| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rokeya Akter, Rackhyun Park, Soo Kyung Lee, Eun Ju Han, Kyu-Sang Park, Junsoo Park, Mee-Yon Ch. Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3 Signaling Pathway in Tumor Cells. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673975. |
jak2/stat3 inhibition decreased the levels of emr1, jak2, stat1, and stat3, significantly impeded the proliferation, migration, and mobility of cells, and increased the apoptosis of emr1 |
2024-04-27 |
2024-04-29 |
Not clear |
| Jiang Cao, Xiao Yu, Jingcheng Liu, Jiaju Fu, Binyu Wang, Chaoqin Wu, Sheng Zhang, Hongtao Chen, Zi Wang, Yinyang Xu, Tao Sui, Jie Chang, Xiaojian Ca. Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury. Neural regeneration research. vol 19. issue 11. 2024-03-25. PMID:38526286. |
furthermore, ruxolitinib inhibited the phosphorylation of jak2 and stat3 in the injured spinal cord and decreased the phosphorylation level of nuclear factor kappa-b and the expression of inflammatory factors interleukin-1β, interleukin-6, and tumor necrosis factor-α. |
2024-03-25 |
2024-03-27 |
mouse |
| Prisca K Lin, Zheying Sun, George E Davi. Defining the Functional Influence of Endothelial Cell-Expressed Oncogenic Activating Mutations on Vascular Morphogenesis and Capillary Assembly. The American journal of pathology. vol 194. issue 4. 2024-03-23. PMID:37838010. |
the morphogenic impact of endothelial cell (ec) expression of activating mutants of kirsten rat sarcoma virus (kras), mitogen-activated protein kinase 1 (mek1), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), akt serine/threonine kinase 1 (akt1), ras homolog enriched in brain (rheb) janus kinase 2 (jak2), or signal transducer and activator of transcription 3 (stat3) expression versus controls was evaluated, along with ec signaling events, pharmacologic inhibitor assays, and sirna suppression experiments. |
2024-03-23 |
2024-03-25 |
rat |
| Q Ye, L Ren, Z M Jiang, X Y Li, G Y Wei, Y F Ren, L H Re. Cryptanshinone extract of Salvia miltiorrhiza stimulates pediatric acute myeloid leukemia stem cell apoptosis and the anti-inflammatory mechanism via accelerating microRNA-211-5p to supress Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway activation. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 6. 2024-02-13. PMID:38345448. |
this study was designed to explore cryptanshinone (cpt) extract of salvia miltiorrhiza stimulating pediatric acute myeloid leukemia (aml) stem cell (lsc) apoptosis and anti-inflammatory mechanism via accelerating microrna (mir)-211-5p to restrain janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway activation. |
2024-02-13 |
2024-02-15 |
human |
| Da-He Qi, Hua Ma, Yuan-Yuan Chen, Ke-Xin Wang, Meng-Meng Ding, Yun-Long Hao, Ye Guo, Ling-Bo Kon. [Research progress in mechanism of puerarin in treating vascular dementia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 22. 2023-12-19. PMID:38114205. |
the pathways of action include activating nuclear factor erythroid 2-related factor 2(nrf2)/antioxidant response element(are), vascular endothelial growth factor(vegf), extracellular regulated protein kinases(erk), phosphatidylinositol-3-kinase(pi3k)/protein kinase b(akt), janus-activating kinase 2(jak2)/signal transducer and activator of transcription 3(stat3), amp-activated protein kinase(ampk), as well as inhibiting the tumor necrosis factor α(tnf-α), transient receptor potential melastatin 2(trpm2)/n-methyl-d-aspartate receptor(nmdar), p38 mitogen-activated protein kinase(p38 mapk), toll-like receptor 4(tlr4)/nuclear factor-kappab(nf-κb), early growth response 1(egr-1), and matrix metalloproteinase 9(mmp-9). |
2023-12-19 |
2023-12-23 |
Not clear |
| Zhen Li, Meng-Xing Li, Yun-Peng Qin, Wei Tan. Electroacupuncture improves cognitive dysfunction in rats with Alzheimer's disease by regulating microglial cells. Zhen ci yan jiu = Acupuncture research. vol 48. issue 11. 2023-11-24. PMID:37984903. |
to observe the effect of electroacupuncture (ea) on microglia (mg), janus kinase-2 (jak2) and signal transducer and activator of transcription-3 (stat3) in hippocampal ca1 region of alzheimer's di-sease (ad) rats, so as to explore its mechanisms in the treatment of ad. |
