| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rokeya Akter, Rackhyun Park, Soo Kyung Lee, Eun Ju Han, Kyu-Sang Park, Junsoo Park, Mee-Yon Ch. Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3 Signaling Pathway in Tumor Cells. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673975. |
jak2/stat3 inhibition decreased the levels of emr1, jak2, stat1, and stat3, significantly impeded the proliferation, migration, and mobility of cells, and increased the apoptosis of emr1 |
2024-04-27 |
2024-04-29 |
Not clear |
| Anima Kumari, Anugya Srivastava, Pankaj Jagdale, Anjaneya Ayanur, Vinay Kumar Khann. Lambda-cyhalothrin Enhances Inflammation in Nigrostriatal Region in Rats:Regulatory Role of NF-κβ and JAK-STAT Signaling. Neurotoxicology. 2023-04-15. PMID:37060950. |
exposure of rats to lct also caused alteration in the levelsof heat shock protein 60 (hsp60) and mrna expression of toll-like receptors(tlr2 and tlr4) in the substantia nigra and corpus striatum.an increase in the phosphorylation of key proteins involved in nf-kβ (p65, iκβ, ikkα, ikkβ)signalingand stat1 and stat3 and alteration in the protein levels of jak1 and jak2 were prominent in lct-treated rats.histological studies revealed damage of dopaminergic neurons and reactive gliosis as evidenced by the presence of darkly stained pyknotic neurons anddecrease in nisslsubstance and an increase in infiltration of immune cells both in substantia nigra and corpus striatum of lct-treated rats. |
2023-04-15 |
2023-08-14 |
rat |
| Yong Luo, Xiaobing Yang, Spyridon P Basourakos, Xuemei Zuo, Dechao Wei, Jiahui Zhao, Mingchuan Li, Qiankun Li, Tao Feng, Pengju Guo, Yongguang Jian. Enzalutamide-Resistant Progression of Castration-Resistant Prostate Cancer Is Driven via the JAK2/STAT1-Dependent Pathway. Frontiers in molecular biosciences. vol 8. 2021-11-10. PMID:34746227. |
then, we verified that targeting the inhibition of jak2 or stat1 could remarkably increase apoptosis and dna damage and decrease the migration of crpc cells. |
2021-11-10 |
2023-08-13 |
Not clear |
| Rukhsana Gul, Vincent G Demarco, James R Sowers, Adam Whaley-Connell, Lakshmi Pulaka. Regulation of Overnutrition-Induced Cardiac Inflammatory Mechanisms. Cardiorenal medicine. vol 2. issue 3. 2021-10-21. PMID:22969779. |
nebivolol also attenuated excessive activation of the nutrient sensor kinases mtor and s6k1 and their substrate rps6 as well as the inflammatory marker jak2 and substrate stat1 in zo myocardium (p < 0.05). |
2021-10-21 |
2023-08-12 |
rat |
| Dandan Chen, Yaoyu Liu, Junqi Chen, Hua Lin, Huijuan Guo, Yifan Wu, Yuan Xu, Yuan Zhou, Wei Zhou, Ruirui Lu, Jiuyao Zhou, Junbiao W. JAK/STAT pathway promotes the progression of diabetic kidney disease via autophagy in podocytes. European journal of pharmacology. vol 902. 2021-09-27. PMID:33901462. |
further, a lower number of autophagosomes, reduced expression of map1lc3 (lc3) in glomeruli, and increased expression of jak/stat pathway-related proteins, namely jak1, jak2, stat1, stat3, stat5, and stat6, were observed in dkd mice. |
2021-09-27 |
2023-08-13 |
mouse |
| Hua Fang, Fang-Xiang Zhang, Hua-Feng Li, Miao Yang, Ren Liao, Ru-Rong Wang, Quan-Yun Wang, Peng-Cheng Zheng, Jian-Ping Zhan. PRR34-AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1-dependent JAK-STAT signaling pathway. Journal of cellular physiology. vol 235. issue 3. 2020-12-17. PMID:31556112. |
upregulated prr34-as1 diminished expression of jak1, stat1, jak2, and stat3 as well as cell apoptosis, while enhancing cell proliferation in vitro. |
2020-12-17 |
2023-08-13 |
mouse |
| Donglai Zhou, Tingting Ding, Bin Ni, Yunyan Jing, Shanxin Li. Hydroxysafflor Yellow A mitigated myocardial ischemia/reperfusion injury by inhibiting the activation of the JAK2/STAT1 pathway. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173173. |
