| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giorgia Targa, Francesca Mottarlini, Beatrice Rizzi, Sofia Taddini, Susanna Parolaro, Fabio Fumagalli, Lucia Caffin. Anorexia-Induced Hypoleptinemia Drives Adaptations in the JAK2/STAT3 Pathway in the Ventral and Dorsal Hippocampus of Female Rats. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674862. |
however, it remains unknown how leptin receptor (lepr) and its jak2-stat3 downstream pathway in extrahypothalamic brain areas, such as the dorsal (dhip) and ventral (vhip) hippocampus, crucial for spatial memory and emotion regulation, may contribute to the maintenance of an behaviors. |
2024-04-27 |
2024-04-29 |
rat |
| Lamia M Hafez, Hebatallah Mohammed Aboudeya, Noura A Matar, Ashraf S El-Sebeay, Azhar Mohamed Nomair, Shaymaa Ali El-Hamshary, Hanan Mohamed Nomeir, Fawziya A R Ibrahi. Ameliorative effects of zinc supplementation on cognitive function and hippocampal leptin signaling pathway in obese male and female rats. Scientific reports. vol 13. issue 1. 2023-03-28. PMID:36977735. |
additionally, downregulated expression of leptin receptor (lepr) gene and increased levels of activated signal transducer and activator of transcription 3 (p-stat3) that observed in hippocampal tissues of obese rats were successfully normalized by both doses of zn. |
2023-03-28 |
2023-08-14 |
rat |
| Vilasagaram Srinivas, Saikanth Varma, Suryam Reddy Kona, Ahamed Ibrahim, Asim K Duttaroy, Sanjay Basa. Dietary omega-3 fatty acid deficiency from pre-pregnancy to lactation affects expression of genes involved in hippocampal neurogenesis of the offspring. Prostaglandins, leukotrienes, and essential fatty acids. vol 191. 2023-03-16. PMID:36924605. |
the n-3 pufa deficient mice exhibited upregulation of fads1, fads2, elovl2, elovl5, elovl6, gpr40, gpr120, lepr, igf1 and downregulation of glut1, glut3, and glut4 mrna expression in hippocampus (p<0.05). |
2023-03-16 |
2023-08-14 |
mouse |
| V Naranjo, Beatriz Merino, N Del Olmo, L M Frago, J A Chowen, M Ruiz-Gayo, Victoria Cano Gonzále. Effect of a high-fat diet and leptin on STAT3 phosphorylation in hippocampal astrocytes. Neuroreport. vol 34. issue 1. 2022-12-12. PMID:36504039. |
the aim of the current study was to evaluate the influence of hfd on the functionality of lepr by quantifying phosphorylated levels of 705tyr-stat3 in hippocampus astrocytes from mice that consumed an hfd either during the juvenile or the adult period. |
2022-12-12 |
2023-08-14 |
mouse |
| Jesús Fernández-Felipe, Lucía L López, Victoria Cano, Enrique Sánchez-Hita, A Belén Sanz, Julie A Chowen, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merin. Regional specific effect of saturated vs unsaturated fat on leptin receptor signalling in mice brain areas regulating feeding. Neuroscience letters. 2022-12-08. PMID:36481371. |
the current study aims at investigating the effect of foods high in either saturated (solf) or monounsaturated fat (uolf) on lepr functionality in the hippocampus and the prefrontal cortex. |
2022-12-08 |
2023-08-14 |
mouse |
| Jesús Fernández-Felipe, Lucía L López, Victoria Cano, Enrique Sánchez-Hita, A Belén Sanz, Julie A Chowen, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merin. Regional specific effect of saturated vs unsaturated fat on leptin receptor signalling in mice brain areas regulating feeding. Neuroscience letters. 2022-12-08. PMID:36481371. |
our results show that solf and uolf differently affect lepr signalling within the hippocampus and the prefrontal cortex, which points to the complex effect of saturated and unsaturated fat on brain function, particularly in areas regulating food intake. |
2022-12-08 |
2023-08-14 |
mouse |
| Jesús Fernández-Felipe, Lucía L López, Victoria Cano, Enrique Sánchez-Hita, A Belén Sanz, Julie A Chowen, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merin. Regional specific effect of saturated vs unsaturated fat on leptin receptor signalling in mice brain areas regulating feeding. Neuroscience letters. 2022-12-08. PMID:36481371. |
leptin receptors (lepr) are expressed in brain areas controlling food intake homeostasis, such as the hypothalamus, the hippocampus and the prefrontal cortex. |
2022-12-08 |
2023-08-14 |
mouse |
| Kiyomi Nakagawa, Saiful Islam, Masashi Ueda, Toshiyuki Nakagaw. Endoplasmic reticulum stress contributes to the decline in doublecortin expression in the immature neurons of mice with long-term obesity. Scientific reports. vol 12. issue 1. 2022-01-20. PMID:35046482. |
here, we show that endoplasmic reticulum (er) stress was activated in the hippocampus and processes of dcx-expressing immature neurons were shortened, coexpressing chop in app23 ad model mice with high-fat diet-induced long-term obesity and in aged lepr |
2022-01-20 |
2023-08-13 |
mouse |
| Caroline D David, Brianna N Wyrosdic, HoYin Wan, Hannah E Lapp, Andrew A Bartlett, Shewit Yitbarek, Jin Ho Par. B6D2F1 mice that retain sexual behavior long term after castration outperform those that cease in the radial arm maze. Psychoneuroendocrinology. vol 136. 2021-12-19. PMID:34923212. |
