| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Andrés García-Loredo, Michelle G Santoyo-Suarez, Oscar Rodríguez-Nuñez, Diego Francisco Benitez Chao, Elsa N Garza-Treviño, Patricio Adrián Zapata-Morin, Gerardo R Padilla-Rivas, Jose Francisco Isla. Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors. Life (Basel, Switzerland). vol 14. issue 4. 2024-04-27. PMID:38672763. |
our analysis reveals klf's interactions with gata4, mef2c, nkx2.5 and other ~90 potential genes that participate in the regulation of the hypertrophic environment (or cvds' environment). |
2024-04-27 |
2024-04-29 |
Not clear |
| Wardah Abdullah Alasmari, Somaya Hosny, Hanan Fouad, Khalid Al Quthami, Essa Abdulaziz Mohammed Althobiany, Eman Mohamed Faru. Molecular and cellular mechanisms involved in mesenchymal stem cells derived exosomes and adipose tissue stem cells therapy of an experimental model of cardio-renal syndrome type 3: Histological and biochemical study. Tissue & cell. vol 77. 2022-06-14. PMID:35700665. |
the effects of adscs-evs and adscs against induced crsiii were evaluated by both renal and cardiac oxidant/antioxidant biomarkers, renal function, and mrna gene expression quantitation for atrial natriuretic peptide (anp), p300, and myocyte enhancer factor 2 (mef2c and mef2a), as well as myocardin (myocd), as molecules associated with cardiac hypertrophy. |
2022-06-14 |
2023-08-14 |
rat |
| Svitlana Melnik, Jessica Gabler, Simon I Dreher, Nicole Hecht, Nina Hofmann, Tobias Großner, Wiltrud Richte. MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1. Stem cell research & therapy. vol 11. issue 1. 2021-06-18. PMID:33303006. |
mir-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting runx2, mef2c, and col10a1. |
2021-06-18 |
2023-08-13 |
human |
| J Roque-Jorge, S Hernández-Gutiérrez, G Díaz-Rosas, A J García-Chequer, A López-Torres, A Contreras-Ramo. Data on sodium tetraborate as a modulation of hypertrophic intracellular signals. Data in brief. vol 35. 2021-04-16. PMID:33850976. |
the expression of transcription factors linked to hypertrophy such as gata-4, mef2c, nfat, cdk9, and myogenin was also quantified by immunofluorescence. |
2021-04-16 |
2023-08-13 |
Not clear |
| Riko Nishimura, Kenji Hata, Yoshifumi Takahata, Tomohiko Murakami, Eriko Nakamura, Hiroko Yag. Regulation of Cartilage Development and Diseases by Transcription Factors. Journal of bone metabolism. vol 24. issue 3. 2020-09-30. PMID:28955690. |
in addition, myocyte-enhancer factor 2c (mef2c) is required for initiation of chondrocyte hypertrophy, presumably by functioning upstream of runx2. |
2020-09-30 |
2023-08-13 |
Not clear |
| Simon I Dreher, Jennifer Fischer, Tilman Walker, Solvig Diederichs, Wiltrud Richte. Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32195247. |
transcription factors runx2, runx3, and mef2c play prominent roles for chondrocyte hypertrophy during mouse development, but little is known on the importance of these key fate-determining factors for endochondral development of human mpcs. |
2020-09-28 |
2023-08-13 |
mouse |
| Simon I Dreher, Jennifer Fischer, Tilman Walker, Solvig Diederichs, Wiltrud Richte. Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32195247. |
the aim of this study was to unravel the regulation of runx2, runx3, and mef2c during mpc chondrogenesis, the pathways driving their expression, and the downstream hypertrophic targets affected by their regulation. |
2020-09-28 |
2023-08-13 |
mouse |
| Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Alfred Gugerell, Dominika Lukovic, Johannes Winkler, Julia Mester-Tonczar, Bruno Podesser, Mariann Gyöngyös. MiR-21, MiR-29a, GATA4, and MEF2c Expression Changes in Endothelin-1 and Angiotensin II Cardiac Hypertrophy Stimulated Isl-1 Cells. vol 8. issue 11. 2020-07-06. PMID:31717562. |
mir-21, mir-29a, gata4, and mef2c expression changes in endothelin-1 and angiotensin ii cardiac hypertrophy stimulated isl-1 cost- and time-intensive porcine translational disease models offer great opportunities to test drugs and therapies for pathological cardiac hypertrophy and can be supported by porcine cell culture models that provide further insights into basic disease mechanisms. |
2020-07-06 |
2023-08-13 |
Not clear |
| Solvig Diederichs, Veronika Tonnier, Melanie März, Simon I Dreher, Andreas Geisbüsch, Wiltrud Richte. Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy. Cellular and molecular life sciences : CMLS. vol 76. issue 19. 2019-10-17. PMID:30980110. |
along with the pro-hypertrophic transcription factor mef2c, multiple hypertrophic downstream targets including ibsp and alkaline phosphatase activity were reduced by iwp-2, demonstrating that wnt activity drives bmp and hedgehog upregulation, and msc hypertrophy. |
2019-10-17 |
2023-08-13 |
human |
| Chun-Mei Tang, Fang-Zhou Liu, Jie-Ning Zhu, Yong-Heng Fu, Qiu-Xiong Lin, Chun-Yu Deng, Zhi-Qin Hu, Hui Yang, Xi-Long Zheng, Jian-Ding Cheng, Shu-Lin Wu, Zhi-Xin Sha. Myocyte-specific enhancer factor 2C: a novel target gene of miR-214-3p in suppressing angiotensin II-induced cardiomyocyte hypertrophy. Scientific reports. vol 6. 2018-05-14. PMID:27796324. |
myocyte-specific enhancer factor 2c (mef2c), which was increased in ang-ii-induced hypertrophic mouse myocardium and cardiomyocytes, was identified as a target gene of mir-214-3p. |
2018-05-14 |
2023-08-13 |
mouse |
| Chun-Mei Tang, Fang-Zhou Liu, Jie-Ning Zhu, Yong-Heng Fu, Qiu-Xiong Lin, Chun-Yu Deng, Zhi-Qin Hu, Hui Yang, Xi-Long Zheng, Jian-Ding Cheng, Shu-Lin Wu, Zhi-Xin Sha. Myocyte-specific enhancer factor 2C: a novel target gene of miR-214-3p in suppressing angiotensin II-induced cardiomyocyte hypertrophy. Scientific reports. vol 6. 2018-05-14. PMID:27796324. |
taken together, our results revealed that mef2c is a novel target of mir-214-3p, and attenuation of mir-214-3p expression may contribute to mef2cexpressionin cardiac hypertrophy. |
2018-05-14 |
2023-08-13 |
mouse |
| Jennifer Fischer, Marlen Ortel, Sebastien Hagmann, Andreas Hoeflich, Wiltrud Richte. Role of PTHrP(1-34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis. Journal of cellular physiology. vol 231. issue 12. 2017-05-01. PMID:27548511. |
pulse duration was critically important to significantly reduce ihh expression, but irrelevant for pthrp-induced suppression of the hypertrophic markers mef2c and ibsp. |
2017-05-01 |
2023-08-13 |
human |
| Chao Li, Kent Vu, Krystina Hazelgrove, John F Kuemmerl. Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn's disease and smooth muscle hypertrophy. American journal of physiology. Gastrointestinal and liver physiology. vol 309. issue 11. 2016-03-29. PMID:26428636. |
erk5 inhibition or mef2c sirna blocked smooth muscle-specific gene expression and hypertrophy induced by synthetic mgf. |
2016-03-29 |
2023-08-13 |
Not clear |
| Varun Kesherwani, Shyam Sundar Nandi, Surender K Sharawat, Hamid R Shahshahan, Paras Kumar Mishr. Hydrogen sulfide mitigates homocysteine-mediated pathological remodeling by inducing miR-133a in cardiomyocytes. Molecular and cellular biochemistry. vol 404. issue 1-2. 2016-01-25. PMID:25763715. |