in vivo, animals treated with hsya presented less severe myocardial injury and decreased janus kinase 2 (jak2)/signal transducer and activator of transcription 1 (stat1) activity, improved antioxidant capacity and decreased apoptosis. |
2019-12-23 |
2023-08-13 |
Not clear |
| Won Jin Lee, Sun Ah Ham, Hyunjin Yoo, Jung Seok Hwang, Taesik Yoo, Kyung Shin Paek, Dae-Seog Lim, Sung Gu Han, Chi-Ho Lee, Kwonho Hong, Han Geuk Se. Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells. Journal of cellular biochemistry. vol 119. issue 7. 2019-04-12. PMID:29388693. |
the inhibitory effect of gw501516 on gp91phox expression and glutamate release was further potentiated in the presence of ag490, a specific inhibitor of janus kinase 2 (jak2), leading to the inhibition of signal transducer and activator of transcription 1 (stat1). |
2019-04-12 |
2023-08-13 |
Not clear |
| Lei Gong, Anatol Manaenko, Ruiming Fan, Lei Huang, Budbazar Enkhjargal, DevinW McBride, Yan Ding, Jiping Tang, Xiaoqiu Xiao, John H Zhan. Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage. Neuropharmacology. vol 138. 2019-02-13. PMID:29885817. |
the administration of opn (3 μg) significantly improved neurobehavior and increased expression of opn and integrin-β1 receptor in the brain followed with decrease of neutrophil infiltration, jak2, stat1, tnf-a, il-1b, mmp-9 and brain edema in the ich + hg + opn rats compared with ich + hg rats. |
2019-02-13 |
2023-08-13 |
rat |
| Danny Hung-Chieh Chou, Amedeo Vetere, Amit Choudhary, Stephen S Scully, Monica Schenone, Alicia Tang, Rachel Gomez, Sean M Burns, Morten Lundh, Tamara Vital, Eamon Comer, Patrick W Faloon, Vlado Dančík, Christie Ciarlo, Joshiawa Paulk, Mingji Dai, Clark Reddy, Hanshi Sun, Matthew Young, Nicholas Donato, Jacob Jaffe, Paul A Clemons, Michelle Palmer, Steven A Carr, Stuart L Schreiber, Bridget K Wagne. Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. Journal of the American Chemical Society. vol 137. issue 24. 2016-03-21. PMID:26042473. |
here, we show that the small-molecule brd0476, a novel suppressor of pancreatic β-cell apoptosis, inhibits interferon-gamma (ifn-γ)-induced janus kinase 2 (jak2) and signal transducer and activation of transcription 1 (stat1) signaling to promote β-cell survival. |
2016-03-21 |
2023-08-13 |
rat |
| Jin-bing Zhao, Yang Zhang, Guang-zhao Li, Xing-fen Su, Chun-hua Han. Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats. Neuroscience letters. vol 498. issue 2. 2011-10-18. PMID:21596098. |
the activation of jak2, stat1 and stat3 in pericontusional cortex was determined by western blotting, electrophoretic mobility shift assay (emsa), immunohistochemistry and immunofluorescence. |
2011-10-18 |
2023-08-12 |
rat |
| Chia-Wen Chang, Wan-Hua Tsai, Woei-Jer Chuang, Yee-Shin Lin, Jiunn-Jong Wu, Ching-Chuan Liu, Pei-Jane Tsai, Ming T Li. Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis. The Journal of biological chemistry. vol 284. issue 48. 2010-01-21. PMID:19801665. |
in the current study we found that after binding to alpha(v)beta(3), spe b stimulated the tyrosine phosphorylation of jak2 and stat1. |
2010-01-21 |
2023-08-12 |
Not clear |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery. Journal of nephrology. vol 21. issue 6. 2009-03-24. PMID:19034877. |
effect of jak2 kinase inhibition on stat1 and stat3 activation and apoptosis of tubular epithelial cells induced by atp depletion/recovery. |
2009-03-24 |
2023-08-12 |
human |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery. Journal of nephrology. vol 21. issue 6. 2009-03-24. PMID:19034877. |
in an in vitro model of renal ischemia/reperfusion injury (iri), we investigated the role of jak2 kinase inhibition on signal transducer and activator of transcription 1 (stat1) and stat3 activations as well as apoptosis of human proximal tubular epithelial cells (hkcs) induced by adenosine triphosphate (atp) depletion/recovery. |
2009-03-24 |
2023-08-12 |
human |
