| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eliza Wolska, Karolina Sadowsk. Drug Release from Lipid Microparticles-Insights into Drug Incorporation and the Influence of Physiological Factors. Pharmaceutics. vol 16. issue 4. 2024-04-27. PMID:38675206. |
the examination of the residues after the release studies indicated the possibility of releasing 100% of ind from slm without complete degradation of the microparticles' matrix. |
2024-04-27 |
2024-04-29 |
Not clear |
| Wedja Timóteo Vieira, Meuris Gurgel Carlos da Silva, Laura de Oliveira Nascimento, Melissa Gurgel Adeodato Vieir. Development and characterization of crosslinked k-carrageenan/sericin blend with covalent agents or thermal crosslink for indomethacin extended release. International journal of biological macromolecules. 2023-07-01. PMID:37392907. |
this research focused on the encapsulation of indomethacin (ind) in the crosslinked k-car/ser polymeric matrix by covalent and thermal methods to evaluate drug delivery modulation and properties of the crosslinked blend. |
2023-07-01 |
2023-08-14 |
Not clear |
| Wedja Timóteo Vieira, Meuris Gurgel Carlos da Silva, Laura de Oliveira Nascimento, Melissa Gurgel Adeodato Vieir. k-Carrageenan/sericin-based multiparticulate systems: A novel gastro-resistant polymer matrix for indomethacin delivery. International journal of biological macromolecules. 2023-02-02. PMID:36731703. |
increasing the amount of ind in the formulations subtly reduced the entrapment efficiency (ee) and drug loading (dl) due to matrix saturation. |
2023-02-02 |
2023-08-14 |
Not clear |
| Wedja Timóteo Vieira, Meuris Gurgel Carlos da Silva, Laura de Oliveira Nascimento, Melissa Gurgel Adeodato Vieir. k-Carrageenan/sericin-based multiparticulate systems: A novel gastro-resistant polymer matrix for indomethacin delivery. International journal of biological macromolecules. 2023-02-02. PMID:36731703. |
additionally, the k-car/ser matrix was ph-responsive with low ind release at ph 1.2 and extended-release at ph 6.8. |
2023-02-02 |
2023-08-14 |
Not clear |
| Barbara Mikolaszek, Marzena Jamrógiewicz, Krystyna Mojsiewicz-Pieńkowska, Małgorzata Sznitowsk. Microscopic and Spectroscopic Imaging and Thermal Analysis of Acrylates, Silicones and Active Pharmaceutical Ingredients in Adhesive Transdermal Patches. Polymers. vol 14. issue 14. 2022-07-27. PMID:35890664. |
in silicone matrices, all three apis were suspended, whereas in the case of the acrylic psa, raman microscopy confirmed that only ind was dissolved in all three acrylic matrices, and the dissolved fraction of the cyt differed depending on the matrix type. |
2022-07-27 |
2023-08-14 |
Not clear |
| Xiujuan Huang, Yan Xiao, Meidong Lan. Micelles/sodium-alginate composite gel beads: A new matrix for oral drug delivery of indomethacin. Carbohydrate polymers. vol 87. issue 1. 2021-10-19. PMID:34663038. |
micelles/sodium-alginate composite gel beads (micelles/sa beads) were constructed from sa matrix and indomethacin (ind) loaded six-arm block copolymer poly(ɛ-caprolactone)-block-(dimethylamino)ethyl methacrylate (s(pcl-b-pdma) |
2021-10-19 |
2023-08-13 |
Not clear |
| Na Yin, Xueting Guo, Rong Sun, Hongbing Liu, Lihua Tang, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tan. Intra-articular injection of indomethacin-methotrexate in situ hydrogel for the synergistic treatment of rheumatoid arthritis. Journal of materials chemistry. B. vol 8. issue 5. 2021-03-01. PMID:31930243. |
d-nps were formed by multiple non-covalent interactions between pei-ss and the carboxyl-containing hydrophobic small molecule drugs ind and mtx, which were then loaded into a temperature-sensitive hydrogel matrix. |
2021-03-01 |
2023-08-13 |
Not clear |
| Islam Ibrahim Hegab, Rania Nagi Abd-Ellatif, Mona Tayssir Sade. The gastroprotective effect of N-acetylcysteine and genistein in indomethacin-induced gastric injury in rats. Canadian journal of physiology and pharmacology. vol 96. issue 11. 2019-02-18. PMID:30011378. |
they also significantly decreased malondialdehyde, tumour necrosis factor α levels, and myeloperoxidase activity, and downregulated matrix metalloproteinase 9 (mmp-9) gene expression compared to the ind group. |
2019-02-18 |
2023-08-13 |
rat |
| Luz María Martínez, Marcelo Videa, Tania López Silva, Samuel Castro, Adolfo Caballero, Víctor J Lara-Díaz, Fabiola Castorena-Torre. Two-phase amorphous-amorphous solid drug dispersion with enhanced stability, solubility and bioavailability resulting from ultrasonic dispersion of an immiscible system. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 119. 2018-05-04. PMID:28648863. |
by introducing this novel ultrasound assisted method, the immiscible api particles were uniformly dispersed as microscopic glassy clusters of the drug in the solid amorphous glu matrix; particle sizes of ind in the aasd range from 600nm to 1.4μm. |
2018-05-04 |
2023-08-13 |
Not clear |
