodilatation and reduced resting steady-state nitric oxide levels in the blood collectively, our data point towards haemoglobin scavenging of nitric oxide as a key regulatory factor of brachial flow-mediated dilatation and highlight the importance of the simultaneous consideration of nitric oxide production and inactivation when investigating vascular function in humans abstract: haemoglobin (hb) may impact the transduction of endothelium-dependent and nitric oxide (no)-mediated vasodilator activity, given its contribution to shear stress stimuli and diverse biochemical reactions with no. |
2021-02-15 |
2023-08-13 |
Not clear |
| Ramin Bahmani, DongGwan Kim, JongDuk Na, Seongbin Hwan. Expression of the Tobacco Non-symbiotic Class 1 Hemoglobin Gene Hb1 Reduces Cadmium Levels by Modulating Cd Transporter Expression Through Decreasing Nitric Oxide and ROS Level in Frontiers in plant science. vol 10. 2020-10-01. PMID:30853969. |
expression of the tobacco non-symbiotic class 1 hemoglobin gene hb1 reduces cadmium levels by modulating cd transporter expression through decreasing nitric oxide and ros level in hemoglobin (hb) proteins are ubiquitous in plants, and non-symbiotic class 1 hemoglobin (hb1) is involved in various biotic and abiotic stress responses. |
2020-10-01 |
2023-08-13 |
Not clear |
| Renata M N Eleutério, Francisco O Nascimento, Tamara G Araújo, Marilena F Castro, Tarcísio P Almeida Filho, Pedro A Maia Filho, José Eleutério, Darcielle B D Elias, Romélia P G Leme. Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia. Advances in hematology. vol 2019. 2020-10-01. PMID:30853991. |
intravascular haemolysis occurs, in which free hb and free radicals degrade nitric oxide (no) and release arginase, which reduces arginine levels. |
2020-10-01 |
2023-08-13 |
Not clear |
| Katherine C Wood, Brittany G Durgin, Heidi M Schmidt, Scott A Hahn, Jeffrey J Baust, Tim Bachman, Dario A Vitturi, Samit Ghosh, Solomon F Ofori-Acquah, Ana L Mora, Mark T Gladwin, Adam C Strau. Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice. Blood advances. vol 3. issue 23. 2020-09-22. PMID:31821458. |
an underlying mechanism of scd vasculopathy is vascular smooth muscle (vsm) nitric oxide (no) resistance, which is mediated by no scavenging reactions with plasma hemoglobin (hb) and reactive oxygen species that can oxidize soluble guanylyl cyclase (sgc), the no receptor. |
2020-09-22 |
2023-08-13 |
mouse |