| Mario B Marrero, Merouane Bencheri. Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB. Brain research. vol 1256. 2009-03-16. PMID:19063868. |
we report that nicotine induced the production of bcl-2 and increased the transcriptional activation of nf-kappab, ap-1, stat1, and stat3, and with the exception of ap-1, the other transcription factors (nf-kappab, stat1, and stat3) were significantly reduced by jak2 inhibition. |
2009-03-16 |
2023-08-12 |
Not clear |
| Roser Gorina, Coral Sanfeliu, Aida Galitó, Angel Messeguer, Anna M Plana. Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490. Glia. vol 55. issue 13. 2007-11-13. PMID:17607690. |
exposure of glia to pro-oxidant agents revealed selective stat1 activation by h2o2 and jak2-independent antioxidant features of the jak2 inhibitor ag490. |
2007-11-13 |
2023-08-12 |
rat |
| H M Yu, J L Zhi, Y Cui, E H Tang, S N Sun, J Q Feng, P X Che. Role of the JAK-STAT pathway in protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells. Apoptosis : an international journal on programmed cell death. vol 11. issue 6. 2007-11-01. PMID:16547593. |
it was shown that (1) preconditioning with 100 micromol/l h(2)o(2) can markedly protect pc12 cells against apoptosis and cytotoxicity induced by 300 micromol/l h(2)o(2); (2) the expression and tyrosine phosphorylation of jak2, not jak1 were rapidly increased at 5 min after h(2)o(2) preconditioning; (3) the expression of stat1 and stat3 were significantly increased at 15 min after h(2)o(2) preconditioning, and the ptyr-stat1 and ptyr-stat3 were markedly increased at 60 min after h(2)o(2) preconditioning; (4) pretreatment with the jak inhibitor ag-490 (10 micromol/l) 20 min before h(2)o(2) preconditioning blocked not only the activation of jak2, stat1 and stat3, but also the cytoprotection of h(2)o(2) preconditioning against apoptosis and cytotoxicity induced by oxidative stress. |
2007-11-01 |
2023-08-12 |
Not clear |
| Amy K L Banes-Berceli, Pimonrat Ketsawatsomkron, Safia Ogbi, Bela Patel, David M Pollock, Mario B Marrer. Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation. American journal of physiology. Heart and circulatory physiology. vol 293. issue 2. 2007-09-18. PMID:17526654. |
using male sprague-dawley rats, we performed a time course study [days 7, 14, and 28 after streptozotocin (stz) injection] to determine changes in phosphorylation of jak2, stat1, and stat3 in thoracic aorta using standard western blot techniques. |
2007-09-18 |
2023-08-12 |
rat |
| Amy K Banes-Berceli, Sean Shaw, Guochuan Ma, Michael Brands, Douglas C Eaton, David M Stern, David Fulton, R William Caldwell, Mario B Marrer. Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells. American journal of physiology. Renal physiology. vol 291. issue 1. 2006-07-26. PMID:16449352. |
consistent with these in vitro results, both albumin protein excretion and phosphorylation of jak2, stat1, and stat3 were attenuated in renal glomeruli by administration of simvastatin in a streptozotocin-induced rat model of hg diabetes. |
2006-07-26 |
2023-08-12 |
rat |
| E Puxeddu, J A Knauf, M A Sartor, N Mitsutake, E P Smith, M Medvedovic, C R Tomlinson, S Moretti, J A Fagi. RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response. Endocrine-related cancer. vol 12. issue 2. 2005-08-22. PMID:15947106. |
functional clustering of genes with greater than or less than 1.75-fold expression change (86 genes) revealed ret/ptc3-induced regulation of genes with key functions in apoptosis (ripk3, tdga), cell-cell signaling (cdh6, fn1), cell cycle (il24), immune and inflammation response (cxcl10, scya2, il6, gbp2, oas1, tap1, rt1aw2, c2ta, irf1, lmp2, psme2, prkr), metabolism (aldob, ptges, nd2, gss, gstt1), signal transduction (socs3, nf1, jak2, cpg21, dusp6, socs1, stat1, stat3, cish) and transcription (nr4a1, junb, hfh1, runx1, foxe1). |
2005-08-22 |
2023-08-12 |
Not clear |