2023-11-24 |
2023-11-28 |
rat |
| Rajina Shakya, Mi Ran Byun, Sang Hoon Joo, Kyung-Soo Chun, Joon-Seok Cho. Domperidone Exerts Antitumor Activity in Triple-Negative Breast Cancer Cells by Modulating Reactive Oxygen Species and JAK/STAT3 Signaling. Biomolecules & therapeutics. vol 31. issue 6. 2023-10-30. PMID:37899746. |
immunoblot analysis showed that domperidone-induced apoptosis occurred through the down-regulation of the phosphorylation of jak2 and stat3. |
2023-10-30 |
2023-11-08 |
human |
| Kayvan Khoramipour, Maryam Hossein Rezaei, Elham Madadizadeh, Mahdieh Sadat Hosseini, Zahra Soltani, Janis Schierbauer, Othmar Mose. High Intensity Interval Training can Ameliorate Hypothalamic Appetite Regulation in Male Rats with Type 2 Diabetes: The Role of Leptin. Cellular and molecular neurobiology. 2023-10-12. PMID:37828299. |
graphical abstract (leptin signaling in the hypothalamus), leptin (lep), leptin receptor (lep-r), janus kinase 2 (jak2), signal transducer and activator of transcription 3 (stat3), expressing neuropeptide y (npy), agouti-related protein (agrp), anorexigenic neurons (expressing pro-opiomelanocortin cocaine (pomc), amphetamine-related transcript (cart), suppressor of cytokine signaling (socs3), forkhead box protein o1 (foxo1). |
2023-10-12 |
2023-10-15 |
rat |
| Guang Yang, Yuting Tong, Xingyu Wang, Chenyi Zhao, Zongtao Ba, Reaila Ahelijiang, Xinjuan Liu, Waimao Gao, Yan Zhao, Yining Gu, Jianmei Yang, Ying X. Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout mice. Frontiers in immunology. vol 14. 2023-07-19. PMID:37465679. |
furthermore, primary microglia were obtained from neonatal sprague-dawley rats and pretreated with or without gzfl (50 μg/ml) for 1 h in the absence or presence of lipopolysaccharide (lps) (100 ng/ml) stimulation to speculate whether the underlying mechanism of gzfl's anti-inflammatory potential was closely associated with janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2023-07-19 |
2023-08-14 |
mouse |
| Anima Kumari, Anugya Srivastava, Pankaj Jagdale, Anjaneya Ayanur, Vinay Kumar Khann. Lambda-cyhalothrin Enhances Inflammation in Nigrostriatal Region in Rats:Regulatory Role of NF-κβ and JAK-STAT Signaling. Neurotoxicology. 2023-04-15. PMID:37060950. |
exposure of rats to lct also caused alteration in the levelsof heat shock protein 60 (hsp60) and mrna expression of toll-like receptors(tlr2 and tlr4) in the substantia nigra and corpus striatum.an increase in the phosphorylation of key proteins involved in nf-kβ (p65, iκβ, ikkα, ikkβ)signalingand stat1 and stat3 and alteration in the protein levels of jak1 and jak2 were prominent in lct-treated rats.histological studies revealed damage of dopaminergic neurons and reactive gliosis as evidenced by the presence of darkly stained pyknotic neurons anddecrease in nisslsubstance and an increase in infiltration of immune cells both in substantia nigra and corpus striatum of lct-treated rats. |
2023-04-15 |
2023-08-14 |
rat |
| Nan-Nan Zhao, Yan-Jie Li, He-Wei Qin, Hui-Min Ding, Xiao-Qiong Hua, Bo-Chao Zhu, Yu-Pu Wan. [Research progress on the modulation mechanism of electroacupuncture for learning and memory impairment after ischemic stroke]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 43. issue 2. 2023-02-22. PMID:36808522. |
electroacupuncture may play a role in treatment of learning and memory impairment after ischemic stroke by regulating phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt) signaling pathway, cyclic adenosine monophosphate (camp)-dependent protein kinase a (pka)/camp response element binding protein (creb) signaling pathway, nerve growth factor (ngf)/tyrosine kinase-a (trka) signaling pathway, janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway, notch signaling pathway, erythropoietin-producing hepatocyte (eph)/ephrin signaling pathway. |
2023-02-22 |
2023-08-14 |
Not clear |
| Yongmei Zhao, Mao Ding, Feng Yan, Jie Yin, Wenjuan Shi, Nan Yang, Haiping Zhao, Yalan Fang, Yuyou Huang, Yangmin Zheng, Xueqi Yang, Wei Li, Xunming Ji, Yumin Lu. Inhibition of the JAK2/STAT3 pathway and cell cycle re-entry contribute to the protective effect of remote ischemic pre-conditioning of rat hindlimbs on cerebral ischemia/reperfusion injury. CNS neuroscience & therapeutics. 2022-11-24. PMID:36419252. |