| Kristian Semjonov, Karin Kogermann, Ivo Laidmäe, Osmo Antikainen, Clare J Strachan, Henrik Ehlers, Jouko Yliruusi, Jyrki Heinämäk. The formation and physical stability of two-phase solid dispersion systems of indomethacin in supercooled molten mixtures with different matrix formers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 97. 2017-05-23. PMID:27890595. |
supercooled molten sds of ind with sol were two-phase glassy suspension in which the amorphous drug was dispersed in an amorphous polymer matrix. |
2017-05-23 |
2023-08-13 |
Not clear |
| A M El-Kosasy, L A Hussin, Miriam F Ayad, N V Fare. Optimization of Extraction, HPLC and Kinetic Studies for Determination of Some Food Tainting Compounds in Different Food Matrices. Journal of chromatographic science. vol 53. issue 9. 2016-05-11. PMID:25944091. |
solid-liquid extraction, ultrasonic-assisted extraction and matrix solid-phase dispersion (mspd) were optimized and compared in terms of recoveries for the simultaneous extraction of indole (ind) and 2,4-dichlorophenol (dcp) from catfish samples and for the extraction of ind alone from potato samples. |
2016-05-11 |
2023-08-13 |
Not clear |
| Dajun D Sun, Ping I Le. Evolution of supersaturation of amorphous pharmaceuticals: nonlinear rate of supersaturation generation regulated by matrix diffusion. Molecular pharmaceutics. vol 12. issue 4. 2016-01-04. PMID:25775257. |
our model predictions also support our experimental findings that ind asd in cross-linked phema exhibits a unique kinetic solubility profile because the resulting supersaturation level is governed by a matrix diffusion regulated mechanism opposite to that resulted from a high level of initial supersaturation or a rapid dissolution of amorphous solids. |
2016-01-04 |
2023-08-13 |
Not clear |
| Dajun D Sun, Ping I Le. Evolution of supersaturation of amorphous pharmaceuticals: nonlinear rate of supersaturation generation regulated by matrix diffusion. Molecular pharmaceutics. vol 12. issue 4. 2016-01-04. PMID:25775257. |
the objective of the current study is to further examine the effect of nonlinear rate profiles of supersaturation generation in amorphous systems, including (1) instantaneous or infinite rate (i.e., initial degree of supersaturation), (2) first-order rate (e.g., from dissolution of amorphous drug particles), and (3) matrix diffusion regulated rate (e.g., drug release from amorphous solid dispersions (asds) based on cross-linked poly(2-hydroxyethyl methacrylate) (phema) hydrogels), on the kinetic solubility profiles of a model poorly soluble drug indomethacin (ind) under nonsink dissolution conditions. |
2016-01-04 |
2023-08-13 |
Not clear |
| Rafaelle Christine Gomes Fares, Juliana de Assis Silva Gomes, Luciana Ribeiro Garzoni, Mariana Caldas Waghabi, Roberto Magalhães Saraiva, Nayara Ingrid Medeiros, Roberta Oliveira-Prado, Luiz Henrique Conde Sangenis, Mayara da Costa Chambela, Fernanda Fortes de Araújo, Andréa Teixeira-Carvalho, Marcos Paulo Damásio, Vanessa Azevedo Valente, Karine Silvestre Ferreira, Giovane Rodrigo Sousa, Manoel Otávio da Costa Rocha, Rodrigo Correa-Oliveir. Matrix metalloproteinases 2 and 9 are differentially expressed in patients with indeterminate and cardiac clinical forms of Chagas disease. Infection and immunity. vol 81. issue 10. 2013-11-25. PMID:23856618. |
in this study, we characterized for the first time the serum matrix metalloproteinase 2 (mmp-2) and mmp-9 levels, as well as their main cell sources in peripheral blood mononuclear cells from patients presenting with the indeterminate (ind) or cardiac (card) clinical form of chagas disease. |
2013-11-25 |
2023-08-12 |
Not clear |
| Gyoung Nyoun Kim, C Yong Kan. Matrix protein of VSV New Jersey serotype containing methionine to arginine substitutions at positions 48 and 51 allows near-normal host cell gene expression. Virology. vol 357. issue 1. 2007-01-19. PMID:16962155. |
the presence of methionine at position 51 (m51) of the matrix (m) protein of the vsv indiana serotype (vsv(ind)) has been proven to be crucial for cell rounding and inhibition of host cell gene expression. |
2007-01-19 |
2023-08-12 |
human |
| W Scott Helton, Piero M Fisichella, Robert Berger, Santiago Horgan, Nocif Joseph Espat, Herand Abcaria. Short-term outcomes with small intestinal submucosa for ventral abdominal hernia. Archives of surgery (Chicago, Ill. : 1960). vol 140. issue 6. 2005-07-05. PMID:15967902. |
a bioabsorbable tissue scaffold of porcine submucosal small intestine extracellular matrix (surgisis gold [sis]; cook biotech inc, west lafayette, ind) mesh is safe and effective for ventral hernia repair. |
2005-07-05 |
2023-08-12 |
Not clear |
| Georgia Kostopanagiotou, Vassilios Smyrniotis, Kassiani Theodoraki, Yannis Skalkidis, Nigel Heaton, Dennis Potte. Oxygen availability during orthotopic liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 9. issue 11. 2004-03-12. PMID:14586884. |
statistical analysis was performed using anova for repeated measures and spearman correlation coefficient matrix among the six variables (do(2 ind), vo(2 ind), o(2)er, p(50), cavlo(2), and o(2)eravl) taken two at a time at every phase. |
2004-03-12 |
2023-08-12 |
Not clear |