to test the hypothesis, hl1 cardiomyocytes were treated with (1) plain medium (control, ct), (2) 100 µm of homocysteine (hcy), (3) hcy with 30 µm of h2s (hcy + h2s), and (4) h2s for 24 h. the levels of hypertrophy markers: c-fos, atrial natriuretic peptide (anp), and beta-myosin heavy chain (β-mhc), mir-133a, and its transcriptional inducer myosin enhancer factor-2c (mef2c) were determined by western blotting, rt-qpcr, and immunofluorescence. |
2016-01-25 |
2023-08-13 |
Not clear |
| Varun Kesherwani, Shyam Sundar Nandi, Surender K Sharawat, Hamid R Shahshahan, Paras Kumar Mishr. Hydrogen sulfide mitigates homocysteine-mediated pathological remodeling by inducing miR-133a in cardiomyocytes. Molecular and cellular biochemistry. vol 404. issue 1-2. 2016-01-25. PMID:25763715. |
these findings elicit that hhcy induces cardiac hypertrophy by promoting mef2c-hdac1 complex formation that inactivates mef2c causing suppression of anti-hypertrophy mir-133a in cardiomyocytes. |
2016-01-25 |
2023-08-13 |
Not clear |
| Varun Kesherwani, Shyam Sundar Nandi, Surender K Sharawat, Hamid R Shahshahan, Paras Kumar Mishr. Hydrogen sulfide mitigates homocysteine-mediated pathological remodeling by inducing miR-133a in cardiomyocytes. Molecular and cellular biochemistry. vol 404. issue 1-2. 2016-01-25. PMID:25763715. |
h2s mitigates hypertrophy by inducing mir-133a through activation of mef2c in hhcy cardiomyocytes. |
2016-01-25 |
2023-08-13 |
Not clear |
| Varun Kesherwani, Shyam Sundar Nandi, Surender K Sharawat, Hamid R Shahshahan, Paras Kumar Mishr. Hydrogen sulfide mitigates homocysteine-mediated pathological remodeling by inducing miR-133a in cardiomyocytes. Molecular and cellular biochemistry. vol 404. issue 1-2. 2016-01-25. PMID:25763715. |
to our knowledge, this is a novel mechanism of h2s-mediated activation of mef2c and induction of mir-133a and inhibition of hypertrophy in hhcy cardiomyocytes. |
2016-01-25 |
2023-08-13 |
Not clear |
| Xiefan Fang, Jourdon Robinson, John Wang-Hu, Lingli Jiang, Daniel A Freeman, Scott A Rivkees, Christopher C Wendle. cAMP induces hypertrophy and alters DNA methylation in HL-1 cardiomyocytes. American journal of physiology. Cell physiology. vol 309. issue 6. 2015-12-04. PMID:26224577. |
elevated camp levels increased cell size and altered expression levels of cardiac genes and micro-rnas associated with hypertrophic cardiomyopathy (hcm), including myh6, myh7, myh7b, tnni3, anp, bnp, gata4, mef2c, mef2d, nfatc1, mir208a, and mir208b. |
2015-12-04 |
2023-08-13 |
mouse |
| Vicente Castro, Barbara Grisdale-Helland, Ståle J Helland, Jacob Torgersen, Torstein Kristensen, Guy Claireaux, Anthony P Farrell, Harald Takl. Cardiac molecular-acclimation mechanisms in response to swimming-induced exercise in Atlantic salmon. PloS one. vol 8. issue 1. 2013-07-26. PMID:23372811. |
higher protein levels of pcna were indicative of cardiac growth being driven by cardiomyocyte hyperplasia, while elevated cardiac mrna levels of mef2c, gata4 and acta1 suggested cardiomyocyte hypertrophy. |
2013-07-26 |
2023-08-12 |
Not clear |
| Cristina Alonso-Montes, Manuel Naves-Diaz, Jose Luis Fernandez-Martin, Julian Rodriguez-Reguero, Cesar Moris, Eliecer Coto, Jorge B Cannata-Andia, Isabel Rodrigue. New polymorphisms in human MEF2C gene as potential modifier of hypertrophic cardiomyopathy. Molecular biology reports. vol 39. issue 9. 2012-12-14. PMID:22718505. |
new polymorphisms in human mef2c gene as potential modifier of hypertrophic cardiomyopathy. |
2012-12-14 |
2023-08-12 |
human |