uniquely among maters, increased relative expression of d2r and lepr in the hippocampus was associated with a longer latency to complete the maze during the last 3 or across all trials, respectively. |
2021-12-19 |
2023-08-13 |
mouse |
| Víctor Naranjo, Ana Contreras, Beatriz Merino, Adrián Plaza, María P Lorenzo, Cristina García-Cáceres, Antonia García, Julie A Chowen, Mariano Ruiz-Gayo, Nuria Del Olmo, Victoria Can. Specific Deletion of the Astrocyte Leptin Receptor Induces Changes in Hippocampus Glutamate Metabolism, Synaptic Transmission and Plasticity. Neuroscience. vol 447. 2021-05-14. PMID:31705891. |
the aim of this study was to indentify the involvement of leptin receptors (lepr) in astrocytes in hippocampal synaptic transmission and plasticity and metabolism. |
2021-05-14 |
2023-08-13 |
mouse |
| K A Glendining, M B A Higgins, L C Fisher, C L Jason. Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32173454. |
maternal diet did not alter hippocampal insr in the fetal brain, or lepr or insr in prefrontal cortex, amygdala, or hypothalamus of female or male offspring. |
2021-04-27 |
2023-08-13 |
mouse |
| K A Glendining, M B A Higgins, L C Fisher, C L Jason. Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32173454. |
sex-specific deregulation of lepr could be reproduced in vitro by exposing female hippocampal neurons to the obesity related proinflammatory cytokine il-6, but not il-17a or ifng. |
2021-04-27 |
2023-08-13 |
mouse |
| K A Glendining, M B A Higgins, L C Fisher, C L Jason. Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32173454. |
we found a significant effect of maternal diet and offspring sex on lepr regulation in the developing hippocampus, with increased lepr expression in female mhfd offspring (p < 0.05) compared to controls. |
2021-04-27 |
2023-08-13 |
mouse |
| K A Glendining, M B A Higgins, L C Fisher, C L Jason. Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32173454. |
our findings indicate that the obesity-related proinflammatory cytokine il-6 during pregnancy leads to sexually dimorphic changes in the modifications of histones binding at the lepr gene promoter, and concomitant changes to lepr transcription in the developing hippocampus. |
2021-04-27 |
2023-08-13 |
mouse |
| K A Glendining, M B A Higgins, L C Fisher, C L Jason. Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32173454. |
chromatin immunoprecipitation revealed decreased binding of histones possessing the repressive histone mark h3k9me3 at the lepr promoter (p < 0.05) in hippocampus of female mhfd offspring compared to controls, but not in males. |
2021-04-27 |
2023-08-13 |
mouse |
| Yu-Hui You, Zhi-Qiang Qin, Huan-Li Zhang, Zhao-Hong Yuan, Xin Y. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Bioscience reports. vol 39. issue 6. 2020-08-07. PMID:30975733. |
therefore, we evaluate the ability of mir-153 to influence brain-derived neurotrophic factor (bdnf) of autism as well as proliferation and apoptosis of hippocampal neuron through the janus kinase-signal transducer and activator of transcription (jak-stat) signaling pathway by targeting leptin receptor (lepr). |
2020-08-07 |
2023-08-13 |
mouse |
| Yu-Hui You, Zhi-Qiang Qin, Huan-Li Zhang, Zhao-Hong Yuan, Xin Y. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Bioscience reports. vol 39. issue 6. 2020-08-07. PMID:30975733. |
in conclusion, the high expression of mir-153 can inhibit activation of jak-stat signaling pathway by lepr, thus improving bdnf expression and the proliferative ability of hippocampal neurons. |
2020-08-07 |
2023-08-13 |
mouse |
| Yu-Hui You, Zhi-Qiang Qin, Huan-Li Zhang, Zhao-Hong Yuan, Xin Y. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Bioscience reports. vol 39. issue 6. 2020-08-07. PMID:30975733. |
microrna-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of jak-stat pathway by lepr. |
2020-08-07 |
2023-08-13 |
mouse |
| Yu-Hui You, Zhi-Qiang Qin, Huan-Li Zhang, Zhao-Hong Yuan, Xin Y. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Bioscience reports. vol 39. issue 6. 2020-08-07. PMID:30975733. |
besides, in vitro experiments were conducted with the transfection of different mimic, inhibitor, or sirna into the hippocampal neuron cells, after which the effect of mir-153 on lepr and the jak-stat signaling pathway-related factors was investigated. |
2020-08-07 |
2023-08-13 |
mouse |
| Zachary A Cordner, Seva G Khambadkone, Gretha J Boersma, Lin Song, Tyler N Summers, Timothy H Moran, Kellie L K Tamashir. Maternal high-fat diet results in cognitive impairment and hippocampal gene expression changes in rat offspring. Experimental neurology. vol 318. 2020-03-02. PMID:31051155. |
in hippocampus, we found decreased expression of insr, lepr, and slc2a1 (glut1) among offspring of high-fat fed dams at postnatal day 21. |
2020-03-02 |
2023-08-13 |
rat |