in the present study, we investigated the role of janus-activated kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway and cell cycle arrest, and their relationship with neuronal apoptosis following ripc. |
2022-11-24 |
2023-08-14 |
rat |
| Wenjie Ding, Zixuan Zhao, Yudan Zheng, Rui Wang, Zeyao Zhang, Ziyang Zhang, Xiangdong Wang, Shali Yu, Lei Liu, Rongrong Huang, Xinyuan Zhao, Qiyun W. Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway. Ecotoxicology and environmental safety. vol 248. 2022-11-14. PMID:36375367. |
both jak2 and stat3 inhibition effectively attenuated sccp-induced astrocyte activation. |
2022-11-14 |
2023-08-14 |
Not clear |
| Rajina Shakya, Gyu Hwan Park, Sang Hoon Joo, Jung-Hyun Shim, Joon-Seok Cho. Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling. Biomolecules & therapeutics. vol 30. issue 6. 2022-10-28. PMID:36305293. |
western blot analysis showed that hydroxyzine-induced apoptosis was through down-regulation of the phosphorylation of jak2 and stat3 by hydroxyzine treatment. |
2022-10-28 |
2023-08-14 |
human |
| Lin Li, Mengxing Zhang, Tiantian Liu, Jing Li, Shili Sun, Junjie Chen, Zhenmi Liu, Zhirong Zhang, Ling Zhan. Quercetin-ferrum nanoparticles enhance photothermal therapy by modulating the tumor immunosuppressive microenvironment. Acta biomaterialia. 2022-10-15. PMID:36243377. |
the released quercetin from qfn could reduce programmed death ligand 1 (pd-l1) in tumor cells by inhibiting the phosphorylation of jak2 and stat3, and reshape extracellular matrix (ecm) by down-regulating α-sma |
2022-10-15 |
2023-08-14 |
Not clear |
| Shuzhen Liu, Dongmei Yu, Peng Wei, Jiansheng Cai, Min Xu, Haoyu He, Xu Tang, Chuntao Nong, Yi Wei, Xia Xu, Xiaoting Mo, Zhiyong Zhang, Jian Qi. JAK2/STAT3 Signaling Pathway and Klotho Gene in Cadmium-induced Neurotoxicity In Vitro and In Vivo. Biological trace element research. 2022-09-27. PMID:36166115. |
in comparison with the high-dose cd exposure group, after adding tyrphostin ag490 (ag490), the apoptosis rate of pc12 cells increased, whereas the phosphorylation levels of jak2 and stat3 in the cells decreased significantly (p < 0.05). |
2022-09-27 |
2023-08-14 |
rat |
| Yue Xie, Zhao-Wei Zheng, Hao-Ting He, Zhi-Bo Chan. LncRNA NEAT1 induces autophagy through the miR-128-3p/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer. The Kaohsiung journal of medical sciences. 2022-09-02. PMID:36054559. |
furthermore, adam28 overexpression attenuated mir-128-3p overexpression-induced apoptosis and autophagy inhibition in nsclc by increasing the phosphorylation of jak2 and stat3. |
2022-09-02 |
2023-08-14 |
mouse |
| Ahlam G Khalifa, Walaa A Moselhy, Hanaa M Mohammed, Fatma Khalil, Mohamed Shaban, El-Shaymaa El-Nahass, Hessah Mohammed Al-Muzafar, Kamal Adel Amin, Khaled A Abdo. Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway. Toxics. vol 10. issue 6. 2022-06-23. PMID:35736911. |
in addition, brain antioxidant/oxidant, serum neurotransmitters such as acetylcholine esterase (ache) and monoamine oxidase (mao), jak2 and stat3 gene and proteins expression were measured. |
2022-06-23 |
2023-08-14 |
rat |
| Shun Wang, Aihua Yu, Mengyao Han, Xiaomin Chen, Zhi Li, Min Ke, Xiaojun Cai, Ming Ai, Yiqiao Xin. Pathological Changes and Expression of JAK-STAT Signaling Pathway Hallmark Proteins in Rat Retinas at Different Time Points After Retinal Ischemia Reperfusion Injury. Pathology oncology research : POR. vol 28. 2022-05-06. PMID:35515015. |
immunohistochemistry showed that jak2, stat3, p-jak2, p-stat3, bax, and bcl-2 proteins mainly located in ganglion cell layer and inner nuclear layer, the relative expression of former five proteins had significant differences vs. control group ( |
2022-05-06 |
2023-08-13 |
rat |
| Futoon Abedrabbu Al-Rawashde, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Hamid Ali Nagi Al-Jama. Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 12. 2021-12-30. PMID:34967577. |
the present study aimed to evaluate the effect of tq on the expression of bcr abl, jak2, stat3, stat5a and stat5b genes and their consequences on the cell proliferation and apoptosis in k562 cml cells. |
2021-12-30 |
2023-08-13 |
Not clear |